Article
Multidisciplinary Sciences
Yoshihisa Tokumaru, Masanori Oshi, Michelle R. Huyser, Li Yan, Masahiro Fukada, Nobuhisa Matsuhashi, Manabu Futamura, Yukihiro Akao, Kazuhiro Yoshida, Kazuaki Takabe
Summary: The study found that low expression of miR-29a is associated with aggressive cancer biology and worse survival in gastric cancer patients, serving as an independent prognostic biomarker of poor overall survival and disease-specific survival.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Kelin She, Shaoqi Yu, Shushuai He, Wen Wang, Biao Chen
Summary: This study found that circ_0009043 is upregulated in NSCLC cells and tissues, and lower expression of circ_0009043 is associated with poorer overall survival in NSCLC patients. Mechanistically, circ_0009043 acts as a molecular sponge, sequestering miR-148a-3p and promoting the expression of DNAJB4, thereby acting as a tumor suppressor in NSCLC.
BIOMARKER RESEARCH
(2022)
Article
Oncology
Levent Emirzeoglu, Ozgur Olmez, Fatma Nihan Akkoc Mustafayev, Ufuk Berber, Ismail Yilmaz, Serkan Celik, Bala Basak Oven, Mehmet Alpaslan Ozgun
Summary: Aberrant expression of human leukocyte antigen G (HLA-G) has been observed in various cancer types. This study investigated the relationship between HLA-G expression and the expression levels of miR-148a and miR-152 in colon cancer and their association with survival outcomes and clinicopathological data. The study found that HLA-G expression was associated with poor prognosis in colon cancer, and decreased miR-148a expression in colon cancer tissues may be associated with HLA-G-mediated carcinogenesis.
Article
Multidisciplinary Sciences
Sho Okumura, Yu Hirano, Yasuo Komatsu
Summary: The study reveals that microRNA-148a plays a crucial role in breast cancer cell proliferation, with knockdown of miR-148a leading to a greater and longer-lasting inhibition of cell growth compared to targeting oncogenic microRNA-21. Additionally, the study identifies thioredoxin-interacting protein (TXNIP) as a target gene of miR-148a, showing that sequestering miR-148a can provoke an increase in TXNIP mRNA expression.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Fengge Ma, Yating Zhan, Rocio Bartolome-Cabrero, Wei Ying, Masahide Asano, Zhe Huang, Changchun Xiao, Alicia Gonzalez-Martin
Summary: miRNAs often exert their biological functions through regulating a small number of key target genes, rather than through small changes in the expression of hundreds of target genes. This study provides evidence for the role of key target genes in mediating the function of miR-148a.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ming Song, Jun Liu, Xin Zheng, Xin Zhou, Zehui Feng, Wei Hu
Summary: The study found that the expression of CEMIP was significantly elevated while miR-148a-3p level was downregulated in gastric cancer tissues and cell lines. miR-148a-3p suppressed the development of gastric cancer by inhibiting the expression of CEMIP.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Oncology
Chunli OuYang, Guang Shu, Jiaxin Liu, Shumin Deng, Pengyan Lu, Yimin Li, Yaqi Gan, Bintao Xie, Junwen Liu, Gang Yin
Summary: HDAC5 overexpression is associated with tumor progression and cell migration in colon adenocarcinoma, which can be inhibited by miR-148a-3p.
Article
Oncology
Christos Miliotis, Frank J. Slack
Summary: In gastric cancer, miR-105-5p has been identified as a key regulator of PD-L1 expression, impacting T cell activation, and could serve as a potential biomarker and target for combination immunotherapy targeting PD-1/PD-L1 interactions.
