First-in-human, phase I dose-escalation study of single and multiple doses of a first-in-class enhancer of fluoropyrimidines, a dUTPase inhibitor (TAS-114) in healthy male volunteers

Title
First-in-human, phase I dose-escalation study of single and multiple doses of a first-in-class enhancer of fluoropyrimidines, a dUTPase inhibitor (TAS-114) in healthy male volunteers
Authors
Keywords
First-in-human study, dUTPase, 5-Fluorouracil, PK, Safety, DPD, CYP3A4
Journal
CANCER CHEMOTHERAPY AND PHARMACOLOGY
Volume 73, Issue 3, Pages 577-583
Publisher
Springer Nature
Online
2014-01-22
DOI
10.1007/s00280-014-2383-2

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