Article
Chemistry, Medicinal
Yingge Wang, Moran Sun, Yuyang Wang, Jinling Qin, Yixin Zhang, Yingyue Pang, Yongfang Yao, Hua Yang, Yongtao Duan
Summary: A novel series of compounds designed as tubulin/HDAC dual-targeting inhibitors demonstrated potent anti-proliferative activities against human cancer cell lines, while also inhibiting tubulin polymerization and specific HDAC activity. These compounds were found to act through various cellular mechanisms to achieve anti-tumor and anti-angiogenic effects.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Oncology
Russell Moser, James Annis, Olga Nikolova, Cliff Whatcott, Kay Gurley, Eduardo Mendez, Kim Moran-Jones, Craig Dorrell, Rosalie C. Sears, Calvin Kuo, Haiyong Han, Andrew Biankin, Carla Grandori, Daniel D. Von Hoff, Christopher J. Kemp
Summary: This study explores functional genetics and pharmacological profiling of KRAS-mutant pancreatic adenocarcinoma, and finds that TFIIH inhibition synergizes with TRAIL to induce apoptosis.
Article
Engineering, Biomedical
Afeng Yang, Shupei Sheng, Yun Bai, Guozheng Xing, Xuya Yu, Dunwan Zhu, Lin Mei, Xia Dong, Feng Lv
Summary: Vascular abnormalities are a major obstacle to effective immunotherapy, and the combination of antiangiogenesis therapy and immunotherapy can enhance the effectiveness of immunotherapy. This study proposes a hydrogel/nanosystem-mediated antiangiogenesis combined immunotherapy strategy to regulate the tumor microenvironment and achieve synergistic effects in tumor treatment.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Multidisciplinary
Ana I. I. Matos, Carina Peres, Barbara Carreira, Liane I. F. Moura, Rita C. C. Acurcio, Theresa Vogel, Erik Wegener, Filipa Ribeiro, Marta B. B. Afonso, Fabio M. F. Santos, Agueda Martinez-Barriocanal, Diego Arango, Ana S. S. Viana, Pedro M. P. Gois, Liana C. C. Silva, Cecilia M. P. Rodrigues, Luis Graca, Rainer Jordan, Ronit Satchi-Fainaro, Helena F. F. Florindo
Summary: Activation of host immunity by using a POx-PLGA nanovaccine to modulate TAM function and block PD-1, combined with the delivery of peptide antigens, adjuvants, and regulators of TGF-β expression, provides an alternative approach for cancer immunotherapy.
Article
Chemistry, Multidisciplinary
Xiang Ling, Xiaomin Jiang, Youyou Li, Wenbo Han, Megan Rodriguez, Ziwan Xu, Wenbin Lin
Summary: The combination of antiangiogenesis and chemotherapy regimens with cancer immunotherapy using bioresponsive nanoparticles could inhibit angiogenesis, induce tumor cell apoptosis, and activate immune responses in tumor microenvironments, thus promoting antitumor immunity and inhibiting tumor growth.
Article
Oncology
Antoine Galmiche, Zuzana Saidak, Francois Ghiringhelli
Summary: In addition to various physical consequences, the coagulation cascade may play a specific role in regulating antitumor immunity. A recent study used systems biology and genomics to investigate how coagulation affects the tumor immune microenvironment.
Article
Chemistry, Multidisciplinary
Xiaomin Jiang, Morten Lee, Junjie Xia, Taokun Luo, Jianqiao Liu, Megan Rodriguez, Wenbin Lin
Summary: This study reports a two-stage release strategy to effectively deliver oxaliplatin and SN38 chemotherapy drugs to tumors using nanoparticles, reducing general toxicity. Compared to other chemotherapy drugs, this strategy can decrease the exposure of SN38 in the blood and increase exposure in tumors. The results show that these nanoparticles have a significant inhibitory effect on tumors in vivo without causing side effects. Furthermore, the study also found that the nanoparticles can enhance immunogenic cell death and promote tumor immune response. This research highlights the potential of combining prodrug design and nanomedicine formulation.
