Article
Agriculture, Dairy & Animal Science
Xiaoyu Men, Su Li, Xiaojing Cai, Lian Fu, Yi Shao, Yan Zhu
Summary: Pseudorabies virus (PRV) is a major threat to swine industry and can potentially cause viral encephalitis in humans. Due to emerging variants, finding effective antiviral agents against PRV is crucial. This study evaluated the antiviral activity of luteolin against PRV both in vitro and in vivo. Luteolin demonstrated significant inhibition of PRV replication, reduced viral RNA and protein expression, decreased apoptosis, improved survival rate in mice, and reduced viral loads and brain lesions. These findings suggest that luteolin holds promise as a new alternative antiviral drug for PRV infection.
Article
Pharmacology & Pharmacy
Deepak Kumar, Arti Gautam, Patit Paban Kundu
Summary: The present research aimed to synthesize capecitabine-loaded core-shell nanoparticles (Cap@AAM-g-ML/IA-g-Psy-NPs) to deliver the drug to the targeted colonic area, improving its anti-cancer activity. The drug release behavior of Cap@AAM-g-ML/IA-g-Psy-NPs was studied at different biological pH levels, and the highest drug release rate (95%) was observed at pH 7.2. Cytotoxicity experiments on HCT-15 cell line showed that Cap@AAM-g-ML/IA-g-Psy-NPs exhibited significant toxicity. In-vivo studies on a DMH-induced colon cancer rat model demonstrated that Cap@AAM-g-ML/IA-g-Psy-NPs enhanced anticancer activity compared to capecitabine. Histology studies indicated that treatment with Cap@AAM-g-ML/IA-g-Psy-NPs reduced the inflation caused by DMH-induced cancer. This study provides a valuable approach for the synthesis of Cap@AAM-g-ML/IA-g-Psy-NPs for anticancer applications.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Ritesh Fule, Mohammed Kaleem, Turky Omar Asar, Md Abdur Rashid, Rasheed A. Shaik, Basma G. Eid, Mohammed Z. Nasrullah, Aftab Ahmad, Imran Kazmi
Summary: Innovative drug delivery systems based on iron oxide nanoparticles (INPs) have attracted significant interest globally for their potential benefits in anticancer therapy. However, issues such as stability, absorption, and toxicity have been reported with the administration of INPs due to surface oxidation and agglomeration. To address this, trehalose-coated stabilized iron oxide nanoparticles (TINPs) were synthesized and loaded with the anticancer drug cytarabine, resulting in engineered CY-TINPs with improved stability, prevention of protein binding, and increased absorption. CY-TINPs showed remarkable enhancement in pharmacokinetic parameters and demonstrated effective delayed release, improved bioavailability, and enhanced cytotoxic activity against tumors compared to traditional drug delivery.
Article
Materials Science, Multidisciplinary
Ashok Kumar Jangid, Krunal Patel, Poonam Jain, Sunita Patel, Kanakaraju Medicherla, Deep Pooja, Hitesh Kulhari
Summary: Resveratrol nanoparticles (RNP) formulation with enhanced bioavailability was prepared and evaluated for anticancer activity against human colorectal cancer cells. The developed formulation showed significantly higher AUC and Cmax compared to pure RSV, indicating improved effectiveness for cancer treatment.
