Article
Food Science & Technology
Hexiang Xie, Liqiong Zhang, Kefan Ouyang, Yong Wang, Hua Xiong, Qiang Zhao
Summary: The effect of genipin concentration on the properties of chitosan/rice protein hydrolysate composite films was studied. Genipin increased the stability of the conjugate and affected the crosslinking degree. At the optimal genipin concentration, the film had the lowest moisture content and water vapor transmission rate. Genipin also improved the tensile strength and thermal stability of the films, but decreased the DPPH scavenging activity.
FOOD AND BIOPROCESS TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
M. Angelica M. Rocha, Manuel A. Coimbra, Silvia M. Rocha, Claudia Nunes
Summary: The use of chitosan-genipin films as a technological adjuvant for white wine preservation offers new opportunities for winemaking industries, replacing sulfur dioxide while maintaining the varietal key odorants and organoleptic characteristics. The study shows that the contact of these films with white and red wines can retain long carbon chain volatile compounds and promote the formation of compounds that enhance the wines aroma, maintaining their varietal notes.
APPLIED SCIENCES-BASEL
(2021)
Article
Polymer Science
Jun Zeng, Youcheng Gao, Siming Zhu, Hongyuan He, Ming Yu
Summary: In this study, chitosan-soy protein isolate crosslinked films were prepared using genipin as a crosslinking agent. The crosslinking reaction with high contents of genipin changed the rheological properties of the film matrixes. It was found that the crosslinking reaction decreased the crystallinity degree and enhanced the surface roughness of the films, resulting in improved light barrier capacity but reduced tensile strength and thermal stability.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Seda Ceylan
Summary: Loading of propolis using genipin as a crosslinking agent and fabrication of PVA/Chitosan-Propolis membrane scaffolds for wound dressing applications were studied. Propolis significantly affected the properties of the membrane, with the propolis-incorporated membrane showing high cell proliferation rates.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Physical
Zhanyong Wang, Tingting Su, Jingjing Zhao
Summary: The utilization of genipin-crosslinked chitosan beads as a carrier for immobilizing recombinant cutinase from Fusarium solani (FSC) resulted in improved thermal and pH stability of the enzyme, enhancing its performance for industrial applications.
Article
Biochemistry & Molecular Biology
Qun Liu, Yan Li, Shu Xing, Ling Wang, Xiaodeng Yang, Fei Hao, Mingxia Liu
Summary: In this study, two amphiphilic chitosan derivative films were prepared by crosslinking with genipin, and they showed excellent mechanical properties, antibacterial activity, and preservation effects on fruits.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Physical
Jonathan Miras, Chao Liu, Eva Blomberg, Esben Thormann, Susana Vilchez, Jordi Esquena
Summary: Crosslinked chitosan-based nanofilms prepared with the nontoxic reagent genipin showed pH-responsive behavior, swelling at pH 3 and shrinking at pH 6, with reversible changes between these two pH values. The wettability of the nanofilms decreased with increased crosslinking. Quartz crystal microbalance with dissipation (QCM-D) and atomic force microscopy (AFM) were used to study the swelling capacity and elastic properties of the nanofilms, showing irreversible changes at pH 9. AFM results also demonstrated an increase in elastic modulus from approximately 500 MPa at pH 3 to around 700 MPa at pH 6.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Chemistry, Applied
Ning Ma, Liming Liu, Yu Zhang, Lu Wang, Weiping Qian
Summary: Carbohydrate-protein interactions can improve the properties and texture of proteins. This study investigated the effects of pH and preheating on the interaction between chitosan/chitosan oligosaccharide and whey protein isolate (WPI). It was found that chitosan exhibited greater efficacy in preventing denaturation and aggregation of WPI caused by heat treatment at pH 4.0. Changes in electrostatic interactions and protein structure influenced the formation of the complex system structure as pH expanded. In vitro digestion experiments showed that chitosan and chitosan oligosaccharide had opposite effects on WPI digestion in the gastric.
