Article
Materials Science, Multidisciplinary
Jose Manuel Gutierrez-Hernandez, Claudia Castorena-Alejandro, Diana Maria Escobar-Garcia, Alfredo Escalante, Hector Flores, Amaury Pozos-Guillen, Paul Gatenholm, Guillermo Toriz
Summary: This study evaluated hydrogels made from spruce xylan (SX) mixed with functionalized multi-walled carbon nanotubes (MWCNTs) as a scaffold for in vitro culture of osteoblastic cells. The hydrogels were obtained through chemical conjugation of spruce xylan with tyramine (TA) to enable enzymatic crosslinking. Morphological analysis and wettability properties of the hydrogel scaffolds were performed, and osteoblastic cell culture and evaluation were conducted. The results showed that the SX-TA/MWCNTs hydrogel scaffolds have the potential to be used as bionanomaterials for bone regeneration due to their increased cell viability, proliferation, and adhesion.
MATERIALS TODAY COMMUNICATIONS
(2023)
Article
Materials Science, Paper & Wood
Yan Lyu, Tatsuya Matsumoto, Shogo Taira, Kazumasa Ijiri, Arata Yoshinaga, Kengo Shigetomi, Yasumitsu Uraki
Summary: The study found that in lignification processes, xyloglucan (XG) plays an important role in promoting the reaction, while galactoglucomannan (GGM) inhibits the reaction.
Review
Developmental Biology
Naoya Yamaguchi, Holger Knaut
Summary: Cell-extracellular matrix interactions are essential for cell anchoring and migration, with focal adhesions (FAs) playing a key role. However, the role of FAs in vivo is still not well understood.
Article
Polymer Science
Jovana S. Vukovic, Vuk V. Filipovic, Marija M. Babic Radic, Marija Vukomanovic, Dusan Milivojevic, Tatjana Ilic-Tomic, Jasmina Nikodinovic-Runic, Simonida Lj Tomic
Summary: This study focuses on the development of hydrogel scaffolds that mimic living tissue for biomedical applications. By crosslinking two novel series of interpenetrating hydrogel networks (IPNs) using specific crosslinkers, the engineered IPN hydrogel scaffolds show favorable properties, such as interconnected porous structure, high swelling capacity, and biocompatibility. The controlled release of therapeutic agents can also be achieved with these novel scaffolding systems. This research demonstrates the potential of IPN hydrogel scaffolds in biomedical tissue engineering.
Article
Dentistry, Oral Surgery & Medicine
Kelly Maria Moreira, Luiz Eduardo Bertassoni, Robert Phill Davies, Felipe Joia, Jose Francisco Hofling, Fabio Duprat Nascimento, Regina Maria Puppin-Rontani
Summary: Treating caries-affected dentin with remineralizing agents such as CPP-ACP and Curodont(TM) Repair has the potential to be a clinically significant treatment protocol to increase the longevity of adhesive restorations.
Article
Environmental Sciences
Zarrar Salahuddin, Sarah Farrukh, Rahim Jan, Atif Ayub, Arshad Hussain, Maxime Pontie, Anas Ahmed, Muhammad Mubashir
Summary: This study successfully modifies cellulose acetate membranes by incorporating high aspect ratio h-BN nanosheets, leading to a reduction in CO2 gas permeability. The dimensional analysis, functional group analysis, and crystalline phase analysis of nanocomposites were conducted using SEM, FT-IR spectroscopy, and XRD, respectively. Tensile testing and tribological property analysis showed that the nanocomposite samples exhibited higher mechanical strength and adhesion compared to pristine samples.
Article
Chemistry, Multidisciplinary
Junchang Guo, Liansong Ye, Yuan Gao, Shuangyang Li, Lifan Zhang, Wei Liu, Tingfa Peng, Yi Mou, Chuncheng Wu, Chaoming Xie, Bing Hu, Xu Deng
Summary: In this study, a hybrid dry powder (HDP) strategy is proposed for rapid sealing of wet tissues during gastric endoscopic submucosal dissection (ESD). The HDPs form a hydrogel layer over the target tissue by absorbing water and forming electrostatic interactions, achieving strong adhesion through hydrogen bonding. The HDP-assembled hydrogel demonstrates fast adhesion to wet tissues, low swelling rate, and resistance to acidic degradation.
