Hypoxia-inducible factor-1α inhibition by a pyrrolopyrazine metabolite of oltipraz as a consequence of microRNAs 199a-5p and 20a induction

Biaryl modification of the 5′-terminus of one strand of a microRNA duplex induces strand specificity

(2010) Aya Ogata et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

MicroRNA-519c Suppresses Hypoxia-Inducible Factor-1α Expression and Tumor Angiogenesis

(2010) Shih-Ting Cha et al.   CANCER RESEARCH

Pharmacokinetics of Oltipraz and Its Major Metabolite (RM) in Patients With Liver Fibrosis or Cirrhosis: Relationship With Suppression of Circulating TGF-β1

(2010) S G Kim et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Regulation of microRNAs by Natural Agents: An Emerging Field in Chemoprevention and Chemotherapy Research

(2010) Yiwei Li et al.   PHARMACEUTICAL RESEARCH

Oxidized Metabolites of Oltipraz Exert Cytoprotective Effects against Arachidonic Acid through AMP-Activated Protein Kinase-Dependent Cellular Antioxidant Effect and Mitochondrial Protection

(2009) Y. N. Kwon et al.   DRUG METABOLISM AND DISPOSITION

Ethanol-Induced Expression of ET-1 and ET-BR in Liver Sinusoidal Endothelial Cells and Human Endothelial Cells Involves Hypoxia-Inducible Factor-1  and MicroRNA-199

(2009) S. Yeligar et al.   JOURNAL OF IMMUNOLOGY

Oltipraz and dithiolethione congeners inhibit hypoxia-inducible factor-1  activity through p70 ribosomal S6 kinase-1 inhibition and H2O2-scavenging effect

(2009) W. H. Lee et al.   MOLECULAR CANCER THERAPEUTICS

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

(2009) G L Semenza   ONCOGENE

Therapeutic potential of dithiolethiones for hepatic diseases

(2009) Samuel Carroll Brooks et al.   PHARMACOLOGY & THERAPEUTICS

Identification of Hypoxia-Inducible Factor-1  as a Novel Target for miR-17-92 MicroRNA Cluster

(2008) A. Taguchi et al.   CANCER RESEARCH

Cancer Cell Metabolism: Warburg and Beyond

(2008) Peggy P. Hsu et al.   CELL

Sulforaphane inhibited expression of hypoxia‐inducible factor‐1α in human tongue squamous cancer cells and prostate cancer cells

(2008) Hua Yao et al.   INTERNATIONAL JOURNAL OF CANCER