FOOD HYDROCOLLOIDS
(2024)
Article
Biochemical Research Methods
Xinyue Zhao, Jian Tang, Yanhua Liu, Bing Hu, Quan Chen, Yonggang Liu
Summary: Crosslinking of chitosan chains with genipin leads to the formation of biocompatible nanogels. The reaction is first-order and size-dependent. The crosslinking reaction results in an increase in the hydrodynamic radius and weight average molar mass of the chitosan chains. The reaction also leads to the formation of branched chains/nanogels with a wide range of molar masses but similar sizes, and the largest nanogels show a scaling relation with a hard sphere particle structure. The reaction is accompanied by a reduction of charge density and an increase in hydrophobicity, which plays a key role in the formation of uniform size nanogels.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Biochemistry & Molecular Biology
Xin Meng, Yang Lu, Ying Gao, Suying Cheng, Feng Tian, Yuliang Xiao, Fan Li
Summary: Polyelectrolyte complexes wound dressing based on chitosan/alginate/hyaluronic acid crosslinked with genipin were prepared, showing excellent biocompatibility and adjustable physical, mechanical, and biological properties. The dressing promoted wound healing in a rat model and exhibited great potential for use as promising wound dressings.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Tyler R. Priddy-Arrington, Reagan E. Edwards, Claire E. Colley, Marissa M. Nguyen, Tess Hamilton-Adaire, Mary E. Caldorera-Moore
Summary: Recently, there has been a growing interest in injectable, in situ crosslinking hydrogels that can conform to their environment with minimal invasion. Current in situ crosslinking chitosan hydrogels either lack biocompatibility and degrade slowly due to toxic crosslinking agents, or are mechanically weak and degrade rapidly due to insufficient crosslinking. In this study, the authors developed a thermally-driven, injectable chitosan-genipin hydrogel that can be crosslinked at 37 degrees C, which demonstrates mechanical strength, biodegradability, and high biocompatibility. The natural crosslinker used is genipin, which is non-toxic and activated by temperature. The characteristics of the chitosan-genipin hydrogel, such as crosslinking kinetics, injectability, viscoelasticity, swelling and pH response, and biocompatibility with keratinocyte cells, were analyzed. The results showed that the hydrogel can be successfully crosslinked at 37 degrees C, and it remains mechanically stable while being biodegradable. Long-term cell viability tests demonstrated excellent biocompatibility of the chitosan-genipin hydrogel, even during the crosslinking phase. Overall, these findings support the development of an injectable, in situ crosslinking chitosan-genipin hydrogel for minimally invasive biomedical applications.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Ning Ma, Yizhen Wan, Lele Zhou, Lu Wang, Weiping Qian
Summary: This study investigated the interaction between chitosan and pepsin at different concentrations and pH values using silica colloidal crystal films and ordered porous layer interferometry. The results showed that the protonation of chitosan and the net charge carried by pepsin caused various degrees of electrostatic attraction under different pH values, and the rate and degree of hydrolysis were positively correlated with pepsin concentration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Yike Jiang, Wen Wang, Qingrong Huang
Summary: Polysaccharide-polypeptide nanocomplexes are effective stabilizers for Pickering emulsions, but are prone to instability with changes in pH and ionic strength. To overcome this issue, the CS-CPPs nanocomplexes were crosslinked using genipin, resulting in GCNs that improved the stability of Pickering emulsions. The physical properties of GCNs and the resulting GPEs were influenced by the genipin concentration, crosslinking temperature, and duration. GPEs prepared with lower temperature and shorter duration of crosslinking exhibited stronger gel-like characteristics and higher stability in terms of pH and ionic strength.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Food Science & Technology
Yihui Zhao, Yalan Zhang, Hao Dong, Weiliang Wu, Xingfen Yang, Qi He
Summary: Due to global environmental concerns, chitosan has been explored as a sustainable polymer for eco-friendly food packaging. The low mechanical stability and high water sensitivity of pure chitosan films have been improved through the formation of derivatives with better performance. This review provides insight into the network interactions of chitosan and its compounds, highlighting the implications for improvement in antimicrobial ability, mechanical properties, and gas barrier properties of chitosan-based food packaging.
Article
Polymer Science
Lorenzo Mio, Pasquale Sacco, Ivan Donati
Summary: This study examines the effect of temperature and polymer concentration on the strain hardening of chitosan hydrogels. The results show that the extent of hardening can be modulated by varying the gel temperature, but is independent of other experimental conditions. The study suggests that this effect is due to a delicate balance between physical entanglements and covalent crosslinks in highly acetylated chitosan hydrogels under large deformations.
