Ranolazine prevents INaL enhancement and blunts myocardial remodelling in a model of pulmonary hypertension

Inhibition of the late sodium current slows t-tubule disruption during the progression of hypertensive heart disease in the rat

(2013) Gary L. Aistrup et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Antiarrhythmic effects of the highly selective late sodium channel current blocker GS-458967

(2013) Serge Sicouri et al.   HEART RHYTHM

Cardiac arrhythmia mechanisms in rats with heart failure induced by pulmonary hypertension

(2012) David Benoist et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Effects of Ranolazine on Vasomotor Responses of Rat Aortic Rings

(2012) Ma. Cristina Paredes-Carbajal et al.   ARCHIVES OF MEDICAL RESEARCH

The Late Na+ Current - Origin and Pathophysiological Relevance

(2012) Antonio Zaza et al.   CARDIOVASCULAR DRUGS AND THERAPY

Effect of ranolazine on rat intrarenal arteries in vitro

(2012) Chun-Yu Deng et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Electrophysiologic Remodeling of the Left Ventricle in Pressure Overload-Induced Right Ventricular Failure

(2012) Maxim Hardziyenka et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Extreme sarcoplasmic reticulum volume loss and compensatory T-tubule remodeling after Serca2 knockout

(2012) F. Swift et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arrhythmogenic substrate in hearts of rats with monocrotaline-induced pulmonary hypertension and right ventricular hypertrophy

(2011) David Benoist et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Pathophysiology of the cardiac late Na current and its potential as a drug target

(2011) Jonathan D. Moreno et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Therapeutic inhibition of fatty acid oxidation in right ventricular hypertrophy: exploiting Randle’s cycle

(2011) Yong-Hu Fang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Block of Tetrodotoxin-sensitive, Nav1.7, and Tetrodotoxin-resistant, Nav1.8, Na+channels by Ranolazine

(2010) Sridharan Rajamani et al.   Channels

There Goes the Neighborhood: Pathological Alterations in T-Tubule Morphology and Consequences for Cardiomyocyte Handling

(2010) William E. Louch et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Spontaneous Ca waves in ventricular myocytes from failing hearts depend on Ca2+-calmodulin-dependent protein kinase II

(2010) Jerry Curran et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure

(2009) Kurt R. Stenmark et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Time course and mechanisms of left ventricular systolic and diastolic dysfunction in monocrotaline-induced pulmonary hypertension

(2009) Jorge Correia-Pinto et al.   BASIC RESEARCH IN CARDIOLOGY

A Novel Mechanism for the Treatment of Angina, Arrhythmias, and Diastolic Dysfunction: Inhibition of Late INa Using Ranolazine

(2009) Lars S Maier   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Ranolazine combined with enalapril or metoprolol prevents progressive LV dysfunction and remodeling in dogs with moderate heart failure

(2008) Sharad Rastogi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Emerging Concepts and Translational Priorities in Pulmonary Arterial Hypertension

(2008) Evangelos D. Michelakis et al.   CIRCULATION

Pathophysiology and pharmacology of the cardiac “late sodium current”

(2008) Antonio Zaza et al.   PHARMACOLOGY & THERAPEUTICS