The Role of Homocysteine-Lowering B-Vitamins in the Primary Prevention of Cardiovascular Disease

A multi-center, open label, crossover designed prospective study evaluating the effects of lipid lowering treatment on steroid synthesis in patients with Type 2 diabetes (MODEST Study)

(2014) M. Kanat et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Emerging Risk Factors for Coronary Heart Disease: A Summary of Systematic Reviews Conducted for the U.S. Preventive Services Task Force

(2013) Mark Helfand et al.   ANNALS OF INTERNAL MEDICINE

Vitamin B supplementation, homocysteine levels, and the risk of cerebrovascular disease: A meta-analysis

(2013) Y. Ji et al.   NEUROLOGY

Increased endogenous H2S generation by CBS, CSE, and 3MST gene therapy improves ex vivo renovascular relaxation in hyperhomocysteinemia

(2012) Utpal Sen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Statins use and coronary artery plaque composition: Results from the International Multicenter CONFIRM Registry

(2012) Ryo Nakazato et al.   ATHEROSCLEROSIS

Progression of Vascular Calcification Is Increased With Statin Use in the Veterans Affairs Diabetes Trial (VADT)

(2012) A. Saremi et al.   DIABETES CARE

Statin Myopathy: Significant Problem With Minimal Awareness by Clinicians and no Emphasis by Clinical Investigators

(2011) Thomas F. Whayne   ANGIOLOGY

Effect of folic acid supplementation on the progression of carotid intima-media thickness: A meta-analysis of randomized controlled trials

(2011) Xianhui Qin et al.   ATHEROSCLEROSIS

PLP-dependent H2S biogenesis

(2011) Sangita Singh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Why Do Homocysteine-Lowering B Vitamin and Antioxidant E Vitamin Supplementations Appear To Be Ineffective in the Prevention of Cardiovascular Diseases?

(2011) Balazs Debreceni et al.   Cardiovascular Therapeutics

Homocysteine-Lowering and Cardiovascular Disease Outcomes in Kidney Transplant Recipients

(2011) Andrew G. Bostom et al.   CIRCULATION

Hydrogen Sulfide as Endothelium-Derived Hyperpolarizing Factor Sulfhydrates Potassium Channels

(2011) Asif K. Mustafa et al.   CIRCULATION RESEARCH

Are statins diabetogenic?

(2011) Uchechukwu K Sampson et al.   CURRENT OPINION IN CARDIOLOGY

Understanding the Complexity of Homocysteine Lowering With Vitamins

(2011) J. David Spence et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Homocysteine and Reclassification of Cardiovascular Disease Risk

(2011) Vikas Veeranna et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Hydrogen Sulfide Protects against Chemical Hypoxia-Induced Injury by Inhibiting ROS-Activated ERK1/2 and p38MAPK Signaling Pathways in PC12 Cells

(2011) Aiping Lan et al.   PLoS One

Multivitamin use and the risk of myocardial infarction: a population-based cohort of Swedish women

(2010) Susanne Rautiainen et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Homocysteine impairs coronary artery endothelial function by inhibiting tetrahydrobiopterin in patients with hyperhomocysteinemia

(2010) Liyun He et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Folic acid mitigated cardiac dysfunction by normalizing the levels of tissue inhibitor of metalloproteinase and homocysteine-metabolizing enzymes postmyocardial infarction in mice

(2010) Natia Qipshidze et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Vascular complications of cystathionine β-synthase deficiency: future directions for homocysteine-to-hydrogen sulfide research

(2010) Richard S. Beard et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mechanisms of Cardiovascular Remodeling in Hyperhomocysteinemia

(2010) Mesia M. Steed et al.   ANTIOXIDANTS & REDOX SIGNALING

Statins and All-Cause Mortality in High-Risk Primary Prevention

(2010) Kausik K. Ray   ARCHIVES OF INTERNAL MEDICINE

Hydrogen sulphide and angiogenesis: mechanisms and applications

(2010) Csaba Szabó et al.   BRITISH JOURNAL OF PHARMACOLOGY

Homocysteine Induces Oxidative–Nitrative Stress in Heart of Rats: Prevention by Folic Acid

(2010) Janaína Kolling et al.   Cardiovascular Toxicology

B Vitamins and the Risk of Total Mortality and Cardiovascular Disease in End-Stage Renal Disease

