Article
Pharmacology & Pharmacy
Nitjawan Sahatsapan, Boonnada Pamornpathomkul, Theerasak Rojanarata, Tanasait Ngawhirunpat, Raksawan Poonkhum, Praneet Opanasopit, Prasopchai Patrojanasophon
Summary: Chitosan-maleimide coated liposomes showed improved buccal delivery of protein, with strong mucoadhesive capability and high buccal permeation.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Roman V. Moiseev, Daulet B. Kaldybekov, Sergey K. Filippov, Aurel Radulescu, Vitaliy V. Khutoryanskiy
Summary: Liposomes with different modifications were formulated and their physicochemical characteristics and retention on ex vivo eye tissues were evaluated. The maleimide-decorated liposomes showed the best retention performance on bovine conjunctiva compared to other liposomal formulations.
Article
Pharmacology & Pharmacy
Muhammet Davut Arpa, Neslihan Ustundag Okur, Mehmet Koray Gok, Saadet Ozgumusc, Erdal Cevher
Summary: In this study, buccal patches were prepared using chitosan glutamate (Chi-Glu) and novel chitosan azelate (Chi-Aze) to enhance the bioavailability of TZN. Chi-Aze patches showed longer integrity and higher drug permeability compared to Chi-Glu patches. In vivo studies revealed that buccal formulation with Chi-Aze showed approximately 3 times higher bioavailability than the orally administered commercial product.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Applied
Chaiyakarn Pornpitchanarong, Theerasak Rojanarata, Praneet Opanasopit, Tanasait Ngawhirunpat, Mark Bradley, Prasopchai Patrojanasophon
Summary: The objective of this research was to develop a novel mucoadhesive polymer for drug delivery applications based on N-(2-aminoethyl) maleimide-functionalized carboxymethyl cellulose. The weight ratios of the materials were tuned to explore the condition providing the highest maleimide content on the polymer. The synthesized polymer exhibited superior mucoadhesive capability and the ability to control drug release.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Richard Wibel, Doris E. Braun, Laurenz Haemmerle, Arne M. Joergensen, Patrick Knoll, Willi Salvenmoser, Christian Steinbring, Andreas Bernkop-Schnuerch
Summary: In this study, thiolated chitosan was used as a coating material for solid lipid nanoparticles, with the protection of thiol groups playing a key role in their interaction with mucosa. Different coating materials showed varying effects on mucus interaction and diffusion behavior on intestinal mucosa.
Article
Agricultural Engineering
Qun Zhang, Yangyang Sun, Yu Liu
Summary: In this study, chitosan (CS) and phytic acid (PA) polymers and nanoparticles were synthesized and characterized for the preparation of materials with dye adsorption and drug delivery properties. The CS-PA polymers and nanoparticles were prepared through a simple one-step ionic cross-linking protocol, with their formation depending on solution pH, CS and PA molecular weight, and concentration. The materials exhibited different morphologies and sizes based on the experimental conditions, and showed good stability under specific conditions. The study provides insights for the construction and application of CS-based materials.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Pharmacology & Pharmacy
Fhataheya Buang, Manfei Fu, Afroditi Chatzifragkou, Mohd Cairul Iqbal Mohd Amin, Vitaliy V. Khutoryanskiy
Summary: Hydroxyethylcellulose (HEC) is a water-soluble polymer with poor mucoadhesive properties. This study explores the modification of HEC by conjugation with maleimide groups to improve its mucoadhesive properties. The modified HEC exhibits superior mucoadhesive properties compared to unmodified HEC, forming a strong bond with mucin. The safety and efficacy of the newly synthesized polymer derivatives were also evaluated.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Biochemistry & Molecular Biology
Felipe Orozco, Zafarjon Niyazov, Timon Garnier, Nicola Migliore, Alexander T. Zdvizhkov, Patrizio Raffa, Ignacio Moreno-Villoslada, Francesco Picchioni, Ranjita K. Bose
Summary: Polymers crosslinked via furan/maleimide thermo-reversible chemistry have potential for reprocessable and self-healing applications, but may undergo irreversible changes in mechanical properties due to maleimide self-reaction at temperatures around 150 degrees Celsius. This finding suggests limitations for reprocessing and self-healing procedures and highlights the potential use of side reactions to tune polymer properties through in situ thermal treatments.
Article
Pharmacology & Pharmacy
A. Abruzzo, B. Giordani, A. Miti, B. Vitali, G. Zuccheri, T. Cerchiara, B. Luppi, F. Bigucci
Summary: The study designed chitosan nanoparticles and evaluated their use as mucoadhesive and/or mucopenetrating systems for vancomycin delivery. The nanoparticles showed sizes ranging from 150 nm to 350 nm with good polydispersity index and positive zeta-potential, allowing for fast and complete release of vancomycin while maintaining antibacterial activity.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Talena Rambarran, Heather D. Sheardown
Summary: The method described in the text utilizes free-radical polymerization and subsequent polymer conjugation to make block copolymers. It is versatile, as it can be applied to the synthesis of various block copolymers without requiring controlled/living radical polymerization methods.
