Article
Plant Sciences
Li Tan, Jianfeng Xu, Michael Held, Derek T. A. Lamport, Marcia Kieliszewski
Summary: This study found that Hyp-O-polysaccharides isolated from transgenic Arabidopsis suspension culture have similar structural features to AGPs isolated from tobacco. It also confirmed the presence of a previously identified β-1,6-linkage on the galactan backbone in AGP fusion glycoproteins expressed in tobacco. Furthermore, AGPs expressed in Arabidopsis suspension culture have differences in terminal-rhamnosyl residues and glucuronosylation compared to those expressed in tobacco suspension culture, suggesting the presence of distinct glycosyl transferases and minimum AG structures for type II AG functional features.
Article
Biochemistry & Molecular Biology
Elena Neagu, Gabriela Paun, Camelia Albu, Oana Teodora Apreutesei, Gabriel Lucian Radu
Summary: This study analyzed the potential of Artemisia absinthium, Artemisia vulgaris, and Trigonella foenum-graecum herbs in treating diabetes and inflammatory diseases. The extracts of these herbs showed significant inhibitory activity, indicating their potential as natural remedies.
Article
Environmental Sciences
Chunyu Jiang, Shixing Zhou, Lin Liu, Zokir Toshmatov, Ling Huang, Kai Shi, Chi Zhang, Hua Shao
Summary: The chemical profile and phytotoxicity of Artemisia absinthium essential oil were investigated, identifying linalool as the major active compound responsible for its suppressive activity on receiver species. This study highlights the potential value of the essential oil and its major constituents as environmentally friendly herbicides.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Meizhu He, Kamarya Yasin, Shaoqi Yu, Jinyao Li, Lijie Xia
Summary: In this experiment, ultrasound-assisted enzymatic hydrolysis was used to improve the yield of total flavonoids in Artemisia absinthium L., and molecular docking and network pharmacology were combined to predict its core constituent targets and evaluate its antitumor activity. The main components in Artemisia absinthium L. were found to have inhibitory effects on cervical cancer by regulating several signaling proteins, and the anticancer activity was associated with the ErbB signaling pathway and FoxO signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Chemical
Aiste Balciunaitiene, Pranas Viskelis, Jonas Viskelis, Paulina Streimikyte, Mindaugas Liaudanskas, Elena Bartkiene, Paulina Zavistanaviciute, Egle Zokaityte, Vytaute Starkute, Modestas Ruzauskas, Vita Lele
Summary: This study demonstrates the synthesis of silver nanoparticles using plant extracts, showing significant antioxidant and antibacterial activities. Through physico-chemical and morphological analysis, different shapes and sizes were observed in AgNPs from different plant extracts.
Article
Plant Sciences
Braulio M. Fraga, Carmen E. Diaz, Maria Bailen, Azucena Gonzalez-Coloma
Summary: Three new compounds were isolated from a cultivated variety of Artemisia absinthium, including the sesquiterpenes absilactone and hansonlactone and the acetophenone derivative ajenjol. The biotransformation of the major lactone 3 alpha-hydroxypelenolide by the fungus Mucor plumbeus resulted in the corresponding 1 beta, 10 alpha-epoxide. These compounds showed strong antifeedant and cytotoxic effects, with the biotransformed compounds also demonstrating antifeedant postingestive effects against Spodoptera littoralis.
Article
Engineering, Environmental
Karen A. Ghazaryan, Hasmik S. Movsesyan, Tatiana M. Minkina, Dina G. Nevidomskaya, Vishnu D. Rajput
Summary: The study found that Artemisia absinthium is well-adapted to growing in copper-contaminated soils and plant growth in contaminated soil can be restored using ammonium nitrate. The plant can accumulate high levels of copper in its roots without transferring this metal to the above-ground part, making it suitable for remediation without chelating agents. For phytoextraction, chemical amendments are needed to enhance copper bioavailability and transport it to the above-ground parts, with the combination of NH4NO3, citric acid, and malic acid being the most effective approach.
ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
(2022)
Article
Chemistry, Analytical
Sandra Saunoriute, Ona Ragazinskiene, Liudas Ivanauskas, Mindaugas Marksa, Kristina Lauzike, Lina Raudone
Summary: In the past ten years, there has been a particular focus on Artemisia L. genus plants and their chemical composition. This study aimed to determine the variation in polyphenols in two Artemisia species at different growth stages and evaluate their antioxidant activity. The research found significant differences in phenolic compound diversity among Artemisia species during vegetation stages, with chlorogenic acid, 3,5-dicaffeoylquinic acid, and rutin being the predominant compounds.
