Article
Plant Sciences
Avinash Sanap, Kalpana Joshi, Tejas Shah, Girish Tillu, Ramesh Bhonde
Summary: The study showed that Piper longum L. fruit extract significantly increased proliferation of WJMSCs and enhanced Ca2+ accumulation and matrix mineralization, along with promoting alkaline phosphatase (ALP) activity and the expression of key gene mRNAs. This suggests that the fruit extract can enhance osteogenic differentiation of WJMSCs, potentially serving as an anti-osteoporotic agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Chemistry, Medicinal
Protha Biswas, Mimosa Ghorai, Tulika Mishra, Abilash Valsala Gopalakrishnan, Debleena Roy, Abhijit Bhagwan Mane, Avinash Mundhra, Neela Das, Vikas Moreshwar Mohture, Manoj Tukaram Patil, Md Habibur Rahman, Niraj Kumar Jha, Gaber El-Saber Batiha, Suchismita Chatterjee Saha, Mahipal S. Shekhawat, Radha, Manoj Kumar, Devendra Kumar Pandey, Abhijit Dey
Summary: Piper longum, commonly known as long-pepper or Pippali, is a plant with wide medicinal importance. Its fruits are used as culinary spice, preservatives, and in traditional medicine to treat various ailments. The plant extracts and essential oils contain bioactive compounds with antimicrobial, anti-inflammatory, and analgesic properties. This review provides comprehensive information on the plant's habit, distribution, ethnobotany, phytochemistry, and pharmacology, validating its traditional medicinal claims and suggesting future research directions.
PHYTOTHERAPY RESEARCH
(2022)
Article
Chemistry, Applied
Yazhong Ge, Huamai Qiu, Jianxian Zheng
Summary: The study found that polysaccharide extracted from Helvella leucopus can lower the levels of cholesterol, triglycerides, and low-density lipoprotein cholesterol, while increasing high-density lipoprotein cholesterol in hyperlipidemic mice. It also regulates liver function and blood lipid metabolism. This suggests that Helvella leucopus polysaccharide could be a new complementary alternative strategy for managing hyperlipidemia.
Article
Oncology
Indrajeet Singh, Richa Das, Ajay Kumar
Summary: Colorectal cancer is the second most common and deadliest malignancy. Piperlonguminine, an alkaloid found in Piper longum, shows potential as a medicine for treating colorectal cancer. Network pharmacology analysis identified the targets of piperlonguminine and the colorectal cancer-related pathways.
Article
Biochemistry & Molecular Biology
Atsuyoshi Nishina, Motohiko Ukiya, Kazuki Motegi, Risa Kiryu, Daisuke Sato, Mitsuru Sada, Yuki Hori, Hideo Satsu, Kazuhiro Uemura, Mamoru Koketsu, Masayuki Ninomiya, Lwin Mon Mon Myint, Hirokazu Kimura
Summary: This study focused on Piper longum L., a herbal drug with renoprotective effect produced in Myanmar. The researchers isolated and identified two compounds, licarin A and neopomatene, from the aerial parts of the plant. These compounds showed a promotion effect on the expression of the ABCG2 gene in Caco-2 cells.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2023)
Article
Agriculture, Multidisciplinary
Qian Wan, Jie Xu, Chengjing Zhu, Xingxing Liu, Yijun Tu, Jiachuan Lei, Jianqing Yu
Summary: In this study, 16 compounds, including 9 new amide alkaloids, were isolated from the roots of Piper longum L. These compounds exhibited better anti-inflammatory activities compared to indomethacin. Among them, five dimeric amide alkaloids showed synergistic effects with chemotherapeutic drugs against cervical cancer cells and enhanced the efficacy of paclitaxel in paclitaxel-resistant cervical cancer cells. Additionally, these dimeric amide alkaloids could promote cancer cell apoptosis through the Src/ERK/STAT3 signaling pathway.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Le Thi Huyen, Nguyen Thi Thu Hau, Phan Van Kiem
Summary: Phytochemical study on the methanolic extract of the aerial parts of this plant led to the isolation of 7 phenolic compounds, including 3 new ones. Their chemical structures were determined and compounds 3 to 7 showed significant inhibition of NO production in LPS-activated RAW264.7 cells with IC50 values ranging from 32.09 to 38.16 μM, similar to the positive control N-G-monomethyl-L-arginine acetate (IC50 32.51 +/- 3.70 μM).
