Article
Oncology
Bo Zhou, Jie Xiang, Ming Jin, Xiang Zheng, Guogang Li, Sheng Yan
Summary: The study showed that high vimentin expression with loss of E-cadherin expression in patients with grade 1 and 2 pNETs undergoing resection was correlated with risks of lymph node metastasis, distant metastasis, disease progression, and poor prognosis.
Article
Oncology
Weimin Wang, Jun Jin, Zhen Zhou, Yunfan Wang, Ke Min, Xin Zuo, Jiaping Jiang, Yan Zhou, Jun Shi
Summary: The overall survival rate of colorectal cancer patients is low, and the identification of valuable prognostic markers is urgently needed. This study investigated the clinical significance of Snail and E-cad expression in colorectal cancer and found that low Snail and high E-cad expression are associated with better prognosis.
Article
Oncology
Hai-Ling Wang, Xue-Ke Zhao, Fu-You Zhou, Xin Song, Liu-Yu Li, Gai-Rong Huang, Qi-De Bao, Ling-Ling Lei, Hai-Jun Yang, Li Li, Rui-Hua Xu, Ai-Li Li, Xian-Zeng Wang, Wen-Li Han, Jing-Li Ren, Li-Dong Wang
Summary: Gastric cardia adenocarcinoma (GCA) is similar in geographical distribution to esophageal squamous cell carcinoma in China. The molecular mechanism for GCA is largely unknown. Recent studies have shown that decreased expression of E-cadherin is associated with the invasion and metastasis of multiple cancers. This study aimed to investigate the expression of E-cadherin in GCA and its impact on prognosis.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2022)
Review
Oncology
Hannah Cessna, Stavroula Baritaki, Apostolos Zaravinos, Benjamin Bonavida
Summary: This article summarizes the relationship between the expression of Raf kinase inhibitor protein (RKIP) and cancer cell growth, invasiveness, EMT, and metastasis. The study found that RKIP inhibits EMT gene products through signaling cross-talks, leading to the inhibition of tumor metastasis and growth. The article also suggests that the development of drugs that can induce RKIP expression may be beneficial in inhibiting tumor growth and metastasis.
Article
Multidisciplinary Sciences
Tobias Wijshake, Zhongju Zou, Beibei Chen, Lin Zhong, Guanghua Xiao, Yang Xie, John G. Doench, Lynda Bennett, Beth Levine
Summary: The study revealed previously unrecognized cooperation between Beclin 1 and E-cadherin in mediating tumor suppression in breast cancer cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biotechnology & Applied Microbiology
Qinglin Zhang, Jiadong Pan, Fangmei An, He Nie, Qiang Zhan
Summary: This study found that decreased expression of SLC39A1 is associated with clinical features and survival rates in early-stage hepatocellular carcinoma (EHCC), with patients showing lower expression having poorer prognosis. The expression level of SLC39A1 may serve as a potential diagnostic and prognostic biomarker for EHCC patients.
Article
Biochemistry & Molecular Biology
Han-Heom Na, Jae-Min Ryu, Keun-Cheol Kim
Summary: Our study indicates that the FosB gene plays a critical role in regulating drug sensitivity and invasion-related genes, affecting the expression of Bcl2, E-cadherin, fi-catenin, and Vimentin at the transcriptional level, and shows coordinated function with SETDB1.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Oncology
Pengbo Wang, Zengkuan Zhu
Summary: Expression of E-cadherin is closely associated with the risk, clinical features, and prognosis of pancreatic cancer, suggesting it may serve as an effective biomarker for clinical assessments and predicting prognosis in patients with pancreatic cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Mourad Assidi
Summary: This study investigates the expression patterns of N-CAD protein in ovarian cancer (OC) patients and its correlations with clinicopathological features. The study finds that N-CAD protein is often overexpressed in OC and its cytoplasmic overexpression is significantly correlated with tumor grade, subtype, necrosis, and age at menarche. Patients with cytoplasmic N-CAD overexpression have a shorter disease-free survival and higher recurrence rate. These findings highlight the poor prognostic role of N-CAD in OC and its involvement in EMT and distant metastasis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Wafaey Gomaa, Haneen Al-Maghrabi, Jaudah Al-Maghrabi
Summary: The study found that reduced E-cadherin and beta-catenin immunostaining in colorectal carcinoma is associated with prognostic factors, indicating the potential role of the Wnt/beta-catenin pathway in CRC progression and the importance of close follow-up for high-risk patients.
ARAB JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Oncology
Kang Hu, Qi-Ming Zheng, Ye-Peng Wang, Meng-Meng Zhao, Zhi-Gang Sun
Summary: This study evaluated the expression and clinical significance of E-cadherin in adenocarcinoma of the esophagogastric junction (AEG). The results showed that E-cadherin expression was significantly reduced in AEG tissues, and it was closely associated with tumor differentiation, infiltration depth, and clinicopathological stage. Low expression of E-cadherin was correlated with poor prognosis in AEG patients.
EUROPEAN JOURNAL OF CANCER PREVENTION
(2023)
Article
Biochemistry & Molecular Biology
Hsien-Lin Chen, Yu-Chieh Su, Huang-Chi Chen, Jui-Hsin Su, Chang-Yi Wu, Shih-Wei Wang, In-Pin Lin, Chung-Yi Chen, Chien-Hsing Lee
Summary: The study focused on investigating the anti-lymphangiogenic effect of heteronemin (SP-1) from a sponge in human lymphatic endothelial cells (LECs) and in vivo models. Results showed that SP-1 inhibits lymphangiogenesis by downregulating the VEGFR-3 cascade, ARF-1, and MMP-9/VE-cadherin/vimentin pathways. These findings suggest that SP-1 could be a potential candidate for treating lymphangiogenesis-associated diseases.
Article
Medicine, General & Internal
Enke Baldini, Chiara Tuccilli, Daniele Pironi, Antonio Catania, Francesco Tartaglia, Filippo Maria Di Matteo, Piergaspare Palumbo, Stefano Arcieri, Domenico Mascagni, Giorgio Palazzini, Domenico Tripodi, Alessandro Maturo, Massimo Vergine, Danilo Tarroni, Eleonora Lori, Iulia Catalina Ferent, Corrado De Vito, Poupak Fallahi, Alessandro Antonelli, Simona Censi, Matteo D'Armiento, Susy Barollo, Caterina Mian, Aldo Morrone, Vito D'Andrea, Salvatore Sorrenti, Salvatore Ulisse
Summary: The study revealed that during thyroid cancer progression, the role of EMT-TFs is incomplete, with Twist1 possibly playing a key role in EMT but lacking significant prognostic value.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Health Care Sciences & Services
Jun Liu, Jinghui Song, Qifang Yang, Yingmei Wang
Summary: This study investigated the correlation between Lactobacillus vaginalis and postmenopausal cervical lesions, and found that it is associated with epithelial-mesenchymal transition (EMT) and promotes the development of cervical lesions.
ANNALS OF PALLIATIVE MEDICINE
(2022)
Article
Oncology
Georgia Levidou, Pawel Gajdzis, Nathalie Cassoux, Piotr Donizy, Christos Masaoutis, Malgorzata Gajdzis, Sophie Gardrat, Alexandros Pergaris, Eougken Danas, Jerzy Klijanienko, Stamatios Theocharis
Summary: HDACs, especially HDAC-2, may play a significant role in the development and progression of uveal melanoma, with potential implications for patient prognosis. This study evaluated the expression of HDAC-1, -2, -4, and -6 in UM cases and found associations with tumor characteristics and patient survival.