4.5 Article

Concentrations of IGF-I and IGFBP-3 and Brain Tumor Risk in the European Prospective Investigation into Cancer and Nutrition

Journal

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
Volume 20, Issue 10, Pages 2174-2182

Publisher

AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1055-9965.EPI-11-0179

Keywords

-

Funding

  1. European Commission (SANCO)
  2. Deutsche Krebshilfe
  3. Deutsches Krebsforschungszentrum
  4. German Federal Ministry of Education and Research
  5. Danish Cancer Society
  6. Spanish Ministry of Health
  7. Spanish Regional Governments of Andalucia
  8. Asturias
  9. Basque Country
  10. Murcia
  11. Navarra
  12. ISCIII RCESP, Spain [C03/09]
  13. Cancer Research UK
  14. Medical Research Council, United Kingdom
  15. Stroke Association, United Kingdom
  16. British Heart Foundation
  17. Department of Health, United Kingdom
  18. Food Standards Agency, United Kingdom
  19. Wellcome Trust, United Kingdom
  20. Hellenic Ministry of Health
  21. Stavros Niarchos Foundation
  22. Hellenic Health Foundation
  23. Italian Association for Research on Cancer (AIRC)
  24. Italian National Research Council
  25. Fondazione-Istituto Banco Napoli, Italy
  26. Dutch Ministry of Public Health, Welfare and Sports
  27. Netherlands Cancer Registry
  28. LK Research Funds
  29. Dutch Prevention Funds
  30. Dutch ZON (Zorg Onderzoek Nederland)
  31. World Cancer Research Fund (WCRF)
  32. Statistics Netherlands (the Netherlands)
  33. Swedish Cancer Society
  34. Swedish Scientific Council
  35. Regional Government of Skane, Sweden
  36. Medical Research Council [G0801056B, G1000143, G0401527] Funding Source: researchfish

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Background: Insulin-like growth factor-1 (IGF-I) is important in normal brain development but in the adult brain, IGF-I overexpression may be a risk factor for tumor development. Methods: We examined the association between circulating concentrations of IGF-I and IGFBP-3 in relation to risk of gliomas (74 low-grade, 206 high-grade gliomas), meningiomas (n = 174) and acoustic neuromas (n = 49) by using a case-control design nested in the European Prospective Investigation into Cancer and Nutrition. IGF-I and IGFBP-3 were measured by ELISAs. Conditional logistic regression was used to compute ORs and corresponding 95% CIs. Results: The risk of low-grade gliomas was elevated with increased IGF-I (OR = 3.60, 95% CI: 1.11-11.7; top vs. bottom quartile) and decreased with elevated IGFBP-3 concentrations (OR = 0.28, 95% CI: 0.09-0.84) after mutual adjustment of these two factors; these results became nonsignificant after exclusion of the first year of follow-up. No association was observed for high-grade gliomas or meningiomas. Both high IGF-I and IGFBP-3 concentrations were associated with risk of acoustic neuromas (IGF-I: OR = 6.63, 95% CI: 2.27-19.4, top vs. bottom tertile; IGFBP-3: OR = 7.07, 95% CI: 2.32-21.6), even after excluding the first year of follow-up. Conclusion: High concentrations of IGF-I might be positively associated with risk of low-grade gliomas and acoustic neuromas, although we cannot exclude reverse causation, in particular for low-grade gliomas. Impact: Factors of the IGF axis might be involved in the etiology of some types of brain tumors. Cancer Epidemiol Biomarkers Prev; 20(10); 2174-82. (C) 2011 AACR.

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