Enhancement of CPT-11 antitumor activity by adenovirus-mediated expression of β–glucuronidase in tumors

Phase I and biodistribution study of recombinant adenovirus vector-mediated herpes simplex virus thymidine kinase gene and ganciclovir administration in patients with head and neck cancer and other malignant tumors

(2009) F Xu et al.   CANCER GENE THERAPY

Bacterial Cytosine Deaminase Mutants Created by Molecular Engineering Show Improved 5-Fluorocytosine-Mediated Cell Killing In vitro and In vivo

(2009) M. Fuchita et al.   CANCER RESEARCH

The Topoisomerase I Poison CPT-11 Enhances the Effect of the Aurora B Kinase Inhibitor AZD1152 both In vitro and In vivo

(2009) J. S. Nair et al.   CLINICAL CANCER RESEARCH

Antiangiogenesis Targeting Tumor Microenvironment Synergizes Glucuronide Prodrug Antitumor Activity

(2009) T.-Y. Juan et al.   CLINICAL CANCER RESEARCH

Bevacizumab Alone and in Combination With Irinotecan in Recurrent Glioblastoma

(2009) Henry S. Friedman et al.   JOURNAL OF CLINICAL ONCOLOGY

Local enzymatic hydrolysis of an endogenously generated metabolite can enhance CPT-11 anticancer efficacy

(2009) Z. M. Prijovich et al.   MOLECULAR CANCER THERAPEUTICS

A Phase I/II Clinical Trial in Localized Prostate Cancer of an Adenovirus Expressing Nitroreductase with CB1984

(2009) Prashant Patel et al.   MOLECULAR THERAPY

Bystander or No Bystander for Gene Directed Enzyme Prodrug Therapy

(2009) Gabi Dachs et al.   MOLECULES

Micro-PET Imaging of β-Glucuronidase Activity by the Hydrophobic Conversion of a Glucuronide Probe

(2009) Shey-Cherng Tzou et al.   RADIOLOGY

Phase II study of sequentially administered low-dose mitomycin-C (MMC) and irinotecan (CPT-11) in women with metastatic breast cancer (MBC)

(2008) E. Mrozek et al.   ANNALS OF ONCOLOGY

Pharmacokinetic and pharmacogenetic determinants of the activity and toxicity of irinotecan in metastatic colorectal cancer patients

(2008) E Rouits et al.   BRITISH JOURNAL OF CANCER

Cisplatin plus weekly CPT-11/docetaxel in advanced esophagogastric cancer: a phase I study with pharmacogenetic assessment of XPD, XRCC3 and UGT1A1 polymorphisms

(2008) Albert Font et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

An improved human carboxylesterase for enzyme/prodrug therapy with CPT-11

(2008) M Wierdl et al.   CANCER GENE THERAPY

Tumor-targeting prodrug-activating bacteria for cancer therapy

(2008) C-M Cheng et al.   CANCER GENE THERAPY

Directed Evolution of a Lysosomal Enzyme with Enhanced Activity at Neutral pH by Mammalian Cell-Surface Display

(2008) Kai-Chuan Chen et al.   CHEMISTRY & BIOLOGY

Membrane-tethered proteins for basic research, imaging, and therapy

(2008) Tian-Lu Cheng et al.   MEDICINAL RESEARCH REVIEWS