Article
Pathology
Priscilla A. Furth, Weisheng Wang, Keunsoo Kang, Brendan L. Rooney, Grace Keegan, Vinona Muralidaran, Xiaojun Zou, Jodi A. Flaws
Summary: Genetically engineered mouse models with overexpression of Esr1 and CYP19A1 revealed divergent disease processes in mammary glands due to distinct molecular pathophysiological intrusions into estrogen signaling during reproductive senescence. Esr1 overexpression led to higher rates of preneoplasia and cancer compared to CYP19A1 overexpression. Tamoxifen and letrozole exposure down-regulated cell proliferation genes and resolved differences between the two models.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Article
Biology
Mara D. Saenz-de-Juano, Giulia Silvestrelli, Andres Weber, Christian Rohrig, Mathias Schmelcher, Susanne E. Ulbrich
Summary: This study investigates the impact of Staphylococcus aureus extracellular vesicles on mammary epithelial cells, providing insights into how the bacteria evades host defense mechanisms and colonizes the mammary gland effectively.
Article
Agriculture, Dairy & Animal Science
Xinlu Liu, Jinglin Shen, Jinxin Zong, Jiayi Liu, Yongcheng Jin
Summary: Beta-sitosterol, at concentrations ranging from 0.1 to 10 µM, has been shown to promote the expression of milk protein and fat synthesis-related genes and proteins in bovine mammary epithelial cells, suggesting its potential use as a feed additive to improve milk quality in dairy cows.
Article
Immunology
Peerzada Tajamul Mumtaz, Qamar Taban, Basharat Bhat, Syed Mudasir Ahmad, Mashooq Ahmad Dar, Zahid Amin Kashoo, Nazir A. Ganie, Riaz Ahmad Shah
Summary: This study discovered that bacterial challenge triggers the expression of lncRNAs associated with immune response and defense mechanisms in goat mammary epithelial cells.
MICROBIAL PATHOGENESIS
(2022)
Article
Multidisciplinary Sciences
Helen Tower, Genevieve Dall, Ashleigh Davey, Melanie Stewart, Patrick Lanteri, Meagan Ruppert, Maria Lambouras, Ibraheem Nasir, Serene Yeow, Phillip K. Darcy, Wendy Ingman, Belinda Parker, Nicole M. Haynes, Kara L. Britt
Summary: Breast cancer incidence is influenced by aberrant hormone exposure. In this study, inhibiting estrogen action was found to decrease immune suppressive myeloid cells and increase antigen presentation and cytotoxic effects mediated by eosinophils.
SCIENTIFIC REPORTS
(2022)
Article
Agriculture, Dairy & Animal Science
Renxu Chang, Xudong Sun, Hongdou Jia, Qiushi Xu, Zhihao Dong, Yan Tang, Shengbin Luo, Qianming Jiang, Juan J. Loor, Chuang Xu
Summary: The study investigated the role of NFE2L2-mediated autophagy on oxidative stress in bovine mammary epithelial cells exposed to exogenous free fatty acids (FFA). The results showed that FFA decreased the activities of antioxidant enzymes, increased reactive oxygen species (ROS) levels, and disrupted autophagy. Activation of autophagy attenuated FFA-induced oxidative stress. FFA inhibited the abundance of NFE2L2 and its translocation to the nucleus. Knockdown of NFE2L2 decreased autophagy while increasing p62 levels. Pre-treatment with sulforaphane (SFN) alleviated FFA-induced oxidative stress through NFE2L2-mediated autophagy.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Cell Biology
Kai Xu, Sen Chen, Le Xie, Yue Qiu, Xue Bai, Xiao-Zhou Liu, Hui-Min Zhang, Xiao-Hui Wang, Yuan Jin, Yu Sun, Wei-Jia Kong
Summary: The study reveals different macrophage and immune responses in Cx26-null mouse models, providing insights into the role of immune response in hereditary deafness caused by genetic mutations.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemical Research Methods
Zuming Xiong, Wenxin Li, Xiangrong Luo, Yirong Lin, Wei Huang, Sen Zhang
Summary: In this study, a risk model was constructed based on bacterial response-related genes to identify new markers for predicting colon cancer prognosis. A seven-gene prognostic signature (LGALS4, RORC, DDIT3, NSUN5, RBCK1, RGL2, and SERPINE1) was found to accurately predict the outcomes of colon cancer patients and these genes were also identified as independent diagnostic factors.
