Article
Dentistry, Oral Surgery & Medicine
Hisham M. Abada, Ahmed Abdel Rahman Hashem, Ashraf Mohamed Abu-Seida, Mohamed Mokhtar Nagy
Summary: This study evaluated the regenerative potential of permanent necrotic mature teeth with different apical foramen diameters compared to conventional endodontic treatment. Results showed that increasing the apical size diameter was associated with less inflammatory cell count, less bone resorption, more tissue ingrowth, and more percentage of new hard tissue formation inside the root canal. The minimum apical diameter that should be enlarged for regenerative endodontic therapy is 0.4 mm.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Multidisciplinary Sciences
Heeresh Shetty, Shishir Shetty, Adesh Kakade, Aditya Shetty, Mohmed Isaqali Karobari, Ajinkya M. Pawar, Anand Marya, Artak Heboyan, Adith Venugopal, The Hanh Nguyen, Dinesh Rokaya
Summary: This study compared the accuracy of two artificial intelligence-based medical imaging programs, OsiriX MD and 3D Slicer, in estimating the volume of pulp space following regenerative endodontic procedures (REPs). The results showed a significant decrease in pulp space volume measured by both programs, with no significant difference in accuracy between them. 3D Slicer, an open-source software program, was found to be as accurate as the commercially available OsiriX MD in volumetric assessment of post-REP pulp space.
SCIENTIFIC REPORTS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Aalaa E. Eldessoky, Mohammed M. Khalefa, Ashraf M. Abu-Seida
Summary: This study compared the effectiveness of 980 nm diode laser and double antibiotic paste in regenerative endodontic therapy for mature teeth with necrotic pulp and apical periodontitis in a dog model. The results showed that 980 nm diode laser can be an alternative to double antibiotic paste for root canal disinfection, leading to accelerated regenerative endodontic therapy.
Article
Dentistry, Oral Surgery & Medicine
Isabelly Vidal do Nascimento, Maria Imaculada de Queiroz Rodrigues, Pedro Henrique Chaves Isaias, Paulo Goberlanio Barros-Silva, Fabricio Bitu Sousa, Ana Paula Negreiros Nunes Alves, Mario Rogerio Lima Mota
Summary: The study aimed to evaluate the inflammatory response and development of apical periodontitis in rats chronically treated with glucocorticoids. The results showed that glucocorticoid treatment caused an early increase in bone resorption and pulp necrosis, accompanied by alterations in cytokine levels, inflammatory response, and collagen deposition.
INTERNATIONAL ENDODONTIC JOURNAL
(2022)
Article
Dentistry, Oral Surgery & Medicine
Dewi L. I. Nasution, Michiko Furuta, Huihua Li, Myrna Nurlatifah Zakaria, Toru Takeshita, Marco A. Peres, Yoshihisa Yamashita
Summary: The aim of this study was to investigate the bidirectional temporal relationship between periodontal condition and glycaemic status. The results showed that HbA1c at baseline had a significant effect on mean PPD at follow-up, while fasting glucose had a marginal effect on mean PPD. However, there was no effect of mean PPD or CAL at baseline on fasting glucose or HbA1c at follow-up.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Engineering, Biomedical
Zain Siddiqui, Biplab Sarkar, Ka-Kyung Kim, Nurten Kadincesme, Reshma Paul, Arjun Kumar, Yoshifumi Kobayashi, Abhishek Roy, Marwa Choudhury, Jian Yang, Emi Shimizu, Vivek A. Kumar
Summary: The study demonstrates the potential of acellular self-assembling peptide hydrogels in promoting tissue revascularization and soft tissue regeneration after endodontic treatment. The hydrogels show promise in guiding the development of neovasculature and tissue deposition, providing a scaffold for soft tissue regeneration in vivo.
