Article
Oncology
Hossein Sendi, Mostafa Yazdimamaghani, Mengying Hu, Nikhila Sultanpuram, Jie Wang, Amber S. Moody, Ellie McCabe, Jiajie Zhang, Amanda Graboski, Liantao Li, Juan D. Rojas, Paul A. Dayton, Leaf Huang, Andrew Z. Wang
Summary: Efficient delivery of miR-122 to hepatocytes using a nanomedicine-based formulation has the potential to prevent and treat colorectal cancer liver metastasis. Mechanistically, it downregulates key genes involved in metastatic and cancer inflammation pathways, increases CD8(+)/CD4(+) T-cell ratio, and decreases immunosuppressive cell infiltration, making the liver more conducive to antitumor immune response.
Article
Oncology
Xiaoyun Hu, Qiuchen Chen, Hao Guo, Kuo Li, Boshi Fu, Yu Chen, Haishan Zhao, Minjie Wei, Yalun Li, Huizhe Wu
Summary: Elevated miR-425 and miR-576 promote colorectal cancer liver metastases (CRLM) by inhibiting PTEN-mediated cellular immune function. They were found to be closely associated with tumor deterioration, especially liver metastases, and may serve as novel biomarkers for CRLM prevention and immunotherapy, as well as upstream inhibitors of the PTEN-P53/TGF-beta function axis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Dingsheng Liu, Chunsheng Chen, Mingming Cui, Hong Zhang
Summary: Recent studies have identified miR-140-3p as a tumor suppressor in colorectal cancer (CRC) progression by targeting BCL9 and BCL2, inhibiting cell proliferation, migration, invasion, and promoting apoptosis. This suggests that the miR-140-3p-BCL9/BCL2 axis may be a potential target for miRNA-based therapy and prognostication of CRC.
Article
Oncology
Poonam Yadav, Priyanshu Sharma, Sandhya Sundaram, Ganesh Venkatraman, Amal Kanti Bera, Devarajan Karunagaran
Summary: miR-5096 induces ferroptotic cell death in breast cancer cells by targeting and downregulating SLC7A11, reducing ROS, lipid peroxides, and iron accumulation levels, as well as decreasing GSH levels and mitochondrial membrane potential, inhibiting cell survival, migration, and invasion.
Article
Oncology
Takayuki Minoji, Hidekazu Takahashi, Tadashi Watabe, Satoshi Ishikawa, Hiroki Kato, Ryuichi Ohgaki, Yoshikatsu Kanai, Yuki Sekido, Tsuyoshi Hata, Atsushi Hamabe, Takayuki Ogino, Norikatsu Miyoshi, Mamoru Uemura, Hirofumi Yamamoto, Yuichiro Doki, Hidetoshi Eguchi
Summary: LAT1 protein expression is correlated with liver metastases and recurrence in colorectal cancer. 18F-FBPA-PET can be safely performed in patients with colorectal cancer.
ANTICANCER RESEARCH
(2023)
Review
Oncology
Raghav Chandra, John D. Karalis, Charles Liu, Gilbert Z. Murimwa, Josiah Voth Park, Christopher A. Heid, Scott I. Reznik, Emina Huang, John D. Minna, Rolf A. Brekken
Summary: Colorectal cancer (CRC) ranks as the third most common malignancy globally and the second leading cause of cancer-related deaths. The cellular components of the tumor microenvironment (TME) play crucial roles in tumor engraftment and metastasis to distant organs such as the liver and lungs.
