Article
Pharmacology & Pharmacy
Yaqiong Sun, Kui Huang, Linhai Mo, Akhlaq Ahmad, Dejia Wang, Zijie Rong, Honghui Peng, Honghua Cai, Guihua Liu
Summary: Eucommia ulmoides polysaccharides (EUP) have a beneficial effect on the proliferation of macrophages. In an osteoarthritis model, EUP can inhibit the expression of inflammation-related genes and promote the expression of osteogenic and cartilage-related genes, thus reducing the degree of articular cartilage destruction. EUP may delay the progression of osteoarthritis by regulating the polarization state of macrophages.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Haibo Feng, Jie Yang, Hui Zhi, Xin Hu, Yan Yang, Linzi Zhang, Qianqian Liu, Yangyang Feng, Daiyan Wu, Hangyu Li
Summary: By coupling PsEUL and OVA to form PsEUL-OVA, the phagocytic activity of macrophages and dendritic cells is promoted, inducing both humoral and cellular immune responses. This novel delivery system significantly increases antibody and cytokine levels, activates T lymphocytes, and promotes DC maturation.
Review
Integrative & Complementary Medicine
Lichuang Huang, Qiang Lyu, Wanying Zheng, Qiao Yang, Gang Cao
Summary: Eucommia ulmoides Oliv. as a Traditional Chinese Medicine has been used for treating various diseases since ancient times, and modern pharmacological research has shown its therapeutic effects on conditions such as hypertension, diabetes, Parkinson's disease, and its antioxidant, anti-inflammatory, and anti-cancer activities.
Article
Chemistry, Analytical
Lian Yu, Liu Cao, Yuan-Hang Chang, Cong-Jia Duan, Chang Liu, Xue-Lian Zhao, Gan-Lu Yue, Xi-Qing Wang, Yu-Jie Fu
Summary: An efficient and environmentally friendly extraction process using integrated microwave-assisted ternary deep eutectic solvent extraction (TDES-MAE) was proposed for simultaneous extraction of iridoids and phenolic acids from Eucommia ulmoides Oliver leaves. Through optimization of the TDES solvent preparation and extraction conditions, the extraction efficiency was significantly increased, making it an economically productive method for extracting beneficial products from plants.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Donghui Wang, Shang Chen, Youji Li, Zhangying Han, Yahao Dai, Yanrong Huang
Summary: In this study, Eucommia ulmoides rubber (EUR) was extracted from deseeding nutshell of Eucommia ulmoides using high-power ultrasound, achieving high extraction efficiency within a relatively low temperature. The extraction solvent, liquid-to-material ratio, ultrasonic temperature, time, and power were investigated to optimize the extraction yields and molecular weights of EUR. The results show that petroleum ether is the most suitable solvent, and under the optimized parameters, a high yield of 89.13% can be achieved.
GREEN CHEMISTRY LETTERS AND REVIEWS
(2022)
Article
Agriculture, Multidisciplinary
Haibo Feng, Linzi Zhang, Jie Yang, Sheng Li, Feng Tang, Hangyu Li, Xinnan Zhang, Daiyan Wu, Yangyang Feng, Qianqian Liu, Ziwei Liu
Summary: PsEUL-OVA cubosomes (Cubs) stimulated both cellular and humoral immune responses, enhancing the phagocytic activity of dendritic cells and macrophages and increasing the antigen presentation efficiency.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Medicine, Research & Experimental
Akira Ishimitsu, Akihiro Tojo, Hiroshi Satonaka, Toshihiko Ishimitsu
Summary: Tochu tea and geniposidic acid can suppress NADPH oxidase, increase eNOS activity, and improve blood pressure and renal hemodynamics.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Agriculture, Multidisciplinary
Mengpei Liu, Yan Wang, Rong Wang, Qingxin Du, Lu Wang
Summary: Eucommia ulmoides (E. ulmoides) leaves are a new resource of medicine and food homology. This study explores the structural characterization, physicochemical properties, and antioxidant activity of E. ulmoides polysaccharides (EUP). Three components with different molecular weights were purified from E. ulmoides leaves. The monosaccharide composition and apparent morphology of these components differ, leading to varying scavenging abilities against free radicals.
CHEMICAL AND BIOLOGICAL TECHNOLOGIES IN AGRICULTURE
(2023)
Article
Plant Sciences
Huimin Gong, Min Yang, Chaochun Wang, Chunlian Tian
Summary: This study investigates the variation patterns of intra-specific and inter-specific trait variation in Eucommia ulmoides leaves and explores the response of leaf characteristics to geographical and climatic changes. The results provide insights into the leaf morphological characteristics of Eucommia ulmoides and the extent to which the environment influences leaf trait variation, offering a scientific basis for the protection and application of Eucommia ulmoides leaf resources in the future.
Article
Food Science & Technology
Fuangfah Punthi, Bara Yudhistira, Mohsen Gavahian, Chao-Kai Chang, Naila Husnayain, Chih-Yao Hou, Cheng-Chia Yu, Chang-Wei Hsieh
Summary: This study focuses on optimizing the extraction of P. ostreatus polysaccharides (POPs) using plasma-activated water (PAW). The results show that PAW treatment significantly increases the polysaccharide yield and biological activities.
Article
Biochemistry & Molecular Biology
An Li, Jin-Feng Yuan, Qin Gong, Ni Zhang, Lan-Ying Chen, Ying-Ying Luo, Ya-Ru Cui, Hui-Ling Wang, Rong-Hua Liu
Summary: The study demonstrated that Eucommia ulmoides extract has a protective effect on renal injury caused by long-term high purine diets in rats, reducing serum creatinine and blood urea nitrogen levels, alleviating inflammation and fibrosis in the kidneys, and improving pathological morphology.
Article
Agriculture, Dairy & Animal Science
Ting Hu, Yue Lei, Minxue Li, Qin Liu, Li Song, Degang Zhao
Summary: The study found that adding Eucommia ulmoides extract to the feed can improve the growth performance, antioxidant capacity, and immune level of chicks under cold stress, while reducing organ damage. This has significant value in addressing issues related to chick production under cold stress.
Article
Biochemistry & Molecular Biology
Maged E. Mohamed, Mohammad A. Elmorsy, Nancy S. Younis
Summary: Geraniol may protect against renal ischemia/reperfusion injury by inhibiting the TLR2,4/MYD88/NF kappa B pathway, mediating anti-inflammation, and activating the Nrf2 pathway, leading to antioxidative effects.
Article
Biochemistry & Molecular Biology
Yunxia Liu, Meina Li, Meihua Sun, Yaoting Zhang, Xuan Li, Wanqing Sun, Nanhu Quan
Summary: Sestrin2 (Sesn2) is a stress-inducible protein that plays a critical role in responding to ischemic stress by reducing the generation of reactive oxygen species (ROS). Rescue of Sesn2 levels in Sesn2 KO hearts improved cardiac function, ameliorated ROS generation, and improved cardiomyocyte contractile function under ischemia and reperfusion. Overall, these findings highlight the role of Sesn2 as an endogenous antioxidant in maintaining intracellular redox homeostasis during ischemic stress.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Dongyu Huang, Jian Zhu, Lu Zhang, Xianping Ge, Mingchun Ren, Hualiang Liang
Summary: This study demonstrates that the supplementation of Eucommia ulmoides leaf extract (ELE) in the diet can enhance the antioxidant capacity, immune response, and disease resistance of GIFT fish against Streptococcus agalactiae.
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)