Alterations in T-tubule and dyad structure in heart disease: challenges and opportunities for computational analyses

Can the Sodium-Calcium Exchanger Initiate or Suppress Calcium Sparks in Cardiac Myocytes?

(2012) Daisuke Sato et al.   BIOPHYSICAL JOURNAL

Ultrastructural remodelling of Ca2+ signalling apparatus in failing heart cells

(2012) Hao-Di Wu et al.   CARDIOVASCULAR RESEARCH

Subcellular Structures and Function of Myocytes Impaired During Heart Failure Are Restored by Cardiac Resynchronization Therapy

(2012) Frank B. Sachse et al.   CIRCULATION RESEARCH

Ryanodine Receptor Current Amplitude Controls Ca 2+ Sparks in Cardiac Muscle

(2012) Tao Guo et al.   CIRCULATION RESEARCH

Mir-24 Regulates Junctophilin-2 Expression in Cardiomyocytes

(2012) Ming Xu et al.   CIRCULATION RESEARCH

Stimulated Emission Depletion Live-Cell Super-Resolution Imaging Shows Proliferative Remodeling of T-Tubule Membrane Structures After Myocardial Infarction

(2012) Eva Wagner et al.   CIRCULATION RESEARCH

Critical role of cardiac t-tubule system for the maintenance of contractile function revealed by a 3D integrated model of cardiomyocytes

(2012) Asuka Hatano et al.   JOURNAL OF BIOMECHANICS

Termination of calcium-induced calcium release by induction decay: An emergent property of stochastic channel gating and molecular scale architecture

(2012) D.R. Laver et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Modelling cardiac calcium sparks in a three-dimensional reconstruction of a calcium release unit

(2012) Johan Hake et al.   JOURNAL OF PHYSIOLOGY-LONDON

Exploiting mathematical models to illuminate electrophysiological variability between individuals

(2012) Amrita X. Sarkar et al.   JOURNAL OF PHYSIOLOGY-LONDON

Extreme sarcoplasmic reticulum volume loss and compensatory T-tubule remodeling after Serca2 knockout

(2012) F. Swift et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modeling Effects of L-Type Ca2+ Current and Na+-Ca2+ Exchanger on Ca2+ Trigger Flux in Rabbit Myocytes with Realistic T-Tubule Geometries

(2012) Peter M. Kekenes-Huskey et al.   Frontiers in Physiology

Calsequestrin 2 and arrhythmias

(2011) Michela Faggioni et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Multiscale Modeling of Calcium Cycling in Cardiac Ventricular Myocyte: Macroscopic Consequences of Microscopic Dyadic Function

(2011) Namit Gaur et al.   BIOPHYSICAL JOURNAL

Dynamics of Calcium Sparks and Calcium Leak in the Heart

(2011) George S.B. Williams et al.   BIOPHYSICAL JOURNAL

How Does Stochastic Ryanodine Receptor-Mediated Ca Leak Fail to Initiate a Ca Spark?

(2011) Daisuke Sato et al.   BIOPHYSICAL JOURNAL

Recovery of cardiac calcium release is controlled by sarcoplasmic reticulum refilling and ryanodine receptor sensitivity

(2011) Hena R. Ramay et al.   CARDIOVASCULAR RESEARCH

Disrupted Junctional Membrane Complexes and Hyperactive Ryanodine Receptors After Acute Junctophilin Knockdown in Mice

(2011) Ralph J. van Oort et al.   CIRCULATION

Dynamic Calcium Movement Inside Cardiac Sarcoplasmic Reticulum During Release

(2011) Eckard Picht et al.   CIRCULATION RESEARCH

Dynamic local changes in sarcoplasmic reticulum calcium: Physiological and pathophysiological roles

(2011) Eric A. Sobie et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Changes in the Organization of Excitation-Contraction Coupling Structures in Failing Human Heart

(2011) David J. Crossman et al.   PLoS One

PI3Ks Maintain the Structural Integrity of T-Tubules in Cardiac Myocytes

(2011) Chia-Yen C. Wu et al.   PLoS One

Subcellular Heterogeneity of Ryanodine Receptor Properties in Ventricular Myocytes with Low T-Tubule Density

