Article
Immunology
Chenshen Huang, Na Zhang, Hao Xiong, Ning Wang, Zhizhong Chen, Zhizhan Ni, Xiaohong Liu, Boxu Lin, Bujun Ge, Bing Du, Qi Huang
Summary: This study aims to explore a novel method for transcriptional regulation and proposes a new pipeline for analyzing the role of GPRC5B in COAD. By using RNA-seq, ATAC-seq, and ChIP-seq, researchers found the correlation between GPRC5B and macrophages and identified TF GATA4 as a key upstream factor.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Tesa M. Severson, Yanyun Zhu, Angelo M. De Marzo, Tracy Jones, Jonathan W. Simons, William G. Nelson, Srinivasan Yegnasubramanian, Matthew L. Freedman, Lodewyk Wessels, Andries M. Bergman, Michael C. Haffner, Wilbert Zwart
Summary: The study investigated the epigenomic landscape of prostate cancer drivers in four clonal metastatic tumors from a single patient, revealing a core transcriptional program in clonal metastatic prostate cancer despite differences in the AR cistrome. Shared AR binding sites among healthy prostate, primary prostate cancer, and metastatic tumors signify core AR-driven transcriptional regulation within the prostate cell lineage.
MOLECULAR ONCOLOGY
(2021)
Review
Rheumatology
Reema R. Barik, Lokesh Kumar Bhatt
Summary: Rheumatoid arthritis is a complex disorder influenced by environmental and genetic factors, with epigenetic changes contributing to disease activation and aggressiveness. These reversible epigenetic modifications can be modulated by drugs, diet, and environment. Understanding epigenetic mechanisms and therapies may provide insights for disease management and prevention.
RHEUMATOLOGY INTERNATIONAL
(2021)
Review
Infectious Diseases
Qigang Huang, Yingwei Ding, Chao Fang, Hao Wang, Laifa Kong
Summary: Sepsis is a syndrome characterized by multi-organ dysfunction triggered by abnormal immune responses. Recent research has shown that abnormal metabolism of trace nutrients, such as iron, plays a significant role in the pathogenesis of sepsis. Ferroptosis, a form of cell death driven by lipid peroxidation, has been identified as a key mechanism in sepsis and has the potential to reduce inflammation. However, there is a lack of studies investigating the multi-organ dysfunction caused by ferroptosis in sepsis.
INFECTION AND DRUG RESISTANCE
(2023)
Review
Immunology
Lujian Zhu, Shengnan Luo, Yin Zhu, Shiyue Tang, Chenge Li, Xiaozhi Jin, Faling Wu, Huimian Jiang, Lina Wu, Yejin Xu
Summary: Ferroptosis is a form of intracellular cell death that is iron-dependent and mediated by the accumulation of lipid peroxides. It has distinct characteristics such as the loss of lipid peroxidase repair activity, the presence of redox-active iron, and the oxidation of phospholipids-containing polyunsaturated fatty acids. Recent studies have shown its involvement in various liver diseases, but there is controversy regarding its mechanism and regulation in different liver cell types. This review summarizes the current understanding of ferroptosis in chronic liver disease and highlights its potential as a therapeutic option.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Linh Ho, Nazir Hossen, Trieu Nguyen, Au Vo, Fakhrul Ahsan
Summary: Pulmonary arterial hypertension (PAH) is a disease that leads to right-ventricular failure and death. Epigenetic modifications play an important role in the pathology of PAH. Dysregulation of epigenetic mechanisms is strongly associated with the pathological vascular remodeling during PAH development. Targeting these epigenetic regulators offers potential candidates for drug discovery and treatment of PAH.
Article
Biochemistry & Molecular Biology
Ziyan Liu, Zhuoyang Li, Shifeng Wu, Chunxin Yu, Xi Wang, Ye Wang, Zhen Peng, Yuerong Gao, Runzhi Li, Yuanyue Shen, Liusheng Duan
Summary: Coronatine enhances the chilling tolerance of tomato plants by inducing epigenetic adaptations and transcriptional reprogramming.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Priyanka Dey Talukdar, Urmi Chatterji
Summary: This review provides an in-depth account of the role and regulation of transcription co-activators, as well as their context-specific contributions in pathophysiological conditions. It also highlights the importance of patient-centered therapeutic strategies and the potential benefits of drugs targeting co-activators in reducing side effects and enhancing efficacy.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Chemistry, Medicinal
Giulia Cazzaniga, Matteo Mori, Laurent Roberto Chiarelli, Arianna Gelain, Fiorella Meneghetti, Stefania Villa
Summary: Natural products have served as powerful resources for treating human diseases and have potential in combatting tuberculosis.
