Bevacizumab-enhanced antitumor effect of 5-fluorouracil via upregulation of thymidine phosphorylase through vascular endothelial growth factor A/vascular endothelial growth factor receptor 2-specificity protein 1 pathway

A prospective study of XELIRI plus bevacizumab as a first-line therapy in Japanese patients with unresectable or recurrent colorectal cancer (KSCC1101)

(2017) Koji Ando et al.   International Journal of Clinical Oncology

Systematic Review and Network Meta-Analysis of Bevacizumab Plus First-Line Topotecan-Paclitaxel or Cisplatin-Paclitaxel Versus Non–Bevacizumab-Containing Therapies in Persistent, Recurrent, or Metastatic Cervical Cancer

(2017) Virginia M. Rosen et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Optimizing Oral Bioavailability in Drug Discovery: An Overview of Design and Testing Strategies and Formulation Options

(2017) Bruce J. Aungst   JOURNAL OF PHARMACEUTICAL SCIENCES

Recent discovery of non-nucleobase thymidine phosphorylase inhibitors targeting cancer

(2016) Hriday Bera et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Continuous administration of bevacizumab plus capecitabine, even after acquired resistance to bevacizumab, restored anti-angiogenic and antitumor effect in a human colorectal cancer xenograft model

(2016) Toshiki Iwai et al.   ONCOLOGY REPORTS

Concurrent gastrointestinal perforation and pulmonary embolism due to bevacizumab in an adult undergoing treatment for stage IV colon cancer

(2016) Sana Qureshi et al.   JOURNAL OF ONCOLOGY PHARMACY PRACTICE

Astrocytic TYMP and VEGFA drive blood–brain barrier opening in inflammatory central nervous system lesions

(2015) Candice Chapouly et al.   BRAIN

Influence of metastatic disease on the usefulness of uracil pharmacokinetics as a screening tool for DPD activity in colorectal cancer patients

(2015) Maurice C. van Staveren et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Clinicopathological significance of vascular endothelial growth factor, thymidine phosphorylase and microvessel density in colorectal cancer

(2015) YUTAKA KIMURA et al.   Molecular Medicine Reports

Thymidine Phosphorylase Participates in Platelet Signaling and Promotes Thrombosis

(2014) Wei Li et al.   CIRCULATION RESEARCH

Recent studies of 5-fluorouracil resistance in pancreatic cancer

(2014) Wei-Bin Wang   WORLD JOURNAL OF GASTROENTEROLOGY

Normalizing Tumor Microenvironment to Treat Cancer: Bench to Bedside to Biomarkers

(2013) Rakesh K. Jain   JOURNAL OF CLINICAL ONCOLOGY

DPYD,TYMS,TYMP,TK1, andTK2Genetic Expressions as Response Markers in Locally Advanced Rectal Cancer Patients Treated with Fluoropyrimidine-Based Chemoradiotherapy

(2013) Ming-Yii Huang et al.   Biomed Research International

Thymidine phosphorylase in cancer cells stimulates human endothelial cell migration and invasion by the secretion of angiogenic factors

(2011) I V Bijnsdorp et al.   BRITISH JOURNAL OF CANCER

Bevacizumab Has Differential and Dose-Dependent Effects on Glioma Blood Vessels and Tumor Cells

(2011) L. von Baumgarten et al.   CLINICAL CANCER RESEARCH

Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases

(2011) Peter Carmeliet et al.   NATURE REVIEWS DRUG DISCOVERY

Normalization of the Vasculature for Treatment of Cancer and Other Diseases

(2011) Shom Goel et al.   PHYSIOLOGICAL REVIEWS

The dual role of thymidine phosphorylase in cancer development and chemotherapy

(2009) Annelies Bronckaers et al.   MEDICINAL RESEARCH REVIEWS

Thymidine phosphorylase inhibits the expression of proapoptotic protein BNIP3

(2008) Ryuji Ikeda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS