Article
Oncology
Mattia Russel Pantalone, Nerea Martin Almazan, Rossano Lattanzio, Chato Taher, Simone De Fabritiis, Silvia Valentinuzzi, Faraz Bishehsari, Mahboobeh Mahdavinia, Fabio Verginelli, Afsar Rahbar, Renato Mariani-Costantini, Cecilia Soderberg-Naucler
Summary: This study investigated the association between human cytomegalovirus (HCMV) infection and colorectal cancer (CRC). The findings showed that HCMV infection was correlated with the expression of pro-inflammatory enzymes and other genetic and clinicopathological features of CRC. In vitro experiments also demonstrated that HCMV infection promoted cell proliferation in CRC cells, which could be inhibited by antiviral and anti-inflammatory drugs.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Ling Sun
Summary: The study showed that low doses of celecoxib improved the histopathology of the ileum, alleviated oxidative stress and inflammation, and reduced apoptotic epithelial cells in NEC rats, indicating its potential as a therapy for NEC.
Article
Biotechnology & Applied Microbiology
Ryan N. Fuller, Janviere Kabagwira, Paul A. Vallejos, Andrew D. Folkerts, Nathan R. Wall
Summary: The study suggests a potential role of survivin splice variants, especially SSV 2 beta, in innate and acquired PDAC chemoresistance. Knockdown of SSVs using siRNA sensitized the GR cells to Gem, indicating their involvement in PDAC chemoresistance.
ONCOTARGETS AND THERAPY
(2022)
Article
Immunology
Jiajun Chen, Shiqi Cai, Renjie Li, Jie Xie, Fan Yang, Tao Liu
Summary: This study found that MDSCs play an important role in sepsis-induced immune dysfunction. Inhibiting COX-2 may be a promising therapy for MDSCs-induced immunosuppression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Oncology
Evelien J. M. de Jong, Quisette P. Janssen, Tessa F. A. Simons, Marc G. Besselink, Bert A. Bonsing, Stefan A. W. Bouwense, Sandra M. E. Geurts, Marjolein Y. Homs, Vincent E. de Meijer, Vivianne C. G. Tjan-Heijnen, Hanneke W. M. van Laarhoven, Liselot B. J. Valkenburg-van Iersel, Johanna W. Wilmink, Lydia G. van der Geest, Bas Groot Koerkamp, Judith de Vos-Geelen
Summary: In a nationwide cohort of patients with pancreatic ductal adenocarcinoma, adjuvant GEMCAP was associated with superior survival compared to GEM monotherapy.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Shuang Liang, Lu-Ying Shi, Jing-Ya Duan, Huan-Huan Liu, Ting-Ting Wang, Can-Yu Li
Summary: The study demonstrated that the COX-2 selective inhibitor celecoxib can reduce the depth of endometrial infiltration in mouse adenomyosis, and significantly decrease the expression levels of COX-2 and VEGF after inhibiting COX-2.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Tadataka Takagi, Rina Fujiwara-Tani, Shiori Mori, Shingo Kishi, Yukiko Nishiguchi, Takamitsu Sasaki, Ruiko Ogata, Ayaka Ikemoto, Rika Sasaki, Hitoshi Ohmori, Yi Luo, Ujjal Kumar Bhawal, Masayuki Sho, Hiroki Kuniyasu
Summary: Gemcitabine resistance in pancreatic ductal adenocarcinoma cells is associated with decreased energy production, decreased mitochondrial reactive oxygen species levels, and increased stemness caused by mitochondrial damage. Hypoxia may promote this process. Treatment with lauric acid restores gemcitabine sensitivity by activating oxidative phosphorylation. Further clinical validation of lauric acid in gemcitabine resistance is needed in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Xiaohui Zhang, Lisa Detering, Deborah Sultan, Hannah Luehmann, Lin Li, Gyu Seong Heo, Xiuli Zhang, Lanlan Lou, Patrick M. Grierson, Suellen Greco, Marianna Ruzinova, Richard Laforest, Farrokh Dehdashti, Kian-Huat Lim, Yongjian Liu
Summary: The CCR2-targeted ultrasmall nanoparticles not only enable sensitive and accurate detection of PDAC, but also effectively suppress tumor growth and prolong survival. These nanoparticles exhibit efficient in vivo clearance and minimal toxicity.
Article
Oncology
R. Nicolle, O. Gayet, P. Duconseil, C. Vanbrugghe, J. Roques, M. Bigonnet, Y. Blum, N. Elarouci, L. Armenoult, M. Ayadi, A. de Reynies, F. Puleo, J. Augustin, J. F. Emile, M. Svrcek, T. Arsenijevic, P. Hammel, M. Giovannini, P. Grandval, L. Dahan, V Moutardier, M. Gilabert, J. L. Van Laethem, J. B. Bachet, J. Cros, J. Iovanna, N. J. Dusetti
Summary: The study demonstrates that the RNA-based GemPred stratification can predict the benefit of adjuvant gemcitabine in PDAC patients.
