Review
Oncology
Nicholas Lee, Ashan Canagasingham, Mohit Bajaj, Ramesh Shanmugasundaram, Anthony Hutton, Joseph Bucci, Peter Graham, James Thompson, Jie Ni
Summary: Bladder cancer is one of the top ten most common cancers and top ten causes of cancer death globally. Survival rates have decreased, and the current gold standard for diagnosis is invasive. Exosomes show potential as biomarkers for bladder cancer diagnosis and treatment.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Xiaoqi Yang, Tao Ye, Haoran Liu, Peng Lv, Chen Duan, Xiaoliang Wu, Kehua Jiang, Hongyan Lu, Ding Xia, Ejun Peng, Zhiqiang Chen, Kun Tang, Zhangqun Ye
Summary: circRNAs play crucial regulatory roles in BCa by modulating various biological behaviors through miRNA sponging mechanisms. The expression levels of circRNAs are significantly associated with clinicopathologic characteristics and can be used to predict patient survival parameters. Due to their abundance, conservation, stability, specificity, and detectability, circRNAs are considered potential diagnostic and prognostic biomarkers for BCa.
Article
Medicine, General & Internal
Monika Gudowska-Sawczuk, Jacek Kudelski, Michal Olkowicz, Grzegorz Mlynarczyk, Piotr Chlosta, Barbara Mroczko
Summary: This study aimed to assess the clinical usefulness of serum kappa (?) and lambda (?) free light chains (FLCs) in patients with bladder cancer. The concentrations of FLCs, CEA, and CA19-9 were significantly higher in bladder cancer patients compared to the control group. There was also a correlation between FLC and other biomarkers. The findings suggest that FLC measurements may be useful in the diagnosis and prognosis of bladder cancer.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Rajwinder Kaur, Pran Kishore Deb, Vishal Diwan, Balraj Saini
Summary: Heparanase enzyme HPSE degrades HS, leading to conditions like inflammation, angiogenesis, and metastasis. Recent research has focused on HPIns for anti-metastatic tumors and chronic inflammatory diseases, with discussions on potential for future development of more potent and specific HPIns.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Oncology
Paolo Piatti, Yap Ching Chew, Michiko Suwoto, Taikun Yamada, Benjamin Jara, Xi-Yu Jia, Wei Guo, Saum Ghodoussipour, Siamak Daneshmand, Hamed Ahmadi, Jeffrey Rice, Jeffrey Bhasin, Faith Holloway, Yvonne Tsai, Yoshitomo Chihara, Gangning Liang
Summary: Bladder CARE is a highly sensitive and non-invasive test for detecting bladder cancer in urine samples. By measuring methylation levels of specific biomarkers, it has great potential for early detection and routine screening of BC patients. The test has a low limit of detection, reduces unnecessary invasive testing, and improves patient monitoring.
CLINICAL EPIGENETICS
(2021)
Review
Chemistry, Multidisciplinary
Fengyan Yuan, Yiyuan Yang, Huiqin Zhou, Jing Quan, Chongyang Liu, Yi Wang, Yujing Zhang, Xing Yu
Summary: Heparanase, an enzyme capable of degrading heparan sulphate proteoglycans, plays a crucial role in tumour progress, angiogenesis, and inflammation. Recent crystallographic studies have revealed the structures of human and bacterial heparanases, uncovering differences in their substrate recognition mode. Understanding the regulatory mechanisms of heparanase can lead to the development of anti-heparanase inhibitors with potential clinical applications.
FRONTIERS IN CHEMISTRY
(2022)
Article
Biotechnology & Applied Microbiology
Gaofeng Yuan, Wenwen Ding, Bingjie Sun, Lin Zhu, Yuewen Gao, Lulu Chen
Summary: The study revealed that CircRNA_102231 is significantly upregulated in gastric cancer tissues and plasma, serving as a potential biomarker for diagnosis and prognosis. Functional experiments demonstrated that inhibition of CircRNA_102231 can suppress GC cell proliferation and invasion in vitro and in vivo. CircRNA_102231 binds to IRTKS, enhancing IRTKS protein stability to promote GC progression.
