Article
Plant Sciences
Juan Zou, Wenkai Li, Guofeng Wang, Su Fang, Jingyi Cai, Tianming Wang, Hua Zhang, Ping Liu, Jiasheng Wu, Yueming Ma
Summary: The study showed that HQD treatment ameliorated DDC-induced cholestatic liver injury, improved gut microbiota dysbiosis, reduced intestinal barrier dysfunction, and inhibited liver inflammation. These findings suggest that HQD may have potential in treating gastrointestinal and hepatobiliary diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Fang-Yuan Gao, Xue-Feng Chen, Li-Xun Cui, Yu-Jia Zhai, Jia-Lin Liu, Cong-Cong Gao, Yi-Chao Fang, Tao-Hong Huang, Jun Wen, Ting -Ting Zhou
Summary: This study proposes a personalized treatment method for depression using ZZCD at different stages and suggests that gut microbiota and gut microbiome could serve as potential diagnostic and therapeutic biomarkers for depression.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Microbiology
Wang Wang, Shujun Jiang, Chengcheng Xu, Lili Tang, Yan Liang, Yang Zhao, Guoxue Zhu
Summary: In this study, the anticholestatic effects of Da-Huang-Xiao-Shi decoction (DHXSD) on an alpha-naphthylisothiocyanate (ANIT)-induced cholestasis rat model were examined using histopathological and molecular analyses. The results showed that DHXSD effectively attenuated ANIT-induced cholestasis, improved liver function, and regulated levels of inflammatory cytokines. Moreover, DHXSD also ameliorated gut microbiota dysbiosis induced by ANIT. Transcriptomic analysis and 16S rRNA gene sequencing analysis were used to study the mechanism of action of DHXSD and identify potential therapeutic targets. Overall, DHXSD appears to be a promising agent for protecting against liver injury.
MICROBIOLOGY SPECTRUM
(2022)
Article
Pharmacology & Pharmacy
YueHua Zhou, YunZhong Zhou, YiFei Li, Wei Sun, ZhaoLong Wang, Long Chen, Ye He, XiaoLong Niu, Jialiang Chen, Guangtao Yao
Summary: This study found that Da-Chai-Hu decoction (DCHD) treatment can improve the condition of cholestatic liver injury by altering the metabolism of bile acids, including reducing serum bile acid levels, relieving inflammation, and improving pathological changes in liver tissue.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Microbiology
Wang Wang, Shujun Jiang, Chengcheng Xu, Lili Tang, Yan Liang, Yang Zhao, Guoxue Zhu
Summary: This study investigated the therapeutic effects and mechanisms of Da-Huang-Xiao-Shi decoction (DHXSD) on cholestasis. Using an animal model and molecular analysis, it was found that DHXSD effectively improved histopathological injuries caused by cholestasis and regulated gut microbiota and intestinal barrier function. This study provides new insights into the treatment of cholestasis.