BMC BIOINFORMATICS
(2023)
Article
Oncology
Wen Yin, Hecheng Zhu, Jun Tan, Zhaoqi Xin, Quanwei Zhou, Yudong Cao, Zhaoping Wu, Lei Wang, Ming Zhao, Xingjun Jiang, Caiping Ren, Guihua Tang
Summary: This study identified that collagen genes play a crucial role in regulating the immunosuppressive microenvironment and EMT process of glioma, suggesting their potential as therapeutic targets for glioma management.
CANCER CELL INTERNATIONAL
(2021)
Article
Biotechnology & Applied Microbiology
Divya Arunachalam, Shruthi Mahalakshmi Ramanathan, Athul Menon, Lekshmi Madhav, Gopalakrishna Ramaswamy, Venkatesh Prajna Namperumalsamy, Lalitha Prajna, Dharmalingam Kuppamuthu
Summary: This study investigated the immune responses of human corneal epithelial cells interacting with Aspergillus flavus. The results showed that there were differentially expressed genes between cell lines and primary cultures. When infected with A. flavus, immune defense genes were up-regulated, while chemokine signaling and B cell signaling pathways were down-regulated.
Article
Environmental Sciences
Won-Young Lee, Ran Lee, Hyun-Jung Park
Summary: Tebuconazole (TEB), a triazole fungicide, was found to decrease cell viability and proliferation and induce apoptotic cell death and endoplasmic reticulum (ER) stress in bovine mammary gland epithelial cells (MAC-T cells). TEB activated pro-apoptotic proteins and upregulated ER stress markers, leading to mitochondria-mediated apoptotic cell death. Additionally, TEB caused a reduction in the expression of genes related to milk protein synthesis in MAC-T cells, suggesting potential negative effects on milk production in dairy cows.
Article
Biotechnology & Applied Microbiology
Ertao Li, Jianhui Qin, Honglin Feng, Jinqiao Li, Xiaofeng Li, Innocent Nyamwasa, Yazhong Cao, Weibin Ruan, Kebin Li, Jiao Yin
Summary: The study found that in response to nematode infection, immune-related genes such as PGRP-SC1, PPAE-I, and GST are involved in the immune response of Holotrichia parallela, with PGRP-SC1 and PPAE-I showing higher expression in the midgut and fat body, respectively, and GST exhibiting high expression in both. Silencing these genes increases susceptibility of H. parallela larvae to nematode infection.
Article
Cell Biology
Xiaogang Shen, Meng Wang, Wenxi Chen, Yu Xu, Qiaoxia Zhou, Tengfei Zhu, Guoqiang Wang, Shangli Cai, Yusheng Han, Chunwei Xu, Wenxian Wang, Lei Meng, Hao Sun
Summary: A prognostic signature based on senescence-related genes was developed using a machine learning algorithm. This model can be used for risk stratification and predicting response to systemic therapy in gastric cancer.
Article
Pharmacology & Pharmacy
Rui Yang, Wengang Zhang, Xiaoling Shang, Hang Chen, Xin Mu, Yuqing Zhang, Qi Zheng, Xiuwen Wang, Yanguo Liu
Summary: Neutrophils play a crucial role in the prognosis of bladder cancer. We developed a prognostic model based on neutrophil-related genes and identified FCGRT as a key gene associated with adverse prognosis. FCGRT may serve as a promising biomarker for anti-cancer drug response, contributing to personalized prognostic prediction and clinical decision-making.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Si Sun, Weipu Mao, Lilin Wan, Kehao Pan, Liting Deng, Lei Zhang, Guangyuan Zhang, Ming Chen
Summary: This study found that FGF17, PRKCG, SSTR1, and SCTR were metastatic immune-related differentially expressed genes (mIR-DEGs) with independent prognostic values in renal clear cell carcinoma. These genes were significantly associated with clinicopathological factors and immune checkpoint-related genes. The risk prognostic model based on these genes showed good predictive potential.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Editorial Material
Pharmacology & Pharmacy
Tarek A. Leil, Sergey Ermakov
FRONTIERS IN PHARMACOLOGY
(2015)
Editorial Material
Endocrinology & Metabolism
William V. Tamborlane, Morey W. Haymond, David Dunger, Ravi Shankar, Rose Gubitosi-Klug, Kathleen Bethin, Janina Karres, Paolo Tomasi, Ingrid Libman, Paula H. Hale, Ronald Portman, Georgeanna Klingensmith, Michael Reed, Jeffrey Blumer, George Giacoia
Article
Endocrinology & Metabolism
W. Tang, T. A. Leil, E. Johnsson, D. W. Boulton, F. LaCreta
DIABETES OBESITY & METABOLISM
(2016)
Article
Pharmacology & Pharmacy
Yasong Lu, Steven C. Griffen, David W. Boulton, Tarek A. Leil
FRONTIERS IN PHARMACOLOGY
(2014)
Article
Pharmacology & Pharmacy
Tarek A. Leil, Richard Bertz
FRONTIERS IN PHARMACOLOGY
(2014)
Article
Pharmacology & Pharmacy
Sergey Ermakov, Peter Forster, Jyotsna Pagidala, Marko Miladinov, Albert Wang, Rebecca Baillie, Derek Bartlett, Mike Reed, Tarek A. Leil
FRONTIERS IN PHARMACOLOGY
(2014)
Article
Pharmacology & Pharmacy
Lora Hamuro, Giridhar S. Tirucherai, Sean M. Crawford, Akbar Nayeem, Renuka C. Pillutla, Binodh S. DeSilva, Tarek A. Leil, Craig J. Thalhauser
Article
Pharmacology & Pharmacy
Weiguo Cai, Tarek A. Leil, Leonid Gibiansky, Murli Krishna, Hongwei Zhang, Huidong Gu, Huadong Sun, John Throup, Subhashis Banerjee, Ihab Girgis
CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT
(2020)
Article
Pharmacology & Pharmacy
Tarek A. Leil, Yasong Lu, Marion Bouillon-Pichault, Robert Wong, Miroslawa Nowak
Summary: This study conducted a model-based meta-analysis of RA drugs and found that most drugs had similar effects on Delta DAS28 in typical RA patient population, except tocilizumab which showed a significantly greater response at 24 weeks possibly due to its effect on interleukin-6. Factors like baseline DAS28, disease duration, percentage of male participants, and year of trial conduct had significant effects on the timing and magnitude of Delta DAS28 in control arms. Clinical trial simulations suggested that several drugs would have a high probability of showing a significant difference vs. control at Week 6 with small sample sizes.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Pharmacology & Pharmacy
Q. Wang, M. Zheng, T. Leil
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY
(2017)
Article
Pharmacology & Pharmacy
Yougan Cheng, Craig J. Thalhauser, Shepard Smithline, Jyotsna Pagidala, Marko Miladinov, Heather E. Vezina, Manish Gupta, Tarek A. Leil, Brian J. Schmidt
Article
Pharmacology & Pharmacy
Ta Leil, C. Frost, X. Wang, M. Pfister, F. LaCreta
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY
(2014)
Article
Pharmacology & Pharmacy
T. A. Leil, S. Kasichayanula, D. W. Boulton, F. LaCreta
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY
(2014)
Article
Pharmacology & Pharmacy
T. A. Leil
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY
(2014)
Article
Pharmacology & Pharmacy
Brenda Cirincione, Kenneth Kowalski, Jace Nielsen, Amit Roy, Neelima Thanneer, Wonkyung Byon, Rebecca Boyd, Xiaoli Wang, Tarek Leil, Frank LaCreta, Takayo Ueno, Masayo Oishi, Charles Frost
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY
(2018)