Article
Multidisciplinary Sciences
Fahad A. Alhumaydhi
Summary: Senna bicapsularis, an important medicinal plant, showed analgesic, muscle relaxant, and sedative effects in an animal model, with potential for treating pain and muscle relaxation. The extracts from the plant exhibited promising activity in inhibiting pain and inducing muscle relaxation.
JOURNAL OF TAIBAH UNIVERSITY FOR SCIENCE
(2021)
Article
Surgery
Timothy G. Gaulton, Hannah Wunsch, Lakisha J. Gaskins, Charles E. Leonard, Sean Hennessy, Michael Ashburn, Colleen Brensinger, Craig Newcomb, Duminda Wijeysundera, Brian T. Bateman, Jennifer Bethell, Mark D. Neuman
Summary: This study investigated the association between preoperative benzodiazepine and Z-drug use and adverse outcomes after surgery, finding that their use increased the odds of adverse postoperative events, particularly when coprescribed with opioids.
Article
Biochemistry & Molecular Biology
Abdullah S. M. Aljohani, Tareq Abu-Izneid, Zafar Ali Shah, Umer Rashid, Khurshid Ayub, Abdur Rauf, Naveed Muhammad, Fahad A. Alhumaydhi, Maria Asghar, Mohammad S. Mubarak, Mohammad Ali Shariati, Haiyuan Zhang
Summary: The article reports the isolation of a compound from the roots of H. adenophyllum and its effects on muscle relaxation, sedation, and analgesia in Swiss albino mice. The compound showed significant sedative and analgesic effects with a high level of safety in acute toxicity studies.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Plant Sciences
Reza Jahani, Sahar Behzad, Maryam Saffariha, Niyusha Toufan Tabrizi, Mehrdad Faizi
Summary: Salvia limbata has been traditionally used for treating central nervous disorders, and its pharmacological activities may be related to the presence of rosmarinic acid. This study evaluated the sedative-hypnotic effect, anxiolytic activity, possible side effects, and mechanism of action of S. limbata extracts. The results suggest modulation of the alpha 1-containing GABA-A receptors as a potential mechanism for its observed effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yunhe Liu, Zhongyao Wang, Caixia Wang, Hanrui Si, Hui Yu, Le Li, Shuzheng Fu, Luying Tan, Pingya Li, Jinping Liu, Yan Zhao
Summary: The study on Acanthopanax senticosus leaves and Acanthopanax sessiliflorus leaves revealed their rich phytochemical composition and similar pharmacological activities. Both leaves exhibited sedative-hypnotic effects and may mediate beneficial bioactivity through serotonin and GABA. Some specific chemical markers could be potential active compounds and quality markers for the future development and utilization of the leaves.
Article
Substance Abuse
David S. Baldwin
Summary: Despite the availability of alternative treatments, benzodiazepines are still widely prescribed for patients with insomnia or anxiety disorders. Patients may experience adverse effects and distress during dosage reduction and cessation. Management of benzodiazepine withdrawal involves preventing dependence, monitoring medical conditions, gradual dose reduction, psychological interventions, occasional medication, and ongoing support to prevent relapse and address psychosocial stressors. Further research is needed to optimize strategies for withdrawal and prevention of dependence.
Article
Multidisciplinary Sciences
Marina Padua-Reis, Diana Aline Noga, Adriano B. L. Tort, Martina Blunder
Summary: The study found that diazepam had no anxiolytic effect on mouse behavior in the elevated plus maze task, and at the highest dose it impaired locomotor activity, likely due to sedation. In contrast, paroxetine significantly reduced anxiety-like behavior without inducing sedative effects. Therefore, preclinical studies screening new anxiolytic drugs should be cautious with the use of diazepam as a potential positive control.
