Article
Polymer Science
Rishabha Malviya, Anchal Tyagi, Shivkanya Fuloria, Vetriselvan Subramaniyan, Kathiresan Sathasivam, Sonali Sundram, Sundram Karupiah, Srikumar Chakravarthi, Dhanalekshmi Unnikrishnan Meenakshi, Nandan Gupta, Mahendran Sekar, Kalvatala Sudhakar, Neeraj Kumar Fuloria
Summary: The study aimed to formulate chitosan-tamarind seed polysaccharide composite films for protein/peptide delivery, with evaluations on various parameters. The prepared films showed stability in physical and chemical properties, which could enhance drug bioavailability and permeability.
Article
Pharmacology & Pharmacy
Karin Korelc, Bjarke Strom Larsen, Mirjana Gasperlinb, Ingunn Tho
Summary: Oromucosal films and wafers are convenient solid dosage forms for drug delivery. In this study, prednisolone containing chitosan-based mucoadhesive films and wafers were developed with different chitosan types. The mucoadhesive properties, drug release rate, and permeability of the formulations were evaluated. The results showed that chitosan type, solvent, and preparation method influenced the mucoadhesive properties, drug release rate, and permeability. The mucoadhesive wafers with a slower drug release rate and stronger mucoadhesion were considered promising alternatives to films.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Applied
Mai Bay Stie, Heidi Oblom, Anders Christian Norgaard Hansen, Jette Jacobsen, Ioannis S. Chronakis, Jukka Rantanen, Hanne Morck Nielsen, Natalja Genina
Summary: The study designed a multi-layered nanofiber-on-foam-on-film (NFF) drug delivery system with mucoadhesive properties and saliva-repelling ability, which improved drug absorption and permeability through oral mucosa. This system has great potential for non-invasive drug administration.
CARBOHYDRATE POLYMERS
(2023)
Review
Biochemical Research Methods
Neeraj Kulkarni, Suchita Dattatray Shinde, Govinda Shivaji Jadhav, Diksha Ramesh Adsare, Kamya Rao, Mihir Kachhia, Mohit Maingle, Shubham Prakash Patil, Neha Arya, Bichismita Sahu
Summary: Peptides and chitosan are important biomolecules with potential for a wide range of biomedical applications. Hybridizing peptides and chitosan into new biomaterials can enhance their biosignaling properties and cell adhesion properties for use in drug delivery, tissue engineering, and other fields.
BIOCONJUGATE CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Parisa Maleki Dana, Jamal Hallajzadeh, Zatollah Asemi, Mohammad Ali Mansournia, Bahman Yousefi
Summary: Osteosarcoma is prevalent in children and adolescents with ineffective conventional treatments, necessitating the development of novel drugs and bone-repairing methods. Chitosan, a natural compound, exhibits anti-tumor activities and can be utilized in drug delivery and diagnostic techniques.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Polymer Science
Yusuke Nakayama, Yutaro Ito, Tsuyoshi Fukaminato, Wei Xu, Takuro Niidome, Seiji Kurihara, Sunnam Kim
Summary: A highly water-soluble and stable hyperbranched curcumin polymer with many carboxylic end groups is synthesized, showing high curcumin content. It exhibits remarkable improvement in stability against degradation and aggregation in aqueous solution, and also demonstrates cellular uptake and cytotoxicity.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Polymer Science
Swati Sharma, Rajesh Kumar, Nishant Kumar Rana, Biplob Koch
Summary: In this study, a biocompatible and self-healing hydrogel was fabricated using chitosan (CS) and crotonaldehyde (CA) through the formation of dynamic imine linkage. The hydrogel showed quick self-healing property and good viscoelastic properties, confirmed by rheology analysis.
EUROPEAN POLYMER JOURNAL
(2022)
Review
Chemistry, Applied
Somaye Rashki, Kasra Asgarpour, Hossein Tarrahimofrad, Maryam Hashemipour, Mohammad Saeid Ebrahimi, Hadis Fathizadeh, Ahmad Khorshidi, Haroon Khan, Zeynab Marzhoseyni, Masoud Salavati-Niasari, Hamed Mirzaei
Summary: Chitosan nanomaterials have gained attention in biomedicine for their high levels of biodegradability and biocompatibility, along with antimicrobial effects. Functional modification with other natural compounds, metallic antimicrobial particles, and antibiotics can enhance the efficiency of chitosan in wound dressing with antimicrobial activity. The antibacterial effect of chitosan is mainly associated with the leakage of intracellular content due to malfunction and altered permeability of the negatively charged cell membrane, on which chitosan is adsorbed. Additionally, chitosan nanoparticles possess favorable features of nanoparticles and their chitosan base, thereby exhibiting strengthened antibacterial potential. Polycations in chitosan nanoparticles target negatively charged bacterial membranes, resulting in a stronger effect on bacterial cells compared to pure chitosan.