Review
Cell Biology
Yan Zhang, Xianwu Chen, Juntao Lin, Xiaodong Jin
Summary: Long noncoding RNAs play a significant role in the development of bladder cancer, and are closely associated with patients' clinicopathological characteristics, with the potential to serve as diagnostic and prognostic biomarkers for bladder cancer patients in the future.
CELL DEATH DISCOVERY
(2021)
Review
Biochemistry & Molecular Biology
Haoran Ji, Chuang Hu, Xuhui Yang, Yuanhao Liu, Guangyu Ji, Shengfang Ge, Xiansong Wang, Mingsong Wang
Summary: Lymph nodes play a crucial role in metastasis and immune modulation in various types of cancers. Understanding the mechanisms of tumor cells metastasizing to lymph nodes and the impact of lymph node metastasis on prognosis and treatment selection is essential for accurate disease assessment and effective treatment strategies. Recent advancements in research have provided a better understanding of the anatomical and physiological characteristics of lymph nodes, as well as the molecular mechanisms and diagnostic and therapeutic approaches for lymph node metastasis.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Review
Oncology
Yonghua Tong, Xiao Liu, Ding Xia, Ejun Peng, Xiaoqi Yang, Hailang Liu, Tao Ye, Xinguang Wang, Yu He, Hua Xu, Zhangqun Ye, Zhiqiang Chen, Kun Tang
Summary: Exosomal ncRNAs play crucial roles in the tumorigenesis and progression of bladder cancer, serving as potential biomarkers for clinical diagnosis and therapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
YiHeng Du, Jin Cao, Xiang Jiang, XiaoWei Cai, Bo Wang, Yi Wang, XiZhi Wang, BoXin Xue
Summary: This study revealed the significantly reduced expression of CXCL12 in BLCA compared with normal tissue, along with the reduced expression of various iCAFs marker genes in BLCA tissues. CXCL12 and iCAFs were associated with pathological features, TME remodeling, and aging in BLCA patients. iCAFs played dual roles in the carcinogenesis and progression of BLCA, impacting the prognosis and immunotherapy responsiveness for BLCA patients.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Ganping Wang, Yarong Dai, Kang Li, Maosheng Cheng, Gan Xiong, Xiaochen Wang, Shuang Chen, Zhi Chen, Jianwen Chen, Xiuyun Xu, Rong-song Ling, Liang Peng, Demeng Chen
Summary: The study demonstrates that Mettl3-mediated m(6)A modification is crucial for the activation of TEK-VEGF-A-mediated tumor progression and angiogenesis in bladder cancer. Experimental results using transgenic mouse models and bladder cancer stem cell populations showed that depletion of Mettl3 inhibits tumor oncogenesis and progression in bladder cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Mariapaola Nitti, Caterina Ivaldo, Nicola Traverso, Anna Lisa Furfaro
Summary: Heme oxygenase 1 (HO-1) plays a crucial role in cancer progression, potentially leading to poor prognosis and treatment failure, with high expression levels often associated with reduced survival rates in tumor specimens.
Article
Genetics & Heredity
Min Wang, Haiyan Tao, Ping Huang
Summary: The study revealed that LARGE1 is upregulated in liver cancer cells and its knockdown significantly inhibits cell proliferation, migration, and invasion. It also affects cell cycle and tumor growth while regulating the Wnt/beta-catenin signaling pathway.
Article
Biophysics
Melanie MacGregor, Hanieh Safizadeh Shirazi, Kit Man Chan, Kola Ostrikov, Kym McNicholas, Alex Jay, Michael Chong, Alexander H. Staudacher, Thomas D. Michl, Aigerim Zhalgasbaikyzy, Michael P. Brown, Moein Navvab Kashani, Adam Di Fiore, Alex Grochowski, Stephen Robb, Simon Belcher, Jordan Li, Jonathan M. Gleadle, Krasimir Vasilev
Summary: The non-invasive diagnostic platform presented in this study combines microfluidic technology with PDD principles and immunocapture technology to detect shed bladder cancer cells in patient urine, achieving highly specific capture rates. In a pilot study, it successfully differentiated bladder cancer patients from non-cancer controls, showing potential for post-treatment surveillance and cancer detection in suspected bladder cancer patients.
BIOSENSORS & BIOELECTRONICS
(2021)