Article
Biochemistry & Molecular Biology
Ke Li
Summary: This study revealed that miR-509-3-5p regulates the malignancy of colon cancer by suppressing target gene GTSE1. Downregulation of miR-509-3-5p in CC and its overexpression can inhibit the proliferation, migration, and invasion of CC cells. MiR-509-3-5p targets GTSE1, identified as an oncogene in colon cancer.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Cell Biology
Min Liang, Wenxia Yao, Boyun Shi, Xiongjie Zhu, Rui Cai, Zhongjian Yu, Weihong Guo, Huaiming Wang, Zhijie Dong, Mingzhen Lin, Xinke Zhou, Yanfang Zheng
Summary: The study identified hsa_circ_0110389 as a novel upregulated circRNA in malignant-transformed gastric cancer cells, and found that it promotes gastric cancer progression via the miR-127-5p/miR-136-5p-SORT1 pathway. This circRNA may serve as a diagnostic/prognostic biomarker and therapeutic target for gastric cancer.
CELL DEATH & DISEASE
(2021)
Article
Cell & Tissue Engineering
Lucile Bansard, Oceane Bouvet, Elisa Moutin, Gaetan Le Gall, Alessandro Giammona, Elodie Pothin, Marion Bacou, Cedric Hassen-Khodja, Benoit Bordignon, Jean Francois Bourgaux, Michel Prudhomme, Frederic Hollande, Julie Pannequin, Jean Marc Pascussi, Chris Planque
Summary: This study identifies miR-148a as a targetable element upstream of PXR signaling in CSCs, which can decrease PXR expression and impair tumor relapse after chemotherapy. The anti-helminthic drug niclosamide is identified as an inducer of miR-148a expression, which decreases PXR expression and CSC numbers, and synergizes with chemotherapeutic agents to prevent tumor relapse.
Article
Cell Biology
Qinglian He, Aihua Ye, Weibiao Ye, Xiaomin Liao, Guoqiang Qin, Yongqiang Xu, Yuting Yin, Huanqian Luo, Muhua Yi, Liying Xian, Shihao Zhang, Xiyuan Qin, Wei Zhu, Yuling Li
Summary: Cancer-secreted exosomes containing miR-21-5p play a crucial role in promoting angiogenesis and vascular permeability in colorectal cancer by suppressing KRIT1 and activating the beta-catenin signaling pathway. The expression levels of miR-21-5p in circulating exosomes are significantly higher in CRC patients compared to healthy donors, suggesting its potential as a therapeutic target for CRC.
CELL DEATH & DISEASE
(2021)
Article
Immunology
Ritu Mishra, Akhil C. Banerjea
Summary: The novel coronavirus infection, SARS-CoV-2, has been found to be associated with neurological anomalies in patients, even after viral load declines. The Spike gene of SARS-CoV-2 can modify host exosomes and trigger neuroinflammation in the Central Nervous System. This study provides novel insights into the impact of Spike gene on host microRNA shuttling via exosomes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Mackenzie L. Davenport, John B. Echols, Austin D. Silva, Joshua C. Anderson, Philip Owens, Clayton Yates, Qing Wei, Shuko Harada, Douglas R. Hurst, Mick D. Edmonds
Summary: miR-31 demonstrates oncogenic properties in specific subtypes of lung cancer, highlighting its potential as a therapeutic target in these subtypes.
Article
Multidisciplinary Sciences
Soon Auck Hong, Sieun Lee, Jihye Park, Mineui Hong, Jung-Sook Yoon, Heejin Lee, Ji Hyun Lee, Seoree Kim, Hye Sung Won, Keunsoo Kang, Yoon Ho Ko, Young-Ho Ahn
Summary: The study found that miR-199a/b promotes the progression of diffuse gastric cancer (DGC) by targeting FZD6, and can be used as prognostic and diagnostic biomarkers for the disease.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Akiko Kogure, Yutaka Naito, Yusuke Yamamoto, Masakazu Yashiro, Tohru Kiyono, Kazuyoshi Yanagihara, Kosei Hirakawa, Takahiro Ochiya
Article
Urology & Nephrology
Moritz Maas, Steffen Rausch, Teresa Guttenberg, Roland Seiler, Jorg Hennenlotter, Htoo Zarni Oo, Ladan Fazli, Ursula Kuehs, Georgios Gakis, Arnulf Stenzl, Christian Schwentner, Peter C. Black, Tilman Todenhoefer
Summary: This study assessed the relevance of RANK expression in patients with muscle-invasive bladder cancer (MIBC). The results showed that RANK expression was significantly increased in both primary tumors and lymph node metastases. In tumor tissue, lower RANK expression was associated with locally advanced disease and lymph node involvement, while higher RANK expression was associated with better prognosis and longer time to recurrence. The prognostic role of RANK expression differed in tumors of different molecular subtypes.