Review
Oncology
Yun Liu, Yang Li, Yuxi Wang, Congcong Lin, Dan Zhang, Juncheng Chen, Liang Ouyang, Fengbo Wu, Jifa Zhang, Lei Chen
Summary: This perspective provides an overview of the development of VEGFR dual-target inhibitors, including rational target combinations, drug discovery strategies, structure-activity relationships, and future directions.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Zeting Yuan, Guohua Fan, Honglei Wu, Chaolian Liu, Yueping Zhan, Yanyan Qiu, Chenting Shou, Feng Gao, Jun Zhang, Peihao Yin, Ke Xu
Summary: Recent studies show that photodynamic therapy (PDT) can enhance the therapeutic effects of PD-L1 blockade in colorectal cancer (CRC) by inducing tumor cell death, stimulating immune response, and preventing tumor recurrence through upregulation of PD-L1 expression via the hypoxia-inducible factor 1a (HIF-1a) signaling pathway. This combination therapy using multifunctional nanoparticles loaded with photosensitized mTHPC (mTHPC@VeC/T-RGD NPs) shows promise in improving the response rate of anti-PD-L1 checkpoint blockade immunotherapies in CRC.
Article
Multidisciplinary Sciences
Michael C. Brown, Mubeen M. Mosaheb, Malte Mohme, Zachary P. McKay, Eda K. Holl, Jonathan P. Kastan, Yuanfan Yang, Georgia M. Beasley, E. Shelley Hwang, David M. Ashley, Darell D. Bigner, Smita K. Nair, Matthias Gromeier
Summary: Recombinant poliovirus therapy primarily mediates antitumor immunotherapy via direct infection of non-malignant tumor microenvironment cells, independent of malignant cell lysis, by inducing selective innate inflammation and sustained type-I/III interferon release, leading to polyfunctional and Th1-differentiated antitumor T cell phenotypes.
NATURE COMMUNICATIONS
(2021)
Article
Food Science & Technology
Korattuvalappil S. Ravikumar, Haridas Ramya, Thekkuttuparambil A. Ajith, Manzoor A. Shah, Kainoor K. Janardhanan
Summary: The study evaluated the anticancer activity of Fomitopsis pinicola extract, showing significant cytotoxicity and antitumor effects, possibly attributed to the major chemical components identified.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Review
Oncology
Shanshan Chen, Anghui Peng, Muhe Chen, Meixiao Zhan
Summary: Immunotherapy has improved cancer treatments, but limited by immune microenvironment. Activation of STING pathway can impact tumor immunity and improve therapy. Nanomedicines have been developed for delivering STING agonists to tumor tissue, and prospects and challenges are discussed.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Qiushi Tang, Shuo Yang, Guangpeng He, Hongyu Zheng, Sheng Zhang, Jiaxing Liu, Shibo Wei, Qing Fan, Xueqiang Peng, Xinyu Li, Dewei Zhang, Liang Yang, Hangyu Li
Summary: Tumor-derived exosomes (TDEs) play a critical role in regulating the immune microenvironment of tumors and have the ability to suppress immune responses, thus impacting the effectiveness of cancer therapy. By delivering suppressive factors to immune cells, TDEs directly or indirectly influence immune cell function and antitumor activities. TDE-based therapy is emerging as a promising strategy for inhibiting tumor progression and enhancing antitumor immunity.
Article
Immunology
Yonglin Chen, Manxue Jia, Sharon Wang, Sherry Xu, Nanhai He
Summary: The TNFR2 blocking antibody AN3025 can enhance anti-tumor immune response, inhibit Tregs-mediated immunosuppression, and suppress tumor growth by targeting TNFR2 expression on Tregs in the tumor microenvironment. Its potent anti-tumor efficacy as a monotherapy or in combination with anti-PD-1 antibody supports further clinical development for various human tumors.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Physical
Wenting Song, Hanzhuang Liu, Sisi Wang, Xu Zhi, Zhen Shen
Summary: Recent advances in photodynamic therapy (PDT) have shown that selective sensitization is crucial for avoiding undesired side effects. A colorless/nonconjugated leuco-BODIPY pro-1 has been developed, which becomes activated after reaching the targeted tumor, effectively inhibiting tumor growth and reducing side effects in normal tissues.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Tien-Ching Chang, Bing-Mae Chen, Jer-Yuan Wu, Tian-Lu Cheng, Steve Roffler
Summary: Antibodies that bind polyethylene glycol (PEG) can accelerate the clearance of pegylated medicines, with higher affinity antibodies leading to greater clearance and reduced drug efficacy. The molar ratio of high affinity anti-PEG antibodies to PEG-EPO correlates with accelerated blood clearance in mice.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biotechnology & Applied Microbiology
Hongjie Wang, Chang Li, Adebimpe O. Obadan, Hannah Frizzell, Tien-Ying Hsiang, Sucheol Gil, Audrey Germond, Connie Fountain, Audrey Baldessari, Steve Roffler, Hans-Peter Kiem, Deborah H. Fuller, Andre Lieber
Summary: This study introduces a new approach for the prevention and treatment of SARS-CoV2 using gene therapy, and evaluates the safety of this method. The results show that this method can provide long-term protection against SARS-CoV2 infection, and has demonstrated promising results in mouse and rhesus macaque models. However, the antiviral efficacy of this approach needs to be improved.
