Article
Biotechnology & Applied Microbiology
Hui-Ching Lau, Yujie Shen, Qiang Huang, Hui-Ying Huang, Liang Zhou
Summary: Research identified and validated two novel glycolytic gene signatures, DDIT4 and PLOD2, as potential independent risk factors for predicting overall survival in laryngeal squamous cell carcinoma (LSCC). These findings may provide a therapeutic target and survival prediction marker for LSCC patients.
Article
Oncology
Chao Huang, Jun He, Yi Dong, Li Huang, Yichao Chen, Anquan Peng, Hao Huang
Summary: This study identified SLC35C1, HOXB7, and TEDC2 as potential therapeutic targets and prognostic biomarkers for LSCC through the analysis of RNA sequencing data.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Adam Ustaszewski, Magdalena Kostrzewska-Poczekaj, Joanna Janiszewska, Malgorzata Jarmuz-Szymczak, Malgorzata Wierzbicka, Joanna Marszal, Reidar Grenman, Maciej Giefing
Summary: The study found that control samples and malignant samples were mainly separated by malignancy and cell culture-microenvironment. It is suggested to use cultured epithelial cells as controls for gene expression profiling of cancer cell lines.
Article
Oncology
Yan Huang, Min Gu, Qi Wu, Juanfen Zhu, Jian Wu, Peipei Wang, Meihua Wang, Judong Luo
Summary: This study conducted a systematic review and meta-analysis to investigate the association between Helicobacter pylori infection in the larynx and laryngeal cancer. The results showed that Helicobacter pylori infection significantly increased the risk of malignant tumors in the larynx, even when controlling for smoking factors.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Kinga Bednarek, Magdalena Kostrzewska-Poczekaj, Adam Ustaszewski, Joanna Janiszewska, Katarzyna Kiwerska, Julia Paczkowska, Reidar Grenman, Maciej Giefing, Malgorzata Jarmuz-Szymczak
Summary: CDK1 is essential for cell proliferation and cycle regulation, making it a potential target in cancer therapy. Knockdown of CDK1 in LSCC cell lines did not impact cell proliferation and viability, with analysis showing enriched pathways in differentially expressed genes. Some genes, such as CDK6, CALD1, and FYN, are potentially dependent on CDK1.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Oncology
Viviana Triaca, Elena Fico, Pamela Rosso, Massimo Ralli, Alessandro Corsi, Cinzia Severini, Alvaro Crevenna, Enzo Agostinelli, Emma Rullo, Mara Riminucci, Andrea Colizza, Antonella Polimeni, Antonio Greco, Paola Tirassa
Summary: Laryngeal Squamous Cell Carcinoma (LSCC) is a type of head and neck cancer with high mortality and new diagnosis rates. A study found that p75NTR, a receptor for neurotrophins, is highly expressed in LSCC and may be a promising therapeutic target. Preliminary investigation suggests that p75ICD expression in LSCC may be a feature of tumorigenesis and metastasis.
Article
Cell Biology
Francois Kuonen, Nancy Yanzhe Li, Daniel Haensel, Tiffany Patel, Sadhana Gaddam, Laura Yerly, Kerri Rieger, Sumaira Aasi, Anthony E. Oro
Summary: The study reveals the dynamic process of transition from basal cell carcinoma to squamous cell carcinoma, identifying the crucial role of AP-1 family members and c-FOS in regulating tumor plasticity. It demonstrates the reversibility of c-FOS-mediated transition and shows that blocking EGFR pathway activation can partially reverse the process. The findings suggest a therapeutic opportunity targeting plasticity as a mechanism of tumor resistance.
Article
Oncology
Jing Zhao, Pu Zhang, Xin Wang
Summary: YBX1 is overexpressed in various cancer tissues, especially in head and neck cancers. Silencing YBX1 promotes apoptosis and inhibits proliferation, migration, and invasion of LSCC cells, possibly through the PI3K/AKT pathway. This study provides new insights into the potential use of YBX1 as a biomarker and therapeutic target for LSCC.
