Metronomic chemotherapy for cancer treatment: a decade of clinical studies
Published 2013 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Metronomic chemotherapy for cancer treatment: a decade of clinical studies
Authors
Keywords
Metronomic chemotherapy, Cancer therapy, “Continuous low dose” chemotherapy, Solid tumours
Journal
CANCER CHEMOTHERAPY AND PHARMACOLOGY
Volume 72, Issue 1, Pages 13-33
Publisher
Springer Nature
Online
2013-03-08
DOI
10.1007/s00280-013-2125-x
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Bevacizumab in Combination with Metronomic Chemotherapy in Patients with Anthracycline- and Taxane-Refractory Breast Cancer
- (2014) J.A. García-Sáenz et al. JOURNAL OF CHEMOTHERAPY
- Oral Metronomic Chemo-Hormonal-Therapy of Metastatic Breast Cancer with Cyclophosphamide and Megestrol Acetate
- (2014) A. Licchetta et al. JOURNAL OF CHEMOTHERAPY
- Tumor Endothelial Cells Acquire Drug Resistance by MDR1 Up-Regulation via VEGF Signaling in Tumor Microenvironment
- (2012) Kosuke Akiyama et al. AMERICAN JOURNAL OF PATHOLOGY
- Clinical, pharmacokinetic and pharmacodynamic evaluations of metronomic UFT and cyclophosphamide plus celecoxib in patients with advanced refractory gastrointestinal cancers
- (2012) Giacomo Allegrini et al. ANGIOGENESIS
- Metronomic oral combination chemotherapy with capecitabine and cyclophosphamide: a phase II study in patients with HER2-negative metastatic breast cancer
- (2012) Masataka Yoshimoto et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Metronomic Chemotherapy Combined With Bevacizumab and Erlotinib in Patients With Metastatic HER2-Negative Breast Cancer: Clinical and Biological Activity
- (2012) Emilia Montagna et al. Clinical Breast Cancer
- Phase ii trial of a metronomic schedule of docetaxel and capecitabine with concurrent celecoxib in patients with prior anthracycline exposure for metastatic breast cancer
- (2012) S.D. Young et al. Current Oncology
- Phase II study of vinorelbine and continuous low doses cyclophosphamide in children and young adults with a relapsed or refractory malignant solid tumour: Good tolerance profile and efficacy in rhabdomyosarcoma – A report from the Société Française des Cancers et leucémies de l’Enfant et de l’adolescent (SFCE)
- (2012) Véronique Minard-Colin et al. EUROPEAN JOURNAL OF CANCER
- Overcoming evasive resistance from vascular endothelial growth factor a inhibition in sarcomas by genetic or pharmacologic targeting of hypoxia-inducible factor 1α
- (2012) Yeo-Jung Kim et al. INTERNATIONAL JOURNAL OF CANCER
- Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial
- (2012) Winette TA van der Graaf et al. LANCET
- Efficacy, Safety, and Potential Biomarkers of Thalidomide plus Metronomic Chemotherapy for Advanced Hepatocellular Carcinoma
- (2012) Yu-Yun Shao et al. ONCOLOGY
- Metronomic Chemotherapy with the COMBAT Regimen in Advanced Pediatric Malignancies: A Multicenter Experience
- (2012) D. Zapletalova et al. ONCOLOGY
- Exploratory predictive and prognostic factors in advanced breast cancer treated with metronomic chemotherapy
- (2011) Manuela Miscoria et al. ANTI-CANCER DRUGS
- Pegylated liposomal doxorubicin in combination with low-dose metronomic cyclophosphamide as preoperative treatment for patients with locally advanced breast cancer
- (2011) Silvia Dellapasqua et al. BREAST
- Continuous low-dose cyclophosphamide and methotrexate combined with celecoxib for patients with advanced cancer
- (2011) O A Khan et al. BRITISH JOURNAL OF CANCER
