Article
Clinical Neurology
Laura Diaz-Marugan, Mattia Gallizioli, Leonardo Marquez-Kisinousky, Silvia Arboleya, Annalaura Mastrangelo, Francisca Ruiz-Jaen, Jordi Pedragosa, Climent Casals, Francisco Javier Morales, Sara Ramos-Romero, Sara Traserra, Carles Justicia, Miguel Gueimonde, Marcel Jimenez, Josep Lluis Torres, Xabier Urra, Angel Chamorro, David Sancho, Clara G. de los Reyes-Gavilan, Francesc Miro-Mur, Anna M. Planas
Summary: Severe stroke patients often experience respiratory and urinary tract infections. This is mainly due to opportunistic commensal bacteria translocating from the gut. This study investigated the mechanisms behind gut dysbiosis and poststroke infection.
Article
Pharmacology & Pharmacy
Fei Tong, Ji-xing Zhao, Zi-yuan Fang, Xiao-teng Cui, Dong-yuan Su, Xing Liu, Jun-hu Zhou, Guang-xiu Wang, Zhi-jun Qiu, Shi-zhong Liu, Jun-qi Fu, Chun-sheng Kang, Jia-chong Wang, Qi-xue Wang
Summary: Based on CRISPR-Cas9 library screening, we found that MUC1-C is essential for EGFRvIII glioma cell survival and TMZ resistance. By inhibiting the NF-kappa B pathway, EPIC-1027 disrupts the EGFRvIII-MUC1-C positive feedback loop, inhibits glioma progression, and increases sensitivity to TMZ.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Bo Shen, Cui Zhou, Tianyi Gu, Zhenyang Shen, Yuecheng Guo, Weiming Dai, Yang Liu, Jie Zhang, Lungen Lu, Hui Dong
Summary: The study suggests that Kuhuang plays a protective role during the progression of liver fibrosis by altering the composition of the gut microbiota, activating interferon signaling, and inhibiting bile acid synthesis in the liver.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Mukulika Bose, Priyanka Grover, Alexa J. Sanders, Ru Zhou, Mohammad Ahmad, Sophia Shwartz, Priyanka Lala, Sritama Nath, Mahboubeh Yazdanifar, Cory Brouwer, Pinku Mukherjee
Summary: This study finds that MUC1 plays a significant role in the development of pancreatic ductal adenocarcinoma (PDA). Overexpression of MUC1 activates the JNK pathway and increases cell viability. Conversely, low expression of MUC1 allows TGF-beta to retain its tumor-suppressive function. These findings contribute to a better understanding of the mechanisms behind PDA development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Physiology
Mohammad M. Al-bataineh, Carol L. Kinlough, Zaichuan Mi, Edwin K. Jackson, Stephanie M. Mutchler, David R. Emlet, John A. Kellum, Rebecca P. Hughey
Summary: The study showed that MUC1 protects the activity of KIM-1 post-kidney injury, preserving its anti-inflammatory effects and promoting efferocytosis by inhibiting KIM-1 cleavage. This finding provides a new therapeutic direction for treating kidney diseases.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Sinah Reiter, Andreas Dunkel, Corinna Dawid, Thomas Hofmann
Summary: Bile acids are increasingly investigated as markers for various diseases in humans and animals. A high-throughput workflow was used for bile acid analysis in animal studies, mapping complex bile acid profiles in tissues and body fluids. This method can also be used for screening food and studying the bioavailability of bile acids in the GI tract.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Jing Zhong, Xiaofang He, Xinxin Gao, Qiaohong Liu, Yu Zhao, Ying Hong, Weize Zhu, Juan Yan, Yifan Li, Yan Li, Ningning Zheng, Yiyang Bao, Hao Wang, Junli Ma, Wenjin Huang, Zekun Liu, Yuanzhi Lyu, Xisong Ke, Wei Jia, Cen Xie, Yiyang Hu, Lili Sheng, Houkai Li
Summary: Nonalcoholic fatty liver disease (NAFLD) is associated with disrupted bile acid homeostasis. The authors demonstrate that hyodeoxycholic acid (HDCA) ameliorates NAFLD by inhibiting the formation of RAN/CRM1/PPARα nuclear export heterotrimer, which leads to increased nuclear localization of PPARα and activation of fatty acid oxidation.