TRANSLATIONAL CANCER RESEARCH
(2021)
Article
Otorhinolaryngology
Aman Prasad, Ryan M. Carey, Kush Panara, Karthik Rajasekaran, Steven B. Cannady, Jason G. Newman, Jason A. Brant, Robert M. Brody
Summary: Management of the neck is crucial in the treatment of laryngeal squamous cell carcinoma (LSCC). This study aimed to examine patterns and rates of lymph node disease, elective neck dissection (END), and occult lymph node metastasis (LNM) in surgically-managed LSCC patients.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Biochemistry & Molecular Biology
Joanna Janiszewska, Magdalena Bodnar, Julia Paczkowska, Adam Ustaszewski, Maciej J. Smialek, Lukasz Szylberg, Andrzej Marszalek, Katarzyna Kiwerska, Reidar Grenman, Krzysztof Szyfter, Malgorzata Wierzbicka, Maciej Giefing, Malgorzata Jarmuz-Szymczak
Summary: The study demonstrates that miR-1290 suppresses MAF expression in LSCC, revealing the underlying interaction between the two. Immunohistochemistry staining showed loss of nuclear MAF expression in 58% of LSCC samples. Through data analysis, it was determined that loss-of-function mutations, promoter region DNA methylation or CNV are not responsible for MAF loss in LSCC.
Article
Multidisciplinary Sciences
Jixuan Liu, Hongyan Ban, Yafang Liu, Jinsong Ni
Summary: AKR1B10 is a significant biomarker with potential value in prognosis and treatment of cancer, particularly laryngeal cancer. Its overexpression in cancer cells indicates possible involvement in cancer development.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Li Qi, Wenzhao Bao, Wei Li, Xiaoxu Ding, Aihui Yan
Summary: The study found significant upregulation of genes in the IL-17 signaling pathway in two Chinese datasets of Laryngeal squamous cell carcinoma (LSCC), while not in the Caucasian dataset. IL17RC was identified as a key hub gene regulating this pathway and could be a potential target for treating Chinese LSCC patients.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Surgery
Jae Hyun Kwon, Jin Wook Yi
Summary: Higher telomerase reverse transcriptase messenger RNA expression is associated with poorer survival in patients with papillary thyroid carcinoma, and may serve as a better predictor for death than telomerase reverse transcriptase promoter mutations.
Article
Oncology
Leonardo Franz, Lorenzo Nicole, Anna Chiara Frigo, Giancarlo Ottaviano, Piergiorgio Gaudioso, Tommaso Saccardo, Francesca Visconti, Rocco Cappellesso, Stella Blandamura, Ambrogio Fassina, Gino Marioni
Summary: The mechanism of epithelial-mesenchymal transition (EMT) plays a crucial role in cancer development, tumor progression, and therapy resistance. In laryngeal carcinoma, the predictive value of pN+ status and Slug expression on disease-free survival was identified, supporting the hypothesis of a mutual concurrence of EMT and angiogenesis in driving aggressive phenotype in LSCC. Further studies are needed to characterize the predictive performance of prognostic models based on EMT and angiogenesis.
Article
Immunology
Juan Wang, Limin Lun, Xin Jiang, Yi Wang, Xiaopeng Li, Guoqiang Du, Jin Wang
Summary: Laryngeal squamous cell carcinoma (LSCC) and hypopharyngeal squamous cell carcinoma (HSCC) significantly impact patients' quality of life, and immunotherapy plays a crucial role in cancer treatment. Studies have shown that the upregulation of PD-L1 and APE1 is associated with tumorigenesis and poor prognosis, while PD-1 and PD-L1 are overexpressed in LSCC and HSCC tissues.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Engineering, Civil
Yongsheng Cao, Yun Zhou, Genquan Zhong, Xuesong Deng, Jiro Takagi
Summary: This paper examines the differences in hysteretic behavior of buckling-restrained brace subsystem frames (BRBFs) with concentric and out-of-plane eccentric configurations. The study found that the out-of-plane eccentric BRBFs have different mechanical properties and deformation patterns compared to the concentric BRBFs under in-plane quasi-static loads.