Article
Chemistry, Medicinal
Na Li, Manyi Xu, Lulu Zhang, Zhichao Lei, Cheng Chen, Tianyuan Zhang, Li Chen, Jianbo Sun
Summary: By introducing substituted imidazoles, significant improvements in antiproliferation, covalent-binding ability, and Hsp90-Cdc37 inhibition were achieved compared to CEL. Compound 9, the most potent derivative, showed higher activity in inducing apoptosis and inhibiting tumor growth in vivo. This study provides support for the development of CEL and other Michael acceptors as antitumor agents.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Kaichao Song, Liping Zhou, Cuicui Wang, Zhixin Yuan, Qilong Cao, Xianggen Wu, Mengshuang Li
Summary: A novel nanoformulation named Lut@pro-phytomicelles was developed for the oral delivery of luteolin. It showed excellent characteristics including good storage stability, fast in vitro release, improved antioxidant activity, and high safety potential. In vivo evaluations demonstrated significantly improved oral bioavailability, increased concentration in organs and gastrointestinal segments, and strong protection efficacy against acetaminophen-induced hepatotoxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Aleksandra Maria Juszczak, Robert Czarnomysy, Jakub Wladyslaw Strawa, Marijana Zovko Koncic, Krzysztof Bielawski, Michal Tomczyk
Summary: This study evaluated the activity of J. montana in traditional Belarusian herbal medicine for sleep disorders in children, revealing significant cytotoxic and proapoptotic effects on melanoma cells and normal fibroblasts. The herbal extract shows promising potential as a new topical preparation with anticancer properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Mohammed Elmowafy, Khaled Shalaby, Mohammad M. Al-Sanea, Omnia M. Hendawy, Ayman Salama, Mohamed F. Ibrahim, Mohammed M. Ghoneim
Summary: This study prepared a luteolin-loaded nanosuspension and compared the effects of four stabilizers, finding that nanosuspensions stabilized by alginate showed the smallest particle size and the highest zeta potential value. Alginate increased stability through dual stabilizing effects, while Pluronic F127 improved skin delivery and pharmacodynamic efficacy.
Article
Plant Sciences
Janani Manochkumar, C. George Priya Doss, Hesham R. El-Seedi, Thomas Efferth, Siva Ramamoorthy
Summary: Carotenoids have been shown to play an important role in treating neurodegenerative diseases by providing neuroprotection through various pathways and lowering the risk of disease progression. Dietary intake of carotenoids in humans has been linked to a reduced risk of neurodegenerative diseases.
Review
Food Science & Technology
Amin Gasmi, Asma Gasmi Benahmed, Mariia Shanaida, Salvatore Chirumbolo, Alain Menzel, Wajiha Anzar, Mehreen Arshad, Natalia Cruz-Martins, Roman Lysiuk, Nataliya Beley, Petro Oliinyk, Volodymyr Shanaida, Antonina Denys, Massimiliano Peana, Geir Bjorklund
Summary: The use of natural bioactive constituents from various food sources, such as broccoli, for anticancer purposes is gaining popularity worldwide. Broccoli contains phytochemicals, vitamins, and minerals, which provide strong antioxidant effects and modulate molecules involved in cell cycle regulation and apoptosis, reducing the risk of cancer development.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Pharmacology & Pharmacy
Jing Mu, Huisheng Ma, Hong Chen, Xiaoxia Zhang, Mengyi Ye
Summary: This study demonstrated that luteolin plays a protective role against UVB-induced photoaging by targeting SIRT3, reducing oxidative stress levels, inhibiting MMPs activation, and increasing collagen expression.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Liqing Zheng, Lixia Shen, Ze Li, Xiaoli Zhang, Miaomiao Wu, Yuanyuan Zhang, Jianhua Liu
Summary: In this study, polybutyl cyanoacrylate (PBCA) nanoparticles were used to improve the solubility and bioavailability of osthol, a neuroprotective drug with anticancer activity. The physicochemical properties, release behavior, cellular uptake, and anticancer activity of osthol-PBCA nanoparticles were investigated. The results showed that the nanoparticles had a spherical shape, small particle size, good stability, sustained release pattern, enhanced cellular absorption, and cytotoxicity compared to free osthol. The pharmacokinetic study revealed higher area under the curve (AUC) for osthol-PBCA nanoparticles compared to free osthol. These findings suggest that osthol-PBCA nanoparticles can serve as a promising drug delivery system to enhance the bioactivity of osthol.
Article
Biochemistry & Molecular Biology
Nour H. Aboalhaija, Heba Syaj, Fatma Afifi, Suhair Sunoqrot, Eveen Al-Shalabi, Wamidh Talib
Summary: This study evaluates the chemical composition and biological activities of Lavandula angustifolia extracts obtained using different solvents. It finds that the ethanol extract exhibits anti-tumor activity against breast cancer cells and reduces tumor size. Additionally, the extract shows potent antioxidant potential.
Review
Oncology
Simone Perna, Hajar Alawadhi, Antonella Riva, Pietro Allegrini, Giovanna Petrangolini, Clara Gasparri, Tariq A. Alalwan, Mariangela Rondanelli
Summary: Basil is a medicinal herb that contains potential bioactive compounds and shows antimicrobial and immune-stimulating effects. It exhibits important anticancer activities, such as slowing down tumor growth and inducing cell cycle arrest, both in vivo and in vitro.