Article
Plant Sciences
Thaise Boeing, Josiane de Souza, Rita de Cassia Vilhena da Silva, Lusia Nathalia Bolda Mariano, Luisa Mota da Silva, Guilherme Moreschi Gerhardt, Sylvian Cretton, Luiz Carlos Klein-Junior, Priscila de Souza
Summary: This study evaluated the gastroprotective effect of aqueous extracts obtained from Artemisia absinthium on rats and found that the room-temperature aqueous extract had a protective effect on gastric ulcers, possibly by maintaining the integrity of the gastric mucosal barrier.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Chemistry, Applied
Wenqi Huang, Mengwei Zhao, Xinyi Wang, Yang Tian, Chengjian Wang, Jing Sun, Zhongfu Wang, Guiping Gong, Linjuan Huang
Summary: In this study, LBGP70, LBGP70-OL, and LBGP70-OL-I were obtained from crude Lycium barbarum polysaccharides (LBP) by stepwise precipitation, and the structural features of LBGP70-OL were investigated. The results showed that LBGP70-OL exhibited high anti-ageing activity, with its side chain and backbone synergistically contributing to the activity.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Medicinal
Farman Ali Khan, Nasir Mehmood Khan, Shujaat Ahmad, Nasruddin, Riffat Aziz, Ihsan Ullah, Mazen Almehmadi, Mamdouh Allahyani, Ahad Amer Alsaiari, Abdulelah Aljuaid
Summary: The current studies focused on the phytochemical profiling and evaluation of antioxidant, antimicrobial, and anticholinergic effects of the essential oils extracted from two local wild Artemisia species. The oils showed promising results with different phytochemical compositions.
Article
Agricultural Engineering
Agnieszka Szparaga, Slawomir Kocira, Ireneusz Kapusta, Grzegorz Zagula
Summary: Several alternative solutions for sustainable agriculture have emerged in recent years, aiming to increase crop yield while reducing environmental pollution. Extracts from Artemisia absinthium leaves were found to be effective biostimulants for soybean cultivation, showing improvement in crop yield and economic benefits.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Polymer Science
Yuriy N. Malyar, Valentina S. Borovkova, Alexander S. Kazachenko, Olga Yu. Fetisova, Andrey M. Skripnikov, Valentin V. Sychev, Oxana P. Taran
Summary: To ensure high-quality water, toxic pollutants must be removed. Currently, various sorbents are used for water purification. Modified polysaccharides are efficient sorption materials. This study presents a new environmentally friendly method for modifying larch hemicellulose-arabinogalactan with polybasic carboxylic acids to obtain composite materials. The synthesized derivatives were characterized using various physicochemical methods, and it was found that the modified samples had promising potentials as drug carriers, sorbents, and water treatment agents due to their high sorption capacity and developed mesoporous surface.
Article
Multidisciplinary Sciences
Mohammad Sadegh Damavandi, Hasan Shojaei, Bahram Nasr Esfahani
Summary: This study investigated the diversity of bacterial endophytes in the medicinal plant A. absinthium and explored the antibacterial and anticancer potential of their bioactive secondary metabolites. Among the studied bacteria, P. aeruginosa SD01 exhibited notable activity against bacterial pathogens and malignancies.
SCIENTIFIC REPORTS
(2023)
Article
Materials Science, Textiles
Yasir Afzal Beigh, Abdul Majeed Ganai, Asif Hassan Sofi, Zulfiqarul Haq
Summary: The study found that adding wormwood and exogenous fibrolytic enzymes to the diet of sheep can increase wool yield, reduce production costs, and have no adverse effects on wool quality.