Article
Cell Biology
Xisheng Liu, Xiaole Meng, Xiao Peng, Qianlan Yao, Fangming Zhu, Zhongyi Ding, Hongze Sun, Xueni Liu, Dan Li, Ying Lu, Huamei Tang, Bin Li, Zhihai Peng
Summary: The global downregulation of miRNA expression, potentially due to defects in miRNA processing machinery, is a hallmark of human cancer. In colorectal cancer (CRC), downregulation of the key regulator of miRNA processing, Argonaute 2 (AGO2), has been found to promote epithelial-mesenchymal transition (EMT) and indicate poor prognosis. Knockdown of AGO2 in CRC cells enhanced migration, invasion, and metastasis, while integrated analyses revealed neuropilin 1 (NRP1) as a new substrate of AGO2 via miR-185-3p. Therapeutically targeting the AGO2/miR-185-3p/NRP1 axis may offer a potential treatment approach for CRC.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Cristina Morsiani, Salvatore Collura, Federica Sevini, Erika Ciurca, Valentina Rosa Bertuzzo, Claudio Franceschi, Gian Luca Grazi, Matteo Cescon, Miriam Capri
Summary: The study aimed to evaluate the changes in circulating microRNA (c-miR) in the blood of liver transplant recipients before and after transplantation, and to correlate their levels with gold standard biomarkers and outcomes such as rejection or complications. The results showed that c-miR changes were associated with follow-up time, and miR-122-5p, miR-92a-3p, and miR-18a-5p exhibited the same trend after transplantation, with an increase in their levels in patients with complications. Compared to changes in standard haemato-biochemical parameters, the importance of c-miRs as potential noninvasive biomarkers for monitoring patient outcomes was confirmed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Mehmet Aziret, Gamze Guney Eskiler, Gozde Cakirsoy Cakar, Asuman Deveci Ozkan, Metin Ercan, Cemil Bilir, Erdal Polat, Havva Belma Kocer, Ebru Kayra Yildirim, Mustafa Duman
Summary: This study evaluated the expression levels of miR-99b and miR-135b in peritoneal carcinoma and liver metastases associated with colorectal cancer. It also examined their association with KRAS and Akt proteins and their effects on survival. The findings suggest that miR-99b has a protective effect against liver metastasis and peritoneal carcinomatosis, while miR-135b facilitates their development. Both miR-99b and miR-135b are associated with overall survival in colorectal cancer.
Article
Agronomy
Songchong Lu, Xuan Ji, Xinshuang Zhang, Hao Wu, Yan Sun, Ying Zhu, Shanshan Su, Shumin Wei, Xin Liu
Summary: The cationic amino acid transporter NtCAT1 plays an important role in leaf senescence in tobacco. Overexpression of NtCAT1 accelerates leaf senescence, while the mutant ntcAT1-36 shows delayed senescence phenotype. NtCAT1 is involved in leaf senescence through regulating ABA biosynthesis and TOR kinase gene expression. Moreover, NtCAT1 transgenic plants exhibit significant changes in amino acid concentrations during leaf senescence.
Article
Multidisciplinary Sciences
Mengjiao Zhang, Yifeng Wang, Longchen Yu, Yanli Zhang, Yanlei Wang, Ziqi Shang, Yiwei Xin, Xinyang Li, Nannan Ning, Yi Zhang, Xin Zhang
Summary: A study found that Fn infection significantly increased the levels of exosomal miR-122-5p in the serum of CRC patients, and the downregulation of miR-122-5p enhanced the metastatic abilities of CRC cells. Fn activated the TGF-beta 1/Smads signaling pathway through the regulation of the miR-122-5p/FUT8 axis to promote EMT.
Article
Biochemistry & Molecular Biology
Annia A. Martinez-Pena, Kendrick Lee, Madison Pereira, Ahmed Ayyash, James J. Petrik, Daniel B. Hardy, Alison C. Holloway
Summary: As cannabis use during pregnancy increases, understanding its effects on the developing fetus becomes important. This study found that gestational THC exposure can impact the miRNA profile in adult rat ovaries and have negative consequences on ovarian health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Fei Tian, Peiyun Wang, Dan Lin, Jiajia Dai, Qibing Liu, Yu Guan, Yang Zhan, Yichen Yang, Wenpeng Wang, Jiefu Wang, Jia Liu, Lei Zheng, Yan Zhuang, Jun Hu, Junfeng Wang, Dalu Kong, Kegan Zhu
Summary: The study identified an upregulated gene cluster miR-221/222 in serum exosome samples of CRC patients with liver metastasis, predicting poor overall survival. In vitro and in vivo experiments confirmed that miR-221/222 promotes the aggressive nature of CRC and formation of a premetastatic niche. These results suggest miR-221/222 as a potential therapeutic target and prognostic marker for CRC.