- Bevacizumab and daily temozolomide for recurrent glioblastoma
- (2011) Annick Desjardins et al. CANCER
- Phase II trial of bevacizumab and dose/dense chemotherapy with cisplatin and metronomic daily oral etoposide in advanced non-small-cell-lung cancer patients
- (2011) Pierpaolo Correale et al. CANCER BIOLOGY & THERAPY
- An all-oral combination of metronomic cyclophosphamide plus capecitabine in patients with anthracycline- and taxane-pretreated metastatic breast cancer: a phase II study
- (2011) Zhonghua Wang et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Metronomic docetaxel chemotherapy inhibits angiogenesis and tumor growth in a gastric cancer model
- (2011) Hongju Wu et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Metronomic cyclophosphamide treatment in metastasized breast cancer patients: immunological effects and clinical outcome
- (2011) Yingzi Ge et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Oral/metronomic cyclophosphamide-based chemotherapy as option for patients with castration-refractory prostate cancer – Review of the literature
- (2011) T. Nelius et al. CANCER TREATMENT REVIEWS
- Management Strategies for Recurrent Platinum-Resistant Ovarian Cancer
- (2011) R. Wendel Naumann et al. DRUGS
- Feasibility of metronomic oral cyclophosphamide plus prednisolone in elderly patients with inoperable or metastatic soft tissue sarcoma
- (2011) Olivier Mir et al. EUROPEAN JOURNAL OF CANCER
- Efficacy and safety of low-dose metronomic chemotherapy with capecitabine in heavily pretreated patients with metastatic breast cancer
- (2011) P. Fedele et al. EUROPEAN JOURNAL OF CANCER
- Metronomic scheduling of anticancer treatment: the next generation of multitarget therapy?
- (2011) Nicolas André et al. Future Oncology
- Cetuximab Plus Irinotecan, Fluorouracil, and Leucovorin As First-Line Treatment for Metastatic Colorectal Cancer: Updated Analysis of Overall Survival According to Tumor KRAS and BRAF Mutation Status
- (2011) Eric Van Cutsem et al. JOURNAL OF CLINICAL ONCOLOGY
- A Phase II Randomized Trial of Gefitinib Alone or with Tegafur/Uracil Treatment in Patients with Pulmonary Adenocarcinoma Who had Failed Previous Chemotherapy
- (2011) Yuh-Min Chen et al. Journal of Thoracic Oncology
- Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial
- (2011) Brian I Rini et al. LANCET
- Pioglitazone, etoricoxib, interferon-α, and metronomic capecitabine for metastatic renal cell carcinoma: final results of a prospective phase II trial
- (2011) B. Walter et al. MEDICAL ONCOLOGY
- Low-Dose Metronomic Oral Dosing of a Prodrug of Gemcitabine (LY2334737) Causes Antitumor Effects in the Absence of Inhibition of Systemic Vasculogenesis
- (2011) G. Francia et al. MOLECULAR CANCER THERAPEUTICS
- Phase II trial of low-dose continuous (metronomic) treatment of temozolomide for recurrent glioblastoma
- (2011) D.-S. Kong et al. NEURO-ONCOLOGY
- Abiraterone and Increased Survival in Metastatic Prostate Cancer
- (2011) Johann S. de Bono et al. NEW ENGLAND JOURNAL OF MEDICINE
- Incorporation of Bevacizumab in the Primary Treatment of Ovarian Cancer
- (2011) Robert A. Burger et al. NEW ENGLAND JOURNAL OF MEDICINE
- Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation
- (2011) Paul B. Chapman et al. NEW ENGLAND JOURNAL OF MEDICINE
- Ipilimumab plus Dacarbazine for Previously Untreated Metastatic Melanoma
- (2011) Caroline Robert et al. NEW ENGLAND JOURNAL OF MEDICINE