MICROBIOLOGY SPECTRUM
(2022)
Article
Cell Biology
Peijie Wu, Ling Qiao, Han Yu, Hui Ming, Chao Liu, Wenjun Wu, Baixue Li
Summary: The study demonstrates that arbutin has a protective effect on cholestatic liver injury induced by ANIT by upregulating FXR and downstream enzymes associated with bile acid homeostasis. Furthermore, the findings suggest that arbutin may be a potential chemical molecule for cholestatic diseases by partly acting through the FXR pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xin Feng, Yuelin Bi, Jiaqi Wang, Tianyi Li, Gengyuan Yu, Tonghua Zhang, Haoran Xu, Chenning Zhang, Yikun Sun
Summary: This study aims to explore the phenomenon of co-decoction in complex traditional Chinese medicine formulas. By using LC-MS technology, data analysis, and molecular docking, the study identifies the active ingredients in ZZHPD and shows that co-decoction leads to the production of new compounds. The study also provides insights into the mechanism of action of ZZHPD in treating insomnia and depression.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yongtao Bai, Yingchun Zhang, Shuolei Li, Wenzhou Zhang, Xinhui Wang, Baoxia He, Wenzheng Ju
Summary: The study investigated the pharmacological mechanisms of ZZHPD in depression using UFLC-Q-TOF/MS and network pharmacology strategy. It was found that ZZHPD targets various genes and pathways to exert its antidepressant effect.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Jiannan Qiu, Jingyu Yan, Wei Liu, Xinzhu Liu, Jingchao Lin, Zeng Du, Li Qi, Jia Liu, Guoxiang Xie, Ping Liu, Xiaoning Wang
Summary: The study investigated the therapeutic effect of Huangqi decoction (HQD) and astragalosides on alpha-naphthylisothiocyanate (ANIT)-induced cholestasis in rats. The results showed that HQD and astragalosides treatment could alleviate the perturbation of bile acids and free fatty acids, improve liver function, and mitigate liver histopathological damage caused by ANIT.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Chuan Chai, Bo Jin, Yinyu Yan, Qi Yuan, Hongmei Wen, Weiwei Tao, Xiaobing Cui, Chenxiao Shan, Sheng Yu
Summary: This study demonstrated the positive treatment effect of ZZCD on CUMS depression model mice. Metabolomics results revealed the holistic and interconnected metabolic changes of ZZCD in CUMS mice. The metabolic pathway annotation suggested that the anti-depression mechanism of ZZCD might be related to signaling pathway in brain.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yin Zhang, Yi-Chao Fang, Li-Xun Cui, Yue-Tong Jiang, Yu-Sha Luo, Wen Zhang, De-Xun Yu, Jun Wen, Ting-Ting Zhou
Summary: This study analyzed the brain metabolic profile of depressed rats and identified differential metabolites and metabolic pathways related to the antidepressant effect of Zhi-zi-chi decoction. The levels of reactive oxygen species and antioxidant enzymes in the brain were also measured. The results indicate that Zhi-zi-chi decoction has a potential antidepressant effect associated with reversing the imbalance of glutathione and oxidative stress.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Environmental Sciences
Zhengyuan Chen, Yuhuan Wu, Bixia Wang, Jiamin Fang, Changlian Gan, Chuanlan Sang, Zhu Dun, Tajie Luosang, Qing Wang, Dawa Zeren, Tianqin Xiong
Summary: Clinical studies have shown a close relationship between intrahepatic cholestasis and intestinal injury, suggesting a disruption in the gut-liver axis. Treatment with Transmetil alleviated liver and gut injuries caused by intrahepatic cholestasis, indicating the importance of bile acids in linking the intestine and liver.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Plant Sciences
Haoyu Xue, Su Fang, Min Zheng, Jiasheng Wu, Hongyu Li, Mengdie Zhang, Yuanyuan Li, Tianming Wang, Rong Shi, Yueming Ma
Summary: The study found that DHXSD has a protective effect on chronic cholestasis in mice by increasing the expression of BA-related metabolic enzymes and efflux transporters to improve the disease state.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yongtao Bai, Guoliang Dai, Lihua Song, Xiaolei Gu, Ning Ba, Wenzheng Ju, Wenzhou Zhang
Summary: This study aimed to investigate the antidepressant effects of Zhi-Zi Hou-Po Decoction (ZHD) and explore its neuroprotective effects on PC12 cell injury induced by corticosterone. The results showed that ZHD-EE significantly decreased immobility time and increased BDNF levels in mice, while ZHD-EE improved cell viability and reduced apoptosis in PC12 cells. The study suggests that ZHD-EE has antidepressant and neuroprotective effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Lixia Li, Yingjie Wang, Ling Zhao, Gang Ye, Fei Shi, Yinglun Li, Yuanfeng Zou, Xu Song, Xinghong Zhao, Zhongqiong Yin, Xueyuan Wu, Wen Li, Huaqiao Tang
Summary: SanHuang XieXin decoction (SXD) is a potential traditional Chinese medicine for treating liver damage secondary to ulcerative colitis (UC), which may work through regulating the gut-liver axis, inhibiting inflammation, and modulating bile acid metabolism pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)