Article
Immunology
Yuyan Zhou, Ruoxuan Xiang, Guozheng Qin, Baozhen Ji, Shuo Yang, Guodong Wang, Jun Han
Summary: This study found that the xanthone-rich fraction of Securidaca inappendiculata can reduce the severity of collagen-induced arthritis in rats, regulate the polarization of macrophages, and achieve joint protection by inhibiting the NAMPT/glycolysis pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xiaojun Pang, Emmanuel Ayobami Makinde, Fredrick Nwude Eze, Opeyemi Joshua Olatunji
Summary: In this study, SiPE showed significant neuroprotective effects against diabetic encephalopathy in rats. SiPE administration improved cognitive functions, reduced depressive behaviors, and alleviated neuropathic pain in diabetic rats. The mechanism of action involved modulation of oxidative stress and inflammation pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Jian Zuo, Meng-Qing Tao, Xin-Yue Wu, Tian-Tian Jiang, Opeyemi Joshua Olatunji, Jiyang Dong, Jun Han, Cong-Lan Ji
Summary: The bioactive fraction from S. inappendiculata showed joint protective advantages in CIA rats over MTX, with xanthones derived from S. inappendiculata suppressing the erosive nature of synovioblast by regulating PPAR-gamma signaling-controlled metabolism-immunity feedback.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Plant Sciences
Yue Shen, Li Teng, Yuhan Qu, Jie Liu, Xudong Zhu, Shan Chen, Longfei Yang, Yuehui Huang, Qin Song, Qiang Fu
Summary: The dried aboveground part of Geranium Wilfordii Maxim., known as lao-guan-cao in Traditional Chinese Medicine, has been used for its anti-inflammatory and anti-proliferation activities. Specifically, the compound Corilagin (COR) found in this plant has shown various pharmacological effects, such as anti-inflammatory, anti-tumor, and anti-microbial properties. In a study focusing on rheumatoid arthritis (RA), COR demonstrated anti-proliferation and anti-inflammation effects by inhibiting synovial fibroblasts and suppressing inflammatory responses through NF-kappa B and MAPK signaling pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Dan-Dan Wang, Yan Li, Yi-Jin Wu, Yi-Lai Wu, Jun Han, Opeyemi Joshua Olatunji, Li Wang, Jian Zuo
Summary: This study found that xanthones derived from Securidaca inappendiculata antagonized the anti-rheumatic effects of MTX in vivo, reducing MTX concentration and promoting its excretion, resulting in hindered renal excretion of MTX. In vitro assays also showed that xanthones can enhance the cellular intake of MTX.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jing Han, Jingwen Wang, Yicun Wang, Zhiqi Zhu, Siwang Zhang, Bingrong Wu, Mingsong Meng, Jianning Zhao, Dongsheng Wang
Summary: A fraction enriched with sesquiterpene lactones (SL-XM) extracted from Xanthium mongolicum showed strong anti-rheumatoid arthritis (RA) activity in vitro and in vivo. It exerted its effect by inhibiting M1 macrophage polarization and the phosphorylation of NF-kappa B and MAPK signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Cell Biology
Yi-jin Wu, Li Wang, Chao-fan Ji, Shao-fei Gu, Qin Yin, Jian Zuo
Summary: Research suggests that Alpha 7 nicotinic acetylcholine receptor (α7nAChR) plays a crucial role in regulating inflammatory responses, with activation of this receptor significantly reducing inflammation. However, the mechanism through which the cholinergic anti-inflammatory pathway (CAP) curbs excessive pro-inflammatory responses and maintains immune homeostasis is not fully understood, requiring further studies to elucidate.
Article
Immunology
Jian Zuo, Meng-Qing Tao, Xin-Yue Wu, Tian-Tian Jiang, Opeyemi Joshua Olatunji, Jiyang Dong, Jun Han, Cong-Lan Ji
Summary: The bioactive fraction from S. inappendiculata showed joint protective advantages in CIA rats over MTX, with xanthones derived from S. inappendiculata suppressing the erosive nature of synovioblast by regulating PPAR-gamma signaling-controlled metabolism-immunity feedback.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Opeyemi Joshua Olatunji, Jian Zuo, Oladipupo Odunayo Olatunde
Summary: The study showed that SIE has significant antihyperglycemic, antihyperlipidemic, and antioxidant effects, with the potential to restore pancreatic beta-cell function.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Immunology
Qi-Hai Wang, Yan Li, De-Yu Dou, Rui Wang, Tian-Tian Jiang, Lin Wang, Ming-Qiang Li, Opeyemi Joshua Olatunji, Jian Zuo
Summary: Supplementation of NMN exacerbated the severity of AIA in rats, deteriorated MMP3-controlled tissue damages, and altered the immune profile by increasing Th17/Treg cells ratio. Up-regulation of NAMPT in PBMCs from NMN-treated rats was accompanied by significant increase in iNOS, MCP-1, and IL-1 beta expression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Rui Wang, Dan-Feng Li, Yi-Fang Hu, Qiang Liao, Tian-Tian Jiang, Opeyemi Joshua Olatunji, Kui Yang, Jian Zuo
Summary: The Chinese herbal formula Qing-Luo-Yin (QLY) has been found to improve immune and metabolic dysfunctions in adjuvant-induced arthritis (AIA) by promoting PPAR-gamma expression, affecting monocytes/macrophages polarization and adipocytes differentiation.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Pharmacology & Pharmacy
Ying-Hao Hu, Jun Han, Lin Wang, Chao Shi, Yan Li, Opeyemi Joshua Olatunji, Xiu Wang, Jian Zuo
Summary: The study showed that MAN restored impaired fat metabolism in AIA rats, reduced inflammatory mediators, alleviated oxidative stress, and demonstrated potential therapeutic effects on AIA. MAN upregulated PPAR-gamma, reshaped adipocyte secretion profiles, and facilitated adipocyte differentiation, providing insights into its mechanism of action in regulating metabolism and immune response.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Cong-lan Ji, Sheng Dai, Hong Liu, Ji-yang Dong, Chun-sheng Liu, Jian Zuo
Summary: The study demonstrated that the polyphenolic constituent in Securidaca inappendiculata plays a crucial role in anti-inflammatory activity by regulating the NAMPT and TLR4/NF-kappa B pathways to reduce oxidative stress-sensitive proinflammatory responses.
