Signaling pathways in the molecular pathogenesis of adenocarcinomas of the esophagus and gastroesophageal junction

Cox2 and β-Catenin/T-cell Factor Signaling Intestinalize Human Esophageal Keratinocytes When Cultured under Organotypic Conditions

(2015) Jianping Kong et al.   NEOPLASIA

Cytoplasmic Overexpression of CD95L in Esophageal Adenocarcinoma Cells Overcomes Resistance to CD95-Mediated Apoptosis

(2015) Gregory A. Watson et al.   NEOPLASIA

Loss of TGF-  Adaptor  2SP Activates Notch Signaling and SOX9 Expression in Esophageal Adenocarcinoma

(2013) S. Song et al.   CANCER RESEARCH

Sex-specific associations between body mass index, waist circumference and the risk of Barrett's oesophagus: a pooled analysis from the international BEACON consortium

(2013) Ai Kubo et al.   GUT

Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity

(2013) Austin M Dulak et al.   NATURE GENETICS

Sox9 drives columnar differentiation of esophageal squamous epithelium: a possible role in the pathogenesis of Barrett's esophagus

(2012) Nicholas J. Clemons et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The Crosstalk of mTOR/S6K1 and Hedgehog Pathways

(2012) Yan Wang et al.   CANCER CELL

Bile Acid and Inflammation Activate Gastric Cardia Stem Cells in a Mouse Model of Barrett-Like Metaplasia

(2012) Michael Quante et al.   CANCER CELL

A systematic approach to therapeutic target selection in oesophago-gastric cancer

(2012) Anna L Paterson et al.   GUT

Aberrant p53 protein expression is associated with an increased risk of neoplastic progression in patients with Barrett's oesophagus

(2012) Florine Kastelein et al.   GUT

Body mass index in relation to oesophageal and oesophagogastric junction adenocarcinomas: a pooled analysis from the International BEACON Consortium

(2012) C. Hoyo et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Notch signaling pathway and Cdx2 expression in the development of Barrett's esophagus

(2012) Yuji Tamagawa et al.   LABORATORY INVESTIGATION

Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus

(2012) Zhan Su et al.   NATURE GENETICS

Deoxycholic acid causes DNA damage while inducing apoptotic resistance through NF-κB activation in benign Barrett's epithelial cells

(2011) Xiaofang Huo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

HER-2/neu Gene Amplification in Esophageal Adenocarcinoma and Its Influence on Survival

(2011) Sarah K. Thompson et al.   ANNALS OF SURGICAL ONCOLOGY

Dysfunctional transforming growth factor-β signaling with constitutively active notch signaling in Barrett's esophageal adenocarcinoma

(2011) Jonathan Mendelson et al.   CANCER

The Axl receptor tyrosine kinase is an adverse prognostic factor and a therapeutic target in esophageal adenocarcinoma

(2011) Alvarez Hector et al.   CANCER BIOLOGY & THERAPY

Interactions between genetic polymorphisms in the apoptotic pathway and environmental factors on esophageal adenocarcinoma risk

(2011) I-Chen Wu et al.   CARCINOGENESIS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

DNA methylation profiling in Barrett’s esophagus and esophageal adenocarcinoma reveals unique methylation signatures and molecular subclasses

(2011) Andrew M. Kaz et al.   Epigenetics

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Association of insulin and insulin-like growth factors with Barrett's oesophagus

(2011) Katarina B Greer et al.   GUT

Development and characterization of an organotypic model of Barrett's esophagus

(2011) Rachelle E. Kosoff et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Activation of the BMP4 Pathway and Early Expression of CDX2 Characterize Non-specialized Columnar Metaplasia in a Human Model of Barrett’s Esophagus

(2011) Daniel Castillo et al.   JOURNAL OF GASTROINTESTINAL SURGERY

Functional single-nucleotide polymorphism of epidermal growth factor is associated with the development of Barrett's esophagus and esophageal adenocarcinoma

(2011) Vivianda Menke et al.   JOURNAL OF HUMAN GENETICS

Risk of Malignant Progression in Barrett's Esophagus Patients: Results from a Large Population-Based Study

(2011) S. Bhat et al.   JNCI-Journal of the National Cancer Institute

Aspirin in the prevention of cancer

(2011) Janusz Jankowski et al.   LANCET

HER2 amplification, overexpression and score criteria in esophageal adenocarcinoma

(2011) Yingchuan Hu et al.   MODERN PATHOLOGY

Incidence of Adenocarcinoma among Patients with Barrett's Esophagus

(2011) Frederik Hvid-Jensen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Widespread Hypomethylation Occurs Early and Synergizes with Gene Amplification during Esophageal Carcinogenesis

(2011) Hector Alvarez et al.   PLoS Genetics

Induction of MUC5AC mucin by conjugated bile acids in the esophagus involves the phosphatidylinositol 3-kinase/protein kinase C/activator protein-1 pathway

(2010) Shumei Song et al.   CANCER

Gene expression alterations in formalin-fixed, paraffin-embedded Barrett esophagus and esophageal adenocarcinoma tissues.