- High Circulating Endothelial Progenitor Levels Associated with Poor Survival of Advanced Hepatocellular Carcinoma Patients Receiving Sorafenib Combined with Metronomic Chemotherapy
- (2011) Yu-Yun Shao et al. ONCOLOGY
- Antiangiogenic metronomic therapy for children with recurrent embryonal brain tumors
- (2011) Andreas Peyrl et al. PEDIATRIC BLOOD & CANCER
- Salvage Therapy With Oral Metronomic Cyclophosphamide and Methotrexate for Castration-refractory Metastatic Adenocarcinoma of the Prostate Resistant to Docetaxel
- (2011) Vittorio Gebbia et al. UROLOGY
- Megestrol acetate versus metronomic cyclophosphamide in patients having exhausted all effective therapies under standard care
- (2010) N Penel et al. BRITISH JOURNAL OF CANCER
- A phase 2 pilot trial of low-dose, continuous infusion, or “metronomic” paclitaxel and oral celecoxib in patients with metastatic melanoma
- (2010) Rupal S. Bhatt et al. CANCER
- Everolimus (RAD001) and anti-angiogenic cyclophosphamide show long-term control of gastric cancer growth in vivo
- (2010) Daniel Cejka et al. CANCER BIOLOGY & THERAPY
- Dose/dense metronomic chemotherapy with fractioned cisplatin and oral daily etoposide enhances the anti-angiogenic effects of bevacizumab in advanced non-small-cell-lung cancer patients
- (2010) Pierpaolo Correale et al. CANCER BIOLOGY & THERAPY
- “Metronomic” chemotherapy in advanced soft tissue sarcomas
- (2010) Antoine Italiano et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- A multicenter phase I trial of metronomic oral vinorelbine plus cisplatin in patients with NSCLC
- (2010) Athanasios G. Pallis et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Low-Dose Metronomic Oral Administration of Vinorelbine in the First-line Treatment of Elderly Patients With Metastatic Breast Cancer
- (2010) Raffaele Addeo et al. Clinical Breast Cancer
- Circulating thrombospondin 1 level as a surrogate marker in patients receiving cyclophosphamide-based metronomic chemotherapy
- (2010) Amélie Lansiaux et al. INVESTIGATIONAL NEW DRUGS
- Retrospective Analysis of an Oral Combination of Dexamethasone, Uracil plus Tegafur and Cyclophosphamide for Hormone-refractory Prostate Cancer
- (2010) K. Hatano et al. JAPANESE JOURNAL OF CLINICAL ONCOLOGY
- Phase III Study of Bevacizumab Plus Docetaxel Compared With Placebo Plus Docetaxel for the First-Line Treatment of Human Epidermal Growth Factor Receptor 2–Negative Metastatic Breast Cancer
- (2010) David W. Miles et al. JOURNAL OF CLINICAL ONCOLOGY
- Phase II Trial of Continuous Dose-Intense Temozolomide in Recurrent Malignant Glioma: RESCUE Study
- (2010) James R. Perry et al. JOURNAL OF CLINICAL ONCOLOGY
- Pazopanib in Locally Advanced or Metastatic Renal Cell Carcinoma: Results of a Randomized Phase III Trial
- (2010) Cora N. Sternberg et al. JOURNAL OF CLINICAL ONCOLOGY
- Phase II study of combining sorafenib with metronomic tegafur/uracil for advanced hepatocellular carcinoma
- (2010) Chih-Hung Hsu et al. JOURNAL OF HEPATOLOGY
- Continuous low-dose temozolomide and celecoxib in recurrent glioblastoma
- (2010) Florian Stockhammer et al. JOURNAL OF NEURO-ONCOLOGY
- Phase II study of metronomic chemotherapy with bevacizumab for recurrent glioblastoma after progression on bevacizumab therapy
- (2010) David A. Reardon et al. JOURNAL OF NEURO-ONCOLOGY
- Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial
- (2010) Johann Sebastian de Bono et al. LANCET
- Activity of a multitargeted chemo-switch regimen (sorafenib, gemcitabine, and metronomic capecitabine) in metastatic renal-cell carcinoma: a phase 2 study (SOGUG-02-06)