HUMAN GENE THERAPY
(2022)
Article
Chemistry, Inorganic & Nuclear
Marija Mirkovic, Magdalena Radovic, Dalibor Stankovic, Sanja Vranjes-Duric, Drina Jankovic, Djordje Petrovic, Ljiljana E. Mihajlovic-Lalic, Zeljko Prijovic, Zorana Milanovic
Summary: This article reports the synthesis and characterization of two new Schiff base cobalt(III) and nickel(II) complexes, as well as their binding affinity towards DNA and HSA, and their anticancer activity against cancer cells.
JOURNAL OF COORDINATION CHEMISTRY
(2022)
Article
Oncology
Cheng-Shuo Huang, Chen-Hua Tsai, Cheng-Ping Yu, Ying-Si Wu, Ming-Fong Yee, Jar-Yi Ho, Dah-Shyong Yu
Summary: This study demonstrates that LINC02470 plays a crucial role in promoting TGF-beta-induced EMT through the miR-143-3p/SMAD3 axis, thus aggravating bladder cancer progression. The findings suggest that LINC02470 could be a potential prognostic marker for bladder cancer.
Article
Biology
Mohammad Ameen Al-Aghbar, Ashwin K. Jainarayanan, Michael L. Dustin, Steve R. Roffler
Summary: This study proposes a TCR Bending Mechanosignal (TBM) model which suggests that local mechanical membrane bending of T cells on the nanometer scale may influence T cell receptor binding events and thus T-cell activation. The model highlights how the bending of the T cell membrane can enhance signaling and facilitate better recognition of antigens.
COMMUNICATIONS BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Wei-Jie Cheng, Kuo-Hsiang Chuang, Yu-Ju Lo, Michael Chen, Yi-Jou Chen, Steve R. Roffler, Hsiu-O Ho, Shyr-Yi Lin, Ming-Thau Sheu
Summary: In this study, a biocompatible nanocarrier system loaded with ganetespib was developed to enhance the efficacy of immunotherapies. The system, decorated with bispecific T-cell engagers, showed increased cellular uptake and synergistic effects in T cell-mediated cytotoxicity. In vivo studies also demonstrated tumor growth inhibition and increased T-cell infiltration. This study provides a promising drug delivery strategy for cancer immunochemotherapy.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Pharmacology & Pharmacy
Kai-Wen Cheng, Chih-Hua Tseng, I. -Ju Chen, Bo-Cheng Huang, Hui-Ju Liu, Kai-Wen Ho, Wen-Wei Lin, Chih-Hung Chuang, Ming-Yii Huang, Yu-Lin Leu, Steve R. Roffler, Jaw-Yuan Wang, Yeh-Long Chen, Tian-Lu Cheng
Summary: The bidirectional interaction between gut microbiota and carcinogens in colorectal cancer is complex. Inhibition of microbial beta-glucuronidase (beta G) by TCH-3511 decreases AOM-induced gut microbial dysbiosis and intestinal tumorigenesis, suggesting the chemoprotective benefit of beta G inhibition in maintaining gut microbiota balance and preventing cancer-associated gut microbial dysbiosis.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Jiho Kim, Chang Li, Hongjie Wang, Swarnendu Kaviraj, Sanjay Singh, Laxman Savergave, Arjun Raghuwanshi, Sucheol Gil, Audrey Germond, Audrey Baldessari, Bingmae Chen, Steve Roffler, Pascal Fender, Charles Drescher, Darrick Carter, Andre Lieber
Summary: The study aims to overcome treatment resistance in ovarian cancer patients by developing a recombinant protein that can temporarily open the junctions between malignant cells. The protein, c-JO4, when used in combination with a chemotherapy drug, has shown promising results in pre-clinical studies.