(2010) Natalia K. Botelho et al.   CANCER BIOLOGY & THERAPY

Esophageal Adenocarcinoma Incidence: Are We Reaching the Peak?

(2010) H. Pohl et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

A Comprehensive Survey of Clonal Diversity Measures in Barrett's Esophagus as Biomarkers of Progression to Esophageal Adenocarcinoma

(2010) L. M. F. Merlo et al.   Cancer Prevention Research

Epidermal Growth Factor Receptor and Mutant p53 Expand an Esophageal Cellular Subpopulation Capable of Epithelial-to-Mesenchymal Transition through ZEB Transcription Factors

(2010) S. Ohashi et al.   CANCER RESEARCH

Combinatorial Chemoprevention Reveals a Novel Smoothened-Independent Role of GLI1 in Esophageal Carcinogenesis

(2010) S. Rizvi et al.   CANCER RESEARCH

R428, a Selective Small Molecule Inhibitor of Axl Kinase, Blocks Tumor Spread and Prolongs Survival in Models of Metastatic Breast Cancer

(2010) S. J. Holland et al.   CANCER RESEARCH

A Large-scale genetic association study of esophageal adenocarcinoma risk

(2010) Chen-yu Liu et al.   CARCINOGENESIS

Expression of Sonic hedgehog (SHH) and CDX2 in the columnar epithelium of the lower oesophagus

(2010) Yoshiyuki Yamanaka et al.   DIGESTIVE AND LIVER DISEASE

Esophageal Adenocarcinoma: Treatment Modalities in the Era of Targeted Therapy

(2010) Kaushik Mukherjee et al.   DIGESTIVE DISEASES AND SCIENCES

Conversion of metaplastic Barrett's epithelium into post-mitotic goblet cells by  -secretase inhibition

(2010) V. Menke et al.   Disease Models & Mechanisms

Aberrant Epithelial–Mesenchymal Hedgehog Signaling Characterizes Barrett's Metaplasia

(2010) David H. Wang et al.   GASTROENTEROLOGY

No further increase in the incidence of esophageal adenocarcinoma in Sweden

(2010) Jesper Lagergren et al.   INTERNATIONAL JOURNAL OF CANCER

Insulin-like growth factor-1 receptor as a novel prognostic marker and its implication as a cotarget in the treatment of human adenocarcinoma of the esophagus

(2010) Tatyana Kalinina et al.   INTERNATIONAL JOURNAL OF CANCER

Barrett's esophagus

(2010) Wayne A Phillips et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Bile Salts Differentially Sensitize Esophageal Squamous Cells to CD95 (Fas/Apo-1 Receptor) Mediated Apoptosis

(2010) Sanjay Naran et al.   JOURNAL OF SURGICAL RESEARCH

Verification and Unmasking of Widely Used Human Esophageal Adenocarcinoma Cell Lines

(2010) Jurjen J. Boonstra et al.   JNCI-Journal of the National Cancer Institute

Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial

(2010) Yung-Jue Bang et al.   LANCET

Serum Leptin and Adiponectin Levels and Risk of Barrett's Esophagus and Intestinal Metaplasia of the Gastroesophageal Junction

(2010) Olivia M. Thompson et al.   Obesity

Exploring the Association Between Elevated Body Mass Index and Barrett's Esophagus: A Systematic Review and Meta-Analysis

(2009) Paresh Kamat et al.   ANNALS OF THORACIC SURGERY

Deoxycholate induces COX-2 expression via Erk1/2-, p38-MAPK and AP-1-dependent mechanisms in esophageal cancer cells

(2009) Eileen Looby et al.   BMC CANCER

A polymorphic variant of the insulin-like growth factor type I receptor gene modifies risk of obesity for esophageal adenocarcinoma

(2009) Kimberley Macdonald et al.   Cancer Epidemiology

Unlike Esophageal Squamous Cells, Barrett's Epithelial Cells Resist Apoptosis by Activating the Nuclear Factor- B Pathway

(2009) K. Hormi-Carver et al.   CANCER RESEARCH

P53 and Ki-67 overexpression in gastroesophageal reflux disease - Barrett's esophagus and adenocarcinoma sequence

(2009) M. Binato et al.   DISEASES OF THE ESOPHAGUS

p53 Arg72Pro, MDM2 T309GandCCND1 G870Apolymorphisms are not associated with susceptibility to esophageal adenocarcinoma