Article
Chemistry, Multidisciplinary
Chris C. Hornat, Ying Yang, Marek W. Urban
ADVANCED MATERIALS
(2017)
Review
Polymer Science
Xiaolin Liu, Ying Yang, Marek W. Urban
MACROMOLECULAR RAPID COMMUNICATIONS
(2017)
Article
Polymer Science
Ying Yang, Marek W. Urban
Review
Chemistry, Multidisciplinary
Ying Yang, Marek W. Urban
ADVANCED MATERIALS INTERFACES
(2018)
Article
Chemistry, Multidisciplinary
Ying Yang, Dmitriy Davydovich, Chris C. Hornat, Xiaolin Liu, Marek W. Urban
Article
Multidisciplinary Sciences
Marek W. Urban, Dmitriy Davydovich, Ying Yang, Tugba Demir, Yunzhi Zhang, Leah Casabianca
Article
Nanoscience & Nanotechnology
Bertrand Willocq, Farid Khelifa, Jeremy Odent, Vincent Lemaur, Ying Yang, Philippe Leclere, Jerome Cornil, Philippe Dubois, Marek W. Urban, Jean-Marie Raquez
ACS APPLIED MATERIALS & INTERFACES
(2019)
Article
Polymer Science
Chris C. Hornat, Marlies Nijemeisland, Michele Senardi, Ying Yang, Christian Pattyn, Sybrand van der Zwaag, Marek W. Urban
Article
Chemistry, Multidisciplinary
Bryan Lee, Siyu Tian, Guoping Xiong, Ying Yang, Xiaoshan Zhu
Summary: In this study, iron- and nitrogen-doped carbon nanomaterials (Fe-N-CNMs) and copper- and nitrogen-doped CNMs (Cu-N-CNMs) were synthesized and their peroxidase-like properties were compared. The results showed that these materials have different reaction characteristics and potential applications.
JOURNAL OF NANOPARTICLE RESEARCH
(2022)
Article
Nanoscience & Nanotechnology
Weijian Hua, Kellen Mitchell, Lasith S. Kariyawasam, Changwoo Do, Jihua Chen, Lily Raymond, Naima Valentin, Ryan Coulter, Ying Yang, Yifei Jin
Summary: This study proposes the concept of stimuli-responsive yield-stress fluids with an interactive dual microstructure as support bath materials. The fluid can switch states at different stresses and regulate its rheological properties based on external stimuli, enabling the addition and removal of support bath materials during printing. By studying a nanoclay-Pluronic F127 nanocomposite, the interactions and microstructure evolutions at different stresses are investigated. Three representative 3D structures are successfully printed to validate the printing capability of the fluid.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Physical
Ozan Kokkilic, Shiva Mohammadi-Jam, Pengbo Chu, Christopher Marion, Ying Yang, Kristian E. Waters
Summary: Despite being a major global problem, plastic solid waste can be addressed through plastic recycling. Froth flotation technology, with its potential for high efficiency and environmental friendliness, is being researched as a method for plastic solid waste recycling.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Lasith S. Kariyawasam, Julian Rolsma, Ying Yang
Summary: In this study, a highly desirable polymer recycling technique called monomer-polymer recycling of polydithioacetal (PDTA) was reported. The PDTAs were synthesized from 3,4,5-trimethoxybenzaldehyde and alkyl dithiols and exhibited depolymerizability via ring-closing depolymerization and entropy-driven ring-opening polymerization (ED-ROP). The crosslinked network of PDTA showed thermal reprocessability and could be recycled into macrocyclic monomers in solvent for regenerating the crosslinked network. This study demonstrated the potential of PDTA as a new molecular platform for designing recyclable polymers and highlighted the advantages of ED-ROP for polymerization at higher temperatures.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Nanoscience & Nanotechnology
Weijian Hua, Kellen Mitchell, Lasith S. Kariyawasam, Changwoo Do, Jihua Chen, Lily Raymond, Naima Valentin, Ryan Coulter, Ying Yang, Yifei Jin
Summary: This study proposes a concept of stimuli-responsive yield-stress fluids with an interactive dual microstructure for use as support bath materials in 3D printing. By utilizing a yield-stress additive and stimuli-responsive polymers, the fluids are able to switch between different states at varying stresses and exhibit regulable rheological properties when exposed to external stimuli. The printing capability of these fluids is validated through the successful fabrication of various complex structures, demonstrating their potential for manufacturing arbitrary architectures.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Meeting Abstract
Chemistry, Multidisciplinary
Christopher Hornat, Ying Yang, Marek Urban
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2017)
Meeting Abstract
Chemistry, Multidisciplinary
Ying Yang, Christopher Hornat, Marek Urban
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2017)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
