Article
Food Science & Technology
Aijun Tong, Dengwei Wang, Xiaoyan Liu, Zhiqun Li, Runfan Zhao, Bin Liu, Chao Zhao
Summary: This study evaluated the hypoglycemic effects of low molecular weight polysaccharides fractions from Laminaria japonica (LJOO) on mice with T2DM. The results showed that LJOO decreased FBG and insulin concentrations, altered the gut microbiota composition, increased the population of beneficial bacteria, and decreased the population of harmful bacteria. Additionally, LJOO stimulated the growth of SCFA-producing bacteria, resulting in increased SCFAs levels.
Article
Nutrition & Dietetics
Jiamei Cui, Yunpeng Wang, Eunyoung Kim, Chongyu Zhang, Guiguo Zhang, Yunkyoung Lee
Summary: This study investigated the structural characteristics and bioactivities of a novel long-chain LJPS derived from Laminaria japonica. The LJPS was found to consist of various monomer residues and was a multi-branched, long-chain macromolecule with highly branched and helix domains. The LJPS exhibited no toxicity to mouse macrophage cells and showed biphasic immuno-modulating capacity.
FRONTIERS IN NUTRITION
(2022)
Article
Agriculture, Multidisciplinary
Xue-Ying Li, Yu-Jing Wang, Shun Chen, Li-Hua Pan, Qiang-Ming Li, Jian-Ping Luo, Xue-Qiang Zha
Summary: The present study demonstrated that LJP61A significantly reduced the lesion burden in atherosclerotic mice and alleviated lipid deposition in Ox-LDL-stimulated macrophages. Moreover, LJP61A enhanced autophagy-mediated macrophage polarization, leading to reduced inflammation and atherosclerosis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Zhen Jin, Qingqing Ma, Xuemei Chen, Hongchao Wang, Jinlin Zhu, Yuan-kun Lee, Hao Zhang, Jianxin Zhao, Wenwei Lu, Wei Chen
Summary: This study discovered a novel gluco-oligosaccharide called Laminaria japonica gluco-oligosaccharide (LJGO) from brown alga, which selectively stimulated the growth of specific lactic acid bacteria strains. Comparative genomics revealed that this transport system is species-specific, implying a potential contribution to species evolution.
Article
Biochemistry & Molecular Biology
Na Li, Quancen Li, Xiaoyu He, Xiaoxiang Gao, Linxiu Wu, Meifang Xiao, Wenwen Cai, Bin Liu, Feng Zeng
Summary: In this study, the antioxidant activity of Laminaria japonica polysaccharide (LJP) was investigated in vitro. Additionally, the effects of LJP on thermal tolerance, oxidative stress tolerance, and aging in Caenorhabditis elegans (C. elegans) were studied in vivo. The results showed that LJP exhibited free radical scavenging activity, improved thermal tolerance, and reduced oxidative stress levels in C. elegans. Furthermore, LJP modulated the expression of certain genes and metabolic pathways, contributing to its ability to delay aging.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Agriculture, Multidisciplinary
Anxin Liu, Eunyoung Kim, Jiamei Cui, Jing Li, Yunkyoung Lee, Guiguo Zhang
Summary: This study investigated the beneficial effects of Laminaria japonica polysaccharide (LJPS) on ducks. LJPS supplementation improved overall growth performance, physiological immune response, and antioxidant index. LJPS also increased the abundance of intestinal Bacteroides and Prevotellaceae, while decreasing alpha-diversity. LJPS feeding differentially regulated 186 intestinal metabolites, associated with growth-related metabolic pathways.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Xiaochen Liu, Xiaohong Yu, Jingci Lyu, Fengwei Li, Yueling Shang, Yongmei Lyu, Jinbin Liu
Summary: The polysaccharide extracted from Osmunda japonica Thunb was found to effectively inhibit uterine fibroids by reducing serum estrogen and progesterone levels.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Hui Li, Ming Liu, Zikun Liu, Li Cheng, Mengsha Li, Chongwei Li
Summary: This study elucidated the structure and antitumor activity of PFSP-2-1, providing a theoretical foundation for understanding the molecular mechanism of antitumor activity of Perilla seed polysaccharides. It also offers an important theoretical basis for the development of valuable Perilla.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Applied
Hai-Yang Li, Yan-Ling Yi, Sheng Guo, Fang Zhang, Hui Yan, Zhi-Lai Zhan, Yue Zhu, Jin-Ao Duan
Summary: This review provides a comprehensive summary of the extraction, purification, structural characterization, and biological activities of Laminaria japonica polysaccharides, offering valuable insights for further research, production, and application in functional foods and therapeutic agents.