ANNALS OF ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Yu Tang, Cheng Qian, Yueke Zhou, Chang Yu, Mengyao Song, Teng Zhang, Xuewen Min, Aiyun Wang, Yang Zhao, Yin Lu
Summary: Platelets with high expression of CD36 release growth factors and cytokines, promoting tumor metastasis. Inhibitors targeting CD36 and COX-2 can disrupt the interaction between platelets and tumor cells. Targeting the crosstalk between platelets and tumor cells offers potential therapeutic strategies for inhibiting tumor metastasis.
Article
Oncology
Nicolas A. Fraunhoffer, Analia M. Abuelafia, Carlos Teyssedou, Eduardo Chuluyan, Martin Bigonnet, Laurent Palazzo, Odile Gayet, Remy Nicolle, Jerome Cros, Juan Iovanna, Nelson Dusetti
Summary: The study revealed specific transcriptomic characteristics of hepatic metastases in PDAC, which are associated with cell cycle checkpoint, mitochondria activity, and extracellular matrix reorganization. In addition, squamous lineage emerged as a key feature linked to the chemosensitivity profile of PDAC hepatic metastases.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Oncology
Kaidong Liu, Yiding Geng, Linzhu Wang, Huanhuan Xu, Min Zou, Yawei Li, Zhangxiang Zhao, Tingting Chen, Fengyan Xu, Liang Sun, Shuliang Wu, Yunyan Gu
Summary: Resistance to gemcitabine is a major challenge in treating pancreatic ductal adenocarcinoma (PDAC). Researchers have developed a transcriptome-based gemcitabine signature that can accurately predict the response of PDAC to gemcitabine. This signature outperforms existing quantitative signatures in terms of classification accuracy and prognostic performance. The study also suggests that combining gemcitabine with a phosphoinositide 3-kinase (PI3K) inhibitor could be an alternative treatment strategy for PDAC.
MOLECULAR ONCOLOGY
(2022)
Review
Oncology
Tomas Koltai, Stephan Joel Reshkin, Tiago M. A. Carvalho, Daria Di Molfetta, Maria Raffaella Greco, Khalid Omer Alfarouk, Rosa Angela Cardone
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive tumor with a poor prognosis and inadequate response to treatment. Multiple factors contribute to therapeutic failure, including late diagnosis due to lack of symptoms, early spread, advanced age of patients, hyperfibrotic stroma, genetic heterogeneity, and early resistance to available treatments.
Article
Oncology
Marina Roy-Luzarraga, Louise E. Reynolds, Beatriz de Luxan-Delgado, Oscar Maiques, Laura Wisniewski, Emma Newport, Vinothini Rajeeve, Rebecca J. G. Drake, Jesus Gomez-Escudero, Frances M. Richards, Celine Weller, Christof Dormann, Ya-Ming Meng, Peter B. Vermeulen, Dieter Saur, Victoria Sanz-Moreno, Ping-Pui Wong, Cyrill Geraud, Pedro R. Cutillas, Kairbaan Hodivala-Dilke
Summary: This study reveals that endothelial cell focal adhesion kinase (FAK) plays a role in regulating pancreatic ductal adenocarcinoma (PDAC) metastasis and impacting the outcome of gemcitabine treatment. The findings suggest the potential clinical utility of combinatorial endothelial cell FAK targeting with gemcitabine in controlling metastasis in PDAC patients.