- (2010) Joaquim Bellmunt et al. LANCET ONCOLOGY
- Metronomic chemotherapy: new rationale for new directions
- (2010) Eddy Pasquier et al. Nature Reviews Clinical Oncology
- Improved Survival with Ipilimumab in Patients with Metastatic Melanoma
- (2010) F. Stephen Hodi et al. NEW ENGLAND JOURNAL OF MEDICINE
- Safety, Tolerability and Biological Effects of Long-Term Metronomic Administration of Non-Cytotoxic Anti-Angiogenic Agents
- (2010) Cristina Noberasco et al. ONCOLOGY
- Bevacizumab plus Low-Dose Metronomic Oral Cyclophosphamide in Heavily Pretreated Patients with Recurrent Ovarian Cancer
- (2010) Alfonso Sánchez-Muñoz et al. ONCOLOGY
- A phase II study of metronomic oral topotecan for recurrent childhood brain tumors
- (2010) Jane E. Minturn et al. PEDIATRIC BLOOD & CANCER
- Continuous 5-fluorouracil infusion plus long acting octreotide in advanced well-differentiated neuroendocrine carcinomas. A phase II trial of the Piemonte Oncology Network
- (2009) Maria P Brizzi et al. BMC CANCER
- Efficacy of oral tegafur-uracil (UFT) as adjuvant therapy as compared with classical cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) in early breast cancer: a pooled analysis of two randomized controlled trials (N·SAS-BC 01 trial and CUBC trial)
- (2009) Yasuo Ohashi et al. BREAST CANCER RESEARCH AND TREATMENT
- Long-Term Follow-Up of an Anthracycline-Containing Metronomic Chemotherapy Schedule in Advanced Breast Cancer
- (2009) Enrique González-Billalabeitia et al. Breast Journal
- Metronomic chemotherapy with daily, oral etoposide plus bevacizumab for recurrent malignant glioma: a phase II study
- (2009) D A Reardon et al. BRITISH JOURNAL OF CANCER
- Phase 2 trial of combination thalidomide plus temozolomide in patients with metastatic malignant melanoma: Southwest Oncology Group S0508
- (2009) Joseph I. Clark et al. CANCER
- Treg depletion with a low-dose metronomic temozolomide regimen in a rat glioma model
- (2009) Claire Banissi et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Immunomodulation of FOXP3+ Regulatory T Cells by the Aromatase Inhibitor Letrozole in Breast Cancer Patients
- (2009) D. Generali et al. CLINICAL CANCER RESEARCH
- Clinical and Pharmacodynamic Evaluation of Metronomic Cyclophosphamide, Celecoxib, and Dexamethasone in Advanced Hormone-refractory Prostate Cancer
- (2009) A. Fontana et al. CLINICAL CANCER RESEARCH
- Impact of Epidermal Growth Factor Receptor and KRAS Mutations on Clinical Outcomes in Previously Untreated Non-Small Cell Lung Cancer Patients: Results of an Online Tumor Registry of Clinical Trials
- (2009) D. M. Jackman et al. CLINICAL CANCER RESEARCH
- Dose-Ranging Study of Metronomic Oral Vinorelbine in Patients with Advanced Refractory Cancer
- (2009) E. Briasoulis et al. CLINICAL CANCER RESEARCH
- Predictive Potential of Angiogenic Growth Factors and Circulating Endothelial Cells in Breast Cancer Patients Receiving Metronomic Chemotherapy Plus Bevacizumab
- (2009) A. Calleri et al. CLINICAL CANCER RESEARCH
- Oral metronomic cyclophosphamide in elderly with metastatic melanoma
- (2009) Estelle Borne et al. INVESTIGATIONAL NEW DRUGS
- Randomized Phase II Trial of Chemoradiotherapy Followed by Either Dose-Dense or Metronomic Temozolomide for Newly Diagnosed Glioblastoma
- (2009) Jennifer L. Clarke et al. JOURNAL OF CLINICAL ONCOLOGY
- Oral Uracil and Tegafur Compared With Classic Cyclophosphamide, Methotrexate, Fluorouracil As Postoperative Chemotherapy in Patients With Node-Negative, High-Risk Breast Cancer: National Surgical Adjuvant Study for Breast Cancer 01 Trial
