Article
Multidisciplinary Sciences
Sadaf Sulman, Saher Shahid, Aasia Khaliq, Atiqa Ambreen, Imran H. Khan, Andrea M. Cooper, Muhammad Waheed Akhtar
Summary: The study demonstrated that the fusion protein TriFu64 increased the sensitivity of TB serodiagnosis and was particularly effective in detecting sputum and culture negative patients. By combining Mtb antigens into fusion proteins, a broad sensitivity across different disease types, gender and age groups in a Pakistani population was achieved.
Article
Oncology
Juan Zhou, Jing Zhao, Qingzhu Jia, Qian Chu, Fei Zhou, Xiangling Chu, Wencheng Zhao, Shengxiang Ren, Caicun Zhou, Chunxia Su
Summary: The study identified a panel of five tumor associated autoantibodies (TAAbs) in plasma that can predict the clinical outcome of immunotherapy based treatment in patients with advanced non-small cell lung cancer. The positivity of this 5-TAAbs panel was significantly associated with better response and longer progression-free survival in a validation cohort. Additionally, the presence of these autoantibodies was correlated with a higher incidence of checkpoint inhibitor pneumonitis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Xinzhe Feng, Wenwen Tong, Jia Li, Yihong Xu, Shanbang Zhu, Weidong Xu
Summary: The study found that anti-Kaiso autoantibodies have diagnostic value in the early diagnosis of non-radiographic axial spondyloarthritis (nr-axSpA) and are correlated with clinical disease indicators.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Cuipeng Qiu, Yaru Duan, Bofei Wang, Jianxiang Shi, Peng Wang, Hua Ye, Liping Dai, Jianying Zhang, Xiao Wang
Summary: The study found a positive correlation between the high expression of PDLIM1 autoantibodies in OC patients and high expression of PDLIM1 in tissues, indicating the potential of autoantibodies against PDLIM1 as a novel serological biomarker for OC, serving as a complementary measure to CA125 and improving the accuracy of OC detection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Gabriela Maira Pereira de Assis, Denise Anete Madureira de Alvarenga, Matheus de Oliveira Costa Pereira, Juan Camilo Sanchez-Arcila, Anielle de Pina Costa, Julio Cesar de Souza Junior, Ana Julia Dutra Nunes, Alcides Pissinatti, Silvia Bahadian Moreira, Leticia de Menezes Torres, Helena Lott Costa, Herlandes da Penha Tinoco, Valeria do Socorro Pereira, Irene da Silva Soares, Tais Nobrega de Sousa, Francis Babila Ntumngia, John H. Adams, Flora Satiko Kano, Zelinda Maria Braga Hirano, Claudio Tadeu Daniel-Ribeiro, Joseli Oliveira Ferreira, Luzia Helena Carvalho, Cristiana Ferreira Alves de Brito
Summary: This study evaluated the humoral immune response against pre-erythrocytic and erythrocytic antigens of Neotropical primates in the Atlantic Forest, Brazil, to identify potential reservoirs of malaria. The results showed a high prevalence of antibodies against Plasmodium antigens in monkeys from different areas of the Atlantic Forest, suggesting a significant exposure to infected-mosquitoes bites. Monkeys from the Atelidae family showed higher levels of antibodies against P. vivax erythrocytic antigens, indicating a potential role as reservoirs of malaria in the Atlantic Forest.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Oncology
Christopher Cultrara, Christopher Uhl, Kenneth Kirby, Essam Abed Elrazaq, Amelia Zellander, David W. Andrews, Charles B. Scott, Lorenzo Galluzzi, Mark A. Exley, Jenny Zilberberg
Summary: IGV-001 is a personalized, autologous cancer cell-based immunotherapy that delivers a tumor-derived antigenic payload with immunostimulatory signals for the treatment of glioblastoma (GBM) patients. It has shown promising clinical activity and safety in newly diagnosed GBM patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Immunology
Chengbo Long, Feilong Wu, Qiumin Lu, Bing Xie, Chuanbin Shen, Jiayao Li, Yanling Deng, Ping Liang, Yongzhi Yu, Ren Lai
Summary: A new strategy has been developed for rapid and efficient clinical diagnosis of snakebite, which is crucial for successful treatment. By using multi-omics approaches to choose candidate antigens and preparing a double-antibody sandwich ELISA kit, high accuracy and feasibility in identifying snake venoms have been demonstrated.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Jerome Kervevan, Aurelie Bouteau, Juliane S. Lanza, Adele Hammoudi, Sandra Zurawski, Mathieu Surenaud, Lydie Dieudonne, Marion Bonnet, Cecile Lefebvre, Hakim Hocini, Romain Marlin, Aurelie Guguin, Barbara Hersant, Oana Hermeziu, Elisabeth Menu, Christine Lacabaratz, Jean-Daniel Lelievre, Gerard Zurawski, Veronique Godot, Sandrine Henri, Botond Z. Igyarto, Yves Levy, Sylvain Cardinaud
Summary: Targeting of skin Langerhans cells (LC) may efficiently induce potent anti-HIV immune responses, serving as a promising strategy for developing effective HIV-1 vaccines. This approach demonstrates the potential of directing immune responses through specific cell targeting and may lead to the induction of protective antibodies against HIV-1.