INTERNATIONAL JOURNAL OF STRUCTURAL STABILITY AND DYNAMICS
(2023)
Article
Environmental Sciences
Xiaolong Shi, Yufei Zhou, Pei Guo, Jingyao Ren, He Zhang, Qiqi Dong, Chunji Jiang, Chao Zhong, Zheng Zhang, Shubo Wan, Xinhua Zhao, Haiqiu Yu
Summary: Intercropping of peanut and sorghum can improve soil properties and microbial community structure, enhancing nutrient availability, enzymatic activities, and plant adaptability under salt stress conditions.
LAND DEGRADATION & DEVELOPMENT
(2023)
Article
Environmental Sciences
Haolan Wang, Wenlong Zhang, Yi Li, Yu Gao, Nan Yang, Lihua Niu, Huanjun Zhang, Longfei Wang
Summary: This study investigates the impact of trophic interactions on the assembly of multi-trophic microbial communities and nitrogen transformation potential in typical urban river bends. The results indicate that trophic interactions strongly shape microbial communities, leading to increased abundance in multitrophic microbial communities and enhanced nitrogen transformation potential. This research provides a theoretical basis for the regulation and restoration of urban rivers.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Engineering, Manufacturing
Shenghua Pei, Fei Xue, Yufei Zhou, Chen Pan, Kai Jia
Summary: This study investigates the effects of a dry cutting cooling method with a cryogenic gas jet on the milling performance of GH4169 alloy additive manufacturing parts. The results show that cryogenic gas jet cooling can significantly improve the tool life and machined surface roughness of parts.
JOURNAL OF MANUFACTURING PROCESSES
(2023)
Article
Economics
Fangzhou Dong, Sara Sterling, Xiaohui Li, Yuzhen Li
Summary: This paper examines critical design from a cultural perspective and proposes a framework for integrating cultural resources in the process of speculating futures. Through two online critical design studios conducted in a Chinese social-cultural context, using Chinese weddings as a case study, the effectiveness of the framework is validated. The proposed framework will benefit both design beginners in speculating futures and researchers at the intersection of design and futures.
Article
Engineering, Civil
Junxian Zhao, Jiaguang Zhang, Jiayu Song, Yun Zhou, Jiulin Bai, Haichao Yu
Summary: In this study, two innovative sliding gusset connections are proposed to mitigate the negative frame-to-gusset interaction in buckling-restrained brace (BRB) reinforced concrete frames (RCFs). A damage-control design procedure is presented to prevent undesirable failure of the BRB-RCF joint. Cyclic tests of five BRB-RCF subassemblages were conducted to evaluate the sliding mechanism and the effectiveness of the design procedure.
ENGINEERING STRUCTURES
(2023)
Article
Plant Sciences
Xiaolong Shi, Yufei Zhou, Xinhua Zhao, Pei Guo, Jingyao Ren, He Zhang, Qiqi Dong, Zheng Zhang, Haiqiu Yu, Shubo Wan
Summary: Soil metabolomics and metagenome sequencing were used to investigate the salt-stress response in peanuts intercropped with sorghum. The study found that carbohydrate metabolism was the most differentially expressed pathway, with certain metabolites more abundant in intercropped peanuts under salt stress. In addition, there was a higher abundance of specific microbial taxa in intercropped peanuts under salt stress. These findings suggest that intercropping can indirectly influence beneficial microbial communities and potentially enhance peanut's salt tolerance.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2023)
Article
Cell Biology
Shengjue Xiao, Xiaotong Wang, Gang Zhang, Mingyue Tong, Jian Chen, Yufei Zhou, Qian Ji, Naifeng Liu
Summary: This study aimed to investigate the correlation between the SII index and ePWV, AIP, TyG index, and CVD. Using NHANES data from 1999 to 2018, it was found that the SII index was significantly positively associated with ePWV and TyG index, and showed a U-shaped relationship with AIP. Furthermore, the SII index was negatively associated with TG and positively associated with FBG.