Article
Oncology
Jinsheng Ding, Hui Li, Yang Liu, Yongjie Xie, Jie Yu, Huizhi Sun, Di Xiao, Yizhang Zhou, Li Bao, Hongwei Wang, Chuntao Gao
Summary: This study identified OXCT1 as a key gene leading to GEM resistance in PDAC through the NF-kappa B signaling pathway, with high OXCT1 expression associated with shorter relapse-free survival under GEM treatment. OXCT1 overexpression in PDAC cell lines inhibited apoptosis after GEM treatment, and blocking the NF-kappa B signaling pathway reduced GEM resistance. These findings suggest that OXCT1 could be a potential therapeutic target for patients with PDAC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Vincent J. Picozzi, Ramesh K. Ramanathan, Maeve A. Lowery, Allyson J. Ocean, Edith P. Mitchel, Bert H. O'Neil, Michael J. Guarino, Paul R. Conkling, Steven J. Cohen, Nathan Bahary, Richard C. Frank, Tomislav Dragovich, Benjamin B. Bridges, Fadi S. Braiteh, Alexander N. Starodub, Fa-Chyi Lee, Thomas E. Gribbin, Donald A. Richards, Marie Lee, Ronald L. Korn, Neeta Pandit-Taskar, Stanley J. Goldsmith, Charles M. Intenzo, Arif Sheikh, Timothy C. Manzone, Heather Horne, Robert M. Sharkey, William A. Wegener, Eileen M. O'Reilly, David M. Goldenberg, Daniel D. Von Hoff
EUROPEAN JOURNAL OF CANCER
(2015)
Article
Oncology
Mitesh J. Borad, Shantan G. Reddy, Nathan Bahary, Hope E. Uronis, Darren Sigal, Allen L. Cohn, William R. Schelman, Joe Stephenson, E. Gabriela Chiorean, Peter J. Rosen, Brian Ulrich, Tomislav Dragovich, Salvatore A. Del Prete, Mark Rarick, Clarence Eng, Stew Kroll, David P. Ryan
JOURNAL OF CLINICAL ONCOLOGY
(2015)
Review
Biotechnology & Applied Microbiology
John Chang, Donald Schomer, Tomislav Dragovich
BIOMED RESEARCH INTERNATIONAL
(2015)
Article
Oncology
Emad Elquza, Hani M. Babiker, Krisha J. Howell, Andrew I. Kovoor, Thomas David Brown, Hitendra Patel, Steven A. Malangone, Mitesh J. Borad, Tomislav Dragovich
CANCER INVESTIGATION
(2016)
Article
Oncology
Charles S. Fuchs, Donna Niedzwiecki, Harvey J. Mamon, Joel E. Tepper, Xing Ye, Richard S. Swanson, Peter C. Enzinger, Daniel G. Haller, Tomislav Dragovich, Steven R. Alberts, Georg A. Bjarnason, Christopher G. Willett, Leonard L. Gunderson, Richard M. Goldberg, Alan P. Venook, David Ilson, Eileen O'Reilly, Kristen Ciombor, David J. Berg, Jeffrey Meyerhardt, Robert J. Mayer
JOURNAL OF CLINICAL ONCOLOGY
(2017)
Article
Oncology
Emerson Y. Chen, Charles D. Blanke, Daniel G. Haller, Al B. Benson, Tomislav Dragovich, Heinz-Josef Lenz, Carlos Robles, Hong Li, Motomi Mori, Nora Mattek, Rachel E. Sanborn, Charles D. Lopez
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
(2018)
Article
Oncology
T. Dragovich, D. Laheru, F. Dayyani, V. Bolejack, L. Smith, J. Seng, H. Burris, P. Rosen, M. Hidalgo, P. Ritch, A. F. Baker, N. Raghunand, J. Crowley, D. D. Von Hoff
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2014)
Article
Oncology
A. F. Baker, K. N. Adab, N. Raghunand, H. H. S. Chow, S. P. Stratton, S. W. Squire, M. Boice, L. A. Pestano, D. L. Kirkpatrick, T. Dragovich
INVESTIGATIONAL NEW DRUGS
(2013)
Article
Gastroenterology & Hepatology
D. Li, S. Pant, D. P. Ryan, D. Laheru, N. Bahary, T. Dragovich, P. J. Hosein, L. Rolfe, M. W. Saif, J. LaValle, K. H. Yu, M. A. Lowery, A. Allen, E. M. O'Reilly
Review
Biotechnology & Applied Microbiology
Sunilkumar Kakadia, Naveen Yarlagadda, Ramez Awad, Madappa Kundranda, Jiaxin Niu, Boris Naraev, Lida Mina, Tomislav Dragovich, Mark Gimbel, Fade Mahmoud
ONCOTARGETS AND THERAPY
(2018)
Article
Oncology
P. Hammel, H. L. Kindler, M. Reni, E. Van Cutsem, T. Macarulla, M. J. Hall, J. O. Park, D. Hochhauser, D. Arnold, D-Y Oh, A. Reinacher-Schick, G. Tortora, H. Alguel, E. M. O'Reilly, D. McGuinness, K. Y. Cui, S. Joo, H. K. Yoo, N. Patel, T. Golan, Lorraine Chantrill, David Goldstein, Warren Joubert, Nick Pavlakis, Annette Tognela, Eric Van Cutsem, Frank Van Fraeyenhove, Jean-Luc Van Laethem, Marc Peeters, Neesha Dhani, Petr Kavan, Frederic Lemay, Antoine Adenis, Pascal Artru, Nabil Hamed, Christine Belletier, Meher Ben Abdelghani, Jean-Frederic Blanc, Christophe Borg, Romain Coriat, Gael Deplanque, Roger Faroux, Philippe Follana, Rosine Guimbaud, Farid el Hajbi, Pascal Hammel, Vincent Hautefeuille, David Malka, Jean-Philippe Metges, David Tougeron, Thomas Walter, Hana Alguel, Thomas Ettrich, Ulrich Thorsten Hacker, Elke Hennes, Lutz Jacobasch, Stephan Kanzler, Ursula Pession, Anke Reinacher-Schick, Christian Scholz, Marianne Sinn, Alexander Stein, Christian Strassburg, Arndt Vogel, Menachem Ben-Shahar, Ronen Brenner, Ron Epelbaum, Ravit Geva, Alexander Gluzman, Talia Golan, Efraim Idelevich, Maya Kolin, Valeriya Semenisty, Ayelet Shai, Salomon Stemmer, Nirit Yarom, Luigi Celio, Pierfranco Conte, Carlo Garufi, Luca Gianni, Francesco Leonardi, Evaristo Maiello, Mariacristina Di Marco, Michele Milella, Carmine Pinto, Daniele Santini, Mario Scartozzi, Giampaolo Tortora, Vanja Vaccaro, Enrico Vasile, Ji-Won Kim, Jin-Won Kim, Youn Oh, Joon Oh Park, Hanneke Wilmink, Rafael Alvarez Gallego, Gema Duran Ogalla, Adelaida Garcia Velasco, Elena Garralda Cabanas, Carlos Gomez Martin, Carmen Guillen Ponce, Berta Laquente Saez, Rafael Lopez, Teresa Macarulla, Andres Munoz Martin, Roberto Pazo, Carles Pericay Pijaume, Javier Rodriguez, Ricardo Yaya-Tur, Arvind Arora, David Alan Anthoney, T. R. Jeffrey Evans, Mark Harrison, Daniel Hochhauser, Daniel Palmer, Debashis Sarker, Naureen Starling, Juan Valle, Lucy Wall, Richy Agajanian, James Bearden, Tanios Bekaii-Saab, Corey Carter, Deirdre Cohen, Alfred DiStefano, Tomislav Dragovich, Samuel Ejadi, James Ford, Stephen Grabelsky, Michael Hall, Howard Hochster, Peter Hosein, Milind Javle, Hedy Kindler, Jill Lacy, Daniel Laheru, Stephen Leong, Maeve Lowery, Robert Marsh, Anne Noonan, Paul Oberstein, Allyson Ocean, Eileen O'Reilly, David Ryan, Tara Seery, Somasundaram Subramaniam, David Van Echo, Andrea Wang-Gillam, Colin Weekes, Stephen Welch
ANNALS OF ONCOLOGY
(2019)
Article
Oncology
Vladimir Todorovic, Matti Aapro, Nicholas Pavlidis, Oliver Arsovski, Yazid Belkacemi, Nada Babovic, Francois Clement Bidard, Mouna Bourhafour, Semir Beslija, Hamouda Boussen, Bojana Cetnikovic, Timur Ceric, Nada Cicmil, Nebojsa Crnogorac, Enkelejda Cuedari, Michele De Laurentis, Tomislav Dragovich, Ivana Durutovic, Zoran Dzamic, Radan Dzodic, Zivka Eri, Fady Geara, Ahmed Khalil, Khaldoun Kerrou, Slavica Knezevic-Usaj, Vladimir Kovcin, Dhurata Koroveshi, Anila Kristo Pema, Abraham Kuten, Jadranka Lakicevic, Nevenka Lukovac, Ivan Markovic, Milan Markovic, Nenad Mijalkovic, Daniela Miladinova, Nikola Milasevic, Giorgio Mustachi, Dragana Ognjenovic, Aleksandra Pantelic, Lazar Popovic, Davorin Radosavljevic, Nina Radosevic, Sinisa Radulovic, Milan Ristevski, Ivana Rosic, Nevena Secen, Milan Sorat, Liljana Stamatovic, Petar Stefanovski, Igor Stojkovski, Dusanka Tesanovic, Zorica Tomasevic, Zoran Tomasevic, Pauletta Tsoutsou, Sedat Turkan, Nino Vasev, Suzana Vasovic, Ferenc Vicko, Damir Vrbanec, Filip Vukmirovic, Eduard Vrdoljak, Bojan Zaric, Jean Jacques Zambrovski, Franco Cavalli, Joseph Gligorov
Article
Oncology
Alexandra E. Chambers, Jacob Frick, Natalee Tanner, Richard Gerkin, Madappa Kundranda, Tomislav Dragovich
JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2018)
Article
Oncology
Brenen P. Swofford, Tomislav Dragovich
CASE REPORTS IN ONCOLOGY
(2017)
Article
Oncology
Brenen P. Swofford, Tomislav Dragovich
CASE REPORTS IN ONCOLOGY
(2017)