(2009) G. Liu et al.   DISEASES OF THE ESOPHAGUS

Survival Trends in Patients With Gastric and Esophageal Adenocarcinomas: A Population-Based Study

(2009) Sarah J. Crane et al.   MAYO CLINIC PROCEEDINGS

Insulin-like growth factor type I receptor gene expression and obesity in esophageal adenocarcinoma

(2009) Ronghua Zhao et al.   MOLECULAR CARCINOGENESIS

Increased p53 Expression in the Malignant Transformation of Barrett’s Esophagus is Accompanied by an Upward Shift of the Proliferative Compartment

(2009) Istvan Hritz et al.   PATHOLOGY & ONCOLOGY RESEARCH

Pathogenesis of Barrett's esophagus: Bile acids inhibit the Notch signaling pathway with induction of CDX2 gene expression in human esophageal cells

(2009) David J. Morrow et al.   SURGERY

Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno- or squamous cell carcinoma

(2009) Jón O Kristinsson et al.   WORLD JOURNAL OF GASTROENTEROLOGY

A Pilot Study of the Association of Low Plasma Adiponectin and Barrett's Esophagus

(2008) Joel H. Rubenstein et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Barrett Esophagus

(2008) Aoife M. Ryan et al.   ANNALS OF SURGERY

Met expression is an independent prognostic risk factor in patients with oesophageal adenocarcinoma

(2008) J B Tuynman et al.   BRITISH JOURNAL OF CANCER

Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Gene Polymorphisms and Risk of Reflux Esophagitis, Barrett's Esophagus, and Esophageal Adenocarcinoma

(2008) H. R. Ferguson et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Gains and Amplifications of c-myc, EGFR, and 20.q13 Loci in the No Dysplasia-Dysplasia-Adenocarcinoma Sequence of Barrett's Esophagus

(2008) A. M. Rygiel et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Bile Acid Exposure Up-regulates Tuberous Sclerosis Complex 1/Mammalian Target of Rapamycin Pathway in Barrett's-Associated Esophageal Adenocarcinoma

(2008) C.-J. Yen et al.   CANCER RESEARCH

Oncogene Addiction

(2008) I. B. Weinstein et al.   CANCER RESEARCH

Genome-Wide Copy Number Analysis in Esophageal Adenocarcinoma Using High-Density Single-Nucleotide Polymorphism Arrays

(2008) D. J. Nancarrow et al.   CANCER RESEARCH

Genetic polymorphisms of VEGF, interactions with cigarette smoking exposure and esophageal adenocarcinoma risk

(2008) R. Zhai et al.   CARCINOGENESIS

A Functional Epidermal Growth Factor (EGF) Polymorphism, EGF Serum Levels, and Esophageal Adenocarcinoma Risk and Outcome

(2008) M. Lanuti et al.   CLINICAL CANCER RESEARCH

Individual crypt genetic heterogeneity and the origin of metaplastic glandular epithelium in human Barrett's oesophagus

(2008) S J Leedham et al.   GUT

Ski/SnoN expression in the sequence metaplasia-dysplasia-adenocarcinoma of Barrett's esophagus

(2008) Vincenzo Villanacci et al.   HUMAN PATHOLOGY

Serum Adiponectin Levels in Patients with Esophageal Cancer

(2008) A. Yildirim et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

Globular adiponectin, acting via adiponectin receptor-1, inhibits leptin-stimulated oesophageal adenocarcinoma cell proliferation

(2008) Olorunseun O. Ogunwobi et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Glycine-extended gastrin stimulates proliferation via JAK2- and Akt-dependent NF-κB activation in Barrett’s oesophageal adenocarcinoma cells

(2008) Olorunseun O. Ogunwobi et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The bile acid deoxycholic acid has a non-linear dose response for DNA damage and possibly NF- B activation in oesophageal cells, with a mechanism of action involving ROS

(2008) G. J. S. Jenkins et al.   MUTAGENESIS

Cdx1 and c-Myc Foster the Initiation of Transdifferentiation of the Normal Esophageal Squamous Epithelium toward Barrett's Esophagus

(2008) Douglas B. Stairs et al.   PLoS One

Reconstitution of stratified murine and human oesophageal epithelia in anin vivotransplant culture system

(2008) Daniel Croagh et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Overexpression of Slug is associated with malignant progression of esophageal adenocarcinoma

(2008) Paras Jethwa et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Expression of prostaglandin E synthase in Barrett’s cancer

(2007) B. H. A. von Rahden et al.   DISEASES OF THE ESOPHAGUS

Activation of MUC1 mucin expression by bile acids in human esophageal adenocarcinomatous cells and tissues is mediated by the phosphatidylinositol 3-kinase

(2007) Christophe Mariette et al.   SURGERY