- (2009) Toru Watanabe et al. JOURNAL OF CLINICAL ONCOLOGY
- Bevacizumab Alone and in Combination With Irinotecan in Recurrent Glioblastoma
- (2009) Henry S. Friedman et al. JOURNAL OF CLINICAL ONCOLOGY
- Phase I/II Trial of Metronomic Chemotherapy With Daily Dalteparin and Cyclophosphamide, Twice-Weekly Methotrexate, and Daily Prednisone As Therapy for Metastatic Breast Cancer Using Vascular Endothelial Growth Factor and Soluble Vascular Endothelial Growth Factor Receptor Levels As Markers of Response
- (2009) Nan Soon Wong et al. JOURNAL OF CLINICAL ONCOLOGY
- Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): an open-label randomised phase III trial
- (2009) Robert Pirker et al. LANCET
- Clinical outcome of patients with docetaxel-resistant hormone-refractory prostate cancer treated with second-line cyclophosphamide-based metronomic chemotherapy
- (2009) Thomas Nelius et al. MEDICAL ONCOLOGY
- Continuous Administration of Daily Low-Dose Temozolomide in Pretreated Patients with Advanced Non-Small Cell Lung Cancer: A Phase II Study
- (2009) Charalambos Kouroussis et al. ONCOLOGY
- Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells
- (2009) K. Lee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A pharmacokinetic and pharmacodynamic study on metronomic irinotecan in metastatic colorectal cancer patients
- (2008) G Allegrini et al. BRITISH JOURNAL OF CANCER
- Biologic Markers of Angiogenesis: Circulating Endothelial Cells in Patients with Advanced Malignancies Treated on Phase I Protocol with Metronomic Chemotherapy and Celecoxib
- (2008) Przemyslaw W. Twardowski et al. CANCER INVESTIGATION
- Impact of different anticancer regimens on biomarkers of angiogenesis in patients with advanced hepatocellular cancer
- (2008) G. Treiber et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Docetaxel Plus Prednisone or Mitoxantrone Plus Prednisone for Advanced Prostate Cancer: Updated Survival in the TAX 327 Study
- (2008) Dominik R. Berthold et al. JOURNAL OF CLINICAL ONCOLOGY
- Metronomic Cyclophosphamide and Capecitabine Combined With Bevacizumab in Advanced Breast Cancer
- (2008) Silvia Dellapasqua et al. JOURNAL OF CLINICAL ONCOLOGY
- Phase III Study Comparing Cisplatin Plus Gemcitabine With Cisplatin Plus Pemetrexed in Chemotherapy-Naive Patients With Advanced-Stage Non–Small-Cell Lung Cancer
- (2008) Giorgio Vittorio Scagliotti et al. JOURNAL OF CLINICAL ONCOLOGY
- Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial
- (2008) Robert J Motzer et al. LANCET
- Weekly Paclitaxel in the Adjuvant Treatment of Breast Cancer
- (2008) Joseph A. Sparano et al. NEW ENGLAND JOURNAL OF MEDICINE
- Sorafenib in Advanced Hepatocellular Carcinoma
- (2008) Josep M. Llovet et al. NEW ENGLAND JOURNAL OF MEDICINE
- A Pilot Study of Docetaxel and Trofosfamide as Second-Line ‘Metronomic’ Chemotherapy in the Treatment of Metastatic Non-Small Cell Lung Cancer (NSCLC)
- (2008) Michael Görn et al. ONKOLOGIE
- Phase II Clinical Trial of Bevacizumab and Low-Dose Metronomic Oral Cyclophosphamide in Recurrent Ovarian Cancer: A Trial of the California, Chicago, and Princess Margaret Hospital Phase II Consortia
- (2007) Agustin A. Garcia et al. JOURNAL OF CLINICAL ONCOLOGY
- Feasibility of metronomic maintenance chemotherapy following high-dose chemotherapy for malignant central nervous system tumors
- (2007) L. Mi Rim Choi et al. PEDIATRIC BLOOD & CANCER
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started