Article
Biochemistry & Molecular Biology
Maria Ovejero-Sanchez, Gloria Asensio-Juarez, Myriam Gonzalez, Pilar Puebla, Miguel Vicente-Manzanares, Rafael Pelaez, Rogelio Gonzalez-Sarmiento, Ana Belen Herrero
Summary: This study synthesized and characterized a new microtubule-destabilizing agent, PILA9, which showed strong cytotoxicity against OC cells. Additionally, the combination of microtubule-destabilizing agents with Panobinostat synergistically enhanced cytotoxicity, potentially through inducing alpha-tubulin acetylation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Lu Chen, Wujiang Gao, Chunli Sha, Meiling Yang, Li Lin, Taoqiong Li, Hong Wei, Qi Chen, Jie Xing, Mengxue Zhang, Shijie Zhao, Wenlin Xu, Yuefeng Li, Xiaolan Zhu
Summary: The E3 ligase SIAH1 is decreased in epithelial ovarian cancer (EOC) and negatively correlated with RPS3 levels. Overexpression of SIAH1 can suppress tumor cell growth, invasion, and cisplatin resistance by promoting RPS3 degradation and subsequent NF-kappa B inactivation.
Article
Biology
Peng Zhang, Lijuan Zhang, Xukai Jiang, Xiao-tong Diao, Shuang Li, Dan-dan Li, Zheng Zhang, Junqiang Fang, Ya-jie Tang, Da-lei Wu, Changsheng Wu, Yue-zhong Li
Summary: Zhang et al. identify three hot regions of macrolide glycosyltransferase BsGT-1 that influence the specificity of epothilone B and sugar donor. Further study showed that mutations in these regions could expand donor preference and produce novel epothilone oligosaccharides. This research lays a foundation for rational engineering of other glycosyltransferases to synthesize valuable small molecules.
COMMUNICATIONS BIOLOGY
(2022)
Article
Cell Biology
Fuli Li, Tinglei Huang, Yao Tang, Qingli Li, Jianzheng Wang, Xiaojiao Cheng, Wenhui Zhang, Baiwen Zhang, Cong Zhou, Shuiping Tu
Summary: UTD1, a novel microtubule stabilizing agent, has shown significant anti-tumor activity in colorectal cancer by inhibiting cell proliferation, inducing cell cycle arrest in G2/M phase, and triggering apoptosis. Additionally, UTD1 exhibits a stronger apoptosis-inducing effect in ABCB1 high-expression cells.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Dana M. Roque, Eric R. Siegel, Natalia Buza, Stefania Bellone, Dan-Arin Silasi, Gloria S. Huang, Vaagn Andikyan, Mitchell Clark, Masoud Azodi, Peter E. Schwartz, Gautam G. Rao, Jocelyn C. Reader, Pei Hui, Joan R. Tymon-Rosario, Justin Harold, Dennis Mauricio, Burak Zeybek, Gulden Menderes, Gary Altwerger, Elena Ratner, Alessandro D. Santin
Summary: This multi-center study evaluated the activity and safety of ixabepilone plus bevacizumab compared to ixabepilone alone in platinum-resistant/refractory ovarian cancer. The results showed that the combination of ixabepilone and bevacizumab had a higher overall response rate and longer progression-free survival, with good tolerability. Prior receipt of bevacizumab should not limit the use of ixabepilone plus bevacizumab in treatment.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Kaoru Yamawaki, Yutaro Mori, Hiroaki Sakai, Yusuke Kanda, Daisuke Shiokawa, Haruka Ueda, Tatsuya Ishiguro, Kosuke Yoshihara, Kazunori Nagasaka, Takashi Onda, Tomoyasu Kato, Tadashi Kondo, Takayuki Enomoto, Koji Okamoto
Summary: By analyzing patient-derived ovarian cancer spheroids, it was found that cisplatin resistance is correlated with elevated levels of G6PD and active glutathione. Additionally, the combination of a G6PD inhibitor with cisplatin in vitro effectively inhibited spheroid proliferation.
Article
Oncology
Jia Wang, Haonan Li, Liang Wang, Jing Zhang, Man Li, Liang Qiao, Jun Zhang, Likun Liu, Cuili Zhang, Jingchun Gao, Weiling Li
Summary: Ovarian cancer is the most common and aggressive tumor of the female reproductive system, with a lack of early detection methods contributing to its poor prognosis. Transcriptomic analysis identified 24 tumor suppressor genes associated with poor prognosis in ovarian cancer, with BTG2 showing potential as a therapeutic candidate. BTG2 was found to suppress ovarian cancer cell proliferation and migration, making it a potential biomarker for this type of cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Anuradha Kumari, Omprakash Shriwas, Shailendra Sisodiya, Manas K. Santra, Sankar K. Guchhait, Rupesh Dash, Dulal Panda
Summary: The study demonstrates that microtubule-targeting agents inhibit the signaling of beta-catenin in oral squamous cell carcinoma, leading to a decrease in cancer malignancy. Additionally, the combined use of these agents with Wnt/beta-catenin signaling antagonists shows promise as a strategy for cancer chemotherapy.