JOURNAL OF NATURAL FIBERS
(2022)
Article
Chemistry, Applied
Cristiane Colodel, Carmen Lucia de Oliveira Petkowicz
FOOD HYDROCOLLOIDS
(2019)
Article
Biochemistry & Molecular Biology
Monique Meyenberg Cunha-de Padua, Guilhermina Rodrigues Noleto, Carmen Lucia de Oliveira Petkowicz, Silvia Maria Suter Correia Cadena, Frederic Bost, Jacques Pouyssegur, Nathalie M. Mazure
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2019)
Article
Chemistry, Applied
Cristiane Colodel, Lucia Cristina Vriesmann, Carmen Lucia de Oliveira Petkowicz
FOOD HYDROCOLLOIDS
(2019)
Article
Biochemistry & Molecular Biology
Clitor J. F. Souza, Edwin E. Garcia-Rojas, Clyselen S. F. Souza, Lucia C. Vriesmann, Juarez Vicente, Mario G. de Carvalho, Carmen L. O. Petkowicz, Carmen S. Favaro-Trindade
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2019)
Article
Agriculture, Multidisciplinary
Flavia Roberta B. Marenda, Cristiane Colodel, Maria Helene G. Canteri, Carmen Maria de Olivera Mueller, Edna R. Amante, Carmen Lucia de Oliveira Petkowicz, Renata Dias de Mello Castanho Amboni
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2019)
Article
Pharmacology & Pharmacy
Juan Marcelo Carpio Arevalo, Paulo Emilio Feuser, Gustavo Rodrigues Rossi, Edvaldo S. Trindade, Emily da Silva Corneo, Ricardo Andrez Machado-de-Avila, Claudia Sayer, Silvia Maria Suter C. Cadena, Guilhermina Rodrigues Noleto, Glaucia Regina Martinez, Pedro H. Hermes de Araujo, Maria Eliane Merlin Rocha
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Bianca Busato, Elaine Cristina de Almeida Abreu, Carmen Lucia de Oliveira Petkowicz, Glaucia Regina Martinez, Guilhermina Rodrigues Noleto
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Biochemistry & Molecular Biology
Rafaela Aparecida Pereira, Amanda do Rocio Andrade Pires, Aurea Echevarria, Danilo Sousa-Pereira, Guilhermina Rodrigues Noleto, Silvia Maria Suter Correia Cadena
Summary: Mesoionic compounds MI-J and MI-D show significant antitumor effects on hepatocellular carcinoma cells, exhibiting stronger cytotoxicity in cells grown in galactose medium. Both compounds depress mitochondrial respiration and reduce ATP levels, leading to cytotoxicity in cancer cells.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Biology
Alexandre de Fatima Cobre, Dile Pontarolo Stremel, Guilhermina Rodrigues Noleto, Mariana Millan Fachi, Monica Surek, Astrid Wiens, Fernanda Stumpf Tonin, Roberto Pontarolo
Summary: This study implemented machine learning models to predict COVID-19 diagnosis and disease severity, showing that the models were able to classify negative and positive samples, as well as severe and non-severe disease, with key predictive factors including blood indicators and physiological measures.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Review
Chemistry, Applied
Luis Henrique Reichembach, Carmen Lucia de Oliveira Petkowicz
Summary: Pectin is the second most abundant plant polysaccharide after cellulose. Traditionally, pectins have been industrially produced from citrus peel and apple pomace, but now it has been found that various unutilised agricultural, agroindustry, and food industry wastes can also produce high-purity gelling pectins. The increasing demand for natural-based ingredients in materials, food, and health sectors has highlighted the need for expanding pectin production.
FOOD HYDROCOLLOIDS
(2021)
Article
Biochemistry & Molecular Biology
Leonardo Augusto dos Santos Escaliante, Bianca Busato, Carmen Lucia de Oliveira Petkowicz, Silvia Maria Suter Correia Cadena, Guilhermina Rodrigues Noleto
Summary: The study investigated the cytotoxic effect of xyloglucan complexed with oxovanadium on hepatocellular carcinoma cells, showing that the complex could intensify its effects on the respiratory chain and reduce mitochondrial membrane potential. Moreover, ATP levels were elevated under complexation, possibly due to enhanced glycolytic flux.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Cell Biology
Marilia Locatelli Correa-Ferreira, Amanda do Rocio Andrade Pires, Igor Resendes Barbosa, Aurea Echevarria, Guilherme Henrique Pedrassoli, Sheila Maria Brochado Winnischofer, Guilhermina Rodrigues Noleto, Silvia Maria Suter Correia Cadena
Summary: This study evaluated the cytotoxic effect of MI-D on T98G glioblastoma cells and found that MI-D exerts cytotoxicity by impairing mitochondrial oxidative phosphorylation.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Chemistry, Applied
Kaiany Padilha Bras Costa, Luis Henrique Reichembach, Carmen Lucia de Oliveira Petkowicz
Summary: In this study, pectins were extracted from the peels of Hylocereus fruits using both acid and enzyme methods. Pectins obtained by acid extraction had higher methoxyl content and molecular weight compared to the enzyme-extracted pectins.
FOOD HYDROCOLLOIDS
(2022)
Article
Multidisciplinary Sciences
Nicole Dalonso, Carmen L. O. Petkowicz, Luis G. Lugones, Marcia L. L. Silveira, Regina M. M. Gern
Summary: The study utilized genetic modification to transform Schizophyllum commune and found differences in cell wall polysaccharides composition between the mutant and wild type. Galactose was identified as the major component in the mutant polysaccharide fraction, while glucose was the main monomer in the wild type. Elution profiles from HPSEC and NMR analyses also showed variations between the two.
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2021)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
