Orphan nuclear receptor Nur77 promotes colorectal cancer invasion and metastasis by regulating MMP-9 and E-cadherin

Hypoxia triggers a Nur77–β-catenin feed-forward loop to promote the invasive growth of colon cancer cells

(2014) S K Y To et al.   BRITISH JOURNAL OF CANCER

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TR3 Modulates Platinum Resistance in Ovarian Cancer

(2013) A. J. Wilson et al.   CANCER RESEARCH

Downregulated E-Cadherin Expression Indicates Worse Prognosis in Asian Patients with Colorectal Cancer: Evidence from Meta-Analysis

(2013) Xin He et al.   PLoS One

Orphan receptor TR3 is essential for the maintenance of stem-like properties in gastric cancer cells

(2012) Yan-yan Zhan et al.   CANCER LETTERS

Abstract 2917: Design, synthesis and biological evaluation of two chemical classes as novel small molecule Mcl-1 inhibitors

(2012) Naval Bajwa et al.   CANCER RESEARCH

An epigenetic role for PRL-3 as a regulator of H3K9 methylation in colorectal cancer

(2012) Yongxia Liu et al.   GUT

A tumor hypoxic niche protects human colon cancer stem cells from chemotherapy

(2012) Qin Mao et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Hypoxia enhances colon cancer migration and invasion through promotion of epithelial-mesenchymal transition

(2012) Kumiko Hongo et al.   JOURNAL OF SURGICAL RESEARCH

Orphan receptor TR3 participates in cisplatin-induced apoptosis via Chk2 phosphorylation to repress intestinal tumorigenesis

(2011) Lu-ming Yao et al.   CARCINOGENESIS

Targeting NR4A1 (TR3) in cancer cells and tumors

(2011) Syng-Ook Lee et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Inactivation of the Orphan Nuclear Receptor TR3/Nur77 Inhibits Pancreatic Cancer Cell and Tumor Growth

(2010) S.-O. Lee et al.   CANCER RESEARCH

Nuclear receptor Nur77 inhibits vascular outward remodelling and reduces macrophage accumulation and matrix metalloproteinase levels

(2010) Peter I. Bonta et al.   CARDIOVASCULAR RESEARCH

Hypoxia and Hypoxia-Inducible Factors: Master Regulators of Metastasis

(2010) X. Lu et al.   CLINICAL CANCER RESEARCH

Regulation of Nur77 expression by β-catenin and its mitogenic effect in colon cancer cells

(2010) Hua Wu et al.   FASEB JOURNAL

EGF-induced MMP-9 expression is mediated by the JAK3/ERK pathway, but not by the JAK3/STAT-3 pathway in a SKBR3 breast cancer cell line

(2009) Sangmin Kim et al.   CELLULAR SIGNALLING

Activation of Nerve Growth Factor-Induced B  by Methylene-Substituted Diindolylmethanes in Bladder Cancer Cells Induces Apoptosis and Inhibits Tumor Growth

(2009) S. Dae Cho et al.   MOLECULAR PHARMACOLOGY

MMP-2 geno-phenotype is prognostic for colorectal cancer survival, whereas MMP-9 is not

(2008) A M J Langers et al.   BRITISH JOURNAL OF CANCER

Loss of E-Cadherin Promotes Metastasis via Multiple Downstream Transcriptional Pathways

(2008) T. T. Onder et al.   CANCER RESEARCH

Modulation of Orphan Nuclear Receptor Nur77-Mediated Apoptotic Pathway by Acetylshikonin and Analogues

(2008) Jie Liu et al.   CANCER RESEARCH

Matrix Metalloproteinase 9 Is a Mediator of Epidermal Growth Factor-Dependent E-Cadherin Loss in Ovarian Carcinoma Cells

(2008) K. D. Cowden Dahl et al.   CANCER RESEARCH

Twist is a transcriptional repressor of E-cadherin gene expression in breast cancer

(2007) Farhad Vesuna et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS