Article
Biochemistry & Molecular Biology
Shayla Fernanda Barbieri, Sarah da Costa Amaral, Ester Mazepa, Arquimedes Paixao Santana Filho, Guilherme Lanzi Sassaki, Joana Lea Meira Silveira
Summary: Hemicellulose-type polysaccharides were isolated from Campomanesia xanthocarpa fruits and separated into two fractions. The chemical structure of the polysaccharide was determined to be a (4-O-methyl-alpha-D-glucurono)-D-xylan. The MGX fraction exhibited antioxidant activity and was biocompatible with human dermal fibroblasts.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Materials Science, Multidisciplinary
Yamil N. Solier, Paulina Mocchiutti, Maria C. Inalbon, Miguel A. Zanuttini
Summary: This study investigates the formation of films using polyelectrolyte complexes (PECs) of xylan and polyethylenimine (PEI). The mass ratio and pH value of xylan/PEI have an impact on the size and properties of the complexes. The neutralization charge ratio depends on pH. The film properties are affected by the composition and the method used to prepare the films. Dynamic mechanical thermal analysis shows that the glass transition temperature (T-g) of the films is influenced by composition.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Zhuojun Meng, Daisuke Sawada, Christiane Laine, Yu Ogawa, Tommi Virtanen, Yoshiharu Nishiyama, Tekla Tammelin, Eero Kontturi
Summary: A new type of polysaccharide nanocrystal with anisotropic nanoflake shape emerged from heat-induced crystallization of wood-based xylan in a dimethyl sulfoxide (DMSO) dispersion. The dimensions of these xylan nanocrystals were controlled by crystallization conditions, and DMSO molecules played a vital role in stabilizing the crystalline structure. The manipulation of temperature, concentration, and incubation time provided pathways for the formation of size-adjustable nanocrystals.
Article
Agriculture, Multidisciplinary
Endalkachew Mengistie, Abdulbaset M. Alayat, Farid Sotoudehnia, Norbert Bokros, Seth DeBolt, Armando G. McDonald
Summary: The cell wall composition of two sweet sorghum varieties was evaluated using different analytical techniques. The results showed variations in lignin and polysaccharide content between the varieties. One variety exhibited reduced lignin content and increased syringyl/guaiacyl ratio. Additionally, the glucan content in the stalks was also reduced. These findings suggest that both variety and growing season can influence the characteristics of the stalks.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Agronomy
Iosvany Lopez-Sandin, Rosa M. Rodriguez-Jasso, Guadalupe Gutierrez-Soto, Gilver Rosero-Chasoy, Shiva, K. D. Gonzalez-Gloria, Hector A. Ruiz
Summary: This study evaluated the effect of hydrothermal pretreatment on the availability of fermentable sugars in sweet sorghum bagasse (SSB) and the energy balance of the process. It was found that increasing the severity of pretreatment significantly increased the release of sugars and energy consumption. The PSSF process resulted in a bioethanol production of 22.17 g/L.
Article
Biotechnology & Applied Microbiology
Melaku Mekonen Kasegn, Addis Simachew, Yisehak Tsegaye Redda, Hailay Mehari Gebremedhn
Summary: Sweet sorghum, as a sugar-rich plant, can be utilized as a renewable source of bioenergy with no impact on global warming and food security. This study explores the potential of sweet sorghum juice for generating bioethanol using yeast isolated from the juice. The findings indicate that sweet sorghum juice is an excellent source of potent yeasts, particularly Saccharomyces yeast, which has industrial properties like high ethanol and glucose tolerance.
INTERNATIONAL MICROBIOLOGY
(2023)
Article
Materials Science, Paper & Wood
Yuko Yoneda, Toshinari Kawada, Markus Bacher, Alexander Prado-Roller, Hubert Hettegger, Antje Potthast, Alfred D. French, Thomas Rosenau
Summary: Cellulose model compounds are widely used in cellulose research to study the polymer's properties. By synthesizing methyl 4-O-methyl beta-D-glucopyranoside derivatives with different substitution patterns, the solid-state structures of these compounds were determined using X-ray diffraction. Solid-state C-13 NMR measurements confirmed the influence of packing arrangement on the chemical shifts of the substituted carbons.
Article
Biochemistry & Molecular Biology
Maria Matulova, Peter Capek
Summary: The structure of biopolymers produced by microalgae is crucial for predicting their potential biological activity and applications. In this study, the dominant fractions from an ion exchange chromatography separation of the microalga Dictyosphaerium chlorelloides exopolysaccharide were identified and their sugar components were analyzed. The results showed that the polysaccharide backbone consists of repeating units branched by Man, and a higher molecular weight fraction contained glucuronorhamnan.
CARBOHYDRATE RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Ilona Krabicova, Bohumil Dolensky, Michal Rezanka
Summary: Mannosylated structures have been studied in biomedical applications due to their ability to bind with specific biological receptors. The azide-alkyne click reaction is a common method used to link a functional moiety to a structure. In order to maintain its bioactivity, it is necessary to prepare and isolate a high-purity propargylated mannose derivative. Three known methods of preparing propargyl-alpha-mannopyranoside were revisited, and the products were analyzed using NMR spectroscopy. The experiments showed that one-step procedures did not yield pure propargyl-alpha-mannopyranoside, while a three-step procedure produced the desired compound with high purity.
Article
Engineering, Chemical
Paul Demmelmayer, Lena Steiner, Hansjorg Weber, Marlene Kienberger
Summary: In this study, a thymol-menthol-based deep eutectic solvent (tmDES) was investigated as a green alternative to 1-octanol for the extraction of carboxylic acids. NMR spectroscopy was used to detect molecular interactions and the results showed that tmDES can improve the extraction efficiency. It was found that using tmDES resulted in higher extraction efficiencies compared to 1-octanol at higher pH levels.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Mansour D. Kerim, Laurent Evanno, Laurent Ferrie
Summary: This study describes the first total syntheses of representative congeners of the Mycaperoxides family using a stereodivergent approach. The researchers successfully synthesized several Mycaperoxides and established a pertinent database for further studies, confirming their original assignment.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Le-Ping Miao, Bei-Dou Liang, Tong Jin, Xiang-Bin Han, Wen Zhang
Summary: Geometric H/D isotope effects were observed in two O-H···O hydrogen-bonded organic salts based on monoanions of 2,3,5,6-tetrafluoroterephthalic acid. Deuteration resulted in elongation of the hydrogen bonds, leading to isotopic polymorphism and modulation of cation dynamics. However, the isotopic polymorphism was found to exist within a limited temperature range for the deuterated compounds.
CRYSTAL GROWTH & DESIGN
(2021)
Article
Energy & Fuels
Noa Miguez, David Fernandez-Polo, Paloma Santos-Moriano, Barbara Rodriguez-Colinas, Ana Poveda, Jesus Jimenez-Barbero, Antonio O. Ballesteros, Francisco J. Plou
Summary: This study presents a simple method for the production of acidic xylooligosaccharides (XOS) from hardwood hemicellulose through enzymatic hydrolysis. The enzyme Depol 670L displayed the highest activity and resulted in high yield of acidic XOS. The acidic XOS exhibited high antioxidant activity.
BIOMASS CONVERSION AND BIOREFINERY
(2022)
Article
Energy & Fuels
Gary D. Strahan, Charles A. Mullen, Ryan J. Stoklosa
Summary: Lignin isolated from sweet sorghum bagasse after low moisture anhydrous ammonia (LMAA) pretreatment was characterized using various NMR techniques to correlate structural observations with molecular weight. The study found that LMAA lignin had a wider range of diffusivity and higher weight average molecular weight compared to commercial soda lignin. Additionally, fractionation based on solubility revealed that solubility was largely dependent on molecular weights of components, and a significant amount of residual ammonium was observed in the LMAA lignin.
BIOENERGY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Konstantin Potapov, Roman A. Novikov, Pavel N. Solyev, Sergey N. Kochetkov, Alexander A. Makarov, Vladimir A. Mitkevich
Summary: The article highlights the important role of heptose phosphates in immune system activation and the significance of obtaining a substantial amount of heptose phosphates for biological studies through optimizing synthetic methods. By developing a new synthesis approach, efficiency has been improved and the number of steps reduced, potentially offering practical value for further biological screening.
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)