Article
Biochemistry & Molecular Biology
Xue-Ying Li, Hao-Ran Chen, Dan-Dan Kuang, Li-Hua Pan, Qiang-Ming Li, Jian-Ping Luo, Xue-Qiang Zha
Summary: In this study, the interventional effect and potential mechanism of Laminaria japonica polysaccharide (LJP61A) on podocyte epithelial-mesenchymal transition (EMT) were investigated. Results showed that LJP61A prevented EMT-like morphological changes, proteinuria, and kidney injury by up-regulating epithelial markers and down-regulating mesenchymal markers. The inhibition of TGF-beta 1-mediated Smad3 and p38MAPK pathways may contribute to the preventive effect of LJP61A on podocyte EMT.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nutrition & Dietetics
Xueqian Zhang, Changyu Su, Cui Cao, Guiping Gong, Linjuan Huang, Zhongfu Wang, Shuang Song, Beiwei Zhu
Summary: Intake of Laminaria japonica can balance gut microbiota composition, enhance the ability of microbiota to utilize alginate, and have positive impacts on human health.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Tung-Yi Lin, Hung-Chih Lo, Wei-Lun Qiu, Chi-Hsein Chao, Mei-Kuang Lu, Hsien-Yeh Hsu
Summary: In this study, the anticancer activity of LJPS was optimized using the TFF system. The crude LJPS was divided into two fractions, 10K-R and 10K-F, with molecular masses of approximately 985 and 3 kDa, respectively. The biological functions showed that 10K-R inhibited the viability and mobility of cancer cells, while 10K-F did not. This study provides the first evidence of purifying polysaccharide using the TFF system and reveals the potential mechanism of 10K-R in cancer cell inhibition.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biotechnology & Applied Microbiology
Zhipeng Li, Zeping Du, Hebin Li, Yanhong Chen, Mingjing Zheng, Zedong Jiang, Xiping Du, Hui Ni, Yanbing Zhu
Summary: Marine bacterium Microbulbifer sp. ALW1 can effectively degrade Laminaria japonica thallus fragments and produce various enzymes. ALW1 has unique cell morphology, physiological, and biochemical characteristics compared to other related species. The complete genome of ALW1 has been sequenced and can be utilized in potential industrial applications.
Article
Biochemistry & Molecular Biology
Xuelian Wang, Yeling Li, Wenhui Liu, Yongye Shen, Zhen Lin, Akira Nakajima, Jing Xu, Yuanqiang Guo
Summary: A homogeneous polysaccharide (IJP70-1) with a molecular weight of 1.019 x 105 Da was purified from the flowers of Inula japonica, showing potential antitumor activity by activating the immune system and inhibiting angiogenesis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Xiaona Sun, Chunqing Ai, Chengrong Wen, Haoran Peng, Jingfeng Yang, Yuna Cui, Shuang Song
Summary: Different molecular weight fucoidans were prepared and compared for their chemical structures and anti-pathogenic microbiota activity. Results showed that fucoidan with higher molecular weight had stronger inhibitory effects on pathogenic bacteria and SARS-CoV-2. In addition, it also exhibited better capability to prevent bacterial adhesion to cells. These findings provide insights into the relationship between structure and activity of fucoidan against pathogenic microbiota.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)