Design, Synthesis, and Activity Evaluation of Novel Acyclic Nucleosides as Potential Anticancer Agents In Vitro and In Vivo

Discovery of M-808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin–MLL Interaction with Strong In Vivo Antitumor Activity

(2020) Shilin Xu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Structure–Activity Relationship of 7-Propanamide Benzoxaboroles as Potent Anticancer Agents

(2019) Jiong Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, antitumor activities and biological studies of novel diaryl substituted fused heterocycles as dual ligands targeting tubulin and katanin

(2019) Feng Gao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Highly Potent and Efficient PROTAC Degraders of Androgen Receptor (AR) by Employing Weak Binding Affinity VHL E3 Ligase Ligands

(2019) Xin Han et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Structure–Activity Relationship Study of 2-Oxo-3,4-dihydropyrimido[4,5-d]pyrimidines as New Colony Stimulating Factor 1 Receptor (CSF1R) Kinase Inhibitors

(2018) Qiuju Xun et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe Synthesis

(2018) James R. Hill et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Evaluation of Asymmetric Acyclic Nucleoside Bisphosphonates as Inhibitors of Plasmodium falciparum and Human Hypoxanthine–Guanine–(Xanthine) Phosphoribosyltransferase

(2017) Petr Špaček et al.   JOURNAL OF MEDICINAL CHEMISTRY

Expanding the Antiviral Spectrum of 3-Fluoro-2-(phosphonomethoxy)propyl Acyclic Nucleoside Phosphonates: Diamyl Aspartate Amidate Prodrugs

(2017) Min Luo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Virtual Screening of Acyclovir Derivatives as Potential Antiviral Agents: Design, Synthesis, and Biological Evaluation of New Acyclic Nucleoside ProTides

(2017) Marco Derudas et al.   JOURNAL OF MEDICINAL CHEMISTRY

Benzophenone-nucleoside derivatives as telomerase inhibitors: Design, synthesis and anticancer evaluation in vitro and in vivo

(2016) Jing Bo Shi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Chemoprevention of Low-Molecular-Weight Citrus Pectin (LCP) in Gastrointestinal Cancer Cells

(2016) Shi Wang et al.   International Journal of Biological Sciences

Potent Antitumor Activities and Structure Basis of the Chiral β-Lactam Bridged Analogue of Combretastatin A-4 Binding to Tubulin

(2016) Pengfei Zhou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of 6,8,9 poly-substituted purine analogue libraries as pro-apoptotic inducers of human leukemic lymphocytes and DAPK-1 inhibitors

(2015) Maria J. Pineda de las Infantas et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Discovery of New Acid Ceramidase-Targeted Acyclic 5-Alkynyl and 5-Heteroaryl Uracil Nucleosides

(2015) Andrijana Meščić et al.   ACS Medicinal Chemistry Letters

E. adenophorum induces Cell Cycle Arrest and Apoptosis of Splenocytes through the Mitochondrial Pathway and Caspase Activation in Saanen Goats

(2015) Yajun He et al.   Scientific Reports

Aza-acyclic Nucleoside Phosphonates Containing a Second Phosphonate Group As Inhibitors of the Human, Plasmodium falciparum and vivax 6-Oxopurine Phosphoribosyltransferases and Their Prodrugs As Antimalarial Agents

(2014) Dianne T. Keough et al.   JOURNAL OF MEDICINAL CHEMISTRY

The development for the synthesis of chiral acyclic nucleosides and their phosphonates

(2014) Ming-Sheng Xie et al.   TETRAHEDRON LETTERS

Acyclic Nucleoside Phosphonates Containing a Second Phosphonate Group Are Potent Inhibitors of 6-Oxopurine Phosphoribosyltransferases and Have Antimalarial Activity

(2013) Dianne T. Keough et al.   JOURNAL OF MEDICINAL CHEMISTRY

Medicinal Chemistry of Fluorinated Cyclic and Acyclic Nucleoside Phosphonates

(2013) Ondřej Baszczyňski et al.   MEDICINAL RESEARCH REVIEWS

C-5 Hydroxyethyl and Hydroxypropyl Acyclonucleosides as Substrates for Thymidine Kinase of Herpes Simplex Virus Type 1 (HSV-1 TK): Syntheses and Biological Evaluation

(2013) Andrijana Meščić et al.   MOLECULES

Naringenin prevents high glucose-induced mitochondria-mediated apoptosis involving AIF, Endo-G and caspases

(2012) Radhika Kapoor et al.   APOPTOSIS

Synthesis of Novel N-Branched Acyclic Nucleoside Phosphonates As Potent and Selective Inhibitors of Human, Plasmodium falciparum and Plasmodium vivax 6-Oxopurine Phosphoribosyltransferases

(2012) Dana Hocková et al.   JOURNAL OF MEDICINAL CHEMISTRY

Highly Enantioselective Synthesis of Designed Chiral Acyclonucleosides and Acyclonucleotides by Organocatalytic Aza-Michael Addition

(2011) Hai-Ming Guo et al.   CHEMISTRY-A EUROPEAN JOURNAL

The unsaturated acyclic nucleoside analogues bearing a sterically constrained (Z)-4′-benzamido-2′-butenyl moiety: Synthesis, X-ray crystal structure study, cytostatic and antiviral activity evaluations

(2010) Krešimir Benci et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and Properties of a Novel Type of Acyclic Nucleoside Phosphonates: 2-(Purin-9-yl)ethoxyphenylphosphonic Acids

(2010) Dana Hocková et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Novel Antiviral C5-Substituted Pyrimidine Acyclic Nucleoside Phosphonates Selected as Human Thymidylate Kinase Substrates

(2010) Dimitri Topalis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, cytostatic and anti-viral activity evaluation of the novel acyclic nucleoside analogues containing a sterically constrained (Z)-4-amino-2-butenyl moiety

(2010) Karlo Wittine et al.   MEDICINAL CHEMISTRY RESEARCH

Inhibition of Hypoxanthine-Guanine Phosphoribosyltransferase by Acyclic Nucleoside Phosphonates: A New Class of Antimalarial Therapeutics

(2009) Dianne T. Keough et al.   JOURNAL OF MEDICINAL CHEMISTRY

Linking the p53 tumour suppressor pathway to somatic cell reprogramming

(2009) Teruhisa Kawamura et al.   NATURE

Synthesis, cytostatic and anti-HIV evaluations of the new unsaturated acyclic C-5 pyrimidine nucleoside analogues

(2008) Tatjana Gazivoda et al.   BIOORGANIC & MEDICINAL CHEMISTRY