Article
Biochemistry & Molecular Biology
Ida Szmigiel, Dorota Kwiatkowska, Marcin Lukaszewicz, Anna Krasowska
Summary: This study found that using xylan and its derivatives from plant hemicellulose as substrates can promote efficient biosurfactant production by Bacillus subtilis, providing a new approach for the reutilization of agricultural residues.
Article
Chemistry, Multidisciplinary
Diana Banut Onet, Lucian Barbu Tudoran, Ada Gabriela Delean, Petra Surlin, Andreea Ciurea, Alexandra Roman, Sorana D. Bolboaca, Cristina Gasparik, Alexandrina Muntean, Andrada Soanca
Summary: The study evaluated the adhesive capacities of two flowable and two conventional hybrid resin composite materials for non-carious cervical lesions, showing dentinal microleakage despite good peripheral seal. SEM revealed occasional disruptions at the adhesive interface, while EDX confirmed the manufacturers' qualitative compositions. The four experimental composites are recommended for clinical restoration of NCCLs.
APPLIED SCIENCES-BASEL
(2021)
Article
Engineering, Biomedical
Simin Jiao, Xi Zhang, Hang Cai, Siyu Wu, Xiaolan Ou, Guangda Han, Jie Zhao, Yan Li, Wenlai Guo, Tianzhou Liu, Wenrui Qu
Summary: Despite significant medical advances in the past decade, achieving rapid and effective hemostasis remains a challenge. Uncontrolled bleeding and wound infections continue to be a concern, increasing the risk of death. There has been a growing interest in organisms that have adhesive properties, and applying these properties to hemostatic materials shows promise. This paper reviews the biological behavior, bionics, and mechanisms related to hemostasis, as well as the benefits, challenges, and prospects of biomimetic hemostatic materials.
MATERIALS TODAY BIO
(2023)
Article
Engineering, Environmental
Kai Li, Zitang Xu, Xiaoxiao Liu, Yaojia He, Xiaoke Tian, Xiaoling Xu, Guangxu Bo, Sheng Yuan, Li Xu, Min Yang, Jinyong Yan, Houjin Zhang, Yunjun Yan
Summary: In this study, a reconstructed in vitro system simulating the natural underwater adhesion process was used to prepare a bionic adhesive material that can improve the interfacial adhesion of mussel inspired materials.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Environmental
Nan Zhao, Xiaohua Gao, Zhuo Chen, Yang Feng, Guoqiang Liu, Feng Zhou, Weimin Liu
Summary: A super-lubricating hybrid elastomer with rapid photothermal sterilization and strong anti-cell adhesion capacities is developed by grafting lubricating polymers onto NIR photothermal Fe3O4 nanoparticles-loaded polydimethylsiloxane substrate. This elastomer achieves super low friction through hydration lubrication, rapid photothermal bactericidal performance by NIR irradiation, and shows a strong anti-adhesion effect against HepG2 cells.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Plant Sciences
Sylwia Glazowska, Jozef Mravec
Summary: This study characterizes a cellulose-binding DNA aptamer CELAPT MINI and demonstrates its high specificity towards long non-substituted beta-(1-4)-glucan chains in both crystalline and amorphous forms. The fluorescent conjugates of CELAPT MINI are suitable for various microscopy techniques, including super-resolution imaging. The research highlights the potential to expand the cell wall probing toolbox with specific in vitro generated polynucleotide probes.
Article
Plant Sciences
Carolina Feijao, Kris Morreel, Nadine Anders, Theodora Tryfona, Marta Busse-Wicher, Toshihisa Kotake, Wout Boerjan, Paul Dupree
Summary: The study highlights the critical role of xylan in the structure of grass cell walls, as well as the function of XAX1 in xylan synthesis. The results indicate that XAX1 plays an essential role in cross-linking, suggesting its potential as a target for improving the utilization of grass biomass.