Article
Biochemistry & Molecular Biology
Samantha S. Yee, April L. Risinger
Summary: Research has found that C-22,23-epoxytaccalonolides, a novel class of covalent microtubule stabilizers, demonstrate efficacy against taxane-resistant ovarian cancer models both in vitro and in vivo. The irreversible mechanism of microtubule stabilization of taccalonolide AF shows unique potential for intraperitoneal treatment of locally disseminated taxane-resistant disease, addressing a significant unmet clinical need in the treatment of ovarian cancer patients.
Review
Oncology
Benoit You, Gilles Freyer, Antonio Gonzalez-Martin, Stephanie Lheureux, Iain McNeish, Richard T. Penson, Sandro Pignata, Eric Pujade-Lauraine
Summary: This review highlights the importance of tumor primary chemosensitivity in advanced ovarian carcinomas, emphasizing its impact on patient prognosis and treatment success. It suggests that maximal tumor debulking should be achieved through both biological and physical means, and proposes the integration of chemosensitivity indicators in guiding surgical and medical management in first-line settings. Additionally, it points towards the development of novel approaches to reverse resistance to chemotherapy and PARP inhibitors.
CANCER TREATMENT REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Farhat Firdous, Rida Ibrahim, Muhammad Furqan, Hina Khan, Hadeeqa Raza, Upendra Singh, Abdul-Hamid Emwas, Mariusz Jaremko, Ghayoor Abbas Chotana, Amir Faisal, Rahman Shah Zaib Saleem
Summary: Griseofulvin derivatives showed activity in breast cancer cells, with the most promising compound characterized as a microtubule-stabilizing agent and also inhibiting proliferation of other cancer cells.
Article
Reproductive Biology
Bin Luo, Rong-quan He, Zhi-gang Peng, Jie Ma, Zhen-bo Feng, Gang Chen, Jing-jing Zeng
Summary: Primary ovarian lymphoma is a rare disease that is difficult to diagnose clinically and pathologically. We reported a patient with this disease, whose clinical symptoms were mainly changes in bowel habits and abdominal pain. Through pathological examination and immunohistochemistry, primary ovarian diffuse large B-cell lymphoma was confirmed.
JOURNAL OF OVARIAN RESEARCH
(2022)
Review
Oncology
Ambroise Lauby, Olivier Colomban, Pauline Corbaux, Julien Peron, Lilian Van Wagensveld, Witold Gertych, Naoual Bakrin, Pierre Descargues, Jonathan Lopez, Vahan Kepenekian, Olivier Glehen, Charles Andre Philip, Mojgan Devouassoux-Shisheboran, Michel Tod, Gilles Freyer, Benoit You
Summary: This article summarizes the use of the KELIM calculation model based on CA-125 kinetics in the treatment of ovarian cancer, emphasizing its role as an early marker of tumor sensitivity and its importance in guiding treatment.
Article
Agriculture, Dairy & Animal Science
Yejee Park, Yoon-Been Park, Seok-Won Lim, Byeonghwi Lim, Jun-Mo Kim
Summary: This research identified dynamic changes in gene expression in the pig ovary during the estrous cycle through transcriptome analysis. The study revealed that gene expression changes were more activated in the luteal phase, and the metestrus and diestrus periods were important for pregnancy preparation or the next estrous cycle after ovulation.
Article
Oncology
Xiaocui Zheng, Xinjing Wang, Xi Cheng, Zhaoyuan Liu, Yujia Yin, Xiaoduan Li, Zhihao Huang, Ziliang Wang, Wei Guo, Florent Ginhoux, Ziyi Li, Zemin Zhang, Xipeng Wang
Summary: Wang and colleagues conducted single-cell profiling of human ovarian cancer samples from five anatomic sites, uncovering the immune microenvironment dynamics in malignant ascites and cell subtypes relevant to chemotherapy response. The study provides a comprehensive understanding of the single-cell landscape of ovarian cancer and reveals the potential roles of ascites-enriched memory T cells, tumor-enriched macrophages, MAIT cells, dendritic cells, and endothelial subsets as predictive biomarkers for chemotherapy response in ovarian cancer. These findings contribute to the evaluation of efficacy and development of targeted therapies in ovarian cancer.