Editorial Material
Neurosciences
R. Irene Jacobsen, Tara Keck
Summary: Research demonstrates that downward firing rate homeostasis occurs in vivo only when cellular activity levels exceed baseline, and only during periods of dense sleep.
Editorial Material
Biochemical Research Methods
Vivien Marx
Summary: To gauge academic culture and celebrate being an LGBT+ scientist, one needs independent thinking, courage, and social support.
Article
Economics
Olivier Godechot, Nils Neumann, Paula Apascaritei, Istvan Boza, Martin Hallsten, Lasse Henriksen, Are Hermansen, Feng Hou, Jiwook Jung, Naomi Kodama, Alena Krizkova, Zoltan Lippenyi, Elvira Marta, Silvia Maja Melzer, Eunmi Mun, Halil Sabanci, Matthew Soener, Max Thaning
Summary: The upswing and downswing in finance have asymmetric effects on inequality, with downswings not leading to a symmetric decline in inequality.
SOCIO-ECONOMIC REVIEW
(2023)
Review
Biochemistry & Molecular Biology
Shulun Chen, Jing Tan, Ao Zhang
Summary: Cancer immunotherapy, although showing significant clinical benefits, still falls short of the expected response rates. While some new IDO1 inhibitors have shown promise in preclinical studies, the failure of clinical trials has raised concerns. However, new trends in targeting IDO1 continue to emerge, aiming to bridge the gap between lab research and clinical applications.
BIOORGANIC CHEMISTRY
(2021)
Review
Neurosciences
Anne-Noel Samaha, Shaun Y. -S. Khoo, Carrie R. Ferrario, Terry E. Robinson
Summary: Repeated drug use can alter dopamine function, leading to addiction. Two main viewpoints exist: one suggests that drug use decreases dopamine neurotransmission, while the other argues that it enhances it. Recent evidence supports the latter view, with implications for addiction modeling and treatment.
TRENDS IN NEUROSCIENCES
(2021)
Review
Plant Sciences
Alicia Fick, Velushka Swart, Noelani van den Berg
Summary: Plant Nucleotide binding-Leucine rich repeat (NLR) proteins play a significant role in pathogen detection and the activation of effector-triggered immunity. Understanding the mechanisms of NLR regulation, including epigenetic modifications, cis elements, and post-transcriptional modifications, is crucial for successful immune responses. Furthermore, studying how pathogens interfere with NLR expression can provide insights into increasing resistance against plant pathogens.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Bernhard Moser, Sophie Edtmayer, Agnieszka Witalisz-Siepracka, Dagmar Stoiber
Summary: Aberrant JAK-STAT signaling in acute myeloid leukemia (AML) plays a crucial role in disease pathogenesis. Targeting the JAK-STAT pathway, particularly constitutively activated STAT3 and STAT5, has shown promising results in vitro and in vivo. Ongoing development of new JAK-STAT inhibitors with better disease specificity offers potential for improved disease management.
Editorial Material
Biochemistry & Molecular Biology
Belal Shohayeb, Helen M. Cooper
Summary: Neural stem cells need to adapt quickly to the changing environment during embryonic development, but the regulation of key transcription factors such as Pax6 at the protein level is not well understood. In a recent study published in the JBC, Dong et al identified a novel posttranslational regulatory mechanism where Kat2a-mediated lysine acetylation leads to ubiquitination and degradation of Pax6, determining whether neural stem cells undergo proliferation or neuronal differentiation via the proteasome pathway.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Franziska Ottens, Andre Franz, Thorsten Hoppe
Summary: Metabolic perturbation leads to cellular stress, affecting protein homeostasis and requiring adaptive mechanisms. Protein homeostasis is controlled by mechanisms such as translational control, chaperone-assisted folding, and protein degradation.
CELL DEATH AND DIFFERENTIATION
(2021)
Review
Biochemistry & Molecular Biology
Maria P. Cornejo, Emilio R. Mustafa, Daniela Cassano, Jean-Louis Baneres, Jesica Raingo, Mario Perello
Summary: GHSR is a key molecule in neuroendocrine control, regulating various functions such as growth hormone secretion and food intake. Its signaling pathway displays basal constitutive activity and can be regulated by hormones like ghrelin and LEAP2.
Article
Biochemistry & Molecular Biology
David B. Sauer, Bing Wang, Joseph C. Sudar, Jinmei Song, Jennifer Marden, William J. Rice, Da-Neng Wang
Summary: The DASS family consists of various proteins, with NaCT and LaINDY showing high structural similarity to the VcINDY fold and sharing a similar transport mechanism. Studying different structural states helps in understanding their transport cycle.
Review
Cell Biology
Selina M. Kindelay, Keith A. Maggert
Summary: The ribosomal DNA (rDNA) in Drosophila exists as two independent clusters of individual 35 S cistmns. The multiplicity of rDNA is crucial for ensuring proper translational demands, but the tandem arrays are susceptible to copy number variation within and between populations. This article discusses how cells respond to insufficient rDNA copy number, including the historical concept of rDNA magnification and recent discoveries of rDNA loss and potential mechanisms of magnification.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2023)
Review
Medicine, Research & Experimental
Sebastian J. Hofer, Didac Carmona-Gutierrez, Melanie Mueller, Frank Madeo
Summary: Age-associated diseases are on the rise, leading to a need for efficient and low-cost methods. Caloric restriction (CR) is effective but implementation can be challenging, giving rise to CR-mimicking interventions. The advantages and disadvantages of these dietary interventions in humans must be carefully considered.
EMBO MOLECULAR MEDICINE
(2022)
Article
Mathematics, Interdisciplinary Applications
Katarzyna Gorska, Andrzej Horzela, Karol A. Penson
Summary: Experimental data on dielectric relaxation phenomena can be obtained through time decay of depolarization current or broadband dielectric spectroscopy, and are often fitted with time or frequency dependent functions, potentially using the Laplace transform for comparability analysis. Understanding the use of Mittag-Leffler functions is necessary to go beyond conventional approximations for such comparisons and describe non-Debye relaxations accurately.
FRACTAL AND FRACTIONAL
(2021)
Review
Hematology
Erik Berntorp, Cedric Hermans, Alexander Solms, Lone Poulsen, Maria Elisa Mancuso
Summary: The classical goals of haemophilia A treatment are to prevent bleeds, minimize long-term complications associated with joint damage, and improve quality of life by maintaining appropriate FVIII levels. Understanding the varying dose and frequency required for FVIII replacement therapies among individuals is important for optimal protection. Personalized therapy and a better understanding of pharmacology and pharmacokinetics could lead to improved patient outcomes.
Article
Biochemistry & Molecular Biology
Armine Matevossian, Marilyn D. Resh
Review
Biochemistry & Molecular Biology
Marilyn D. Resh
PROGRESS IN LIPID RESEARCH
(2016)
Article
Biochemistry & Molecular Biology
James J. Asciolla, Matthew M. Miele, Ronald C. Hendrickson, Marilyn D. Resh
JOURNAL OF BIOLOGICAL CHEMISTRY
(2017)
Editorial Material
Biochemistry & Molecular Biology
Marilyn D. Resh
Article
Biochemistry & Molecular Biology
Rayshonda Y. Hardy, Marilyn D. Resh
JOURNAL OF BIOLOGICAL CHEMISTRY
(2012)
Article
Biochemistry & Molecular Biology
Jessica Rios-Esteves, Brittany Haugen, Marilyn D. Resh
JOURNAL OF BIOLOGICAL CHEMISTRY
(2014)
Article
Biochemistry & Molecular Biology
Arnnine Matevossian, Marilyn D. Resh
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Article
Biochemistry & Molecular Biology
Elissaveta Petrova, Jessica Rios-Esteves, Ouathek Ouerfelli, J. Fraser Glickman, Marilyn D. Resh
NATURE CHEMICAL BIOLOGY
(2013)
Article
Biochemistry & Molecular Biology
E. Petrova, A. Matevossian, M. D. Resh
Article
Cell Biology
Jessica Rios-Esteves, Marilyn D. Resh
Article
Genetics & Heredity
Patrick Callier, Pierre Calvel, Armine Matevossian, Periklis Makrythanasis, Pascal Bernard, Hiroshi Kurosaka, Anne Vannier, Christel Thauvin-Robinet, Christelle Borel, Verine Mazaud-Guittot, Antoine Rolland, Christele Desdoits-Lethimonier, Michel Guipponi, Celine Zimmermann, Isabelle Stevant, Francoise Kuhne, Beatrice Conne, Federico Santoni, Sandy Lambert, Frederic Huet, Francine Mugneret, Jadwiga Jaruzelska, Laurence Faivre, Dagmar Wilhelm, Bernard Jegou, Paul A. Trainor, Marilyn D. Resh, Stylianos E. Antonarakis, Serge Nef
Article
Biotechnology & Applied Microbiology
Gustav Y. Cederquist, James J. Asciolla, Jason Tchieu, Ryan M. Walsh, Daniela Cornacchia, Marilyn D. Resh, Lorenz Studer
NATURE BIOTECHNOLOGY
(2019)
Review
Biochemistry & Molecular Biology
Marilyn D. Resh
Summary: This review discusses the role of Hedgehog acyltransferase (Hhat) in Hedgehog signaling, the importance of palmitoylation, and the potential involvement of Hhat in various cancers. Targeting hedgehog palmitoylation by inhibiting Hhat is considered a promising intervention in human disease.
Editorial Material
Biochemistry & Molecular Biology
Marilyn D. Resh
Summary: Fatty acylation is a crucial protein modification that affects protein affinity, signaling pathways, and cellular functions. Research in this field offers new therapeutic opportunities for targeting human diseases.
Review
Biochemistry & Molecular Biology
Marilyn D. Resh
BIOCHEMICAL SOCIETY TRANSACTIONS
(2017)
