Discovery of a novel CDK7 inhibitor YPN-005 in small cell lung cancer

New Approaches to SCLC Therapy: From the Laboratory to the Clinic

(2020) John T. Poirier et al.   Journal of Thoracic Oncology

CDK7 inhibitors as anticancer drugs

(2020) Georgina P. Sava et al.   CANCER AND METASTASIS REVIEWS

CDK7 inhibitor THZ1 enhances antiPD-1 therapy efficacy via the p38α/MYC/PD-L1 signaling in non-small cell lung cancer

(2020) Jian Wang et al.   Journal of Hematology & Oncology

Mechanisms of drugs-resistance in small cell lung cancer: DNA-related, RNA-related, apoptosis-related, drug accumulation and metabolism procedure

(2020) Peixin Chen et al.   Translational Lung Cancer Research

The role of immunotherapy in small cell lung cancer

(2019) A. Calles et al.   Clinical & Translational Oncology

CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer

(2019) Hua Zhang et al.   CANCER CELL

Targeting MYC dependency in ovarian cancer through inhibition of CDK7 and CDK12/13

(2018) Mei Zeng et al.   eLife

Small Cell Lung Cancer: Can Recent Advances in Biology and Molecular Biology Be Translated into Improved Outcomes?

(2016) Paul A. Bunn et al.   Journal of Thoracic Oncology

Treatment of Small-Cell Lung Cancer: American Society of Clinical Oncology Endorsement of the American College of Chest Physicians Guideline

(2015) Charles M. Rudin et al.   JOURNAL OF CLINICAL ONCOLOGY

Small cell lung cancer: Where do we go from here?

(2014) Lauren Averett Byers et al.   CANCER

Inhibit Globally, Act Locally: CDK7 Inhibitors in Cancer Therapy

(2014) Kaixiang Cao et al.   CANCER CELL

Targeting Transcriptional Addictions in Small Cell Lung Cancer with a Covalent CDK7 Inhibitor

(2014) Camilla L. Christensen et al.   CANCER CELL

CDK7 Inhibition Suppresses Super-Enhancer-Linked Oncogenic Transcription in MYCN-Driven Cancer

(2014) Edmond Chipumuro et al.   CELL

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

(2014) Nicholas Kwiatkowski et al.   NATURE

Natural Product Triptolide Mediates Cancer Cell Death by Triggering CDK7-Dependent Degradation of RNA Polymerase II

(2012) S. G. Manzo et al.   CANCER RESEARCH

Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion

(2012) Miguel Ganuza et al.   EMBO JOURNAL

Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II

(2012) Stéphane Larochelle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Small-cell lung cancer

(2011) Jan P van Meerbeeck et al.   LANCET

TFIIH Kinase Places Bivalent Marks on the Carboxy-Terminal Domain of RNA Polymerase II

(2009) Md. Sohail Akhtar et al.   MOLECULAR CELL