SCIENTIFIC REPORTS
(2021)
Article
Plant Sciences
Yu Zhong, Qin Zheng, Pengyi Hu, Xiaoying Huang, Ming Yang, Guilin Ren, Jing Li, Qing Du, Shanshan Liu, Kenan Zhang, Ling Wu, Liyun Zhu, Yuanyuan Guo, Wenjing Li, Shuai Xiao, Shuyuan Shuai, Mingxia Zhang
Summary: The inhalation of Perilla frutescens essential oil (PFEO) has sedative and hypnotic effects by reducing autonomic activity, increasing falling asleep rate, shortening latency of sleeping time, and prolonging duration of sleeping time. PFEO increases the content of 5-HT and GABA in the hypothalamus and cerebral cortex, and may exert its sedative and hypnotic effects through the GABAergic pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Rheumatology
Jasvinder A. Singh
Summary: This study examined the frequency and rates of common drug/substance use disorder hospitalizations in five musculoskeletal diseases, with each drug use disorder hospitalization increasing from 1998 to 2014 in each of the five MSDs.
CLINICAL RHEUMATOLOGY
(2021)
Article
Behavioral Sciences
Bo Tang, Yuanzhi Yu, Fengting Yu, Jinyu Fang, Guibin Wang, Jianwei Jiang, Qinghua Han, Jiangong Shi, Jianjun Zhang
Summary: YZG-331 exerts sedative and hypnotic effects through the activation of A(1)R and A(2a)R, as well as the down regulation of the Ca2+-CaMKII signaling pathway.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Veronika A. Prikhodko, Yuri Sysoev, Elena Gerasimova, Sergey Okovityi
Summary: This study evaluated the psychotropic activity of five different CCAMs in adult zebrafish, demonstrating dose-dependent sedative effects and anxiolytic properties at low concentrations. However, the results contradicted previous in vitro data, suggesting a possible relationship between CCAM metabolism or interspecies differences in target proteins.
Article
Medicine, Research & Experimental
Yahya S. Al-Awthan, Abdur Rauf, Umer Rashid, Sami Bawazeer, Saima Naz, Omar Bahattab, Saud Bawazeer, Naveed Muhammad, Dania Saad Waggas, Gaber El-Saber Batiha, Mohammad Ali Shariati, Marina Derkho, Hafiz Ansar Rasul Suleria
Summary: This study evaluated the sedative and hypnotic effects of dimeric naphthoquinones isolated from Diospyros lotus, showing significant improvement in insomnia symptoms without observed toxicity. Docking simulations on GABA receptors revealed a potential mechanism for these pharmacological actions.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Sara Meirinho, Marcio Rodrigues, Adriana O. Santos, Amilcar Falcao, Gilberto Alves
Summary: The intranasal administration of Perampanel (PER) through the olfactory pathway showed improved brain distribution and demonstrated anticonvulsant and anxiolytic effects in mice, indicating a potential alternative to oral treatment for epilepsy and anxiety. However, it also caused some neuromotor impairment, which was improved with repeated administrations. The study supports the design of clinical trials to evaluate the efficacy of intranasal PER delivery in treating neurological-related conditions.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Psychology, Clinical
Eva Maria Garcia-Atienza, Jesus Lopez-Torres Hidalgo, Maria Minuesa-Garcia, Maria Ruiperez-Moreno, Francisco Javier Lucas-Galan, Jose Luis Agudo-Mena
Summary: This study developed and validated a specific instrument for measuring satisfaction with anxiolytic and hypnotic drug treatment. The results showed that the TSAN questionnaire is valid and reliable, serving as a patient-centered measurement tool that complements clinical evaluation of the effectiveness of anxiolytic/hypnotic drug treatment.