Article
Chemistry, Medicinal
Er-Jun Hao, Gong-Xin Li, Yu-Ru Liang, Ming-Sheng Xie, Dong-Chao Wang, Xiao-Han Jiang, Jia-Yi Cheng, Zhi-Xian Shi, Yang Wang, Hai-Ming Guo
Summary: The study designed, synthesized, and evaluated 103 novel acyclic nucleosides for their anticancer activities, with compound 9b showing promising inhibitory effects on colon cancer cells. All (R)-configured derivatives displayed stronger anticancer activity, with compound 9b inducing apoptosis and inhibiting colony formation. Importantly, compound 9b exhibited low systemic toxicity and inhibited tumor growth in a mouse model, suggesting it as a potential lead compound for future anticancer drug discovery.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Oncology
Abu Syed Md Anisuzzaman, Abedul Haque, Mohammad Aminur Rahman, Dongsheng Wang, James R. Fuchs, Selwyn Hurwitz, Yuan Liu, Gabriel Sica, Fadlo R. Khuri, Zhuo (Georgia) Chen, Dong M. Shin, A. R. M. Ruhul Amin
CANCER PREVENTION RESEARCH
(2016)
Article
Oncology
Dongsheng Wang, Guoqing Qian, Hongzheng Zhang, Kelly R. Magliocca, Sreenivas Nannapaneni, A. R. M. Ruhul Amin, Michael Rossi, Mihir Patel, Mark El-Deiry, J. Trad Wadsworth, Zhengjia Chen, Fadlo R. Khuri, Dong M. Shin, Nabil F. Saba, Zhuo G. Chen
CLINICAL CANCER RESEARCH
(2017)
Article
Otorhinolaryngology
Hongzheng Zhang, Sungjin Kim, Zhengjia Chen, Sreenivas Nannapaneni, Amy Y. Chen, Charles E. Moore, Gabriel Sica, Marina Mosunjac, Minh Ly T. Nguyen, Gypsyamber D'Souza, Thomas E. Carey, Lisa A. Peterson, Jonathan B. McHugh, Martin Graham, Christine M. Komarck, Gregory T. Wolf, Heather M. Walline, Emily Bellile, James Riddell, Sara I. Pai, David Sidransky, William H. Westra, William N. William, J. Jack Lee, Adel K. El-Naggar, Robert L. Ferris, Raja Seethala, Jennifer R. Grandis, Zhuo Georgia Chen, Nabil F. Saba, Dong M. Shin
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2017)
Article
Oncology
Abu Syed Md Anisuzzaman, Abedul Haque, Dongsheng Wang, Mohammad Aminur Rahman, Chao Zhang, Zhengjia Chen, Zhuo Georgia Chen, Dong M. Shin, A. R. M. Ruhul Amin
MOLECULAR CANCER THERAPEUTICS
(2017)
Article
Biochemistry & Molecular Biology
V. Blair Journigan, Zhiwei Feng, Saifur Rahman, Yuanqiang Wang, A. R. M. Ruhul Amin, Colleen E. Heffner, Nicholas Bachtel, Siyi Wang, Sara Gonzalez-Rodriguez, Asia Fernandez-Carvajal, Gregorio Fernandez-Ballester, Jacob K. Hilton, Wade D. Van Horn, Antonio Ferrer-Montiel, Xiang-Qun Xie, Taufiq Rahman
ACS CHEMICAL NEUROSCIENCE
(2020)
Correction
Oncology
Abedul Haque, Mohammad Aminur Rahman, James R. Fuchs, Zhuo Chen (Georgia), Fadlo R. Khuri, Dong M. Shin, A. R. M. Ruhul Amin
Editorial Material
Oncology
Dongsheng Wang, Susan Mueller, A. R. M. Ruhul Amin, Donghai Huang, Ling Su, Zhongliang Hu, Mohammad Aminur Rahman, Sreenivas Nannapaneni, Lydia Koenig, Zhengjia Chen, Mourad Tighiouart, Dong M. Shin, Zhuo G. Chen
CLINICAL CANCER RESEARCH
(2020)
Review
Oncology
Abedul Haque, Daniel Brazeau, Arm R. Amin
Summary: Although cancer is the second deadliest disease worldwide, recent advances in precision treatments are promising. However, challenges remain due to the heterogeneity and mutational burdens of cancer cells. Chemoprevention, especially with natural dietary compounds, is considered a rational and appealing strategy to prevent carcinogenesis, particularly in high-risk populations.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Oncology
A. R. M. Ruhul Amin, Dongsheng Wang, Sreenivas Nannapaneni, Rajan Lamichhane, Zhuo Georgia Chen, Dong M. Shin
Summary: The combination of green tea epigallocatechin gallate (EGCG) and resveratrol has synergistic growth inhibitory effects on head and neck cancer cells, increasing apoptosis and inhibiting tumor growth by suppressing the AKT-mTOR signaling pathway. These findings suggest a potential clinical application for chemoprevention and treatment of head and neck cancer.
