Article
Oncology
Monireh Sadat Seyyedsalehi, Marta Rossi, Maryam Hadji, Hamideh Rashidian, Maryam Marzban, Maria Parpinel, Federica Fiori, Ahmad Naghibzadeh-Tahami, Yusuf A. Hannun, Chiara Luberto, Kazem Zendehdel, Paolo Boffetta
Summary: This study found that dietary betaine, choline, and choline-containing compounds are associated with the risk of colorectal cancer (CRC). Men who consume phosphocholine and sphingomyelin are more likely to develop CRC, while women who consume betaine have a decreased risk. Therefore, modifying the diet to increase betaine intake and managing the consumption of animal products can help reduce the risk of CRC.
Article
Oncology
Qiang Feng, Dongkui Xu, Mingyao Zhou, Zijian Wu, Zhiyuan Wu, Zheng Wang, Jianjun Bi, Wei Pei
Summary: In this study, the role of CDC42EP3 in colorectal cancer (CRC) was investigated. The results showed that CDC42EP3 was significantly upregulated in CRC and its knockdown inhibited proliferation, colony formation, and migration, while promoting apoptosis of CRC cells. Furthermore, in vivo results confirmed that knockdown of CDC42EP3 attenuated tumor growth in CRC, indicating its potential as a target for innovative therapeutic approaches.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Ya'nan Zhen, Guodong Sun, Cunbao Chen, Jianqi Li, Ruixue Xiao, Zhongfa Xu
Summary: This study investigated the role of hsa_circ_0064559 in colorectal cancer (CRC) and found that its knockdown can inhibit cell proliferation and promote apoptosis in vitro, as well as inhibit tumor development in vivo. The study also identified potential genes related to apoptosis and proliferation in CRC cells after hsa_circ_0064559 knockdown. Hsa_circ_0064559 may serve as a potential biomarker for early diagnosis and prognosis of CRC, as well as a novel drug target for CRC therapy.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Zhewen Zheng, Xue Zhang, Jian Bai, Long Long, Di Liu, Yunfeng Zhou
Summary: This study reveals that PGM1 plays a suppressive role in colorectal cancer, inhibiting CRC progression through the PI3K/AKT pathway. These findings suggest the potential of targeting PGM1 for the treatment of CRC.
CANCER CELL INTERNATIONAL
(2022)
Article
Cell Biology
Fei Han, Chao Cheng, Qianqian Xu, Jisong Chen, Zhaohui Yang, Jun Liu
Summary: DEPDC1B is highly expressed in colorectal cancer and has the ability to promote cancer cell proliferation, migration, and apoptosis. In vivo experiments showed that knockdown of DEPDC1B significantly inhibited the growth of xenograft tumors. Additionally, antibody array results revealed increased apoptosis-promoting proteins and decreased apoptosis-inhibiting proteins in DEPDC1B-knockdown colorectal cancer cells. Therefore, DEPDC1B may play a key driver role in colorectal cancer progression, and its inhibition could be a potential therapeutic target for precision medicine in colorectal cancer.
Article
Oncology
Santosh Lamichhane, Ji-Su Mo, Grinsun Sharma, Sun-Myoung Joung, Soo-Cheon Chae
Summary: In this study, it was found that the down-regulation of human microRNA 133A (MIR133A) in colorectal cancer (CRC) tissues could regulate cell proliferation, migration, and apoptosis by targeting the transcription regulator gene SOX9.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
Hang Yuan, Shiliang Tu, Yingyu Ma, Yueming Sun
Summary: Recent studies have shown a close association between long noncoding RNAs (lncRNAs) and colorectal cancer (CRC), with lncRNA RPLP0P2 having unknown role in CRC. Knocking down RPLP0P2 expression in CRC cells led to decreased colony formation, migration, invasion and arrested cell cycle progression, while promoting apoptosis. These findings suggest that RPLP0P2 may act as an oncogene in CRC by promoting proliferation, migration and invasion, and inhibiting apoptosis.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Oncology
Qingan Jia, Xia Liao, Binghui Xu, Yufang Li, Lei Liang
Summary: This study aimed to investigate the level and function of miR-128-1-5p in colorectal cancer (CRC). The results showed that miR-128-1-5p was downregulated in CRC tissues and cell lines, and it inhibited cell proliferation and induced cell apoptosis by targeting PRKCQ.
CANCER BIOLOGY & THERAPY
(2023)
Article
Oncology
Premila D. Leiphrakpam, Audrey J. Lazenby, Lynette M. Smith, Michael G. Brattain, Chandrakanth Are
Summary: The study revealed a correlation between high stathmin expression and CRC metastasis as well as worse prognosis, along with increased cell proliferation. These findings suggest stathmin as a potential marker for increased risk and treatment in CRC patients.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Dong-Ming Lai, Jiang-Jiang Bi, Yong-Hui Chen, Yu-Di Wu, Qing-Wen Huang, Hai-Jie Li, Sheng Zhang, Zheng Fu, Yi-Xin Tong
Summary: This study found that high expression level of CCNI2 in CRC tissues and cell lines was associated with poor prognosis, and knockdown of CCNI2 gene could inhibit CRC cell proliferation and colony formation, promote cell apoptosis.
Article
Integrative & Complementary Medicine
Juan-ni Zeng, Jin-yu Tan, Li Mo
Summary: This study investigated the therapeutic effect of naringin on colorectal cancer (CRC) and the related mechanism. The results showed that naringin could inhibit cell proliferation and promote apoptosis of CRC cells, as well as suppress cell migration. In vivo experiments also demonstrated its inhibitory effect on tumor growth with good bio-compatibility.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
S. Sun, Z. Wang, F. Yao, K. Sun, Z. Li, C. Li
Summary: The study found that microRNA-155 loaded by breast cancer cell-derived exosomes inhibits the generation of white adipose tissue and promotes the formation of brown adipose tissue, leading to cachexia. It was also discovered that this effect is associated with miR-155 targeting UBQLN1.
HUMAN MOLECULAR GENETICS
(2023)
Article
Oncology
Mingliang Zhang, Weigang Dai, Zhanyu Li, Liang Tang, Jianhui Chen, Chuangqi Chen
Summary: This study highlights the important role of heat shock 70 kDa protein 4 (HSPA4) in colorectal cancer (CRC), showing that HSPA4 promotes tumorigenesis in CRC by affecting proliferation, migration, and cell survival. The findings suggest that HSPA4 could serve as a significant prognostic indicator and a potential therapeutic target in CRC.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Oncology
Haowei Wang, Yujia Chen, Qinzi Yuan, Lixia Chen, Peiling Dai, Xuenong Li
Summary: This study found that HRK is lowly expressed in colorectal cancer tissues. For the first time, it was shown that HRK promotes apoptosis and inhibits proliferation of colorectal cancer cells by inhibiting the PI3K/AKT/mTOR signaling pathway. HRK represents a potential target for the treatment of colorectal cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Shuai Yan, Yahui Wang, Yunhui Gu, Mingyue Zhou, Lianlin Su, Tianpeng Yin, Wei Zhang, Yinzi Yue
Summary: This study evaluated the effect of baicalin on the proliferative ability of three CRC cell lines and identified 19 downregulated genes associated with proliferation in HCT-116 cells. Knocking down ARRDC4 gene exhibited the most potent inhibition of cell proliferation. Baicalin attenuated the expression of ARRDC4 to inhibit HCT-116 cell proliferation.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Meeting Abstract
Oncology
Mei Mei Chan, Jean M. Winter, Susanne Kartin Pedersen, Amitesh Chandra Roy, David I. Watson, Damian Hussey, Graeme P. Young, Erin L. Symonds
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Susanne K. Pedersen, Benjamin L. Musher, Lawrence C. LaPointe, Melissa K. Tuck, Erin L. Symonds, Naima Loayza, Graeme P. Young
Summary: Establishing an upper reference limit for the methylated BCAT1 and IKZF1 blood assay improved specificity for detecting CRC recurrence without compromising sensitivity. The BCAT1/IKZF1 test was more sensitive than CEA for identifying recurrences amenable to surgery with curative intent.
Article
Oncology
Jean M. Winter, Lorraine Sheehan-Hennessy, Beibei Yao, Susanne K. Pedersen, Molla M. Wassie, Michael Eaton, Michael Chong, Graeme P. Young, Erin L. Symonds
Summary: Detection of circulating DNA methylated in BCAT1 and IKZF1 is sensitive and specific for colorectal cancer, but not effective for breast or prostate cancer.
Review
Oncology
Natalie Lim, Martha Hickey, Graeme P. Young, Finlay A. Macrae, Christabel Kelly
Summary: There is limited evidence to support screening for endometrial and ovarian cancer in Lynch syndrome. Data on mortality reduction are not available. Further randomized trials comparing targeted screening methods are needed. Risk reducing surgery remains the most reliable way to reduce endometrial and ovarian cancer risk in Lynch syndrome.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2022)
Article
Gastroenterology & Hepatology
Molla M. Wassie, Graeme P. Young, Charles Cock, Peter Bampton, Jean M. Winter, Kalindra Simpson, Hariti Saluja, Anthony Chuang, Robert J. Fraser, Erin L. Symonds
Summary: Delayed surveillance colonoscopy may increase the risk of advanced neoplasia, particularly in individuals with prior advanced adenoma diagnosis, older age, and nonparticipation in interval FIT testing. However, colonoscopy delay does not seem to increase the risk in individuals with negative interval FIT results.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Medicine, General & Internal
Timothy J. H. Lathlean, Molla M. Wassie, Jean M. Winter, Rishabh Goyal, Graeme P. Young, Erin L. Symonds
Summary: Colorectal cancer is the third most diagnosed cancer worldwide and is the second leading cause of cancer mortality. Current screening programs for colorectal cancer have low participation rates. This research aims to evaluate the accuracy of blood-based biomarker tests in detecting advanced precancerous lesions.
Article
Oncology
Susanne K. Pedersen, Erin L. Symonds, Amitesh C. Roy, Kathryn J. Cornthwaite, Lawrence C. LaPointe, Graeme P. Young
Summary: This study found that detection of methylated BCAT1 and IKZF1 after curative-intent treatment for colorectal cancer is significantly associated with an increased risk of recurrence and poorer recurrence-free survival. Patients with detectable methylated BCAT1 and IKZF1 may require personalized surveillance for better management.
Article
Oncology
Maddison Dix, Carlene J. Wilson, Ingrid H. Flight, Molla M. Wassie, Graeme P. Young, Charles Cock, Sarah Cohen-Woods, Erin L. Symonds
Summary: This study aims to determine whether health beliefs regarding colorectal cancer (CRC) screening could predict discomfort with a change to CRC surveillance proposing regular faecal immunochemical tests (FIT) instead of colonoscopy. The results suggest that health beliefs and perceived threat of CRC should be considered when changing CRC surveillance protocols.
EUROPEAN JOURNAL OF CANCER CARE
(2022)
Article
Gastroenterology & Hepatology
Molla M. Wassie, Graeme P. Young, Jean M. Winter, Charles Cock, Peter Bampton, Mahadya Rahman, Richard Heddle, Robert Fraser, Rosie Meng, Erin L. Symonds
Summary: Multiple rounds of negative FIT are associated with a reduced risk of advanced neoplasia in above-average-risk individuals undergoing surveillance colonoscopy.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Medical Laboratory Technology
Geraldine Laven-Law, Dawn Bastin, Robert J. L. Fraser, Charles Cock, Graeme P. Young, Jean M. Winter, Erin L. Symonds
Summary: This study aimed to determine the impact of high temperature on OC-Sensor FIT hemoglobin concentration and found that incubation at temperatures of 30 to 35 degrees Celsius reduced FIT hemoglobin concentration after more than 4 days. During mail transit, the maximum FIT temperature was on average 6.4 degrees Celsius above the maximum ambient temperature, but exposure to temperatures above 30 degrees Celsius was less than 24 hours. Data from a screening program showed no association between FIT hemoglobin concentration and maximum ambient temperatures.