MEDIATORS OF INFLAMMATION
(2023)
Article
Oncology
Yunwen Xue, Minhua Gu, Cuilan Chen, Yujian Yao, Yuzhen Li, Guohu Weng, Yong Gu
Summary: The ApoE mimetic peptide COG1410 can alleviate blood-brain barrier (BBB) damage and neuroinflammation caused by cerebral ischemia-reperfusion injury.
MOLECULAR MEDICINE REPORTS
(2023)
Article
Optics
Yi-Chen Zhang, Li-Ming Zhao, Yun-Song Zhou
Summary: In this paper, the photonic spin Hall effect (PSHE) in the combined structure of periodic dielectric waveguides (PDWs) and photonic crystal waveguide (PCW) is discussed. The arbitrary manipulation of PSHE for the PDW guided mode in the structure is successfully achieved by controlling the polarization of the dipole source. The advantage of PDW is its ability to be designed to different shapes without geometric constraints, while maintaining a relatively high transmission rate. By further changing the structure, including the adjustment of the intersection angle between PDW and PCW, and the alteration of the straight PDW to the bending or bifurcated shapes, it is found that the output of highly unidirectional PSHE is mainly determined by the intersection angle between PDW and PCW and almost independent of the detailed shape of PDW.
Article
Plant Sciences
Chang Liu, Ziqing Yao, Bing Jiang, Wenbo Yu, Yu Wang, Wenhui Dong, Yutong Li, Xiaolong Shi, Chunjuan Liu, Yufei Zhou
Summary: This study aimed to investigate the physiological mechanism of exogenous auxin (IAA) promoting mesocotyl elongation in sorghum. The results showed that exogenous IAA significantly increased cell length and promoted mesocotyl elongation in the short mesocotyl inbred line MS24B, while the application of the IAA inhibitor NPA resulted in a significant decrease in mesocotyl length. In the long mesocotyl inbred line Z210, exogenous IAA had a slight effect on mesocotyl elongation, while NPA treatment considerably reduced mesocotyl length. Overall, exogenous IAA activated energy metabolism, leading to plasma membrane acidification and mesocotyl elongation.
Article
Plant Sciences
Yan Wang, Kaitai Liu, Yunyun Zhou, Yong Chen, Chenzhong Jin, Yihong Hu
Summary: This study investigated the relationship between phenolic acid biosynthesis and continuous cropping (CC) in Polygonatum odoratum roots through miRNA-seq and RNA-seq analysis. Several key DEGs and DEMs involved in phenolic acid synthesis were identified, providing a foundation for further understanding phenolic acid biosynthesis during CC of P. odoratum roots.
Article
Education & Educational Research
Leishan Shi, Shuzhen Chen, Yanfang Zhou
Summary: Based on social capital theory, this study investigates the relationship between social capital and teachers' Creative Teaching Behavior (CTB) in school organizations. The results show that social capital positively predicts primary school teachers' CTB. It is found that social capital influences CTB through the mediating effects of knowledge sharing and creative teaching self-efficacy. The findings have theoretical and empirical implications for teachers' CTB.
THINKING SKILLS AND CREATIVITY
(2023)
Review
Health Care Sciences & Services
Ping Zou, Amy Huang, Yan Luo, Natalie Tchakerian, Hui Zhang, Chunmei Zhang
Summary: The purpose of this systematic review is to summarize the potential effects of WeChat and WhatsApp mobile applications in cancer management. The review included 20 studies with a total of 3110 participants and found that using WeChat/WhatsApp had positive effects on pain management, medication adherence, self-efficacy, quality of life, and depression among oncological patients. The review also highlighted the need for future research in diverse populations and countries to understand the effects of WeChat/WhatsApp in different contexts.
HEALTH INFORMATICS JOURNAL
(2023)
Article
Area Studies
Yufei Zhou
Summary: This paper discusses the commodification of Tibetan Mastiffs and the care relationship between humans and dogs. Tibetan pastoralists and dogs have a reciprocal yet distanced care relationship, while breeders of Tibetan Mastiffs focus on their ferociousness, resulting in a more dedicated but unilateral and dangerous care approach. The unintended consequence of breeders' care is that they raise dogs that sometimes bite, due to the transformation of dogs' guarding abilities from ethical virtue to commercial value.
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.
