Targeting cytochrome P450-dependent cancer cell mitochondria: cancer associated CYPs and where to find them

MONARCH 2: Abemaciclib in Combination With Fulvestrant in Women With HR+/HER2− Advanced Breast Cancer Who Had Progressed While Receiving Endocrine Therapy

(2017) George W. Sledge et al.   JOURNAL OF CLINICAL ONCOLOGY

Functional screening for G protein-coupled receptor targets of 14,15-epoxyeicosatrienoic acid

(2017) Xuehong Liu et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Role of the CYP3A4-mediated 11,12-epoxyeicosatrienoic acid pathway in the development of tamoxifen-resistant breast cancer

(2017) Nguyen Thi Thuy Phuong et al.   Oncotarget

Are Metformin Doses Used in Murine Cancer Models Clinically Relevant?

(2016) Navdeep S. Chandel et al.   Cell Metabolism

Fulvestrant plus palbociclib versus fulvestrant plus placebo for treatment of hormone-receptor-positive, HER2-negative metastatic breast cancer that progressed on previous endocrine therapy (PALOMA-3): final analysis of the multicentre, double-blind, phase 3 randomised controlled trial

(2016) Massimo Cristofanilli et al.   LANCET ONCOLOGY

CYP450-derived oxylipins mediate inflammatory resolution

(2016) Derek W. Gilroy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain

(2016) Marco Sisignano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The factor in EDHF: Cytochrome P450 derived lipid mediators and vascular signaling

(2016) Ingrid Fleming   VASCULAR PHARMACOLOGY

Efficacy of PD-1 Blockade Is Potentiated by Metformin-Induced Reduction of Tumor Hypoxia

(2016) Nicole E. Scharping et al.   Cancer Immunology Research

Involvement of the arachidonic acid cytochrome P450 epoxygenase pathway in the proliferation and invasion of human multiple myeloma cells

(2016) Jing Shao et al.   PeerJ

Structure-Based Inhibitor Design for Evaluation of a CYP3A4 Pharmacophore Model

(2015) Parminder Kaur et al.   JOURNAL OF MEDICINAL CHEMISTRY

The promise and peril of chemical probes

(2015) Cheryl H Arrowsmith et al.   Nature Chemical Biology

Arachidonic acid monooxygenase: Genetic and biochemical approaches to physiological/pathophysiological relevance

(2015) Jorge H. Capdevila et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Rhythmic expression of cytochrome P450 epoxygenases CYP4x1 and CYP2c11 in the rat brain and vasculature

(2014) Koryn A. Carver et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

CYP3A4 Expression in Breast Cancer and its Association with Risk Factors in Mexican Women

(2014) Esau Floriano-Sanchez et al.   Asian Pacific Journal of Cancer Prevention

Elevated 14,15- epoxyeicosatrienoic acid by increasing of cytochrome P450 2C8, 2C9 and 2J2 and decreasing of soluble epoxide hydrolase associated with aggressiveness of human breast cancer

(2014) Xiaolong Wei et al.   BMC CANCER

Targeting of Splice Variants of Human Cytochrome P450 2C8 (CYP2C8) to Mitochondria and Their Role in Arachidonic Acid Metabolism and Respiratory Dysfunction

(2014) Prachi Bajpai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Targeting of Cytochrome P450 (CYP) 1B1 and Its Role in Polycyclic Aromatic Hydrocarbon-induced Mitochondrial Dysfunction

(2014) Seema Bansal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PPARα Activation Can Help Prevent and Treat Non–Small Cell Lung Cancer

(2013) Nataliya Skrypnyk et al.   CANCER RESEARCH

Role of cytochrome P450 epoxygenase in regulating renal membrane transport and hypertension

(2013) Jorge Capdevila et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis

(2013) G. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stabilized epoxygenated fatty acids regulate inflammation, pain, angiogenesis and cancer

(2013) Guodong Zhang et al.   PROGRESS IN LIPID RESEARCH

Roles of the epoxygenase CYP2J2 in the endothelium

(2013) Ara Askari et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Metformin targets Stat3 to inhibit cell growth and induce apoptosis in triple-negative breast cancers

(2012) Xin-Sheng Deng et al.   CELL CYCLE

Pharmacokinetic and pharmacodynamic interaction between nifedipine and metformin in rats: competitive inhibition for metabolism of nifedipine and metformin by each other via CYP isozymes

(2012) Young H. Choi et al.   XENOBIOTICA

The cytochrome P450 pathway in angiogenesis and endothelial cell biology

(2011) Ingrid Fleming   CANCER AND METASTASIS REVIEWS

EET signaling in cancer

(2011) Dipak Panigrahy et al.   CANCER AND METASTASIS REVIEWS

Comparison of the Inhibitory Profiles of Itraconazole and Cimetidine in Cytochrome P450 3A4 Genetic Variants

