Review
Chemistry, Multidisciplinary
Carolina Salvador-Morales, Piotr Grodzinski
Summary: Nanotechnology has been extensively used in engineering, but its potential as a biological discovery tool has not received enough attention. Single-cell analysis and physical manipulation using nanotools help better understand cellular heterogeneity and critical signaling pathways. Integration of nanomaterials provides valuable tools for morphological, structural, and biological information. The exceptional sensitivity of nanozymes makes them ideal components for next-generation mobile diagnostics devices. Nanotechnology has made significant advancements in cancer research and oncology.
Review
Biochemical Research Methods
Stefano Castellana, Tommaso Biagini, Luca Parca, Francesco Petrizzelli, Salvatore Daniele Bianco, Angelo Luigi Vescovi, Massimo Carella, Tommaso Mazza
Summary: This study found that hundreds of human proteins interact with degenerated DNA sequences, and identifying these motifs and genomic sites is a challenging research goal in modern molecular biology and bioinformatics. Over the past twenty years, there has been an explosion of computational tools for this task, and sixteen of them were evaluated for their ability to identify known motifs in simulated sequence datasets.
BRIEFINGS IN BIOINFORMATICS
(2021)
Review
Biochemistry & Molecular Biology
Ravian L. van Ineveld, Esmee J. van Vliet, Ellen J. Wehrens, Maria Alieva, Anne C. Rios
Summary: This article introduces the importance and potential applications of 3D imaging in cancer research. 3D imaging provides more accurate information about the cellular composition and structure of cancer, and offers new strategies and methods for cancer treatment and patient diagnosis.
Review
Immunology
Scarlett E. Lee, Brian D. Rudd, Norah L. Smith
Summary: Fate-mapping mice are essential tools for immunologists to study the development and function of immune cells. They have been expanded to answer fundamental questions about the immune system and are combined with new genetic tools to study cancer, infection, and autoimmunity. This review summarizes different types of fate-mapping mice and describes emerging technologies to expand our functional knowledge of the immune system.
TRENDS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Haoyu Pan, Xia Chen, PeiPei Wang, Junfeng Peng, Judong Li, Kan Ding
Summary: In this study, crude polysaccharide NDH0 extracted from the traditional Chinese medicine Nemacystus decipiens (N. decipiens) was found to significantly relieve symptoms of antibiotic associated diarrhea (AAD) by modulating gut microbiota composition, improving intestinal integrity, and reducing inflammation.
Review
Pharmacology & Pharmacy
Xiyan Wang, Nan Zhou, Baojun Wang
Summary: Bacterial synthetic biology provides powerful tools for drug discovery, including bioinformatic tools, CRISPR tools, engineered transcriptional regulators, and synthetic biosensors. Reprogramming bacteriophages as living drugs is also a recent advancement in this field.
EXPERT OPINION ON DRUG DISCOVERY
(2023)
Article
Chemistry, Medicinal
Danni Rao, Tao Yang, Huixu Feng, Qi An, Shaofeng Zhang, Jinghua Yu, Xuelian Ren, Xingxing Diao, He Huang, Wei Tang, Shilin Xu
Summary: This study identifies a potent and selective covalent ZAP-70 inhibitor with anti-inflammatory activity, which effectively inhibits T cell activation and inflammatory cytokine production. The topical application of this inhibitor also shows promising efficacy in a psoriasis mouse model.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Chemistry, Medicinal
Nikolet Pavlova, Georgi Y. Miloshev, Antoniya Georgieva, Martina Traykovska, Robert Penchovsky
Summary: Synthetic biology is a emerging research field that has already found practical applications in pharmaceutical biotechnology, including metabolic engineering and drug production in genetically modified organisms. It is expected to have a significant impact on drug development and production.
FUTURE MEDICINAL CHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Dongkyoo Park, Abu Syed Md Anisuzzaman, Andrew T. Magis, Guo Chen, Maohua Xie, Guojing Zhang, Madhusmita Behera, Gabriel L. Sica, Suresh S. Ramalingam, Taofeek K. Owonikoko, Xingming Deng
Summary: The proapoptotic protein Bak is a potential target for lung cancer therapy, with the BH3 domain being crucial for Bak activation. Screening identified a small molecule Bak activator, BKA-073, which effectively suppressed lung cancer cell growth and reversed radioresistance.
Article
Cell Biology
Sujin Kim, Younglan Lim, So-Young Lee, Han-Na Yoon, Hayan Yi, Kwi-Hoon Jang, Nam-On Ku
Summary: Research shows that mutations in the K8 gene predispose transgenic mice to lung injury, leading to increased mouse lethality and more severe lung inflammation and damage.
JOURNAL OF CELL SCIENCE
(2021)
Article
Critical Care Medicine
Oana Joean, Tobias Welte, Jens Gottlieb
Summary: Despite progress in follow-up strategies, lung transplant recipients still face high morbidity and mortality due to infection risks and chronic lung allograft dysfunction. Quick diagnosis, early treatment, and follow-up are crucial but challenging due to a wide range of pathogens and compromised immune responses in transplant recipients.
Article
Oncology
Erin L. Schenk, Tejas Patil, Jose Pacheco, Paul A. Bunn
Summary: Lung cancer survival rates have improved due to new prevention, screening, and therapy methods. This review provides an overview of current standards in each area, including targeted and immunotherapies, and offers treatment recommendations for all stages of lung cancer.
Article
Medicine, Research & Experimental
Malarvizhi Gurusamy, Saeed Nasseri, Dileep Reddy Rampa, Huiying Feng, Dongwon Lee, Anton Pekcec, Henri Doods, Dongmei Wu
Summary: BI 1029539 demonstrated significant reductions in lung injury induced by endotoxin and sepsis, with decreased inflammatory cell recruitment, pro-inflammatory cytokines, and expression of mPGES-1. Additionally, the drug significantly prolonged survival in mice with severe sepsis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Materials Science, Biomaterials
Daniel J. Fesenmeier, Madathilparambil V. Suresh, Seyoung Kim, Sungwan Park, Krishnan Raghavendran, You-Yeon Won
Summary: If handled improperly, acute lung injuries have the potential to pose serious risks to patients worldwide. One mechanism for the transition from acute lung injury (ALI) to acute respiratory distress syndrome (ARDS) is the deactivation of native lung surfactant by injury-induced infiltrates. Currently, there are no surfactant replacement therapies for treating ALI and ARDS. In this paper, the efficacy of a novel polymer lung surfactant (PLS) is studied in two different mouse models of lung injury, showing promising results in decreasing the severity of lung injury.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Pharmacology & Pharmacy
Yun Jung Choi, Hyeonjeong Lee, Da-Som Kim, Dong Ha Kim, Myoung-Hee Kang, Yong-Hee Cho, Chang-Min Choi, Jakyung Yoo, Kwang-Ok Lee, Eun Kyung Choi, Jae Cheol Lee, Jin Kyung Rho
Summary: A potent inhibitor of CDK7, YPN-005, was developed and showed antiproliferative effects in SCLC cells and acquired resistance cells, with significant inhibition of RNA polymerase II phosphorylation. YPN-005 also demonstrated potent anticancer effects in organoids derived from SCLC patients, suggesting it may be a promising therapeutic option for SCLC.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)