They possess diverse chemical and structural features, naturally binding proteins and exhibiting bioactivities.
Research on natural products with inhibitory properties from plants, fungi, marine species, and bacteria contributes to future drug discovery and development efforts.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Jingtao Chen, Chao Niu, Ning Yang, Chunyan Liu, Shan-shan Zou, Shan Zhu
Summary: Liver cancer is a common malignancy, with high morbidity and mortality. Despite progress in treatment, the overall survival rate of patients has not significantly improved. This review highlights the importance of identifying specific liver cancer biomarkers for early screening, accurate diagnosis, prognosis, and prevention of tumor progression. It also discusses the latest research progress and potential applications in biomarker discovery.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Genetics & Heredity
Amy A. Eapen, Sreeja Parameswaran, Carmy Forney, Lee E. Edsall, Daniel Miller, Omer Donmez, Katelyn Dunn, Xiaoming Lu, Marissa Granitto, Hope Rowden, Adam Z. Magier, Mario Pujato, Xiaoting Chen, Kenneth Kaufman, David Bernstein, Ashley L. Devonshire, Marc E. Rothenberg, Matthew T. Weirauch, Leah C. Kottyan
Summary: Gene expression in stimulated CD4(+) T cells is regulated in a disease-dependent manner in patients with atopic dermatitis (AD). AD-specific regions of chromatin accessibility and NFKB1 transcription factor binding are enriched for AD genetic risk variants. CD4(+) T cells in the peripheral blood of patients with AD respond to stimulation in a disease- and genotype-dependent manner.
Article
Biochemical Research Methods
Zhaonan Zou, Michio Iwata, Yoshihiro Yamanishi, Shinya Oki
Summary: This study presents a computational method to elucidate the epigenetic landscape of drug responses by analyzing transcription factors. By predicting chemical-transcription factor-disease associations, this method can provide insights into new therapeutic targets and effects, guiding drug discovery and application.
BMC BIOINFORMATICS
(2022)
Review
Endocrinology & Metabolism
Rhema Chandan Khairnar, Niraj Parihar, Kedar S. Prabhavalkar, Lokesh Kumar Bhatt
Summary: Parkinson's disease patients experience both motor and non-motor symptoms. Current pharmacological treatments only provide temporary relief and are unable to restore neural function or halt disease progression. Therefore, there is a need for disease-modifying treatments for PD.
METABOLIC BRAIN DISEASE
(2022)
Article
Oncology
Marcus T. T. Roalso, Oyvind H. Hald, Marina Alexeeva, Kjetil Soreide
Summary: Epigenetic alterations play a crucial role in pancreatic cancer by affecting gene expression, tumor microenvironment, and immune-based treatments. They can also serve as tools for early detection and prognostication.
Article
Infectious Diseases
Guillermin Agueero-Chapin, Agostinho Antunes, Jose R. Mora, Noel Perez, Ernesto Contreras-Torres, Jose R. Valdes-Martini, Felix Martinez-Rios, Cesar H. Zambrano, Yovani Marrero-Ponce
Summary: Microbial biofilms can cause various environmental and industrial issues, as well as impact human health. Despite their antibiotic resistance, there are currently no approved antibiofilm agents for clinical treatments. Antimicrobial peptides (AMPs), with their antibiofilm activity and ability to target multiple microbes, have motivated the development of new antibiofilm agents. However, the use of complex network approaches as assistant tools for this purpose has not been explored.