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
Yanhua Zhang, Baoyu He, Dong Zhang, Yifan Zhang, Chengkun Chen, Wenye Zhang, Shiyi Yang, Meilian Yao, Gaoping Cui, Jun Gu, Ting Wang, Zhang Lin, Youben Fan, Zuquan Xiong, Yujun Hao
Summary: PI3K regulatory subunit p85 normally stabilizes and regulates catalytic subunit p110 in the cytoplasm. Recent studies reveal that p85 without p110 in the nucleus plays important roles in biological processes. However, the mechanisms of p85 translocation into the nucleus are still unclear. In this study, we describe the mechanism by which p850 translocates into the nucleus to promote ccRCC tumorigenesis. Phosphorylation of p850 at Y464 by FAK facilitates its nuclear translocation in the kidney through enhancing p850 binding to KPNA1. PIK3R2/p850 is highly expressed in ccRCC samples and is associated with overall survival of ccRCC patients. Nuclear, but not cytoplasmic, p850 functions as an oncogene by repressing RB1 expression and regulating the G1/S cell cycle transition. Nuclear p850 represses RB1 expression by stabilizing histone methyltransferase EZH1/EZH2 proteins. Lastly, the FAK inhibitor defactinib significantly suppresses tumor growth in ccRCC with high p850 Y464 levels.
Article
Biochemistry & Molecular Biology
Yanyan Wang, Yun-Ling Tai, Grayson Way, Jing Zeng, Derrick Zhao, Lianyong Su, Xixian Jiang, Kaitlyn G. Jackson, Xuan Wang, Emily C. Gurley, Jinze Liu, Jinpeng Liu, Weidong Chen, Xiang-Yang Wang, Arun J. Sanyal, Phillip B. Hylemon, Huiping Zhou
Summary: This study investigated the role of hepatocyte-specific HuR in regulating hepatic lipid metabolism and found that HuR deficiency leads to increased hepatic lipid accumulation, inflammation, disrupted bile acid homeostasis, and enhanced liver fibrosis. Additionally, HuR was identified as a repressor of H19 expression, and the downregulation of H19 alleviated NAFLD in mice with HuR deficiency.
CELL AND BIOSCIENCE
(2022)
Article
Oncology
Zhou Lan, Ke-Long Zou, Hao Cui, Yu-Yue Zhao, Guang-Tao Yu
Summary: Porphyromonas gingivalis, an oral bacteria, can suppress the growth of oral squamous cell carcinoma by inducing cell cycle arrest, suppressing mucin and chemokine expression, and reversing the immunosuppressive tumor microenvironment.
MOLECULAR ONCOLOGY
(2023)
Article
Toxicology
Jingxuan Wang, Wouter Bakker, Weijia Zheng, Laura de Haan, Ivonne M. C. M. Rietjens, Hans Bouwmeester
Summary: This study found that deoxynivalenol (DON) inhibits the reabsorption of bile acids in the intestines by reducing the expression of bile acid transporters. This has an impact on the metabolism of bile acids in the intestines. The results of this study provide new insights into the hazards of DON exposure.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Endocrinology & Metabolism
Karin H. U. Meier, Julian Trouillon, Hai Li, Melanie Lang, Tobias Fuhrer, Nicola Zamboni, Shinichi Sunagawa, Andrew J. Macpherson, Uwe Sauer
Summary: Anatomically resolved maps of small molecules reveal distinct spatial patterns throughout the gut of colonized and germ-free mice, which can be associated with specific microorganisms. The map of the longitudinal metabolome in the gut of healthy mice shows a shift from amino acids to organic acids, vitamins, and nucleotides along the gut. Comparisons between colonized and germ-free mice help identify the origin of metabolites and suggest specific microbial influence on the metabolome.
Article
Gastroenterology & Hepatology
Fu-Wei Zhang, Xiao-Wei Xie, Meng-Hua Chen, Jian Tong, Qun-Qing Chen, Jing Feng, Feng-Ti Chen, Wen-Qi Liu
Summary: The study investigates the relationship between PARN and the proliferation, migration, and invasion of EC cells. The expression of PARN in EC tissues was found to be higher compared to adjacent normal tissues, and its level was positively correlated with lymphatic metastasis. High PARN levels were associated with poor overall survival. Knocking out the PARN gene led to increased apoptosis and inhibited tumor growth, invasion, and migration in EC cells, both in vitro and in vivo. The findings suggest that PARN plays a role in the development of EC and may be a potential target for diagnosis, prognosis prediction, and treatment.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Cell Biology
Karthikeyani Chellappa, Melanie R. McReynolds, Wenyun Lu, Xianfeng Zeng, Mikhail Makarov, Faisal Hayat, Sarmistha Mukherjee, Yashaswini R. Bhat, Siddharth R. Lingala, Rafaella T. Shima, Helene C. Descamps, Timothy Cox, Lixin Ji, Connor Jankowski, Qingwei Chu, Shawn M. Davidson, Christoph A. Thaiss, Marie E. Migaud, Joshua D. Rabinowitz, Joseph A. Baur
Summary: Nicotinamide adenine dinucleotide (NAD) is an essential cofactor in mammals and microbes. This study reveals the ability of host micronutrients to support NAD synthesis in the gut microbiome and enhance host metabolic flexibility.