Article
Biochemistry & Molecular Biology
Renas Rzgar Jalal, Twana Mohammed M. Ways, Mahmoud H. Abu Elella, Diyar Ahmed Hassan, Vitaliy V. Khutoryanskiy
Summary: Mucoadhesive nanoparticles based on methacrylated chitosan (MeCHI) were designed and compared with unmodified chitosan nanoparticles for the delivery of ciprofloxacin. The MeCHI nanoparticles showed smaller particle size, lower polydispersity index, higher encapsulation efficiency, and sustained drug release compared to their chitosan counterpart. The mucoadhesion study also demonstrated that the ciprofloxacin-loaded MeCHI nanoparticles had better retention on the mucosal surface.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
B. N. Kumara, R. Shambhu, Yoon-Bo Shim, Jayabalan Nirmal, K. Sudhakara Prasad
Summary: This study presents the development of a mucoadhesive Timolol-loaded graphene quantum dot-chitosan-nanocomposite for treating glaucoma with enhanced bioavailability. The nanocomposite showed high encapsulation efficiency and drug release in response to lysozyme. It also demonstrated good mucoadhesive properties and biocompatibility on human corneal epithelial cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Zheng Jin, Gaowei Hu, Kai Zhao
Summary: This study demonstrated that the synthesized M-N-2-HACC/N-CMCS nanoparticles showed high efficiency in mucosal delivery by utilizing the interaction with mucosal sites for drug release and delivery.
CARBOHYDRATE POLYMERS
(2022)
Article
Pharmacology & Pharmacy
Linh Phuong Ta, Erika Bujna, Szilard Kun, Dimitris Charalampopoulos, Vitaliy V. Khutoryanskiy
Summary: The study focused on the importance of prolonged gastrointestinal retention for probiotics delivery. Different formulations of alginate microparticles were prepared using electrospray technique, with chitosan-coated microparticles showing the highest mucoadhesive property. A novel in vitro wash-off mucoadhesion test setup was successfully validated for evaluating the performance of these probiotic formulations.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Chopaka Thongbamrer, Wanlapa Roobsoong, Jetsumon Sattabongkot, Praneet Opanasopit, Boon-ek Yingyongnarongkul
Summary: In this study, a series of L-shaped spermine-based cationic lipids with different hydrophobic chain lengths were designed and synthesized. The lipids with nonidentical hydrocarbon chains showed higher transfection efficiency compared to the identical analogues, and exhibited good transfection performance in different cell lines.
Review
Pharmacology & Pharmacy
Supusson Pengnam, Samarwadee Plianwong, Boon-ek Yingyongnarongkul, Prasopchai Patrojanasophon, Praneet Opanasopit
Summary: siRNA therapy can increase the deposition of chemotherapeutic drugs at the tumor site by suppressing the expression of multidrug-resistant genes. Nonviral delivery systems such as nanovesicles can improve siRNA delivery and have shown great potential in cancer therapy.
DRUG METABOLISM AND PHARMACOKINETICS
(2022)
Article
Engineering, Biomedical
Wipada Samprasit, Praneet Opanasopit, Benchawan Chamsai
Summary: The study developed dual-drugs-loaded nanoparticles for colon-specific delivery and synergistic activity against colon cancer cells. The nanoparticles showed enhanced activity and efficiency when both drugs were loaded, indicating potential for targeted nanomedicines in colon cancer treatment.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2022)
Article
Pharmacology & Pharmacy
Taraswi Mitra Ghosh, Teeratas Kansom, Suman Mazumder, Joshua Davis, Ahmed S. Alnaim, Shanese L. Jasper, Chu Zhang, Aedan Bird, Praneet Opanasopit, Amit K. Mitra, Robert D. Arnold
Summary: The study found that the andrographolide analog 3A.1 has anti-tumor activity against mCRPC, either alone or in combination with taxanes, showing synergistic effects. Co-treatment of 3A.1 with taxanes reduced the required dose and regulated key factors such as heat shock proteins and MAT2A to exert its effects.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2022)
Article
Pharmacology & Pharmacy
Yin Yin Myat, Tanasait Ngawhirunpat, Theerasak Rojanarata, Praneet Opanasopit, Mark Bradley, Prasopchai Patrojanasophon, Chaiyakarn Pornpitchanarong
Summary: This study synthesized PEGDA/AA nanoparticles for the delivery of Dox to colorectal cancer cells. The nanoparticles demonstrated good physical properties, drug loading and release capabilities, non-toxicity to intestinal epithelial cells, and effective killing of colorectal cancer cells. These nanoparticles show potential as a drug delivery carrier for targeted, staged-release therapy for colon cancer.