EUROPEAN UROLOGY FOCUS
(2022)
Article
Gastroenterology & Hepatology
Takeshi Matsui, Susumu Hamada-Tsutsumi, Yutaka Naito, Masanori Nojima, Etsuko Iio, Akihiro Tamori, Shoji Kubo, Tatsuya Ide, Yasuteru Kondo, Yuichiro Eguchi, Atsumasa Komori, Yuji Morine, Mitsuo Shimada, Tohru Utsunomiya, Ken Shirabe, Koichi Kimura, Yoichi Hiasa, Natthaya Chuaypen, Pisit Tangkijvanich, Aya Naiki-Ito, Satoru Takahashi, Takahiro Ochiya, Yasuhito Tanaka
Summary: The miRNA clusters miR-183/96/182 and miR-217/216a/216b are significantly upregulated in nonviral hepatocellular carcinoma (NBNC-HCC). High levels of miR-182-5p and miR-217-5p, but low levels of miR-96-5p, in tumor tissues are associated with poor recurrence-free survival of NBNC-HCC patients. Further upregulation of miR-96-5p in tumors may have an inhibitory effect on recurrence, suggesting its potential as a tumor suppressor in NBNC-HCC patients at high risk of recurrence. Transfection of miR-96-5p mimic induced apoptosis of HepG2 cells and suppressed proliferation and invasion, indicating its potential antitumor effects.
HEPATOLOGY RESEARCH
(2022)
Article
Oncology
Tilman Todenhoefer, Ewan A. Gibb, Roland Seiler, Alireza Kamyabi, Joerg Hennenlotter, Paul McDonald, Igor Moskalev, Craig Stewart, Jian Gao, Ladan Fazli, Shoukat Dedhar, Arnulf Stenzl, Arnulf Stenzl, Htoo Zarni Oo, Peter C. Black
Summary: The study found over-expression of CA9 in UC, but it did not correlate with patient outcomes. Inhibition of CA9 did not consistently inhibit tumor growth.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2021)
Article
Oncology
Hai-Feng Zhang, Christopher S. Hughes, Wei Li, Jian-Zhong He, Didier Surdez, Amal M. El-Naggar, Hongwei Cheng, Anna Prudova, Alberto Delaidelli, Gian Luca Negri, Xiaojun Li, Maj Sofie Orum-Madsen, Michael M. Lizardo, Htoo Zarni Oo, Shane Colborne, Taras Shyp, Renata Scopim-Ribeiro, Colin A. Hammond, Anne-Chloe Dhez, Sofya Langman, Jonathan K. M. Lim, Sonia H. Y. Kung, Amy Li, Anne Steino, Mads Daugaard, Seth J. Parker, Ramon I. Klein Geltink, Rimas J. Orentas, Li-Yan Xu, Gregg B. Morin, Olivier Delattre, Dimiter S. Dimitrov, Poul H. Sorensen
Summary: IL1RAP is identified as a key driver of metastasis in Ewing sarcoma, maintaining cyst(e)ine and glutathione pools for redox homeostasis and anoikis resistance, with minimal expression in normal tissues making it a promising target for immunotherapy.
Article
Oncology
Htoo Zarni Oo, Zoltan Lohinai, Nastaran Khazamipour, Joey Lo, Gunjan Kumar, Jessica Pihl, Hans Adomat, Noushin Nabavi, Hakhamanesh Behmanesh, Beibei Zhai, Robert Dagil, Swati Choudhary, Tobias Gustavsson, Thomas M. Clausen, Jeffrey D. Esko, Jeffrey W. Allen, Michael A. Thompson, Nhan L. Tran, Judit Moldvay, Balazs Dome, Ali Salanti, Nader Al-Nakouzi, Glen J. Weiss, Mads Daugaard
Summary: Targeting oncofetal chondroitin sulfate (CS) chains can serve as a prognostic and therapeutic strategy for non-small cell lung cancer (NSCLC), with high expression associated with poorer outcomes. Both clinical and preclinical studies demonstrate the potential of oncofetal CS as a actionable prognostic marker and therapeutic target in NSCLC.