(2011) Liesbeth Biesmans et al.   PLoS One

Control of Ca2+ Release by Action Potential Configuration in Normal and Failing Murine Cardiomyocytes

(2010) William E. Louch et al.   BIOPHYSICAL JOURNAL

Predicting Local SR Ca2+ Dynamics during Ca2+ Wave Propagation in Ventricular Myocytes

(2010) Hena R. Ramay et al.   BIOPHYSICAL JOURNAL

T-Tubule Remodeling During Transition From Hypertrophy to Heart Failure

(2010) Sheng Wei et al.   CIRCULATION RESEARCH

Prolonged mechanical unloading affects cardiomyocyte excitation-contraction coupling, transverse-tubule structure, and the cell surface

(2010) Michael Ibrahim et al.   FASEB JOURNAL

There Goes the Neighborhood: Pathological Alterations in T-Tubule Morphology and Consequences for Cardiomyocyte Handling

(2010) William E. Louch et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

The effect of exercise training on transverse tubules in normal, remodeled, and reverse remodeled hearts

(2010) Ole J. Kemi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Na+currents are required for efficient excitation-contraction coupling in rabbit ventricular myocytes: a possible contribution of neuronal Na+channels

(2010) Natalia S. Torres et al.   JOURNAL OF PHYSIOLOGY-LONDON

Cardiac cell modelling: Observations from the heart of the cardiac physiome project

(2010) Martin Fink et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Integrative modeling of the cardiac ventricular myocyte

(2010) Raimond L. Winslow et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Numerical Analysis of Ca2+ Signaling in Rat Ventricular Myocytes with Realistic Transverse-Axial Tubular Geometry and Inhibited Sarcoplasmic Reticulum

(2010) Yuhui Cheng et al.   PLoS Computational Biology

Slowing of cardiomyocyte Ca2+ release and contraction during heart failure progression in postinfarction mice

(2009) Halvor K. Mørk et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Dynamic Interreceptor Coupling Contributes to the Consistent Open Duration of Ryanodine Receptors

(2009) Xin Liang et al.   BIOPHYSICAL JOURNAL

Organization of Ryanodine Receptors, Transverse Tubules, and Sodium-Calcium Exchanger in Rat Myocytes

(2009) Isuru D. Jayasinghe et al.   BIOPHYSICAL JOURNAL

Control and Regulation of Mitochondrial Energetics in an Integrated Model of Cardiomyocyte Function

(2009) Sonia Cortassa et al.   BIOPHYSICAL JOURNAL

Parameter Sensitivity Analysis in Electrophysiological Models Using Multivariable Regression

(2009) Eric A. Sobie   BIOPHYSICAL JOURNAL

The role of mammalian cardiac t-tubules in excitation-contraction coupling: experimental and computational approaches

(2009) Clive H. Orchard et al.   EXPERIMENTAL PHYSIOLOGY

Sarcoplasmic reticulum Ca2+ATPase as a therapeutic target for heart failure

(2009) Larissa Lipskaia et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Optical single-channel resolution imaging of the ryanodine receptor distribution in rat cardiac myocytes

(2009) David Baddeley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of T-tubules and other changes to surface topography in ventricular myocytes from failing human and rat heart

(2009) A. R. Lyon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allosteric Activation of Na+-Ca2+ Exchange by L-Type Ca2+ Current Augments the Trigger Flux for SR Ca2+ Release in Ventricular Myocytes

(2008) Eric A. Sobie et al.   BIOPHYSICAL JOURNAL

Ca2+-Mobility in the Sarcoplasmic Reticulum of Ventricular Myocytes Is Low

(2008) Pawel Swietach et al.   BIOPHYSICAL JOURNAL

Termination of Cardiac Ca 2+ Sparks

(2008) Aleksey V. Zima et al.   CIRCULATION RESEARCH

Remodeling of T-Tubules and Reduced Synchrony of Ca 2+ Release in Myocytes From Chronically Ischemic Myocardium

(2007) Frank R. Heinzel et al.   CIRCULATION RESEARCH

The role of the Na+/Ca2+ exchangers in Ca2+ dynamics in ventricular myocytes

(2007) Anna A. Sher et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY