The impact of tumor microenvironment on cancer treatment and its modulation by direct and indirect antivascular strategies

Rapid Decrease in Delivery of Chemotherapy to Tumors after Anti-VEGF Therapy: Implications for Scheduling of Anti-Angiogenic Drugs

(2012) Astrid A.M. Van der Veldt et al.   CANCER CELL

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

Inhibition of the Kit Ligand/c-Kit Axis Attenuates Metastasis in a Mouse Model Mimicking Local Breast Cancer Relapse after Radiotherapy

(2012) F. Kuonen et al.   CLINICAL CANCER RESEARCH

Radiation-Induced Vascular Damage in Tumors: Implications of Vascular Damage in Ablative Hypofractionated Radiotherapy (SBRT and SRS)

(2012) Heon Joo Park et al.   RADIATION RESEARCH

Cancer Stem Cells as a Predictive Factor in Radiotherapy

(2012) Thomas B. Brunner et al.   SEMINARS IN RADIATION ONCOLOGY

Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels

(2012) Hiroshi Harada et al.   Nature Communications

Guidelines for preclinical and early phase clinical assessment of novel radiosensitisers

(2011) K J Harrington et al.   BRITISH JOURNAL OF CANCER

HRG Inhibits Tumor Growth and Metastasis by Inducing Macrophage Polarization and Vessel Normalization through Downregulation of PlGF

(2011) Charlotte Rolny et al.   CANCER CELL

Antiangiogenic Agent Sunitinib Transiently Increases Tumor Oxygenation and Suppresses Cycling Hypoxia

(2011) S. Matsumoto et al.   CANCER RESEARCH

Pancreatic Stellate Cells Radioprotect Pancreatic Cancer Cells through  1-Integrin Signaling

(2011) T. S. Mantoni et al.   CANCER RESEARCH

Dual Inhibition of the PI3K/mTOR Pathway Increases Tumor Radiosensitivity by Normalizing Tumor Vasculature

(2011) E. Fokas et al.   CANCER RESEARCH

Increased Survival of Glioblastoma Patients Who Respond to Antiangiogenic Therapy with Elevated Blood Perfusion

(2011) A. G. Sorensen et al.   CANCER RESEARCH

Blockade of TGF-  Signaling by the TGF R-I Kinase Inhibitor LY2109761 Enhances Radiation Response and Prolongs Survival in Glioblastoma

(2011) M. Zhang et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

PDGF-D Improves Drug Delivery and Efficacy via Vascular Normalization, But Promotes Lymphatic Metastasis by Activating CXCR4 in Breast Cancer

(2011) J. Liu et al.   CLINICAL CANCER RESEARCH

Modulation of the Tumor Microvasculature by Phosphoinositide-3 Kinase Inhibition Increases Doxorubicin Delivery In Vivo

(2011) N. Qayum et al.   CLINICAL CANCER RESEARCH

Hypoxia-mediated drug resistance: Novel insights on the functional interaction of HIFs and cell death pathways

(2011) Nadine Rohwer et al.   DRUG RESISTANCE UPDATES

Endogenous Myc maintains the tumor microenvironment

(2011) N. M. Sodir et al.   GENES & DEVELOPMENT

First-in-Man Clinical Trial of the Oral Pan-AKT Inhibitor MK-2206 in Patients With Advanced Solid Tumors

(2011) Timothy A. Yap et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase I, Dose-Escalation Study of BKM120, an Oral Pan-Class I PI3K Inhibitor, in Patients With Advanced Solid Tumors

(2011) Johanna C. Bendell et al.   JOURNAL OF CLINICAL ONCOLOGY

Delta-Like Ligand 4–Notch Blockade and Tumor Radiation Response

(2011) Stanley K. Liu et al.   JNCI-Journal of the National Cancer Institute

Induction of MET by Ionizing Radiation and Its Role in Radioresistance and Invasive Growth of Cancer

(2011) Francesca De Bacco et al.   JNCI-Journal of the National Cancer Institute

Time-Course Imaging of Therapeutic Functional Tumor Vascular Normalization by Antiangiogenic Agents

(2011) Q. Zhang et al.   MOLECULAR CANCER THERAPEUTICS

Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor

(2011) S.-M. Maira et al.   MOLECULAR CANCER THERAPEUTICS

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Caspase 3–mediated stimulation of tumor cell repopulation during cancer radiotherapy

(2011) Qian Huang et al.   NATURE MEDICINE

Antiangiogenic therapy: impact on invasion, disease progression and metastasis

(2011) John M. L. Ebos et al.   Nature Reviews Clinical Oncology

Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases

(2011) Peter Carmeliet et al.   NATURE REVIEWS DRUG DISCOVERY

Improving Quality of Patient Care by Improving Daily Practice in Radiation Oncology

(2011) Bhishamjit S. Chera et al.   SEMINARS IN RADIATION ONCOLOGY

Angiogenesis Inhibitors: Current Strategies and Future Prospects

(2010) K. M. Cook et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Modulating Tumor Vasculature through Signaling Inhibition to Improve Cytotoxic Therapy

(2010) A. Maity et al.   CANCER RESEARCH

Premetastatic Lung "Niche": Is Vascular Endothelial Growth Factor Receptor 1 Activation Required?

(2010) D. G. Duda et al.   CANCER RESEARCH

Predictive Biomarkers of Sensitivity to the Phosphatidylinositol 3' Kinase Inhibitor GDC-0941 in Breast Cancer Preclinical Models

(2010) C. O'Brien et al.   CLINICAL CANCER RESEARCH

Irradiation-Dependent Effects on Tumor Perfusion and Endogenous and Exogenous Hypoxia Markers in an A549 Xenograft Model

(2010) Emmanouil Fokas et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Improved Intratumoral Oxygenation Through Vascular Normalization Increases Glioma Sensitivity to Ionizing Radiation

(2010) Mackenzie C. McGee et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice

(2010) Mitomu Kioi et al.   JOURNAL OF CLINICAL INVESTIGATION

The PI3K Pathway As Drug Target in Human Cancer

(2010) Kevin D. Courtney et al.   JOURNAL OF CLINICAL ONCOLOGY

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Radiotherapy Suppresses Angiogenesis in Mice through TGF-βRI/ALK5-Dependent Inhibition of Endothelial Cell Sprouting

(2010) Natsuko Imaizumi et al.   PLoS One

Low Doses of Ionizing Radiation Promote Tumor Growth and Metastasis by Enhancing Angiogenesis

(2010) Inês Sofia Vala et al.   PLoS One

Inhibition of Mac-1 (CD11b/CD18) enhances tumor response to radiation by reducing myeloid cell recruitment

(2010) G.-O. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CT Findings of Chemotherapy-induced Toxicity: What Radiologists Need to Know about the Clinical and Radiologic Manifestations of Chemotherapy Toxicity

(2010) Jean M. Torrisi et al.   RADIOLOGY

Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Blockade Is an Effective Radiosensitizing Strategy for the Treatment of Non-Small Cell Lung Cancer Harboring K-RAS Mutations

(2009) G. Konstantinidou et al.   CANCER RESEARCH

Tumor Vascular Changes Mediated by Inhibition of Oncogenic Signaling

(2009) N. Qayum et al.   CANCER RESEARCH

PIK3CA Mutations in Colorectal Cancer Are Associated with Clinical Resistance to EGFR-Targeted Monoclonal Antibodies

(2009) A. Sartore-Bianchi et al.   CANCER RESEARCH

 v 3/ v 5 Integrins-FAK-RhoB: A Novel Pathway for Hypoxia Regulation in Glioblastoma

(2009) N. Skuli et al.   CANCER RESEARCH

Contribution of Granulocyte Colony-Stimulating Factor to the Acute Mobilization of Endothelial Precursor Cells by Vascular Disrupting Agents

(2009) Y. Shaked et al.   CANCER RESEARCH

Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

(2009) Massimiliano Mazzone et al.   CELL

The Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase 1/2 Inhibitor AZD6244 (ARRY-142886) Enhances the Radiation Responsiveness of Lung and Colorectal Tumor Xenografts

(2009) A. M. Shannon et al.   CLINICAL CANCER RESEARCH

Antiangiogenic effect of ZSTK474, a novel phosphatidylinositol 3-kinase inhibitor

(2009) Dexin Kong et al.   EUROPEAN JOURNAL OF CANCER

American Society of Clinical Oncology Provisional Clinical Opinion: Testing forKRASGene Mutations in Patients With Metastatic Colorectal Carcinoma to Predict Response to Anti–Epidermal Growth Factor Receptor Monoclonal Antibody Therapy

(2009) Carmen J. Allegra et al.   JOURNAL OF CLINICAL ONCOLOGY

Efficacy, Safety, and Biomarkers of Neoadjuvant Bevacizumab, Radiation Therapy, and Fluorouracil in Rectal Cancer: A Multidisciplinary Phase II Study

(2009) Christopher G. Willett et al.   JOURNAL OF CLINICAL ONCOLOGY

Epidermal Growth Factor Receptor Inhibition Modulates the Microenvironment by Vascular Normalization to Improve Chemotherapy and Radiotherapy Efficacy

(2009) George J. Cerniglia et al.   PLoS One

p53 Controls Radiation-Induced Gastrointestinal Syndrome in Mice Independent of Apoptosis

(2009) D. G. Kirsch et al.   SCIENCE

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

Mast Cells Can Mediate Vascular Permeability through Regulation of the PI3K–HIF-1α–VEGF Axis

(2008) Kyung Sun Lee et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

PI3KCA/PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients

(2008) F. Perrone et al.   ANNALS OF ONCOLOGY

Matrix Metalloproteinase-9 Is Required for Tumor Vasculogenesis but Not for Angiogenesis: Role of Bone Marrow-Derived Myelomonocytic Cells

(2008) G-One Ahn et al.   CANCER CELL

Class I PI3 Kinase Inhibition by the Pyridinylfuranopyrimidine Inhibitor PI-103 Enhances Tumor Radiosensitivity

(2008) R. Prevo et al.   CANCER RESEARCH

A Vascular Targeted Pan Phosphoinositide 3-Kinase Inhibitor Prodrug, SF1126, with Antitumor and Antiangiogenic Activity

(2008) J. R. Garlich et al.   CANCER RESEARCH

Palomid 529, a Novel Small-Molecule Drug, Is a TORC1/TORC2 Inhibitor That Reduces Tumor Growth, Tumor Angiogenesis, and Vascular Permeability

(2008) Q. Xue et al.   CANCER RESEARCH

Effects of the Dual Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor NVP-BEZ235 on the Tumor Vasculature: Implications for Clinical Imaging

(2008) C. R. Schnell et al.   CANCER RESEARCH

CYR61 and  V 5 Integrin Cooperate to Promote Invasion and Metastasis of Tumors Growing in Preirradiated Stroma

(2008) Y. Monnier et al.   CANCER RESEARCH

H-Ras Regulates Angiogenesis and Vascular Permeability by Activation of Distinct Downstream Effectors

(2008) Doinita Serban et al.   CIRCULATION RESEARCH

Antiangiogenic Therapy with Mammalian Target of Rapamycin Inhibitor RAD001 (Everolimus) Increases Radiosensitivity in Solid Cancer

(2008) P. C. Manegold et al.   CLINICAL CANCER RESEARCH

Impact of Angiogenesis Inhibition by Sunitinib on Tumor Distribution of Temozolomide

(2008) Q. Zhou et al.   CLINICAL CANCER RESEARCH

PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo

(2008) D. Hambardzumyan et al.   GENES & DEVELOPMENT

Mitogen-activated protein kinase kinase signaling promotes growth and vascularization of fibrosarcoma

(2008) Y. Ding et al.   MOLECULAR CANCER THERAPEUTICS

Vascular normalization in Rgs5-deficient tumours promotes immune destruction

(2008) Juliana Hamzah et al.   NATURE

Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration

(2008) Mariona Graupera et al.   NATURE

Differential effect of sunitinib on the distribution of temozolomide in an orthotopic glioma model

(2008) Qingyu Zhou et al.   NEURO-ONCOLOGY

Tumor Angiogenesis

(2008) Robert S. Kerbel   NEW ENGLAND JOURNAL OF MEDICINE

K-ras/PI3K-Akt Signaling Is Essential for Zebrafish Hematopoiesis and Angiogenesis

(2008) Lihui Liu et al.   PLoS One

Class 1A PI3K regulates vessel integrity during development and tumorigenesis

(2008) T. L. Yuan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antitumor Activity of Rapamycin in a Phase I Trial for Patients with Recurrent PTEN-Deficient Glioblastoma

(2008) Tim F Cloughesy et al.   PLOS MEDICINE