One-pot Synthesis of 2,4,5-trisubstituted Imidazoles Catalyzed by Lipase

A simple and efficient protocol of synthesizing 2,4,5-trisubstituted imidazoles has been developed using lipase as a novel catalyst under mild conditions. A series of imidazole derivatives were synthesized with good yields. The probable enzymatic mechanism was proposed. This method expands the catalytic scope of lipase and provides a novel method to prepare imidazole derivatives.