Article
Multidisciplinary Sciences
Chris Kedong Wang, Irina Nelepcu, Desmond Hui, Htoo Zarni Oo, Sarah Truong, Sarah Zhao, Zakir Tahiry, Shaghayegh Esfandnia, Fariba Ghaidi, Hans Adomat, Robert Dagil, Tobias Gustavsson, Swati Choudhary, Ali Salanti, Poul H. Sorensen, Nader Al Nakouzi, Mads Daugaard
Summary: In this study, the internalization and cell fate of chondroitin sulfate proteoglycans (CSPGs) in tumor cells were investigated using a recombinant CSPG-binding lectin VAR2CSA (rVAR2). It was found that CSPG-bound rVAR2 proteins were internalized into cancer cells through multiple internalization mechanisms and then trafficked to early endosomes. However, instead of being transported further to the lysosomal compartment, the internalized CSPG-bound rVAR2 proteins were secreted with exosomes in a chondroitin sulfate-dependent manner.
SCIENTIFIC REPORTS
(2022)
Article
Pathology
Collin Pryma, Carlos Villamil, Ewan A. Gibb, Htoo Zarni Oo, Roland Seiler, Alberto Contreras-Sanz, James Douglas, Peter C. Black, Gang Wang
Summary: Bladder cancer is a heterogeneous disease with basal and luminal molecular subtypes. Immunohistochemistry using GATA3 and CK5/6 has been shown to be reliable in predicting bladder cancer subtypes. This study evaluated the accuracy of uroplakin II (UPII) to predict luminal and basal subtypes in muscle-invasive bladder cancer and found that UPII performed better than GATA3 and CK5/6.
Article
Anatomy & Morphology
Jiaming Fan, Henry Li, Chen Zhou, Wei Xiong, Carlos Villamil, Diana Ionescu, Htoo Z. Oo, Alberto Contreras-Sanz, Peter C. Black, Gang Wang
Summary: This study found distinct CK7 staining patterns in SmCC and LCNEC through a large retrospective cohort, which could guide personalized treatment for patients.
APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
(2022)
Article
Multidisciplinary Sciences
Nader Al-Nakouzi, Chris Kedong Wang, Htoo Zarni Oo, Irina Nelepcu, Nada Lallous, Charlotte B. Spliid, Nastaran Khazamipour, Joey Lo, Sarah Truong, Colin Collins, Desmond Hui, Shaghayegh Esfandnia, Hans Adomat, Thomas Mandel Clausen, Tobias Gustavsson, Swati Choudhary, Robert Dagil, Eva Corey, Yuzhuo Wang, Anne Chauchereau, Ladan Fazli, Jeffrey D. Esko, Ali Salanti, Peter S. Nelson, Martin E. Gleave, Mads Daugaard
Summary: Inhibition of the androgen receptor pathway leads to the upregulation of chondroitin sulfate (CS), which promotes the growth and metastasis of prostate cancer.
NATURE COMMUNICATIONS
(2022)
Review
Oncology
Yutaka Naito, Yusuke Yoshioka, Takahiro Ochiya
Summary: Intercellular communication plays a crucial role in cancer initiation and progression, with cancer-associated fibroblasts (CAFs) being a key component in this process. Recent research on extracellular vesicles (EVs) as regulators of intercellular communication has shown significant advancements. EVs facilitate the transfer of functional molecules to recipient cells, influencing the communication between cancer cells and CAFs and promoting cancer progression.