CLINICAL CHEMISTRY
(2023)
Article
Oncology
Norma B. Bulamu, Gang Chen, Ellen Mcgrane, Charles Cock, Graeme P. Young, Erin L. Symonds
Summary: This study compares the sensitivity and discriminant validity of generic and cancer-specific measures for assessing health-related quality of life (HRQoL) for individuals undergoing diagnostic or surveillance colonoscopy for colorectal cancer. The results show that patients undergoing colonoscopy for symptoms have lower HRQoL compared to surveillance or positive FOBT. The cancer-specific QLU-C10D was found to be more sensitive and capable of distinguishing between patients undergoing colonoscopy for different indications.
CANCER CAUSES & CONTROL
(2023)
Article
Gastroenterology & Hepatology
Robert S. Bresalier, Carlo Senore, Graeme P. Young, James Allison, Robert Benamouzig, Sally Benton, Patrick M. M. Bossuyt, Luis Caro, Beatriz Carvalho, Han-Mo Chiu, Veerle M. H. Coupe, Willemijn de Klaver, Clasine Maria de Klerk, Evelien Dekker, Sunil Dolwani, Callum G. Fraser, William Grady, Lydia Guittet, Samir Gupta, Stephen P. Halloran, Ulrike Haug, Geir Hoff, Steven Itzkowitz, Tim Kortlever, Anastasios Koulaouzidis, Uri Ladabaum, Beatrice Lauby-Secretan, Marcis Leja, Bernard Levin, Theodore Robert Levin, Finlay Macrae, Gerrit A. Meijer, Joshua Melson, Colm O'Morain, Susan Parry, Linda Rabeneck, David F. Ransohoff, Roque Saenz, Hiroshi Saito, Silvia Sanduleanu-Dascalescu, Robert E. Schoen, Kevin Selby, Harminder Singh, Robert J. C. Steele, Joseph J. Y. Sung, Erin Leigh Symonds, Sidney J. Winawer
Summary: New non-invasive tests for colorectal cancer (CRC) are emerging, making it challenging to conduct trials with mortality reduction as the main goal. A formal consensus approach involving experts resulted in the revision of previously established principles and the emergence of twelve new principles. The effectiveness of a new test can be evaluated by comparing it with an established non-invasive test, with the faecal immunochemical test considered as the appropriate comparator. Flexible adjustment of the new test's positivity threshold is desirable to meet different screening goals and requirements. A four-phased approach is proposed for the evaluation of new tests, including small studies, prospective estimation of accuracy, evaluation in screening populations, and monitoring for missed lesions.
Article
Gastroenterology & Hepatology
Jean M. Winter, Kathryn J. Cornthwaite, Graeme P. Young, Carlene Wilson, Gang Chen, Richard Woodman, Michelle Coats, Robert Fraser, Charles Cock, Peter Bampton, Erin L. Symonds
Summary: The purpose of this study is to determine the safety, cost-effectiveness, and patient acceptance of extending colonoscopy surveillance intervals using the fecal immunochemical test (FIT) for individuals at elevated risk of colorectal cancer (CRC). Participants with a low FIT result will be randomized to either continue surveillance colonoscopy as scheduled or delay it by 1 or 2 years. The primary endpoint is the incidence of advanced neoplasia.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Letter
Urology & Nephrology
Richard Le Leu, Paul N. Bennett, Kathryn Dansie, Lisa Shanahan, Anna Chur-Hansen, Kathryn L. Collins, Anne L. J. Burke, Fiona Donnelly, Emily Duncanson, Anthony Meade, Stephen McDonald, Shilpanjali Jesudason
JOURNAL OF NEPHROLOGY
(2023)
Article
Nursing
Emily Duncanson, Richard K. Le Leu, Anna Chur-Hansen, Tahlia Masotti, Kathryn L. Collins, Anne L. J. Burke, Luke P. Macauley, Stephen Mcdonald, Shilpanjali Jesudason
Summary: This study aims to identify the key knowledge, skills and attitudes of nephrology nurses working with patients with needle-related distress. Two overarching themes were identified: Flexibility in Practice and Care, and Responsibility of Nephrology Nursing, which are relevant to all nephrology nurses. Additionally, the study found that nurses desire additional education regarding strategies to improve patient experience and nurse confidence and skill in cannulation.
JOURNAL OF RENAL CARE
(2023)