Article
Oncology
Junryo Rii, Shinichi Sakamoto, Masahiro Sugiura, Manato Kanesaka, Ayumu Fujimoto, Yasutaka Yamada, Maihulan Maimaiti, Keisuke Ando, Ken Wakai, Minhui Xu, Yusuke Imamura, Norihisa Shindo, Toru Hirota, Atsushi Kaneda, Yoshikatsu Kanai, Yuzuru Ikehara, Naohiko Anzai, Tomohiko Ichikawa
Summary: LAT3 is abundantly expressed in prostate cancer cells and plays a crucial role in cancer progression by affecting cell proliferation, migration, and invasion. Its high expression is associated with poor prognosis and advanced disease stage in prostate cancer.
Article
Biochemistry & Molecular Biology
Maral Afshinpour, Hamid Mahdiuni
Summary: This study investigates the transportation mechanism of arginine in CAT-1 and finds that water molecules play a leading role in forming the transportation channel. Understanding the arginine transportation mechanism is essential for developing CAT-1 blockers and potential medications for certain types of cancers.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Oncology
Satoru Furuhashi, Yoshifumi Morita, Shinya Ida, Ryuta Muraki, Ryo Kitajima, Katsunori Suzuki, Makoto Takeda, Hirotoshi Kikuchi, Yoshihiro Hiramatsu, Kiyotaka Kurachi, Yoji Shido, Ken Sugimoto, Hiroaki Ito, Yuichiro Maekawa, Hiroyuki Mineta, Hideaki Miyake, Hiroya Takeuchi
Summary: Patients with head and neck malignancy or TICVAP insertion in the upper arm have a potentially increased risk for late-phase TICVAP-related infections.
ANTICANCER RESEARCH
(2021)
Article
Multidisciplinary Sciences
Katsunori Suzuki, Yasuo Takehara, Mayu Sakata, Masanori Kawate, Naoki Ohishi, Kosuke Sugiyama, Toshiya Akai, Yuhi Suzuki, Masataka Sugiyama, Takafumi Kawamura, Yoshifumi Morita, Hirotoshi Kikuchi, Yoshihiro Hiramatsu, Masayoshi Yamamoto, Hatsuko Nasu, Kevin Johnson, Oliver Wieben, Kiyotaka Kurachi, Hiroya Takeuchi
Summary: 4D PC-VIPR is an effective imaging technique for assessing superior mesenteric artery flow, especially after stimulation with herbal medicine, showing significant correlations with DUS and the ability to analyze multiple blood vessels simultaneously.
Article
Surgery
Ryoma Haneda, Eisuke Booka, Kenjiro Ishii, Hirotoshi Kikuchi, Yoshihiro Hiramatsu, Kinji Kamiya, Hirofumi Ogawa, Hirofumi Yasui, Hiroya Takeuchi, Yasuhiro Tsubosa
Summary: Definitive chemoradiotherapy may be a promising alternative therapy comparable with radical esophagectomy in patients with clinical T1bN0M0 esophageal squamous cell carcinoma. Early detection of recurrence by frequent follow-up after definitive chemoradiotherapy is crucial for controlling disease within local recurrence, and salvage therapy for local lesions could contribute to long-term survival.
WORLD JOURNAL OF SURGERY
(2021)
Article
Gastroenterology & Hepatology
Tomohiro Matsumoto, Hirotoshi Kikuchi, Ryoma Haneda, Wataru Soneda, Amane Hirotsu, Sanshiro Kawata, Yoshihiro Hiramatsu, Kinji Kamiya, Yosuke Shibata, Eisaku Okada, Hiroya Takeuchi
Summary: Measuring drain amylase levels after esophagectomy can be a useful method for early detection of anastomotic leakage in esophageal cancer patients, potentially reducing the incidence of severe postoperative complications.
Article
Surgery
Yoshifumi Morita, Takanori Sakaguchi, Shinya Ida, Ryuta Muraki, Ryo Kitajima, Satoru Furuhashi, Makoto Takeda, Hirotoshi Kikuchi, Yoshihiro Hiramatsu, Hiroya Takeuchi
Summary: This study retrospectively analyzed patients who underwent pancreaticoduodenectomy (PD) and proposed a perioperative fluid and nutritional therapy strategy based on the risk stratification by pancreatic fistula (PF) and delayed gastric emptying (DGE). The study found that severe PF and DGE were significant risk factors for body weight loss (>10%). The study also observed that fluid imbalance and stomach preserving PD were associated with the incidence of DGE.
