Article
Plant Sciences
Tingting Guo, Yinan Guo, Qingbing Liu, Yan Xu, Lina Wei, Zhongtian Wang, Si Chen, Caiwen Wang, Ye Tian, Jie Cui, Yijie Wang, Yanbo Wang, Liping Sun
Summary: This study found that Ma-xing-shi-gan-tang (MXSGT) is an effective inhibitor of PLY, a key virulence factor for Streptococcus pneumoniae. MXSGT inhibits PLY oligomerization without impacting bacterial growth or PLY production, and demonstrates effectiveness against S. pneumoniae infection both in vitro and in vivo.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Miao Cheng, Yanan Zhang, Jun Yan, Yuanming Huang, Mingzhe Wang, Zhiguang Zhai, Guoxing Liu, Chang Liu, Jintong Li, Yue Zhang, Yuchun Xiao, Chengxiang Wang, Chengjun Ban, Zhihong Ren, Liqiong Song
Summary: This study evaluated the anti-influenza effect of San-Yang-He-Zhi (SYHZ) decoction and explored its underlying mechanism. The results showed that SYHZ treatment significantly improved survival rate, lung index, colon length, and body weight loss in mice infected with influenza virus. SYHZ decoction also alleviated lung histological damage, reduced viral load, and suppressed excessive immune response. This suggests that SYHZ decoction is an effective treatment for influenza virus infection.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Xiaoying Ling, Jie Zhou, Tianzi Jin, Weichen Xu, Xun Sun, Weifeng Li, Yali Ding, Miaomiao Liang, Chenbi Zhu, Peipei Zhao, Chanchan Hu, Bin Yuan, Tong Xie, Jialei Tao
Summary: The study demonstrated the significant effects of AC in suppressing RSV-induced necroptosis and regulating metabolism, indicating its potential as a new drug candidate for RSV infection.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shao Thing Teoh, Mara L. Leimanis-Laurens, Sarah S. Comstock, John W. Winters, Nikita L. Vandenbosch, Jeremy W. Prokop, Andre S. Bachmann, Sophia Y. Lunt, Surender Rajasekaran
Summary: This study compared metabolic perturbations in viral bronchiolitis and found unique changes in plasma and urine metabolites. The severity of the disease was correlated with specific metabolites, and urinary metabolites showed higher predictive power for future development of asthma.
Article
Plant Sciences
Mengwen Li, Xinsheng Fan, Liping Zhou, Minyue Jiang, Erxin Shang
Summary: This study investigated the protective mechanism of Ma-Xing-GanShi decoction (MXGSD) on respiratory syncytial virus (RSV)-exacerbated asthma. The results showed that MXGSD could reduce the levels of inflammation cells, airway hyperresponsiveness, and pathological damage of lung tissue. Further experimental investigations revealed that MXGSD could regulate the expression of TRPV1 and reduce the levels of Th2 cytokines and neurogenic inflammatory mediators. Additionally, MXGSD could also reduce the increased intracellular Ca2+ concentration in stimulated cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Analytical
Xian Luo, Yiman Wu, Liang Li
Summary: A sensitive method involving dansyl labeling and liquid chromatography separation is described for normalizing limited samples in metabolomics analysis. This approach enables efficient analysis of metabolites in comparative studies, demonstrated with human cancer cell metabolome analysis, utilizing as low as 500 cells as starting material.
ANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Zhanxuan E. Wu, Marlena C. Kruger, Garth J. S. Cooper, Ivana R. Sequeira, Anne-Thea McGill, Sally D. Poppitt, Karl Fraser
Summary: Untargeted metabolomics of blood samples has been widely used to study metabolic alterations in diseases and identify biomarkers. This study found that the concentration of metabolites in plasma was more reflective of the liver profile than muscle or adipose tissue, highlighting the importance of considering the metabolomic relationship between different tissues and plasma.