ACTA BIOMATERIALIA
(2021)
Article
Immunology
Fuhua Yang, Yifei Zhang, Zhi Chen, Lu Zhang
Summary: VISTA is upregulated in inflammatory tissues of apical periodontitis, acting as a negative regulator to suppress inflammation and bone loss.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Andres Torres, Kathleen Lerut, Paul Lambrechts, Reinhilde Jacobs
Summary: This case report presents a novel guided endodontics technique using a sleeveless 3-dimensional-printed guide, which allows for a minimally invasive access cavity up to the root canal. The technique shows promise as an alternative to conventional guided endodontics in cases where vertical space is limited, for negotiating pulp canal obliteration.
JOURNAL OF ENDODONTICS
(2021)
Article
Cell Biology
Elisheva Goldman, Eli Reich, Bar Roshihotzki, Maya Saketkhou, Sharon Wald, Ayana Goldstein, Yehuda Klein, Itzhak Abramovitz, Michael Klutstein
Summary: Young mice with apical periodontitis showed higher periapical cell density and more osteoclasts in the lesions, while the immune reaction in adult mice was attenuated compared to the young counterparts.
Article
Dentistry, Oral Surgery & Medicine
Alessio Buonavoglia, Fausto Zamparini, Gianvito Lanave, Francesco Pellegrini, Georgia Diakoudi, Andrea Spinelli, Maria Stella Lucente, Michele Camero, Violetta Iris Vasinioti, Maria Giovanna Gandolfi, Vito Marte, Carlo Prati
Summary: This study evaluated microbial communities in root canals using Nanopore sequencing and analyzed their relationship with peri-radicular inflammatory diseases. The results showed the presence of various microorganisms in root canals, which were closely related to clinical and endodontic conditions. Future studies should further evaluate these conditions and identify their role in inducing bone damage and local systemic diseases to better understand the relationship between microbes and endodontic pathologies.
JOURNAL OF ENDODONTICS
(2023)
Article
Medicine, General & Internal
Ye-Qing Yang, Bu-Ling Wu, Jun-Kai Zeng, Chong Jiang, Ming Chen
Summary: Pulp revascularization showed favorable results in treating adult patients with chronic periapical periodontitis with immature roots and open apices.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Mariana Pagliusi Justo, Carolina de Barros Morais Cardoso, Cristiane Cantiga-Silva, Pedro Henrique Chaves de Oliveira, Gustavo Sivieri-Araujo, Mariane Maffei Azuma, Edilson Ervolino, Luciano Tavares Angelo Cintra
Summary: This study aimed to evaluate the effect of systemic curcumin administration on the severity of apical periodontitis (AP) in rats. The results showed that oral supplementation with curcumin had a significant effect on reducing the severity of AP, indicating its anti-inflammatory effect.
INTERNATIONAL ENDODONTIC JOURNAL
(2022)
Article
Dentistry, Oral Surgery & Medicine
Bhawna Koli, Amrita Chawla, Ajay Logani, Vijay Kumar, Sidhartha Sharma
Summary: This prospective study evaluated the outcome of a combination of NSET and VPT in the management of mature permanent mandibular molar teeth with symptomatic irreversible pulpitis (SIP) and apical periodontitis (AP). The success rates of the NSET and NSET-VPT groups were 90% and 93.3% respectively, with no significant difference between the two groups, indicating that the combination of NSET and VPT is an effective treatment option.
JOURNAL OF ENDODONTICS
(2021)
Article
Cell Biology
Kanokwan Sriwattanapong, Noppadol Sa-Ard-Iam, Lawan Boonprakong, Keskanya Subbalekha, Vorapat Trachoo, Narissara Suratannon, Thantrira Porntaveetus, Vorasuk Shotelersuk
Summary: This study suggests that in addition to neutropenia, the aberrant levels and functions of ELANE and SLPI in pulp cells play an important role in oral complications in SCN patients. ELANE cells exhibited impaired proliferation, colony forming, migration, attachment and spreading, and were highly responsive to inflammation.