Article
Biochemistry & Molecular Biology
Yong-Fei Zhou, Jiaojiao Nie, Chao Shi, Wei-Wei Zheng, Ke Ning, Jing Kang, Ji-Xiang Sun, Xiaoqiang Cong, Qiuhong Xie, Hongyu Xiang
Summary: A natural polysaccharide purified from Lysimachia christinae was fed to high-fat diet mice, resulting in altered gut microbiota and bile acid pool, reduced cholesterol and triglyceride levels, and enhanced bile acid synthesis. The effects of the polysaccharide were microbiota-dependent.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Letter
Oncology
Frederiek Nuytens, Thibault Voron, Guillaume Piessen
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Lucie Gehenne, Veronique Christophe, Clarisse Eveno, Aurelien Carnot, Anthony Turpin, Diane Pannier, Guillaume Piessen, Sophie Lelorain
Summary: The study aimed to develop and test the validity of video-vignettes manipulating empathy and context in oncology, with results showing that these video-vignettes are valid for experimental use. Differences in assessments of validity were found between lay people and patients in some cases. The study also found that patients' assessments are impacted by their personal experiences, suggesting the need for researchers to control for this in analog patient studies.
PATIENT EDUCATION AND COUNSELING
(2021)
Article
Gastroenterology & Hepatology
Sebastien Degisors, Robert Caiazzo, Safi Dokmak, Stephanie Truant, Beatrice Aussilhou, Clarisse Eveno, Francois Pattou, Mehdi El Amrani, Guillaume Piessen, Alain Sauvanet
Summary: This study reported the incidence of delayed gastric emptying (DGE) following elective distal pancreatectomy (DP) and identified age, surgical approach, and postoperative pancreatic fistula (POPF) grade B-C as predisposing factors for DGE. DGE significantly increased the length of hospital stay. The study suggests that laparoscopic approach and prevention of POPF should be encouraged to reduce the incidence of DGE.
Article
Chemistry, Analytical
Momoko Kumemura, Deniz Pekin, Vivek Anand Menon, Isabelle Van Seuningen, Dominique Collard, Mehmet Cagatay Tarhan
Summary: This paper explores the use of microtechnologies in the fields of biology and medicine, highlighting the untapped potential of silicon-based microelectromechanical systems. Innovative fabrication processes and experimental approaches have addressed performance issues of silicon-based microelectromechanical resonators and actuators in liquid environments.
Article
Oncology
Marine Goujon, Justine Woszczyk, Kelly Gaudelot, Thomas Swierczewski, Sandy Fellah, Jean-Baptiste Gibier, Isabelle Van Seuningen, Romain Larrue, Christelle Cauffiez, Viviane Gnemmi, Sebastien Aubert, Nicolas Pottier, Michael Perrais
Summary: Clear cell renal cell carcinoma (ccRCC) is a highly resistant type of kidney cancer with abnormal lipid accumulation. This study reveals a double-negative feedback interaction between miR-21 and PPAR-alpha, suggesting that miR-21 silencing could restore PPAR-alpha expression and inhibit the oncogenic events mediated by abnormal lipid metabolism in ccRCC.
Article
Oncology
Nihad Boukrout, Mouloud Souidi, Fatima Lahdaoui, Belinda Duchene, Bernadette Neve, Lucie Coppin, Emmanuelle Leteurtre, Jerome Torrisani, Isabelle Van Seuningen, Nicolas Jonckheere
Summary: This study identified a MUC4-miR-210-3p negative feedback loop in early-onset PDAC and revealed new functions of miR-210-3p in proliferation and migration of pancreatic cancer cells in vitro and in vivo, indicating a complex balance between MUC4 pro-oncogenic roles and miR-210-3p anti-tumoral effects.