NATURAL PRODUCT COMMUNICATIONS
(2023)
Article
Environmental Sciences
S. Asha, T. C. Bessy, J. F. Joe Sherin, C. Vijil Vani, C. Vijaya Kumar, M. R. Bindhu, Shanmugam Sureshkumar, Fatimah S. Al-Khattaf, Ashraf Atef Hatamleh
Summary: Piper longum extract is used as a reducing agent in the green synthesis method to synthesize ZnO nanoparticles. This extract has an impact on the structural, optical and surface morphological properties of ZnO-NPs, specifically tuning the band gap. The nanoparticles also show different antibacterial performances and high degradation efficiency of dyes under UV light irradiation. The synthetic nanopowders have important potential for various biochemical and environmental applications.
ENVIRONMENTAL RESEARCH
(2022)
Article
Plant Sciences
Sushma Mishra, Shilpi Sharma
Summary: The female spikes of Piper longum are used in traditional medicine to treat respiratory and digestive disorders. This study analyzed the microbial communities associated with spike development, revealing that spike development significantly impacts the diversity and abundance of microbial communities.
PHYSIOLOGY AND MOLECULAR BIOLOGY OF PLANTS
(2023)
Review
Biochemistry & Molecular Biology
Shuai Chen, Li Qin, Ting Chen, Qiang Yu, Yi Chen, Wenhao Xiao, Xiaoyao Ji, Jianhua Xie
Summary: Starch, a copolymer with unique physicochemical characteristics, has limitations in food applications due to its undesirable properties. Different modification methods are used to improve its performance and expand its application. The addition of small amounts of polysaccharides affects the properties of starch pastes and gels, with factors such as starch type, polysaccharide type, and preparation methods playing a role. This review discusses the changes in starch properties and the mechanism of polysaccharide action on starch after modification.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Food Science & Technology
Fa Zhou, Lijing Su, Jiana Xu, Mengze Wang, Junfeng Fan, Bolin Zhang, Yonghua Li
Summary: Chemical modification of polysaccharides alters their structure, increasing water solubility and reducing the impact on potato starch pasting. This study reveals the potential application of these modified polysaccharides in starch-based foods.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Polymer Science
Azusa Togo, Keiko Uechi, Osamu Mizutani, Satoshi Kimura, Tadahisa Iwata
Summary: In this study, high molecular weight nigeran was extracted from mycelium and various nigeran esters were synthesized with different ester chain lengths. These nigeran esters showed unique crystallization behavior with high melting points, regardless of the length of ester groups. The molecular conformation of nigeran remained stable and highly crystalline even after chemical modification with esterification.
Article
Chemistry, Applied
Manaswini Dash, Subhashree Singh, Bhaskar Chandra Sahoo, Suprava Sahoo, Rajesh Kumar Sahoo, Sanghamitra Nayak, Basudeba Kar
Summary: The study analyzed the volatile components in Piper longum leaf and fruit, showing that the fruit volatiles had higher antioxidant and free radical scavenging activities, exhibiting strong activity against multidrug resistant bacteria, particularly Acinetobacter baumannii. Therefore, dried fruits may be used for drug development.
NATURAL PRODUCT RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Masahiro Komeno, Yuki Yoshihara, Junya Kawasaki, Wataru Nabeshima, Koshi Maeda, Yuki Sasaki, Kiyotaka Fujita, Hisashi Ashida
Summary: In this study, the degradation pathways of AX and AXOs by Bifidobacterium longum subsp. longum were characterized, and the crucial roles of BlArafD and BlArafE in the assimilation of AX were identified.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Nutrition & Dietetics
Dong Ryun Gu, Hyun Yang, Seong Cheol Kim, Youn-Hwan Hwang, Hyunil Ha
Summary: The study found that the water extract of Piper longum Linn (WEPL) can inhibit osteoclast differentiation and alleviate bone loss in ovariectomized mice. Additionally, phytochemicals in WEPL were identified to have inhibitory effects on osteoclastogenesis and bone loss.
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)