CELL PROLIFERATION
(2021)
Review
Medicine, Research & Experimental
Lanxiang Ye, Li Cao, Wencheng Song, Chen Yang, Qingming Tang, Zhenglin Yuan
Summary: Apical periodontitis is a common oral inflammatory disease caused by infection of the pulp chamber and characterized by the destruction and resorption of the periapical bone. It has been found to be associated with various types of systemic diseases, as the pathogens and inflammatory cytokines from periapical tissues enter the bloodstream, triggering systemic immune responses. However, the exact mechanisms and associations between apical periodontitis and systemic diseases are still unclear. Understanding this potential relationship will be beneficial for dentists and physicians in managing both apical periodontitis and systemic diseases.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Xin Zhou, Shan Jiang, Xiao Wang, Shuai Wang, Xiaofei Zhu, Chengfei Zhang
DENTAL MATERIALS JOURNAL
(2015)
Article
Dentistry, Oral Surgery & Medicine
Amy Wai-Yee Wong, Shinan Zhang, Samantha Kar-Yan Li, Xiaofei Zhu, Chengfei Zhang, Chun-Hung Chu
Article
Dentistry, Oral Surgery & Medicine
Amy Wai-yee Wong, Xiaofei Zhu, Shinan Zhang, Samantha Ka-yan Li, Chengfei Zhang, Chun-Hung Chu
Article
Cell Biology
Philippe Gauthier, Zongdong Yu, Quynh T. Tran, Fazal-Ur-Rehman Bhatti, Xiaofei Zhu, George T-J Huang
CELL AND TISSUE RESEARCH
(2017)
Article
Cell & Tissue Engineering
Xiaofei Zhu, Jie Liu, Zongdong Yu, Chao-An Chen, Hacer Aksel, Adham A. Azim, George T. -J. Huang
TISSUE ENGINEERING PART C-METHODS
(2018)
Article
Dentistry, Oral Surgery & Medicine
W. Zhu, X. Zhu, G. T. -J. Huang, G. S. P. Cheung, W. L. Dissanayaka, C. Zhang
INTERNATIONAL ENDODONTIC JOURNAL
(2013)
Article
Dentistry, Oral Surgery & Medicine
Xiaofei Zhu, Qianqian Wang, Chengfei Zhang, Gary S. P. Cheung, Ya Shen
JOURNAL OF ENDODONTICS
(2010)
Article
Dentistry, Oral Surgery & Medicine
Waruna Lakmal Dissanayaka, Xiaofei Zhu, Chengfei Zhang, Lijian Jin
JOURNAL OF ENDODONTICS
(2011)
Article
Dentistry, Oral Surgery & Medicine
Zeyun Ma, Yixiang Wang, Xiaofei Zhu, Chengfei Zhang, Shenglin Li, Lijian Jin, Ya Shen, Markus Haapasalo
JOURNAL OF ENDODONTICS
(2011)
Article
Dentistry, Oral Surgery & Medicine
Xiaofei Zhu, Chengfei Zhang, George T-J Huang, Gary S. P. Cheung, Waruna Lakmal Dissanayaka, Wenhao Zhu
JOURNAL OF ENDODONTICS
(2012)
Article
Dentistry, Oral Surgery & Medicine
Xiaofei Zhu, Yu Wang, Yuan Liu, George T. J. Huang, Chengfei Zhang
JOURNAL OF ENDODONTICS
(2014)
Article
Surgery
Xiaofei Zhu, Xingzhe Yin, Jeffrey W. W. Chang, Yu Wang, Gary S. P. Cheung, Chengfei Zhang
PHOTOMEDICINE AND LASER SURGERY
(2013)
Article
Medicine, General & Internal
Li Xin, Zhu Xiao-fei, Zhang Cheng-fei, Peter Cathro, C. J. Seneviratne, Shen Song
CHINESE MEDICAL JOURNAL
(2013)
Article
Dentistry, Oral Surgery & Medicine
Qian-Qian Wang, Cheng-Fei Zhang, Chun-Hung Chu, Xiao-Fei Zhu
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2012)