CARBOHYDRATE POLYMERS
(2021)
Article
Multidisciplinary Sciences
Krzysztof Pyrc, Aleksandra Milewska, Emilia Barreto Duran, Pawel Botwina, Agnieszka Dabrowska, Malwina Jedrysik, Malgorzata Benedyk, Rui Lopes, Alejandro Arenas-Pinto, Moutaz Badr, Ryan Mellor, Tammy L. Kalber, Delmiro Fernandez-Reyes, Andreas G. Schatzlein, Ijeoma F. Uchegbu
Summary: There are currently no cures for COVID-19, highlighting the importance of prevention. The polymer GCPQ has shown potential in reducing the infectivity of SARS-COV-2 and may be a promising prophylactic for COVID-19.
SCIENTIFIC REPORTS
(2021)
Review
Polymer Science
Iyyakkannu Sivanesan, Judy Gopal, Manikandan Muthu, Juhyun Shin, Selvaraj Mari, Jaewook Oh
Summary: This review discusses the preparation, drug delivery applications, and current status of green synthesis of chitosan. It highlights the lack of systematic research in the green synthesis of chitosan and calls for more innovative green processes to be explored. Additionally, there is a lack of reports on the application of green synthesized chitosan nanoforms and nanocomposites towards drug delivery applications, which is an area that deserves more research focus.
Article
Biochemistry & Molecular Biology
Dong Wan, Yujun Liu, Xinhao Guo, Jianxin Zhang, Jie Pan
Summary: By introducing MMPs responsive peptide chain GPLGVRGDG, the polymeric prodrug can be endowed with smart properties through a safe and simple method. In this study, it was found that during the doxorubicin delivery in TPGS(3350)-GPLGVRGDG-DOX&DOX micelles, the cleavage of the peptide chain triggers de-PEGylation, retaining the VRGDG sequence on the micelles' surface, which acts as a ligand to facilitate cell uptake and enhances cytotoxicity against 4T1 cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Roman Moiseev, Fraser Steele, Vitaliy V. Khutoryanskiy
Summary: As drug delivery to the eye has advanced, researchers have focused on finding better treatments for ocular diseases. This study evaluated different polyaphron formulations and found that the 3% polyquaternium 10-based formulation had the best corneal retention, while the 10% poloxamer 188 and 1% polyquaternium 10-based formulations were the most stable. Toxicological evaluations showed that all four formulations had good biocompatibility with ocular tissues. These drug delivery systems have great potential for ocular drug delivery.
Review
Pharmacology & Pharmacy
Julie Frigaard, Janicke Liaaen Jensen, Hilde Kanli Galtung, Marianne Hiorth
Summary: Nanotechnology has found unique applications in drug delivery, cosmetics, fabrics, water treatment, and food packaging. Chitosan, a nanoparticle derived from natural polysaccharide chitin, has gained attention in modern medicine for its unique properties. This review examines the cytotoxicity of chitosan nanoparticles in biomedical research, revealing low cytotoxicity regardless of particle composition or assay method. However, thorough characterization and cytotoxicity assessment are recommended for new chitosan derivatives and compositions before market implementation.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Vijay Sagar Madamsetty, Shima Tavakol, Saeid Moghassemi, Arezoo Dadashzadeh, John D. Schneible, Iman Fatemi, Abdolsamad Shirvani, Ali Zarrabi, Fereshteh Azedi, Ali Dehshahri, Abbas Aghaei Afshar, Kian Aghaabbasi, Abbas Pardakhty, Reza Mohammadinejad, Prashant Kesharwani
Summary: Breast cancer is a highly deadly neoplastic disease with limited efficacy in existing treatment methods, prompting a search for new remedies. Nanotechnology has shown promise in the field, particularly with chitosan as a potential carrier for anticancer drugs. Further research is ongoing to explore the therapeutic and diagnostic applications of chitosan in breast cancer treatment.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Polymer Science
Anna Maria Strzalka, Jacek Lubczak
Summary: Currently, the majority of polyols used in the synthesis of polyurethane foams are derived from petrochemicals. However, due to the decreasing availability of crude oil, alternative resources such as plant oils, carbohydrates, starch, or cellulose need to be utilized as substrates for polyols. Chitosan, a biopolymer, shows promise as a candidate for polyol synthesis. This paper investigates the use of chitosan to obtain polyols and rigid polyurethane foams through various synthesis methods. The resulting chitosan-derived polyols were characterized and used to produce polyurethane foams with desirable properties. The chitosan-based polyols and polyurethane foams were found to be biodegradable.