Article
Oncology
Nicolas Stoup, Maxime Liberelle, Celine Schulz, Sumeyye Cavdarli, Romain Vasseur, Romain Magnez, Fatima Lahdaoui, Nicolas Skrypek, Fabien Peretti, Frederic Frenois, Xavier Thuru, Patricia Melnyk, Nicolas Renault, Nicolas Jonckheere, Nicolas Lebegue, Isabelle Van Seuningen
Summary: This study elucidated the molecular interaction between MUC4 and HER2 in pancreatic cancer cells, revealing the impact of MUC4's EGF domains on the binding affinities with HER2 and tumorigenicity of PC cells. The findings provide insights into potential MUC4/HER2 inhibitors targeting the EGF domains of MUC4 as a new therapeutic strategy for cancers with MUC4/HER2 overexpression and HER2-targeted therapy resistance.
Article
Oncology
Thierry Andre, David Tougeron, Guillaume Piessen, Christelle de la Fouchardiere, Christophe Louvet, Antoine Adenis, Marine Jary, Christophe Tournigand, Thomas Aparicio, Jerome Desrame, Astrid Lievre, Marie-Line Garcia-Larnicol, Thomas Pudlarz, Romain Cohen, Salome Memmi, Dewi Vernerey, Julie Henriques, Jeremie H. Lefevre, Magali Svrcek
Summary: The NEONIPIGA study found that perioperative platinum-based chemotherapy is the standard treatment for resectable gastric/gastroesophageal junction (GEJ) adenocarcinoma. However, the efficacy of perioperative chemotherapy in gastric/GEJ adenocarcinoma with deficient mismatch repair (dMMR)/microsatellite instability-high (MSI-H) remains debatable. This study showed that neoadjuvant nivolumab-based therapy is feasible, associated with no unexpected toxicity, and has a high pathological complete response (pCR) rate in patients with dMMR/MSI-H resectable gastric/GEJ adenocarcinoma.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Cell Biology
Julie Auwercx, Philippe Kischel, Thibaut Lefebvre, Nicolas Jonckheere, Alison Vanlaeys, Stephanie Guenin, Silviya Radoslavova, Isabelle Van Seuningen, Halima Ouadid-Ahidouch, Hemant M. Kocher, Isabelle Dhennin-Duthille, Mathieu Gautier
Summary: Pancreatic diseases are characterized by activated pancreatic stellate cells (PSCs), which play important roles in tumor stroma. TRPM7 channels have been found to regulate the activation and proliferation of PSCs, and the expression of TRPM7 is associated with the activation status of PSCs.
Article
Gastroenterology & Hepatology
Mathias Brugel, Thibault Marulier, Camille Evrard, Claire Carlier, David Tougeron, Guillaume Piessen, Stephanie Truant, Anthony Turpin, Nicolas Williet, Damien Botsen, Mathilde Brasseur, Marine Perrier, Olivier Bouche
Summary: This study investigated the genetic counselling referral practices for pancreatic adenocarcinoma (PA) in France and assessed the implementation of international guidelines. The results showed inadequate referral for genetic counselling, with a significant portion of patients not receiving the recommended counselling despite indications. The study also identified factors influencing the referral, including suspected CDKN2A or BRCA mutations, familial pancreatic cancer history, and controlled disease with first-line platinum-based chemotherapy, while older age and locally advanced PA decreased the likelihood of referral.
Article
Surgery
Maxime Laydi, Alexandre Doussot, Zaher Lakkis, Pierre Mathieu, Anne Gandon, Louis Martin, Bruno Heyd, Guillaume Piessen
Summary: The presentation of anastomotic leakage after Ivor Lewis esophagectomy can vary on imaging, and these anatomical patterns may influence the management and outcomes of the leakage.
