Signaling pathways in renal cell carcinoma

Sunitinib Acts Primarily on Tumor Endothelium rather than Tumor Cells to Inhibit the Growth of Renal Cell Carcinoma

(2010) D. Huang et al.   CANCER RESEARCH

Everolimus

(2010) P. J. Houghton   CLINICAL CANCER RESEARCH

Carbonic Anhydrase IX in Renal Cell Carcinoma: Implications for Prognosis, Diagnosis, and Therapy

(2010) Alexander B. Stillebroer et al.   EUROPEAN UROLOGY

Pazopanib in Locally Advanced or Metastatic Renal Cell Carcinoma: Results of a Randomized Phase III Trial

(2010) Cora N. Sternberg et al.   JOURNAL OF CLINICAL ONCOLOGY

Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

(2010) Gillian L. Dalgliesh et al.   NATURE

The genetic basis of kidney cancer: a metabolic disease

(2010) W. Marston Linehan et al.   Nature Reviews Urology

Vascular endothelial growth factor and mTOR pathways in renal cell carcinoma: differences and synergies of two targeted mechanisms

(2009) Peter Mulders   BJU INTERNATIONAL

Wnt antagonist gene polymorphisms and renal cancer

(2009) Hiroshi Hirata et al.   CANCER

Functional Significance of Wnt Inhibitory Factor-1 Gene in Kidney Cancer

(2009) K. Kawakami et al.   CANCER RESEARCH

Patterns of Gene Expression and Copy-Number Alterations in von-Hippel Lindau Disease-Associated and Sporadic Clear Cell Carcinoma of the Kidney

(2009) R. Beroukhim et al.   CANCER RESEARCH

Wnt Antagonist Gene DKK2 Is Epigenetically Silenced and Inhibits Renal Cancer Progression through Apoptotic and Cell Cycle Pathways

(2009) H. Hirata et al.   CLINICAL CANCER RESEARCH

Novel Therapeutic Inhibitors of the c-Met Signaling Pathway in Cancer

(2009) J. P. Eder et al.   CLINICAL CANCER RESEARCH

Metastatic Renal Cell Carcinoma: Recent Advances in the Targeted Therapy Era

(2009) Giuseppe Di Lorenzo et al.   EUROPEAN UROLOGY

Targeting the Met signaling pathway in renal cancer

(2009) Alessio Giubellino et al.   Expert Review of Anticancer Therapy

Mechanisms of the epithelial–mesenchymal transition by TGF-β

(2009) Michael K Wendt et al.   Future Oncology

Hypoxia-inducible Factor-1-mediated Regulation of Semaphorin 4D Affects Tumor Growth and Vascularity

(2009) Qiangming Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting the mTOR Signaling Network for Cancer Therapy

(2009) Funda Meric-Bernstam et al.   JOURNAL OF CLINICAL ONCOLOGY

CpG methylation profiling in VHL related and VHL unrelated renal cell carcinoma

(2009) Fiona E McRonald et al.   Molecular Cancer

Hypoxia-Inducible mir-210 Regulates Normoxic Gene Expression Involved in Tumor Initiation

(2009) Xin Huang et al.   MOLECULAR CELL

Immunotherapeutic strategies in kidney cancer—when TKIs are not enough

(2009) Swethajit Biswas et al.   Nature Reviews Clinical Oncology

Src kinases as therapeutic targets for cancer

(2009) Lori C. Kim et al.   Nature Reviews Clinical Oncology

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

(2009) G L Semenza   ONCOGENE

HIF2  inhibition promotes p53 pathway activity, tumor cell death, and radiation responses

(2009) J. A. Bertout et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

β-catenin gets jaded and von Hippel-Lindau is to blame

(2009) Jason D. Berndt et al.   TRENDS IN BIOCHEMICAL SCIENCES

Identification of a MicroRNA Panel for Clear-cell Kidney Cancer

(2009) David Juan et al.   UROLOGY

HIF-α Effects on c-Myc Distinguish Two Subtypes of Sporadic VHL-Deficient Clear Cell Renal Carcinoma

(2008) John D. Gordan et al.   CANCER CELL

Origin of renal cell carcinomas

(2008) Manuel Valladares Ayerbes et al.   Clinical & Translational Oncology

Single-Agent and Combination Therapeutic Strategies to Inhibit Hepatocyte Growth Factor/MET Signaling in Cancer

(2008) L. Toschi et al.   CLINICAL CANCER RESEARCH

A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells

(2008) Ulrike Burk et al.   EMBO REPORTS

The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2

(2008) S.-M. Park et al.   GENES & DEVELOPMENT

VHL loss of function and its impact on oncogenic signaling networks in clear cell renal cell carcinoma

(2008) W. Marston Linehan et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Genome-wide microRNA expression profiling in renal cell carcinoma: significant down-regulation of miR-141 and miR-200c

(2008) C Nakada et al.   JOURNAL OF PATHOLOGY

Classification of renal cell carcinoma based on expression of VEGF and VEGF receptors in both tumor cells and endothelial cells

(2008) Harriet M Kluger et al.   LABORATORY INVESTIGATION

Jade-1 inhibits Wnt signalling by ubiquitylating β-catenin and mediates Wnt pathway inhibition by pVHL

(2008) Vipul C. Chitalia et al.   NATURE CELL BIOLOGY

Direct regulation of TWIST by HIF-1α promotes metastasis

(2008) Muh-Hwa Yang et al.   NATURE CELL BIOLOGY

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

(2008) Philip A. Gregory et al.   NATURE CELL BIOLOGY

Decreased expression of CXXC4 promotes a malignant phenotype in renal cell carcinoma by activating Wnt signaling

(2008) T Kojima et al.   ONCOGENE