Article
Chemistry, Multidisciplinary
Soha A. Hassan, Marwa Beleidy, Yasmine Alaa El-din
Summary: The study aimed to investigate the biocompatibility and sustainability differences between two computer-aided design/computer-aided manufacturing resin-based composites and a resin-modified ceramic. The results showed no significant differences in surface roughness and biofilm formation, with the EN material showing the lowest cytotoxicity and highest viability, while BC material exhibited the highest biofilm formation capacity.
Article
Chemistry, Multidisciplinary
Jahaziel Gasperin-Bulbarela, Ana B. Castro-Cesena, Tanya Camacho-Villegas, Pavel H. Lugo-Fabres, Nestor Emmanuel Diaz-Martinez, Eduardo Padilla-Camberos, Raquel Echavarria, Alexei F. Licea-Navarro
Summary: Hydrogels are effective alternatives for drug delivery when direct application of therapeutics to wounds is not feasible or systemic administration may cause adverse effects. This study investigated the capacity of calcium alginate hydrogels plasticized with PEGMA to deliver anti-TGF-beta antibodies to wounds, showing reduced inflammation and collagen deposition with the hydrogels containing antibodies.
APPLIED SCIENCES-BASEL
(2021)
Article
Materials Science, Multidisciplinary
L. Garcia-Uriostegui, H. Ivan Melendez-Ortiz, T. A. Camacho-Villegas, P. H. Lugo-Fabres, G. Toriz
Summary: Hybrid nanoparticles based on PHEMA grafted onto MSiO2 particles were prepared and showed potential as a drug carrier for cancer therapy. The grafted PHEMA allowed for good dispersion of the hybrid nanoparticles in aqueous solution and efficient loading of the drug 5FU. In vitro cytotoxicity tests demonstrated the effectiveness of the hybrid delivery system against glioblastoma cells.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Review
Immunology
Erendira Villalobos-Sanchez, Mirna Burciaga-Flores, Lorena Zapata-Cuellar, Tanya A. Camacho-Villegas, Darwin E. Elizondo-Quiroga
Summary: This article summarizes the research on the mechanism of prenatal vertical infection of ZIKV, including in vitro, in vivo, and ex vivo experiments, as well as investigations on pregnant women. The study found that ZIKV can be transmitted to the fetus through transplacental, paracellular, transcytosis mediated by extracellular vesicles, and paraplacental routes.
Review
Cell Biology
Jessica Andrea Badillo-Mata, Tanya Amanda Camacho-Villegas, Pavel Hayl Lugo-Fabres
Summary: The researchers discuss the pathophysiology and current treatment strategies of rheumatoid arthritis (RA). They also explore the application of 3D cell culture technology in rheumatological diseases and RA models, and summarize its application in RA treatment.
Article
Materials Science, Ceramics
Lorena Garcia-Uriostegui, H. Ivan Melendez-Ortiz, Jose M. Mata-Padilla, Guillermo Toriz
Summary: This study reports the synthesis of mesoporous MCM-41 nanoparticles using microwave radiation. Silica nanoparticles with large surface area and suitable chemical composition were obtained at low power and short time. The particle size was close to 100 nm with a spherical morphology. The microwave radiation power and heating time affected particle size and aggregation. The MCM-41 synthesized under low microwave radiation power had a high surface area and expanded pore diameters compared to hydrothermal synthesis. The sample labeled as MCM400W10 showed a significant number of free silanol groups on the surface.