Article
Engineering, Biomedical
Diana R. Fonseca, Ana Moura, Victoria Leiro, Ricardo Silva-Carvalho, Berta N. Estevinho, Catarina L. Seabra, Patricia C. Henriques, Monica Lucena, Catia Teixeira, Paula Gomes, Paula Parreira, M. Cristina L. Martins
Summary: The bioengineered approach of grafting MSI-78A onto chitosan microspheres enhances its bactericidal performance against Helicobacter pylori. The conjugation does not compromise the antimicrobial activity of MSI-78A and even boosts its effectiveness against H. pylori, making it a potential alternative for antibiotic therapy.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Medicinal
Ana Teresa Silva, Isabel S. Oliveira, Joana Gomes, Luisa Aguiar, Diana Fontinha, Denise Duarte, Fatima Nogueira, Miguel Prudencio, Eduardo F. Marques, Catia Teixeira, Ricardo Ferraz, Paula Gomes
Summary: By combining room-temperature ionic liquids derived from primaquine and cinnamic acids with natural fatty acids, novel surface-active ionic liquids with enhanced antimalarial activity have been developed, offering new perspectives for the cost-effective recycling of classical drugs.
Article
Chemistry, Physical
Mary Batista, Moises L. Pinto, Renato Carvalho, Joao Pires
Summary: The research demonstrated that glycerin-activated carbons prepared via chemical activation exhibit high selectivity in adsorption-separation of ethane and ethylene, showing a higher adsorption capacity for ethane. This serves as a successful example of utilizing glycerin, a low-cost by-product, to produce promising adsorbents for gas separation.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Biochemistry & Molecular Biology
Clara M. Bento, Ana Teresa Silva, Bruno Mansano, Luisa Aguiar, Catia Teixeira, Maria Salome Gomes, Paula Gomes, Tania Silva, Ricardo Ferraz
Summary: This work presents the synthesis, analysis, and evaluation of the antimicrobial activity of two new organic salts derived from clofazimine and fluoroquinolones. These organic salts have potential as cost-effective formulations with improved features, such as enhanced solubility and stability, compared to their parent drugs. For example, the clofazimine-derived organic salts exhibit improved solubility and thermostability without compromising the drug's bioactivity profile.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Biomaterials
Antonio Miguel Ramoa, Filipa Campos, Luis Moreira, Catia Teixeira, Victoria Leiro, Paula Gomes, Jose das Neves, M. Cristina L. Martins, Claudia Monteiro
Summary: This study explores the use of AMP grafting to PLGA-PEG NPs for wound infection treatment. The functionalized NPs show enhanced antibacterial activity in vivo, and do not exhibit cytotoxicity towards cells.
BIOMATERIALS SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Ana Rita Ferreira, Mariana Ferreira, Claudia Nunes, Salette Reis, Catia Teixeira, Paula Gomes, Paula Gameiro
Summary: Cationic antimicrobial peptides (CAMPs) like W-BP100 can counteract bacterial resistance by targeting the cell membrane. It has been observed that W-BP100 can promote the aggregation and fusion of anionic vesicles, leading to changes in lipid structures. Biophysical tools have been used to study this behavior.
Article
Environmental Sciences
Veronica Baldasso, Neus Bonet-Garcia, Stephanie Sayen, Emmanuel Guillon, Luigi Frunzo, Carlos A. R. Gomes, Maria Joao Alves, Ricardo Castro, Ana Paula Mucha, C. Marisa R. Almeida
Summary: This study investigated the fate of trace metals in anaerobic digestion of municipal solid waste (MSW) digestate-amended soil and the influence of pharmaceutical compounds on their behavior. The results showed that trace metals initially present in the digestate were transferred from the amended soil layer to the underlying soil layer over time, but no transfer was detected to deeper soil layers. Trace metals in soil were mostly in immobile and less bioavailable forms, while in the digestate-amended soil they were in more bioavailable forms. The presence of the antidiabetic drug metformin had no influence on trace metal behavior.