Article
Chemistry, Medicinal
V. Blair Journigan, David Alarcon-Alarcon, Zhiwei Feng, Yuanqiang Wang, Tianjian Liang, Denise C. Dawley, A. R. M. Ruhul Amin, Camila Montano, Wade D. Van Horn, Xiang-Qun Xie, Antonio Ferrer-Montiel, Asia Fernandez-Carvajal
Summary: TRPM8 antagonists derived from its cognate ligand, (-)-menthol, are underrepresented. In this study, we determined the absolute stereochemistry of a well-known TRPM8 antagonist and explored its antagonist effects on human TRPM8, demonstrating its novel potential as a chemical tool for studying hTRPM8 pharmacology.
ACS MEDICINAL CHEMISTRY LETTERS
(2021)
Review
Pharmacology & Pharmacy
Adeoluwa Adeluola, Abu Hasanat Md Zulfiker, Daniel Brazeau, A. R. M. Ruhul Amin
Summary: Curcumin, a compound extracted from turmeric, has been extensively studied for its anti-inflammatory, antioxidant, antimicrobial, and anti-tumour activities. Despite its potential as an anti-cancer agent, its clinical application is hindered by poor solubility and bioavailability, prompting researchers to explore novel formulation techniques and synthesis of analogues. Current research indicates promising results for the synthetic analogues of curcumin in the management of cancer.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Adeoluwa A. Adeluola, Nana Bosomtwe, Timothy E. Long, A. R. M. Ruhul Amin
Summary: This study evaluated the anti-tumor efficacy and mechanism of action of ActD in aerodigestive tract cancers. Results showed that ActD strongly inhibited the growth of aerodigestive tract cancer cells and induced efficient apoptosis. Mechanistic studies revealed that ActD increased the expression of p53 and influenced its downstream targets.
Article
Oncology
Jennifer A. Marks, Jeffrey M. Switchenko, Conor E. Steuer, Martha Ryan, Mihir R. Patel, Mark W. McDonald, Kristin Higgins, Johnathan J. Beitler, Dong M. Shin, Theresa W. Gillespie, Nabil F. Saba
Summary: The study found that in patients with oropharyngeal squamous cell carcinoma, HPV-positive patients with private insurance had improved overall survival compared to those without insurance; HPV-negative patients with private insurance also had improved survival compared to those without insurance. Additionally, there were statistical differences in the impact of insurance status, rural-urban status, and facility location on survival between HPV-positive and HPV-negative patients.
JCO ONCOLOGY PRACTICE
(2021)
Correction
Oncology
Abu Syed Md Anisuzzaman, Abedul Haque, Dongsheng Wang, Mohammad Aminur Rahman, Chao Zhang, Zhengjia Chen, Zhuo Georgia Chen, Dong M. Shin, A. R. M. Ruhul Amin
MOLECULAR CANCER THERAPEUTICS
(2020)
Article
Oncology
Frederico O. Gleber-Netto, Mei Zhao, Sanchit Trivedi, Jiping Wang, Samar Jasser, Christina McDowell, Humam Kadara, Jiexin Zhang, Jing Wang, William N. William, J. Jack Lee, Minh Ly Nguyen, Sara I. Pai, Heather M. Walline, Dong M. Shin, Robert L. Ferris, Thomas E. Carey, Jeffrey N. Myers, Curtis R. Pickering