CERAMICS INTERNATIONAL
(2023)
Article
Materials Science, Multidisciplinary
Luis A. Rivera-Escobedo, Jorge L. Sanchez-Orozco, Luis A. Garcia-Cerda, Bertha Puente-Urbina, Lorena Garcia-Uriostegui, H. Ivan Melendez-Ortiz
Summary: In this study, thermo-responsive nanocomposites were prepared by synthesizing hafnium-doped magnetite nanoparticles and grafting poly(vinylcaprolactam) (PNVCL) onto them. The nanocomposites were characterized using various techniques, and drug release studies were conducted. The results showed successful incorporation of hafnium into the structure of magnetite, as well as covalent interaction between the nanoparticles and the polymer. The PNVCL-modified Hf0.6Fe2.4O4 nanoparticles exhibited sustained drug release, making them suitable for drug delivery systems.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Article
Virology
Erendira Villalobos-Sanchez, Daniel Garcia-Ruiz, Tanya A. Camacho-Villegas, Alejandro A. Canales-Aguirre, Abel Gutierrez-Ortega, Jose E. Munoz-Medina, Darwin E. Elizondo-Quiroga
Summary: This article evaluates the antiviral activity of NDGA against SARS-CoV-2 in vitro, showing that NDGA has a remarkable inhibitory effect on the virus and could be a promising therapeutic candidate for COVID-19.
Article
Multidisciplinary Sciences
Mirna Burciaga-Flores, Ana Laura Marquez-Aguirre, Salvador Duenas, Jahaziel Gasperin-Bulbarela, Alexei F. Licea-Navarro, Tanya A. Camacho-Villegas
Summary: This study obtained a vNAR T1 that binds to TGF-beta isoforms from a non-immunized Heterodontus francisci shark library. The binding ability of vNAR T1 to TGF-beta was demonstrated through direct ELISA assay and surface plasmon resonance (SPR) analysis. This vNAR T1 has the potential to be used as a therapeutic agent.
SCIENTIFIC REPORTS
(2023)
Article
Materials Science, Multidisciplinary
Jose Manuel Gutierrez-Hernandez, Claudia Castorena-Alejandro, Diana Maria Escobar-Garcia, Alfredo Escalante, Hector Flores, Amaury Pozos-Guillen, Paul Gatenholm, Guillermo Toriz
Summary: This study evaluated hydrogels made from spruce xylan (SX) mixed with functionalized multi-walled carbon nanotubes (MWCNTs) as a scaffold for in vitro culture of osteoblastic cells. The hydrogels were obtained through chemical conjugation of spruce xylan with tyramine (TA) to enable enzymatic crosslinking. Morphological analysis and wettability properties of the hydrogel scaffolds were performed, and osteoblastic cell culture and evaluation were conducted. The results showed that the SX-TA/MWCNTs hydrogel scaffolds have the potential to be used as bionanomaterials for bone regeneration due to their increased cell viability, proliferation, and adhesion.
MATERIALS TODAY COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Juan Gallegos, Margarita Cantu-Reyes, Alejandra Ortega, Hector Magana, Xochitl Perez, Lorena Garcia-Uriostegui, Lilia Angelica Hurtado-Ayala, Guillermina Burillo
Summary: A novel antibacterial system was synthesized by surface modification of silicone rubber films with an antimicrobial quaternized 4-vinylpyridine and one antibiofouling 2-hydroxyethylmethacrylate by radiation grafting in two steps. The modified films were characterized and the antimicrobial properties were studied. The quaternized 4VP systems showed more than 90% inhibition for Gram-positive bacteria and one sample achieved 45% inhibition for Gram-negative bacteria.
RADIATION PHYSICS AND CHEMISTRY
(2023)
Article
Polymer Science
G. Tonantzin De Dios-Figueroa, Janette del Rocio Aguilera-Marquez, Lorena Garcia-Uriostegui, Rodolfo Hernandez-Gutierrez, Tanya A. Camacho-Villegas, Pavel H. Lugo-Fabres
Summary: The authors developed a hydrogel using biopolymers to encapsulate HER2-positive breast cancer cells. The hydrogel exhibited suitable physical properties and biocompatibility, maintaining the morphology and viability of the cells. It has potential applications in evaluating new HER2-targeted therapies.
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