ASIAN JOURNAL OF SURGERY
(2022)
Article
Gastroenterology & Hepatology
Ryoma Haneda, Yoshihiro Hiramatsu, Sanshiro Kawata, Junko Honke, Wataru Soneda, Tomohiro Matsumoto, Yoshifumi Morita, Hirotoshi Kikuchi, Kinji Kamiya, Hiroya Takeuchi
Summary: The study found that changes in prognostic nutritional index levels during the perioperative period significantly impact overall survival in esophageal cancer patients. Increasing postoperative nutritional index levels in patients with poor preoperative nutritional status can improve prognosis after esophagectomy.
Article
Gastroenterology & Hepatology
Hirotoshi Kikuchi, Hideki Endo, Hiroyuki Yamamoto, Soji Ozawa, Hiroaki Miyata, Yoshihiro Kakeji, Hisahiro Matsubara, Yuichiro Doki, Yuko Kitagawa, Hiroya Takeuchi
Summary: A study using data from the Japanese National Clinical Database found that the posterior mediastinal (PM) reconstruction route in esophagectomy followed by gastric conduit reconstruction is associated with lower risks of anastomotic leak and surgical site infection (SSI), but a higher risk of pneumonia, while the retrosternal (RS) reconstruction route has higher risks of anastomotic leak and SSI, but a lower risk of pneumonia. This information can help surgeons in designing the reconstruction route following esophagectomy.
ANNALS OF GASTROENTEROLOGICAL SURGERY
(2022)
Article
Gastroenterology & Hepatology
Junko Honke, Yoshihiro Hiramatsu, Sanshiro Kawata, Eisuke Booka, Tomohiro Matsumoto, Yoshifumi Morita, Hirotoshi Kikuchi, Kinji Kamiya, Keiko Mori, Hiroya Takeuchi
Summary: The study found that the use of a WFT can reduce the incidence of postoperative pneumonia, improve postoperative nutritional status, and increase the rate of diary entries. Patients in the WFT group had shorter postoperative hospital stays and significant improvements in nutritional indices one month after surgery.
Article
Medicine, General & Internal
Eisuke Booka, Hirotoshi Kikuchi, Ryoma Haneda, Wataru Soneda, Sanshiro Kawata, Tomohiro Murakami, Tomohiro Matsumoto, Yoshihiro Hiramatsu, Hiroya Takeuchi
Summary: This study investigated the relationship between serum procalcitonin (PCT) levels after esophagectomy and infectious complications and long-term prognosis. The results showed that the association between PCT levels and infectious complications became stronger as the postoperative days passed, with a 100% positive predictive value at 7 days post-operation. Additionally, patients in the low PCT group at 2 days post-operation had significantly worse overall survival and recurrence-free survival. Advanced pathological stage and low PCT levels at 2 days post-operation were identified as independent predictors of worse overall survival.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Ryoma Haneda, Yoshihiro Hiramatsu, Sanshiro Kawata, Wataru Soneda, Eisuke Booka, Tomohiro Murakami, Tomohiro Matsumoto, Yoshifumi Morita, Hirotoshi Kikuchi, Hiroya Takeuchi
Summary: Diarrhea during enteral feeding after esophagectomy can increase the risk of malnutrition and poor prognosis in elderly patients.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Biochemical Research Methods
Amane Hirotsu, Hirotoshi Kikuchi, Hidenao Yamada, Yusuke Ozaki, Ryoma Haneda, Sanshiro Kawata, Tomohiro Murakami, Tomohiro Matsumoto, Yoshihiro Hiramatsu, Kinji Kamiya, Daisuke Yamashita, Yuki Fujimori, Yukio Ueda, Shigetoshi Okazaki, Masatoshi Kitagawa, Hiroyuki Konno, Hiroya Takeuchi
Summary: This study developed a label-free image recognition system that can identify rare cells in the bloodstream and monitor the treatment progress of cancer patients.