Article
Biochemistry & Molecular Biology
Yangyang Sun, Chengxi Liu, Huidong Zhong, Chenguang Wang, Haibo Xu, Wei Chen
Summary: In this study, the researchers identified high expression of certain autoantibodies in serum of renal cancer patients using the human proteome microarray technology, suggesting their potential as biomarkers for renal cancer.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Article
Geriatrics & Gerontology
T. -Y. Lin, S. -C Hung
Summary: This study found that frailty is associated with impaired humoral responses following COVID-19 vaccination among hemodialysis patients. Frail patients had progressively lower levels of antibodies and a lower likelihood of antibody seroconversion after vaccination.
JOURNAL OF NUTRITION HEALTH & AGING
(2023)
Article
Chemistry, Multidisciplinary
Kaige Chen, Zheng Zhang, Jiachen Zhang, Ziyuan Fang, Wang Dong, Yucai Wang, Min Li
Summary: This study explores a new antigen-caged adjuvant strategy, in which a controlled bio-mineralization method is used to prepare antigen-caged metal adjuvants. The results demonstrate that this strategy can enhance the adjuvanticity of aluminum adjuvants and promote the internalization of antigen and adjuvant by antigen-presenting cells, leading to robust humoral and cellular immune responses.
Review
Oncology
Taketo Kato, Jody V. Vykoukal, Johannes F. Fahrmann, Samir Hanash
Summary: Extracellular vesicles (EVs) are nano-sized lipid-bound particles containing proteins, nucleic acids and metabolites released by cells, which are widely distributed in various biological fluids. In tumors, EVs derived from cancer and immune cells mediate intercellular communication and exchange, and can affect immunomodulatory functions. In the context of lung cancer, emerging evidence implicates EV involvement during various stages of tumor development and progression, including angiogenesis, epithelial to mesenchymal transformation, immune system suppression, metastasis and drug resistance.
Article
Biochemistry & Molecular Biology
Cuipeng Qiu, Yangcheng Ma, Bofei Wang, Xiaojun Zhang, Xiao Wang, Jian-Ying Zhang
Summary: This study analyzed the presence of autoantibodies to PAX5, PTCH1, and GNA11 in the sera of Hispanic Americans, including HCC patients, LC patients, CH patients, and normal controls, using an ELISA. The results showed that these autoantibodies could serve as biomarkers for the early detection of HCC and they may monitor the transition of high-risk patients to HCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Liping Zhuang, Changjing Huang, Zhouyu Ning, Lina Yang, Wenbin Zou, Peng Wang, Chien-Shan Cheng, Zhiqiang Meng
Summary: This study is the first to characterize the circulating tumor-associated autoantibodies (TAAbs) signatures in pancreatic adenocarcinoma (PAAC), and demonstrates that the combination of CLDN17 and CA19-9 could serve as novel noninvasive biomarkers for PAAC diagnosis.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Chemistry, Multidisciplinary
Xiang Luo, Qinghai Lian, Wenwei Li, Liqing Chen, Renyu Zhang, Deying Yang, Lingqiang Gao, Xiaoxiao Qi, Zhongqiu Liu, Guochao Liao
Summary: The strategy of using Mincle agonist with STn antigen conjugates shows promising results in inducing robust immune responses and inhibiting tumor growth, demonstrating the potential for developing new vaccine carriers with self-adjuvanting properties for cancer treatment.