CHINESE HERBAL MEDICINES
(2021)
Article
Immunology
Yi-jin Wu, Wen-juan Fang, Shu Pan, Sa-sa Zhang, Dan-feng Li, Zhong-fang Wang, Wen -gang Chen, Qin Yin, Jian Zuo
Summary: Rheumatoid arthritis is a systemic autoimmune disease characterized by metabolic disorders, with Sirt1 playing a significant role in regulating energy metabolism and immune functions. The potential of Sirt1-targeting anti-rheumatic regimens is highlighted as a promising therapeutic strategy for RA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Titilope John Jayeoye, Fredrick Nwude Eze, Oladipupo Odunayo Olatunde, Sudarshan Singh, Jian Zuo, Opeyemi Joshua Olatunji
Summary: This study successfully synthesized biocompatible AgNPs using Securidaca inappendiculata stem extract, which showed excellent antimicrobial, antioxidant, hemolytic, cytotoxicity, and antidiabetic properties. Additionally, the extract was utilized as a colorimetric nanoprobe for Hg2+ detection in water samples, demonstrating good accuracy and practicality in environmental monitoring.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Shu Pan, Yi-Jin Wu, Sa-Sa Zhang, Xiu-Ping Cheng, Opeyemi Joshua Olatunji, Qin Yin, Jian Zuo
Summary: This review summarizes the roles of different T cells and macrophages subsets in the occurrence and progression of RA, and highlights the immune consequences of CAP activation in these cells under RA circumstances. The discussion is intended to inspire the development of novel cell-specific CAP-targeting anti-rheumatic regimens.
NEUROCHEMICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Tian-Tian Jiang, Chao-Fan Ji, Xiu-Ping Cheng, Shao-Fei Gu, Rui Wang, Yan Li, Jian Zuo, Jun Han
Summary: MAN treatment inhibits aerobic glycolysis in AIA rats, which consequently eases inflammation-related hypoxia, and hampers pathological neovascularization. MAN has inhibitory effects on the migration and tube formation capability of both AIA rats and human umbilical vein endothelial cells.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Ming Lei, Meng-Qing Tao, Yi-Jin Wu, Liang Xu, Zhe Yang, Yan Li, Opeyemi Joshua Olatunji, Xiao-Wan Wang, Jian Zuo
Summary: The study found that NAMPT and TPI1 dominate different stages of collagen-induced arthritis (CIA), and both of them similarly provoke monocyte-mediated inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Dan-Dan Wang, Xin-Yue Wu, Ji-Yang Dong, Xiu-Ping Cheng, Shao-Fei Gu, Opeyemi Joshua Olatunji, Yan Li, Jian Zuo
Summary: The study found that Qing-Luo-Yin (QLY) improved the immune environment in rheumatoid arthritis (RA) animal models by regulating Th17 cells and monocytes. Active components in QLY such as matrine, sinomenine, and sophocarpine effectively inhibited the development of inflammatory T cells, demonstrating potential therapeutic benefits for RA.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Medicine, Research & Experimental
Qi-Hai Wang, Shu Pan, Xiu-Ping Cheng, Opeyemi Joshua Olatunji, Qingcheng Mao, Jian Zuo
Summary: This study found that rheumatoid arthritis conditions can increase the oral absorption of MTX, and this is related to changes in MTX absorption-related transporters in the intestines. Additionally, glycolysis-driven high energy metabolism can increase the absorption of MTX in rheumatic subjects, leading to exacerbated toxicity.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Dan-Dan Wang, Yan Li, Yi-Jin Wu, Yi-Lai Wu, Jun Han, Opeyemi Joshua Olatunji, Li Wang, Jian Zuo
Summary: This study found that xanthones derived from Securidaca inappendiculata antagonized the anti-rheumatic effects of MTX in vivo, reducing MTX concentration and promoting its excretion, resulting in hindered renal excretion of MTX. In vitro assays also showed that xanthones can enhance the cellular intake of MTX.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2021)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)