CANCER CELL INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Emma Scott, Kirsty Hodgson, Beatriz Calle, Helen Turner, Kathleen Cheung, Abel Bermudez, Fernando Jose Garcia Marques, Hayley Pye, Edward Christopher Yo, Khirul Islam, Htoo Zarni Oo, Urszula L. McClurg, Laura Wilson, Huw Thomas, Fiona M. Frame, Margarita Orozco-Moreno, Kayla Bastian, Hector M. Arredondo, Chloe Roustan, Melissa Anne Gray, Lois Kelly, Aaron Tolson, Ellie Mellor, Gerald Hysenaj, Emily Archer Goode, Rebecca Garnham, Adam Duxfield, Susan Heavey, Urszula Stopka-Farooqui, Aiman Haider, Alex Freeman, Saurabh Singh, Edward W. Johnston, Shonit Punwani, Bridget Knight, Paul McCullagh, John McGrath, Malcolm Crundwell, Lorna Harries, Denisa Bogdan, Daniel Westaby, Gemma Fowler, Penny Flohr, Wei Yuan, Adam Sharp, Johann de Bono, Norman J. Maitland, Simon Wisnovsky, Carolyn R. Bertozzi, Rakesh Heer, Ramon Hurtado Guerrero, Mads Daugaard, Janne Leivo, Hayley Whitaker, Sharon Pitteri, Ning Wang, David J. Elliott, Benjamin Schumann, Jennifer Munkley
Summary: Prostate cancer is the leading cancer among men, causing over 350,000 deaths worldwide annually. This study reveals that the glycosyltransferase enzyme GALNT7 is upregulated in prostate cancer tissue and can be used as a biomarker to diagnose the disease with higher accuracy than the traditional PSA test. Additionally, GALNT7 is found to play a role in promoting prostate tumor growth and is associated with cell cycle and immune signaling pathways. Overall, this study highlights the importance of GALNT7-mediated O-glycosylation in prostate cancer progression.
Article
Oncology
Louise Ramos, Sarah Truong, Beibei Zhai, Jay Joshi, Fariba Ghaidi, Michael M. Lizardo, Taras Shyp, Sonia H. Y. Kung, Alireza M. Rezakhanlou, Htoo Zarni Oo, Hans Adomat, Stephane Le Bihan, Colin Collins, Jeffrey Bacha, Dennis Brown, John Langlands, Wang Shen, Nada Lallous, Poul H. Sorensen, Mads Daugaard
Summary: This study reports a novel bifunctional PARP inhibitor (kt-3283) that has dual activity towards PARP1/2 and HDAC enzymes in Ewing sarcoma cells. Compared to commonly used PARP and HDAC inhibitors, kt-3283 exhibits enhanced cytotoxicity and inhibition effects.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Yusuke Matsuzaki, Yutaka Naito, Nami Miura, Taisuke Mori, Yukio Watabe, Seiichi Yoshimoto, Takahiko Shibahara, Masayuki Takano, Kazufumi Honda
Summary: The expression of RIOK2 is associated with poorer overall survival in patients with tongue squamous cell carcinoma (TSCC), and it is an independent prognostic factor. Inhibition of RIOK2 expression can decrease cell growth and S6 ribosomal protein expression in oral squamous cell carcinoma cell lines, as well as significantly reduce protein synthesis in cancer cells. RIOK2 has potential as a novel therapeutic target for TSCC treatment.
Article
Oncology
Rebecca M. Richards, Feifei Zhao, Katherine A. Freitas, Kevin R. Parker, Peng Xu, Amy Fan, Elena Sotillo, Mads Daugaard, Htoo Zarni Oo, Jie Liu, Wan-Jen Hong, Poul H. Sorensen, Howard Y. Chang, Ansuman T. Satpathy, Robbie G. Majzner, Ravindra Majeti, Crystal L. Mackall
Summary: CD93 CAR T cells show promising efficacy in eliminating AML while sparing HSPCs, but exhibit on-target, off-tumor toxicity to endothelial cells. Co-expression of other AML targets on endothelial cells is identified, and a novel NOT-gated strategy is introduced to mitigate endothelial toxicity, along with the use of high-dimensional transcriptomic profiling for rational design of combinatorial immunotherapies.
BLOOD CANCER DISCOVERY
(2021)