Editorial Material
Oncology
Michael A. Tainsky, Robert T. Morris
CANCER AND METASTASIS REVIEWS
(2015)
Article
Oncology
Aurelie Ernst, David T. W. Jones, Kendra K. Maass, Agata Rode, Katharina I. Deeg, Billy Michael Chelliah Jebaraj, Andrey Korshunov, Volker Hovestadt, Michael A. Tainsky, Kristian W. Pajtler, Sebastian Bender, Sebastian Brabetz, Susanne Groebner, Marcel Kool, Frauke Devens, Jennifer Edelmann, Cindy Zhang, Pedro Castelo-Branco, Uri Tabori, David Malkin, Karsten Rippe, Stephan Stilgenbauer, Stefan M. Pfister, Marc Zapatka, Peter Lichter
INTERNATIONAL JOURNAL OF CANCER
(2016)
Article
Oncology
Sidra Ahsan, Yubin Ge, Michael A. Tainsky
Article
Oncology
Xia Wang, Jamie K. Teer, Renee N. Tousignant, Albert M. Levin, David Boulware, Dhananjay A. Chitale, Brandon M. Shaw, Zhihua Chen, Yonghong Zhang, Jaishri O. Blakeley, Maria T. Acosta, Ludwine M. Messiaen, Bruce R. Korf, Michael A. Tainsky
GENES CHROMOSOMES & CANCER
(2018)
Article
Multidisciplinary Sciences
Jaime L. Stafford, Gregory Dyson, Nancy K. Levin, Sophia Chaudhry, Rita Rosati, Hasini Kalpage, Courtney Wernette, Nancie Petrucelli, Michael S. Simon, Michael A. Tainsky
Article
Oncology
Xia Wang, Roope A. Kallionpaa, Patrick R. Gonzales, Dhananjay A. Chitale, Renee N. Tousignant, Jacob P. Crowley, Zhihua Chen, Sean J. Yoder, Jaishri O. Blakeley, Maria T. Acosta, Bruce R. Korf, Ludwine M. Messiaen, Michael A. Tainsky
CANCER PREVENTION RESEARCH
(2018)
Article
Oncology
Batoul Farran, Samet Albayrak, Judith Abrams, Michael A. Tainsky, Nancy K. Levin, Robert Morris, Larry H. Matherly, Manohar Ratnam, Ira Winer
Article
Oncology
Jaime L. Lopes, Sophia Chaudhry, Guilherme S. Lopes, Nancy K. Levin, Michael A. Tainsky
Article
Oncology
Laura C. Hurley, Nancy K. Levin, Madhumita Chatterjee, Jasmine Coles, Shlomo Muszkat, Zachary Howarth, Gregory Dyson, Michael A. Tainsky
Review
Oncology
Scott Baughan, Michael A. Tainsky
Summary: Research on the cancer associated protein BRCA2 is ongoing, generating new insights into the relation of specific variants of this gene and cancer. These discoveries shed light on cancer risk and management for patients carrying these mutations. New techniques for variant discovery are being developed, enhancing scientific and clinical understanding of this key protein.
Article
Cell Biology
Sophia R. Chaudhry, Jaime Lopes, Nancy K. Levin, Hasini Kalpage, Michael A. Tainsky
Summary: The study identified several truncating mutations in genes associated with apoptosis in a group of ovarian cancer patients with familial predisposition but negative for pathogenic BRCA1/2 mutations. It also demonstrated that cells expressing TP53I3 p.S252X variant showed decreased repair efficiency and increased sensitivity to chemotherapeutic drugs, as well as reduced formation of reactive oxygen species under oxidative stress. These findings suggest the potential relevance of apoptosis-related genes to hereditary cancer and highlight the importance of combining computational and wet lab approaches for evaluating variants of unknown significance.
CELL DEATH DISCOVERY
(2021)
Article
Oncology
Scott L. Baughan, Fatima Darwiche, Michael A. Tainsky
Summary: This study evaluated the biochemical effects of several missense mutations in the DNA repair gene ATM on ATM activity. It found that some of these mutations showed signs of reduced ATM function, indicating likely pathogenicity. These findings have important clinical implications for the diagnosis, surveillance, and outcome of hereditary cancer.
Review
Oncology
Claire McCarthy-Leo, Fatima Darwiche, Michael A. Tainsky
Summary: The MRN complex plays a crucial role in DNA repair, but the presence of variants of uncertain significance hinders variant classification and clinical decision making.
Article
Oncology
Madhumita Chatterjee, Laura C. Hurley, Nancy K. Levin, Matthew Stack, Michael A. Tainsky
Review
Obstetrics & Gynecology
Madhumita Chatterjee, Laura C. Hurley, Michael A. Tainsky
GYNECOLOGIC ONCOLOGY REPORTS
(2017)