FRONTIERS IN ENVIRONMENTAL SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Beatriz Matos, Mary Batista, Joao Pires
Summary: In the face of global warming and the energy crisis, it is crucial to reduce the emissions of greenhouse gases like CO2 and CH4 and recycle biomethane from landfill biogas. This study demonstrates the potential of converting glycerol, a by-product of biodiesel production, into activated carbon using potassium acetate as an activating agent. The activated carbon exhibits high adsorption capacities for CO2 and CH4, with selectivity values that enable effective separation. Additionally, the study finds that the CO2 emissions produced during activated carbon synthesis can be easily neutralized through their use in small biogas production units.
ENVIRONMENTAL CHEMISTRY LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Mary Batista, Renato Carvalho, Moises L. Pinto, Joao Pires
Summary: Glycerin and dopamine were used as precursors to prepare microporous activated carbon adsorbent materials for the separation of ethane/ethylene and natural gas or landfill gas components. The activated carbons were produced through carbonization and chemical activation, with the introduction of nitrogenated groups to improve selectivity. Methane had the lowest adsorption capacity on the most effective material, followed by carbon dioxide, ethylene, and ethane.
Article
Pharmacology & Pharmacy
Mariana Barbosa, Pedro M. Alves, Fabiola Costa, Claudia Monteiro, Paula Parreira, Catia Teixeira, Paula Gomes, Maria Cristina L. Martins
Summary: Surface immobilization of antimicrobial peptides is a promising strategy to prevent biofilm formation on biomaterials. This study demonstrates that direct surface immobilization of Dhvar5 peptide using copper-catalyzed azide-alkyne cycloaddition method improves antimicrobial activity of chitosan ultrathin coatings.
Article
Entomology
Laura Regalado, Sara Sario, Rafael J. J. Mendes, Javier Valle, Peta J. J. Harvey, Catia Teixeira, Paula Gomes, David Andreu, Conceicao Santos
Summary: In this study, the biological activity of two underexplored spider venom peptides (J-atracotoxin-Hv1c and mu-theraphotoxin-Hhn2b) against adult D. suzukii flies was assessed, as well as the biological response of flies to these peptides through detoxification mechanisms. Results demonstrate that mu-theraphotoxin-Hhn2b enhanced fly longevity. Gene expression analysis suggests that detoxification and stress-related mechanisms are triggered in D. suzukii flies in response to treatment with these peptides. Our results highlight the potential of venom peptides to control D. suzukii and how to ultimately devise improved target-specific formulations.
Review
Biotechnology & Applied Microbiology
Leandro Pereira-Dias, Paulo R. Oliveira-Pinto, Juliana O. Fernandes, Laura Regalado, Rafael Mendes, Catia Teixeira, Nuno Mariz-Ponte, Paula Gomes, Conceicao Santos
Summary: Agricultural systems require low-cost, safe antibiotics to protect crops from pests and diseases. Peptaibiotics have shown potential as alternatives to agrochemicals, with antibacterial, antifungal, and antiviral activity, and the ability to induce plant resistance against phytopathogens. However, their low solubility and difficulty in synthesis and purification have limited their application in agriculture. This review provides a comprehensive analysis of peptaibiotics, including their classification, biosynthesis, relevance to plant protection, and mode of action against phytopathogens, as well as strategies to enhance their solubility and production.
BIOTECHNOLOGY ADVANCES
(2023)
Review
Biochemistry & Molecular Biology
Jose Rafael Almeida, Ana Gomes, Bruno Mendes, Luisa Aguiar, Mariana Ferreira, Mariana Borges Costa Brioschi, Denise Duarte, Fatima Nogueira, Sofia Cortes, David Salazar-Valenzuela, Danilo C. Miguel, Catia Teixeira, Paula Gameiro, Paula Gomes
Summary: Malaria, leishmaniasis, and Chagas disease are neglected tropical diseases that have a major impact on fragile societies. Snake venoms have been found to contain biomacromolecules with antiprotozoal activity, such as peptides and proteins. This review discusses the potential of venom-derived biomacromolecules as pioneering treatments for these diseases and highlights the need for further research and clinical translation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Editorial Material
Pharmacology & Pharmacy
Paula Gomes, Rafael V. C. Guido
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jose R. Almeida, Bruno Mendes, Marcelo Lancellotti, Gilberto C. Franchi Jr, Oscar Passos, Maria J. Ramos, Pedro A. Fernandes, Claudia Alves, Nuno Vale, Paula Gomes, Saulo L. da Silva
Summary: This study found that peptides derived from snake venom have potential as antineoplastic and antibacterial therapies. Two short peptides were synthesized and evaluated for their bioactivity against bacteria and tumor cells. The peptides showed dual activity, with one peptide showing more significant activity. The study highlights the importance of studying biomembrane remodeling proteins and their potential use in developing therapeutic peptides.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