(2011) T. Akiyoshi et al.   DRUG METABOLISM AND DISPOSITION

Overexpression of CYP3A4, but not of CYP2D6, Promotes Hypoxic Response and Cell Growth of Hep3B Cells

(2011) Ami Oguro et al.   Drug Metabolism and Pharmacokinetics

CYP3A4 Mediates Growth of Estrogen Receptor-positive Breast Cancer Cells in Part by Inducing Nuclear Translocation of Phospho-Stat3 through Biosynthesis of (±)-14,15-Epoxyeicosatrienoic Acid (EET)

(2011) Ranjana Mitra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epoxyeicosatrienoic acids: a double-edged sword in cardiovascular diseases and cancer

(2011) Dingzhi Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice

(2011) Dipak Panigrahy et al.   JOURNAL OF CLINICAL INVESTIGATION

P-450-dependent epoxygenase pathway of arachidonic acid is involved in myeloma-induced angiogenesis of endothelial cells

(2011) Jing Shao et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

The Human Immunodeficiency Virus Protease Inhibitor Ritonavir Inhibits Lung Cancer Cells, in Part, by Inhibition of Survivin

(2011) Anjaiah Srirangam et al.   Journal of Thoracic Oncology

Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells

(2010) Mahvash Zakikhani et al.   BREAST CANCER RESEARCH AND TREATMENT

Pharmacokinetic interaction between itraconazole and metformin in rats: competitive inhibition of metabolism of each drug by each other via hepatic and intestinal CYP3A1/2

(2010) YH Choi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Itraconazole, a Commonly Used Antifungal that Inhibits Hedgehog Pathway Activity and Cancer Growth

(2010) James Kim et al.   CANCER CELL

Inhibition of carcinoma cell motility by epoxyeicosatrienoic acid (EET) antagonists

(2010) Kasem Nithipatikom et al.   CANCER SCIENCE

An intimate liaison: spatial organization of the endoplasmic reticulum–mitochondria relationship

(2010) Olga Martins de Brito et al.   EMBO JOURNAL

Profiling the expression of cytochrome P450 in breast cancer

(2010) Graeme I Murray et al.   HISTOPATHOLOGY

The Anti-tumorigenic Properties of Peroxisomal Proliferator-activated Receptor α Are Arachidonic Acid Epoxygenase-mediated

(2010) Ambra Pozzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

1-Aryl-3-(1-acylpiperidin-4-yl)urea Inhibitors of Human and Murine Soluble Epoxide Hydrolase: Structure−Activity Relationships, Pharmacokinetics, and Reduction of Inflammatory Pain

(2010) Tristan E. Rose et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cytochrome P450 2J2 Is Highly Expressed in Hematologic Malignant Diseases and Promotes Tumor Cell Growth

(2010) C. Chen et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Esophageal cancer proliferation is mediated by cytochrome P450 2C9 (CYP2C9)

(2010) Moritz Schmelzle et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Analysis of epoxyeicosatrienoic acids by chiral liquid chromatography/electron capture atmospheric pressure chemical ionization mass spectrometry using [13C]-analog internal standards

(2010) Clementina Mesaros et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Overexpression of CYP2J2 provides protection against doxorubicin-induced cardiotoxicity

(2009) Yunfang Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The arachidonic acid epoxygenase is a component of the signaling mechanisms responsible for VEGF-stimulated angiogenesis

(2009) Shiling Yang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Targeted quantitative analysis of eicosanoid lipids in biological samples using liquid chromatography–tandem mass spectrometry

(2009) Clementina Mesaros et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Epoxyeicosatrienoic acids limit damage to mitochondrial function following stress in cardiac cells

(2009) D. Katragadda et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Selective Inhibitors of CYP2J2 Related to Terfenadine Exhibit Strong Activity against Human Cancers in Vitro and in Vivo

(2009) C. Chen et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Oncogenic and cell survival properties of the retinoic acid metabolizing enzyme, CYP26A1

(2009) M Osanai et al.   ONCOGENE

Epoxyeicosatrienoic acids are part of the VEGF-activated signaling cascade leading to angiogenesis

(2008) Anke C. Webler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

An essential role for SRC-activated STAT-3 in 14,15-EET-induced VEGF expression and angiogenesis

(2008) S. Y. Cheranov et al.   BLOOD

Vascular Cytochrome P450 Enzymes: Physiology and Pathophysiology

(2008) Ingrid Fleming   TRENDS IN CARDIOVASCULAR MEDICINE

PPARαLigands as Antitumorigenic and Antiangiogenic Agents

(2008) Ambra Pozzi et al.   PPAR Research