(2010) Judith Heinz et al.   CIRCULATION

Folic Acid Therapy and Cardiovascular Disease in ESRD or Advanced Chronic Kidney Disease: A Meta-Analysis

(2010) X. Qin et al.   Clinical Journal of the American Society of Nephrology

Pathogenetic role of eNOS uncoupling in cardiopulmonary disorders

(2010) Jan F. Gielis et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effect of B-Vitamin Therapy on Progression of Diabetic Nephropathy

(2010) Andrew A. House et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Effects of Homocysteine-Lowering With Folic Acid Plus Vitamin B12vs Placebo on Mortality and Major Morbidity in Myocardial Infarction Survivors

(2010)   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The homocysteine controversy

(2010) Yvo M. Smulders et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Inhibition of Endogenous Hydrogen Sulfide Generation is Associated with Homocysteine-Induced Neurotoxicity: Role of ERK1/2 Activation

(2010) Xiao-Qing Tang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The Effect of Statin Therapy on Testosterone Levels in Subjects Consulting for Erectile Dysfunction

(2010) Giovanni Corona et al.   Journal of Sexual Medicine

B vitamins in patients with recent transient ischaemic attack or stroke in the VITAmins TO Prevent Stroke (VITATOPS) trial: a randomised, double-blind, parallel, placebo-controlled trial

(2010)   LANCET NEUROLOGY

Stroke in Early Childhood Due to Homocystinuria

(2010) Füsun Alehan et al.   PEDIATRIC NEUROLOGY

Efficacy of Homocysteine-Lowering Therapy With Folic Acid in Stroke Prevention

(2010) Meng Lee et al.   STROKE

Statin Adverse Effects

(2009) Beatrice A Golomb et al.   American Journal of Cardiovascular Drugs

Statin Therapy Decreases Myocardial Function as Evaluated Via Strain Imaging

(2009) Jack Rubinstein et al.   CLINICAL CARDIOLOGY

The effect of folic acid supplementation on carotid intima-media thickness in patients with cardiovascular risk: A randomized, placebo-controlled trial

(2009) George Ntaios et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Homocysteine Level and Coronary Heart Disease Incidence: A Systematic Review and Meta-analysis

(2009) Linda L. Humphrey et al.   MAYO CLINIC PROCEEDINGS

Low folate levels may be an atherogenic factor regardless of homocysteine levels in young healthy nonsmokers

(2009) Akiko Imamura et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Statin-Associated Adverse Cognitive Effects: Survey Results from 171 Patients

(2009) Marcella A Evans et al.   PHARMACOTHERAPY

High-Dose B Vitamin Supplementation and Progression of Subclinical Atherosclerosis

(2009) Howard N. Hodis et al.   STROKE

Homocysteine-Lowering Therapy and Stroke Risk, Severity, and Disability

(2009) Gustavo Saposnik et al.   STROKE

Folate, Vitamin B6, Vitamin B12, and Methionine Intakes and Risk of Stroke Subtypes in Male Smokers

(2008) S. C. Larsson et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Mechanisms and potential therapeutic targets for folic acid in cardiovascular disease

(2008) An L. Moens et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

High-Dose Folic Acid Pretreatment Blunts Cardiac Dysfunction During Ischemia Coupled to Maintenance of High-Energy Phosphates and Reduces Postreperfusion Injury

(2008) An L. Moens et al.   CIRCULATION

Homocysteine and coronary atherosclerosis: from folate fortification to the recent clinical trials

(2008) C. Antoniades et al.   EUROPEAN HEART JOURNAL

Effect of Folic Acid and B Vitamins on Risk of Cardiovascular Events and Total Mortality Among Women at High Risk for Cardiovascular Disease

(2008) Christine M. Albert et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Mortality and Cardiovascular Events in Patients Treated With Homocysteine-Lowering B Vitamins After Coronary Angiography

(2008) Marta Ebbing et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The administration of folic acid reduces intravascular oxidative stress in diabetic rabbits

(2008) Nilima Shukla et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

A cost-effectiveness analysis of folic acid fortification policy in the United States

(2008) Tanya GK Bentley et al.   PUBLIC HEALTH NUTRITION

Correlations between plasma homocysteine and folate concentrations and carotid atherosclerosis in high-risk individuals: baseline data from the Homocysteine and Atherosclerosis Reduction Trial (HART)

(2008) Claes Held et al.   VASCULAR MEDICINE