Article
Pharmacology & Pharmacy
Phuvamin Suriyaamporn, Praneet Opanasopit, Worranan Rangsimawong, Tanasait Ngawhirunpat
Summary: This study designed and developed optimal two-layered dissolving microneedles (MNs) loaded with fluconazole-microemulsions (MEs) for the potential treatment of fungal eye infection. The optimal formulation of MNs exhibited good physical properties, complete insertion, minimally invasive ocular tissue, and high stability, while showing significantly higher FLUZ permeation into the ocular tissue and providing potential antifungal activity.
Article
Pharmacology & Pharmacy
Supusson Pengnam, Purin Charoensuksai, Boon-ek Yingyongnarongkul, Rungnapha Saeeng, Hasan Uludag, Prasopchai Patrojanasophon, Praneet Opanasopit, Samarwadee Plianwong
Summary: Breast cancer is the second leading cause of cancer-related death in the US. This study developed a chitosan derivative-stabilized 3nAG nanosuspension and improved its efficacy in killing breast cancer cells by adding siRNA.
Article
Pharmacology & Pharmacy
Benchawan Chamsai, Sirima Soodvilai, Praneet Opanasopit, Wipada Samprasit
Summary: This study developed a topical film-forming spray for antiseptic application. By evaluating different polymers and solvents, optimal film-forming polymers and solvent systems were selected and their physicochemical properties were evaluated. The in vivo evaluation showed that the spray formed a clear and flexible film quickly with antibacterial activity. In vitro evaluations also demonstrated that the spray was non-toxic to cells and did not interfere with wound healing. Therefore, this spray could be a promising candidate for topical antiseptic application.
Article
Pharmacology & Pharmacy
Kanokwan Singpanna, Chaiyakarn Pornpitchanarong, Prasopchai Patrojanasophon, Theerasak Rojanarata, Tanasait Ngawhirunpat, S. Kevin Li, Praneet Opanasopit
Summary: The present study evaluated the effect of gold nanoparticles stabilized by chitosan (CS-AuNPs) and citrate ions (Ci-AuNPs) on skin permeation of sodium fluorescein (NaFI) and rhodamine b base (RhB). CS-AuNPs showed enhanced permeation of NaFI, superior to Ci-AuNPs, and this enhancement was likely due to improved delivery through the transepidermal pathway. However, CS-AuNPs and Ci-AuNPs had no significant effect on the permeability of the lipophilic molecule RhB. CS-AuNPs also exhibited no cytotoxicity towards human skin fibroblast cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Thapakorn Charoenying, Praneet Opanasopit, Tanasait Ngawhirunpat, Theerasak Rojanarata, Prasert Akkaramongkolporn, Prasopchai Patrojanasophon
Summary: This study aimed to use a 3D printer to fabricate a tablet-shaped floating device for controlling the release and floating time of domperidone tablets. The device was designed with a PVA pathway to provide a predictable floating time, and the air chamber was intentionally detached to allow elimination from the body. The optimal formulation achieved a floating time of 24 hours and a controlled drug release rate.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Benchawan Chamsai, Praneet Opanasopit, Wipada Samprasit
Summary: This study developed fast disintegrating dosage forms for oral insulin delivery by incorporating mucoadhesive thiolated chitosan (TCS)-based nano-particles (NPs). The results showed that the CD-insulin complexes were successfully encapsulated into the mucoadhesive NPs, which were promising for use in oral insulin delivery.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Phuvamin Suriyaamporn, Chaiyakarn Pornpitchanarong, Boonnada Pamornpathomkul, Prasopchai Patrojanasophon, Theerasak Rojanarata, Praneet Opanasopit, Tanasait Ngawhirunpat
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Supusson Pengnam, Praneet Opanasopit, Theerasak Rojanarata, Boon-ek Yingyongnarongkul, Chopaka Thongbamrer, Samarwadee Plianwong
Summary: The challenge in HER2-overexpressing breast cancer therapy is to develop an effective target therapy. This study formulated lipid-based nanoparticles for delivering siRNA into HER2-overexpressing breast cancer cells. The dual-targeted therapy using Mcl-1 siRNA nioplex and trastuzumab showed synergistic effects in inhibiting cell growth and inducing apoptosis.
Review
Pharmacology & Pharmacy
Kanokwan Singpanna, Chaiyakarn Pornpitchanarong, Prasopchai Patrojanasophon, Theerasak Rojanarata, Tanasait Ngawhirunpat, S. Kevin Li, Praneet Opanasopit
Summary: Transdermal drug delivery via the skin is a promising method, and gold nanoparticles (AuNPs) have emerged as a useful tool in this area. This review provides a comprehensive summary of the properties, synthesis, and applications of AuNPs in transdermal drug delivery.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