Article
Multidisciplinary Sciences
Maja Milanovic, Dorothy N. Y. Fan, Dimitri Belenki, J. Henry M. Dabritz, Zhen Zhao, Yong Yu, Jan R. Doerr, Lora Dimitrova, Dido Lenze, Ines A. Monteiro Barbosa, Marco A. Mendoza-Parra, Tamara Kanashova, Marlen Metzner, Katharina Pardon, Maurice Reimann, Andreas Trumpp, Bernd Doerken, Johannes Zuber, Hinrich Gronemeyer, Michael Hummel, Gunnar Dittmar, Soyoung Lee, Clemens A. Schmitt
Article
Chemistry, Medicinal
Shinya Fujii, Shuichi Mori, Hiroyuki Kagechika, Marco Antonio Mendoza Parra, Hinrich Gronemeyer
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2018)
Editorial Material
Oncology
Hinrich Gronemeyer
INTERNATIONAL JOURNAL OF CANCER
(2020)
Editorial Material
Oncology
Hinrich Gronemeyer
INTERNATIONAL JOURNAL OF CANCER
(2020)
Article
Multidisciplinary Sciences
Maha Siouda, Audrey D. Dujardin, Laetitia Barbollat-Boutrand, Marco A. Mendoza-Parra, Benjamin Gibert, Maria Ouzounova, Jebrane Bouaoud, Laurie Tonon, Marie Robert, Jean-Philippe Foy, Vincent Lavergne, Serge N. Manie, Alain Viari, Alain Puisieux, Gabriel Ichim, Hinrich Gronemeyer, Pierre Saintigny, Peter Mulligan
Correction
Biochemistry & Molecular Biology
Angela Nebbioso, Fabio Manzo, Marco Miceli, Mariarosaria Conte, Lucrezia Manente, Alfonso Baldi, Antonio De Luca, Dante Rotili, Sergio Valente, Antonello Mai, Alessandro Usiello, Hinrich Gronemeyer, Lucia Altucci
Editorial Material
Oncology
Hinrich Gronemeyer, Nicole Y. Souren
INTERNATIONAL JOURNAL OF CANCER
(2021)
Editorial Material
Oncology
Hinrich Gronemeyer
INTERNATIONAL JOURNAL OF CANCER
(2022)
Review
Oncology
Yasenya Kasikci, Hinrich Gronemeyer
Summary: Cancer genetics and genomics have provided insights into tumor development and heterogeneity. However, current cancer research may overlook complexity and individual diversity. A systems approach that reconstructs altered information networks and identifies key regulators is suggested. Individualized strategies are favored, as interindividual variability within patient cohorts is too high to extract common polygenic network information. A multinational and multidisciplinary effort is needed to develop dynamic regulatory networks and propose targeted therapies based on altered information transfer in individual cancers.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Cell Biology
A. Huyghe, G. Furlan, J. Schroeder, E. Cascales, A. Trajkova, M. Ruel, F. Studer, M. Larcombe, Y. Bo Yang Sun, F. Mugnier, L. De Matteo, A. Baygin, J. Wang, Y. Yu, N. Rama, B. Gibert, J. Kielbassa, L. Tonon, P. Wajda, N. Gadot, M. Brevet, M. Siouda, P. Mulligan, R. Dante, P. Liu, H. Gronemeyer, M. Mendoza-Parra, J. M. Polo, F. Lavial
Summary: Coordinated changes of cellular plasticity and identity are critical for pluripotent reprogramming and oncogenic transformation. This study provides insights into the partitioned control of cellular plasticity and identity for both regenerative and cancer biology.
NATURE CELL BIOLOGY
(2022)
Article
Oncology
Akinchan Kumar, Yasenya Kasikci, Alaa Badredine, Karim Azzag, Marie L. Quintyn Ranty, Falek Zaidi, Nathalie Aragou, Catherine Mazerolles, Bernard Malavaud, Marco A. Mendoza-Parra, Laurence Vandel, Hinrich Gronemeyer
Summary: Prostate cancer shows diverse patient-specific network alterations, with different signaling pathways affected by mutations and altered gene expression. In individual cases, deregulated pathways share common factors and have synergistic effects on cancer progression, providing a paradigm for identifying druggable key deregulated factors within regulatory networks for personalized therapies.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Biology
Matthias Blum, Pierre-Etienne Cholley, Valeriya Malysheva, Samuel Nicaise, Julien Moehlin, Hinrich Gronemeyer, Marco Antonio Mendoza-Parra
LIFE SCIENCE ALLIANCE
(2020)
Article
Mathematical & Computational Biology
Pierre-Etienne Cholley, Julien Moehlin, Alexia Rohmer, Vincent Zilliox, Samuel Nicaise, Hinrich Gronemeyer, Marco Antonio Mendoza-Parra
NPJ SYSTEMS BIOLOGY AND APPLICATIONS
(2018)
Meeting Abstract
Hematology
Pierre Bories, Nais Prade, Stephanie Lagarde, Bastien Cabarrou, Julien Plenecassagnes, Isabelle Luquet, Veronique De Mas, Thomas Filleron, Manon Cassou, Audrey Sarry, Luc Matthieu Fornecker, Celestine Simand, Sarah Bertoli, Hinrich Gronemeyer, Christian Recher, Eric Delabesse
Meeting Abstract
Hematology
Pierre Bories, Nais Prade, Bastien Cabarrou, Stephanie Lagarde, Julien Plenecassagnes, Isabelle Luquet, Veronique De Mas, Thomas Filleron, Manon Cassou, Audrey Sarry, Luc Matthieu Fornecker, Celestine Simand, Sarah Bertoli, Hinrich Gronemeyer, Christian Recher, Eric Delabesse