INTERNATIONAL JOURNAL OF MENTAL HEALTH AND ADDICTION
(2022)
Article
Oncology
Jacob C. Cogan, Rohit R. Raghunathan, Melissa P. Beauchemin, Melissa K. Accordino, Yongmei Huang, Elena B. Elkin, Alexander Melamed, Jason D. Wright, Dawn L. Hershman
Summary: There is a high rate of breast cancer patients receiving adjuvant chemotherapy becoming new persistent users of sedative-hypnotic medications. Shorter durations of chemotherapy and receipt of opioid prescriptions are associated with new persistent use.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Plant Sciences
O. E. Kale, O. Awodele, A. J. Akindele
JOURNAL OF ETHNOPHARMACOLOGY
(2019)
Editorial Material
Integrative & Complementary Medicine
Christian Agyare, Abidemi J. Akindele, Vanessa Steenkamp
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2019)
Article
Plant Sciences
Akanji A. Murtala, Abidemi J. Akindele
JOURNAL OF ETHNOPHARMACOLOGY
(2020)
Article
Psychiatry
Jaiyeola Abiola Kajero, Soraya Seedat, Jude Ohaeri, Abidemi Akindele, Oluwagbemiga Aina
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2020)
Article
Chemistry, Medicinal
Abidemi J. Akindele, Foluso O. Agunbiade, Margaret O. Sofidiya, Olufunsho Awodele, Abimbola Sowemimo, Omobolanle Ade-Ademilua, Moshood O. Akinleye, Ismail O. Ishola, Ifeoma Orabueze, Olumuyiwa B. Salu, Ibrahim A. Oreagba, Olayinka T. Asekun, Olukemi Odukoya
NATURAL PRODUCT COMMUNICATIONS
(2020)
Article
Chemistry, Multidisciplinary
Francis J. Olatoye, Abidemi J. Akindele
Summary: This study investigated the long-term effects of Garcinia kola Heckel and its extract, Kolaviron (KV), on various aspects of male and female rats. The results showed that KV had no adverse effects on the vital organs and had some gender-specific effects on blood parameters and hormone levels. Furthermore, KV demonstrated lipid-lowering, erythropoiesis-inducing, and immune system-boosting activities. Overall, KV was found to be safe for long-term administration.
DRUG AND CHEMICAL TOXICOLOGY
(2023)
Review
Chemistry, Medicinal
Abidemi J. Akindele, Abimbola Sowemimo, Foluso O. Agunbiade, Margaret O. Sofidiya, Olufunsho Awodele, Omobolanle Ade-Ademilua, Ifeoma Orabueze, Ismail O. Ishola, Christianah Ayolabi, Olumuyiwa B. Salu, Moshood O. Akinleye, Ibrahim A. Oreagba
Summary: This review evaluates plant species used in African traditional medicines with antiviral, anti-inflammatory, immunomodulatory, and COVID-19 symptom relieving effects. The majority of the studied plants demonstrated a wide range of antiviral activities, and some of them also had immunomodulatory, anti-inflammatory, and symptom relieving effects.
NATURAL PRODUCT COMMUNICATIONS
(2022)
Article
Chemistry, Medicinal
Francis J. J. Olatoye, Abidemi James Akindele, Okikioluwa E. E. Balogun, Olufunsho Awodele, Abdullahi A. A. Adejare
Summary: This study evaluated the antihypertensive effect of Kolaviron (KV) in an experimental model of hypertension induced by L-NAME. The results demonstrated that KV significantly lowered blood pressure, possibly through its antioxidant effect.
NATURAL PRODUCT COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Oluwafemi Ezekiel Kale, Olufunsho Awodele, Abidemi James Akindele
BIOCHEMISTRY INSIGHTS
(2019)
Article
Chemistry, Medicinal
Olanrewaju A. Salako, Abidemi J. Akindele, Aishat O. Balogun, Olufunmilayo O. Adeyemi
Meeting Abstract
Pharmacology & Pharmacy
O. Salako, D. Akinoso, A. Akindele, O. Adeyemi
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2019)
Article
Pharmacology & Pharmacy
Abidemi J. Akindele, Gabriel O. Oludadepo, Kennedy I. Amagon, Dhirendra Singh, Daniel D. Osiagwu
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2018)
Article
Pharmacology & Pharmacy
Kennedy I. Amagon, Olufunsho Awodele, Abidemi J. Akindele
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2017)
Article
Toxicology
O. E. Kale, O. Awodele, A. J. Akindele
TOXICOLOGY REPORTS
(2019)
Meeting Abstract
Pharmacology & Pharmacy
O. Salako, S. Adigun, K. Salako, A. Akindele, O. Adeyemi
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2018)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)