Article
Medicine, General & Internal
Timo Hess, Carlo Maj, Jan Gehlen, Oleg Borisov, Stephan L. Haas, Ines Gockel, Michael Vieth, Guillaume Piessen, Hakan Alakus, Yogesh Vashist, Carina Pereira, Michael Knapp, Vitalia Schueller, Alexander Quaas, Heike I. Grabsch, Jessica Trautmann, Ewa Malecka-Wojciesko, Anna Mokrowiecka, Jan Speller, Andreas Mayr, Julia Schroeder, Axel M. Hillmer, Dominik Heider, Florian Lordick, Angeles Perez-Aisa, Rafael Campo, Jesus Espinel, Fernando Geijo, Concha Thomson, Luis Bujanda, Federico Sopena, Angel Lanas, Maria Pellise, Claudia Pauligk, Thorsten Oliver Goetze, Carolin Zelck, Julian Reingruber, Emadeldin Hassanin, Peter Elbe, Sandra Alsabeah, Mats Lindblad, Magnus Nilsson, Nicole Kreuser, Rene Thieme, Francesca Tavano, Roberta Pastorino, Dario Arzani, Roberto Persiani, Jin-On Jung, Henrik Nienhueser, Katja Ott, Ralf R. Schumann, Oliver Kumpf, Susen Burock, Volker Arndt, Anna Jakubowska, Malgorzta Lawniczak, Justyna Dabrowska, Olivier Cussenot, Anne Boland-Auge, Delphine Daian, Jean-Francois Deleuze, Erika Salvi, Maris Teder-Laving, Gianluca Tomasello, Margherita Ratti, Chiara Senti, Valli De Re, Agostino Steffan, Arnulf H. Hoelscher, Katharina Messerle, Christiane Josephine Bruns, Armands Sivins, Inga Bogdanova, Jurgita Skieceviciene, Justina Arstikyte, Markus Moehler, Hauke Lang, Peter P. Grimminger, Martin Kruschewski, Nikolaos Vassos, Claus Schildberg, Philipp Lingohr, Karsten Ridwelski, Hans Lippert, Nadine Fricker, Peter Krawitz, Per Hoffmann, Markus M. Noethen, Lothar Veits, Jakob R. Izbicki, Adrianna Mostowska, Federico Martinon-Torres, Daniele Cusi, Rolf Adolfsson, Geraldine Cancel-Tassin, Aksana Hoeblinger, Ernst Rodermann, Monika Ludwig, Gisela Keller, Andres Metspalu, Hermann Brenner, Joerg Heller, Markus Neef, Michael Schepke, Franz Ludwig Dumoulin, Lutz Hamann, Renato Cannizzaro, Michele Ghidini, Dominik Plassmann, Michael Geppert, Peter Malfertheiner, Olivier Gehlen, Tomasz Skoczylas, Marek Majewski, Jan Lubinski, Orazio Palmieri, Stefania Boccia, Anna Latiano, Nuria Aragones, Thomas Schmidt, Mario Dinis-Ribeiro, Rui Medeiros, Salah-Eddin Al-Batran, Marcis Leja, Juozas Kupcinskas, Maria A. Garcia-Gonzalez, Marino Venerito, Johannes Schumachera
Summary: This study characterized the genetic risk architecture of gastric cancer (GC) and its subtypes, and found that GC is genetically heterogenous. It also revealed the shared genetic aetiology between cardia GC and oesophageal adenocarcinoma (OAC) and its precursor lesion Barrett's oesophagus (BO).
Article
Oncology
Caroline Gronnier, Christophe Mariette, Come Lepage, Carole Monterymard, Marine Jary, Aurelie Ferru, Mathieu Baconnier, Xavier Adhoute, David Tavan, Herve Perrier, Veronique Guerin-Meyer, Cedric Lecaille, Nathalie Bonichon-Lamichhane, Didier Pillon, Oana Cojocarasu, Joelle Egreteau, Xavier Benoit D'journo, Laetitia Dahan, Christophe Locher, Patrick Texereau, Denis Collet, Pierre Michel, Meher Ben Abdelghani, Rosine Guimbaud, Marie Muller, Olivier Bouche, Guillaume Piessen
Summary: The efficacy and safety of perioperative cetuximab combined with 5-fluorouracil and cisplatin for the treatment of gastric and esophageal adenocarcinoma was evaluated in this study. The results showed safety but lack of efficacy in terms of objective tumor response and major toxicity.
Review
Oncology
Sullivan Fontesse, Valentyn Fournier, Pierre Gerain, Charlotte Dassonneville, Sophie Lelorain, Christelle Duprez, Veronique Christophe, Guillaume Piessen, Delphine Grynberg
Summary: This study conducted a systematic review and meta-analysis to identify the positive affect associated with mortality in cancers. The findings suggest that positive affect is linked to longer survival and lower mortality. Emotional and physical well-being, optimism, and vitality are the main predictors of survival.
Review
Endocrinology & Metabolism
Arnaud Jannin, Anne-Frederique Dessein, Christine Do Cao, Marie-Christine Vantyghem, Benjamin Chevalier, Isabelle Van Seuningen, Nicolas Jonckheere, Lucie Coppin
Summary: Reprogramming of cellular metabolism is a hallmark of tumorigenesis. In this review, the metabolic pathways in pancreatic neuroendocrine tumors (pNETs) were investigated by analyzing transcriptomic and metabolomic data. Dysregulations in one-carbon, glutathione, and polyamine metabolisms, fatty acid biosynthesis, and branched-chain amino acid catabolism were identified in pNETs, which are implicated in cell proliferation and metastasis and could potentially serve as prognostic biomarkers or therapeutic targets.
FRONTIERS IN ENDOCRINOLOGY
(2023)