Article
Allergy
Pei Dai, Zhongxiang Tang, Mingming Qi, Dan Liu, Ousman Bajinka, Yurong Tan
Summary: RSV infection induces acute asthma attacks by promoting lipid dispersion and utilization, leading to increased oxidative injuries and pro-inflammatory cytokines, exacerbating airway hyperresponsiveness (AHR).
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Biochemical Research Methods
Thomas Stricker, Ron Bonner, Frederique Lisaek, Gerard Hopfgartner
Summary: Annotation and interpretation of metabolite full scan electrospray mass spectra are complicated due to the presence of a variety of ions. A tool called mzAdan was developed for nonchromatography-based annotation and exploration of high-resolution ESI-MS spectra, showing good results in flow injection analysis. This tool performed well in identifying [M+H](+) candidates and outperformed other annotation tools in untargeted LC-MS data analysis.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Food Science & Technology
Dhara Dixit
Summary: This study reveals the biochemical traits, mineral makeup, and secondary metabolite outline of Iyengaria stellata using untargeted metabolite profiling. A total of 108 putative metabolites were detected, including steroids, terpenoids, ketones, esters, polyphenols, anthraquinones, tocopherol, etc. The study highlights the potential of I. stellata as a natural source in pharmaceutical and nutraceutical compositions.
Article
Plant Sciences
Alison Green, Guillermo Federico Padilla-Gonzalez, Methee Phumthum, Monique S. J. Simmonds, Nicholas J. Sadgrove
Summary: Commercially used for treating chronic venous insufficiency, A. hippocastanum L. fruits contain beta-aescin which exhibits anti-inflammatory effects. However, diverse organ-specific secondary metabolites have been overlooked as potential pharmacological opportunities. Untargeted metabolomics analysis revealed unique chemical profiles in different organs of Aesculus plants, with fruits showing the highest antifungal and antioxidant activities. This suggests potential therapeutic leads for further exploration in the entire genus of Aesculus.
Article
Food Science & Technology
Frank Klont, Stepan Stepanovic, Daan Kremer, Ron Bonner, Daan J. Touw, Eelko Hak, Stephan J. L. Bakker, Gerard Hopfgartner
Summary: This study describes improved strategies for detecting chemical exposures and their application in a non-targeted metabolomics study on kidney transplant recipients. The new methods can detect more chronic exposures and improve the reliability of detecting intermittent exposures.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Chang-Seob Seo, Hyeun-Kyoo Shin
Summary: In this study, a protocol for quality control of Daegunjoong-tang (DGJT) based on reverse-phase HPLC and LC-MS/MS analysis was developed to separate, verify, and quantify four marker analytes. The developed methods successfully detected the marker analytes in the samples, which will be useful for evaluating the quality of DGJT.
APPLIED SCIENCES-BASEL
(2021)
Article
Endocrinology & Metabolism
Jun Kou, Chunyang He, Lin Cui, Zhengping Zhang, Wei Wang, Li Tan, Da Liu, Wei Zheng, Wei Gu, Ning Xia
Summary: The study on Chinese postmenopausal women with osteoporosis identified potential biomarkers related to metabolic pathway disorders, providing new insights for early diagnosis. The findings suggest that metabonomic analysis has great potential for application in postmenopausal women with osteoporosis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Psychiatry
Meng Song, Ya Liu, Jiahui Zhou, Han Shi, Xi Su, Minglong Shao, Yongfeng Yang, Xiujuan Wang, Jingyuan Zhao, Dong Guo, Qing Liu, Luwen Zhang, Yan Zhang, Luxian Lv, Wenqiang Li
Summary: Using liquid chromatography mass spectrometry, the study identified potential biomarkers associated with the diagnosis and treatment of schizophrenia. Biomarker panels were selected to distinguish between schizophrenia and healthy controls, as well as between schizophrenia before and after medication. Disturbances in lipid metabolism, sulfation modification, tryptophan metabolism, anti-inflammatory and antioxidant systems, and unsaturated fatty acids metabolism were observed in schizophrenia. These findings could contribute to the development of objective diagnostic and drug treatment monitoring tools for schizophrenia.
PSYCHIATRY RESEARCH
(2023)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)