SCIENTIFIC REPORTS
(2022)
Article
Nanoscience & Nanotechnology
Aleksandar Vukadinovic, Zorana Milanovic, Milos Ognjanovic, Drina Jankovic, Magdalena Radovic, Marija Mirkovic, Maria-Argyro Karageorgou, Penelope Bouziotis, Slavica Eric, Sanja Vranjes-Duric, Bratislav Antic, Zeljko Prijovic
Summary: Radiolabelled superparamagnetic iron oxide nanoparticles (SPIONs) coated with citrate (CA/SPIONs) exhibit the highest heating rate and strongest hyperthermia effects against cancer cells. Intratumoural injection of Y-90-CA/SPIONs, with or without magnetic hyperthermia, shows significant antitumour effects without systemic toxicity, making it suitable for monotherapy or dual magnetic hyperthermia-radionuclide nanobrachytherapy (NBT) of solid tumours.
Article
Pharmacology & Pharmacy
Hung-Jun Lin, Tien-Li Liang, Yao-Yuan Chang, Der-Zen Liu, Jia-Yu Fan, Steve R. Roffler, Shyr-Yi Lin
Summary: In this study, an anti-EGFR and anti-fibroblast activation protein bispecific antibody-targeted liposomal irinotecan (BS-LipoIRI) was fabricated to target pancreatic cancer cells and tumor-associated fibroblasts. The drug showed better efficacy in cellular uptake compared to LipoIRI and was able to inhibit pancreatic cancer growth in vivo.
Article
Chemistry, Multidisciplinary
Minh-Tram T. Nguyen, Yu-Chien Shih, Meng-Hsuan Lin, Steve R. Roffler, Chiao-Yu Hsiao, Tian-Lu Cheng, Wen-Wei Lin, En-Chi Lin, Yuh-Jyh Jong, Chin-Yuan Chang, Yu-Cheng Su
Summary: Covalent attachment of methoxy poly(ethylene) glycol (mPEG) to therapeutic molecules is commonly used to enhance their systemic circulation time and efficacy, but it can also induce anti-PEG antibodies that negatively affect drug therapeutic effects. In this study, the researchers determined the co-crystal structure of the humanized 15-2b anti-mPEG antibody with mPEG, providing insights into understanding the binding specificity and antigenicity of anti-mPEG antibodies.
COMMUNICATIONS CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Pierre-Alain Burnouf, Steve R. Roffler, Chia-Ching Wu, Yu-Cheng Su
Summary: Glucuronides have played a significant role in the biomedical field, especially in cancer therapy. Utilizing the unique properties of glucuronides, it is possible to improve drug treatment outcomes and reduce systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Pharmacology & Pharmacy
Dragana Stankovic, Magdalena Radovic, Aljosa Stankovic, Marija Mirkovic, Aleksandar Vukadinovic, Milica Mijovic, Zorana Milanovic, Milos Ognjanovic, Drina Jankovic, Bratislav Antic, Sanja Vranjes-Duric, Miroslav Savic, Zeljko Prijovic
Summary: As an alternative to conventional brachytherapy, intratumoral injection of radionuclide-labeled nanoparticles (nanobrachytherapy, NBT) is being explored as a superior delivery method for radionuclide therapy of solid tumors. In this study, Lu-177-DMSA@SPIONs were developed as a potential antitumor agent for nanobrachytherapy. The nanoparticles exhibited stable bonding with minimal leakage and remained localized at the injection site for weeks after intratumoral injection. The therapeutic efficacy was achieved with a relatively low dose without general toxicity.
Article
Medicine, General & Internal
Chien-Peng Huang, Ming-Shen Dai, Chien-Chang Kao, Wen-Chiuan Tsai, Cheng-Ping Yu
Summary: Oncocytic adrenal cortical neoplasms, including oncocytoma, oncocytic neoplasms of uncertain malignant potential, and oncocytic adrenal cortical carcinomas, are rare cases. We present a case of oncocytic adrenal cortical carcinoma with scalp metastasis, which is the first reported case of its kind. Our case highlights the limitations of the current diagnostic algorithm and emphasizes the importance of two parameters (PHH3 and Ki-67) in determining the malignant potential of oncocytic adrenal cortical neoplasms.
MEDICINA-LITHUANIA
(2022)
Meeting Abstract
Biotechnology & Applied Microbiology
Hongjie Wang, Sucheol Gil, Chang Li, Christopher Doering, Philip Ng, Steve Roffler, Hans-Peter Kiem, Andre L. Lieber