RET gene mutations (genotype and phenotype) of multiple endocrine neoplasia type 2 and familial medullary thyroid carcinoma

RET/PTC1-Driven Neoplastic Transformation and Proinvasive Phenotype of Human Thyrocytes Involve Met Induction and β-Catenin Nuclear Translocation

(2015) Giuliana Cassinelli et al.   NEOPLASIA

Cabozantinib in Progressive Medullary Thyroid Cancer

(2013) Rossella Elisei et al.   JOURNAL OF CLINICAL ONCOLOGY

Hereditary Medullary Thyroid Cancer: Age-Appropriate Thyroidectomy Improves Disease-Free Survival

(2012) Kevin Shepet et al.   ANNALS OF SURGICAL ONCOLOGY

Analysis of the efficacy and toxicity of sorafenib in thyroid cancer: a phase II study in a UK based population

(2011) Merina Ahmed et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Multiple endocrine neoplasia type 2: An overview

(2011) Jessica Moline et al.   GENETICS IN MEDICINE

SOX9 controls epithelial branching by activating RET effector genes during kidney development

(2011) Antoine Reginensi et al.   HUMAN MOLECULAR GENETICS

Vandetanib in Patients With Locally Advanced or Metastatic Medullary Thyroid Cancer: A Randomized, Double-Blind Phase III Trial

(2011) Samuel A. Wells et al.   JOURNAL OF CLINICAL ONCOLOGY

RET and GDNF mutations are rare in fetuses with renal agenesis or other severe kidney development defects

(2011) C. Jeanpierre et al.   JOURNAL OF MEDICAL GENETICS

Differential expression of c-Ret in motor neurons versus non-neuronal cells is linked to the pathogenesis of ALS

(2011) Hoon Ryu et al.   LABORATORY INVESTIGATION

Xanthohumol inhibits the neuroendocrine transcription factor achaete-scute complex-like 1, suppresses proliferation, and induces phosphorylated ERK1/2 in medullary thyroid cancer

(2010) Mackenzie R. Cook et al.   AMERICAN JOURNAL OF SURGERY

Resveratrol Induces Notch2-Mediated Apoptosis and Suppression of Neuroendocrine Markers in Medullary Thyroid Cancer

(2010) Matthew Truong et al.   ANNALS OF SURGICAL ONCOLOGY

A Phase I Study of Weekly R1507, A Human Monoclonal Antibody Insulin-like Growth Factor-I Receptor Antagonist, in Patients with Advanced Solid Tumors

(2010) R. Kurzrock et al.   CLINICAL CANCER RESEARCH

Protein kinase A regulates GDNF/RET-dependent but not GDNF/Ret-independent ureteric bud outgrowth from the Wolffian duct

(2010) James B. Tee et al.   DEVELOPMENTAL BIOLOGY

The RET polymorphic allele S836S is associated with early metastatic disease in patients with hereditary or sporadic medullary thyroid carcinoma

(2010) Débora R Siqueira et al.   ENDOCRINE-RELATED CANCER

Update multiple endocrine neoplasia type 2

(2010) Friedhelm Raue et al.   Familial Cancer

Phase II Clinical Trial of Sorafenib in Metastatic Medullary Thyroid Cancer

(2010) Elaine T. Lam et al.   JOURNAL OF CLINICAL ONCOLOGY

RET Signaling Is Required for Survival and Normal Function of Nonpeptidergic Nociceptors

(2010) J. P. Golden et al.   JOURNAL OF NEUROSCIENCE

Efficacy of Sunitinib in Advanced Medullary Thyroid Carcinoma: Intermediate Results of Phase II THYSU

(2010) A. Ravaud et al.   ONCOLOGIST

The North American Neuroendocrine Tumor Society Consensus Guideline for the Diagnosis and Management of Neuroendocrine Tumors

(2010) Herbert Chen et al.   PANCREAS

Multiple Endocrine Neoplasia Type 2B with a RET Proto-Oncogene A883F Mutation Displays a More Indolent Form of Medullary Thyroid Carcinoma Compared with a RET M918T Mutation

(2010) Sina Jasim et al.   THYROID

Factors Predicting Outcome of Total Thyroidectomy in Young Patients with Multiple Endocrine Neoplasia Type 2: A Nationwide Long-Term Follow-up Study

(2010) Jennifer M. J. Schreinemakers et al.   WORLD JOURNAL OF SURGERY

The many faces of RET dysfunction in kidney

(2010) Sanjay Jain   Organogenesis

Targeting the RET Pathway in Thyroid Cancer

(2009) S. A. Wells et al.   CLINICAL CANCER RESEARCH

Overexpression and activation of EGFR and VEGFR2 in medullary thyroid carcinomas is related to metastasis

(2009) Cristina Rodríguez-Antona et al.   ENDOCRINE-RELATED CANCER

Phase II Study of Safety and Efficacy of Motesanib in Patients With Progressive or Symptomatic, Advanced or Metastatic Medullary Thyroid Cancer

(2009) Martin J. Schlumberger et al.   JOURNAL OF CLINICAL ONCOLOGY

Molecular genetics of medullary thyroid carcinoma: the quest for novel therapeutic targets

(2009) Aniello Cerrato et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Tautomycetin and tautomycin suppress the growth of medullary thyroid cancer cells via inhibition of glycogen synthase kinase-3 

(2009) J. T. Adler et al.   MOLECULAR CANCER THERAPEUTICS

Medullary Thyroid Cancer: Management Guidelines of the American Thyroid Association

(2009) Richard T. Kloos (Chair) et al.   THYROID

Renal Aplasia in Humans Is Associated with RET Mutations

(2008) Michael A. Skinner et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Y606CRETmutation causes a receptor gain of function

(2008) T. Ercolino et al.   CLINICAL ENDOCRINOLOGY

Difference in development of medullary thyroid carcinoma among carriers of RET mutations in codons 790 and 791*

(2008) Karin Frank-Raue et al.   CLINICAL ENDOCRINOLOGY

Characterization of the RET protooncogene transmembrane domain mutation S649L associated with nonaggressive medullary thyroid carcinoma.

(2008) Mario Colombo-Benkmann et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

RET oncogene in MEN2, MEN2B, MTC and other forms of thyroid cancer

(2008) Maya B Lodish et al.   Expert Review of Anticancer Therapy

Axitinib Is an Active Treatment for All Histologic Subtypes of Advanced Thyroid Cancer: Results From a Phase II Study

(2008) Ezra E.W. Cohen et al.   JOURNAL OF CLINICAL ONCOLOGY

Neurturin-Mediated Ret Activation Is Required for Retinal Function

(2008) M. A. Brantley et al.   JOURNAL OF NEUROSCIENCE

Inhibition of Growth in Medullary Thyroid Cancer Cells with Histone Deacetylase Inhibitors and Lithium Chloride

(2008) Joel T. Adler et al.   JOURNAL OF SURGICAL RESEARCH

Array CGH demonstrates characteristic aberration signatures in human papillary thyroid carcinomas governed by RET/PTC

(2008) K Unger et al.   ONCOGENE

Current Management of Medullary Thyroid Cancer

(2008) R. S. Sippel et al.   ONCOLOGIST

Multiple endocrine neoplasia syndromes, children, Hirschsprung’s disease and RET

(2008) S. W. Moore et al.   PEDIATRIC SURGERY INTERNATIONAL

A New Germline Point Mutation in Ret Exon 8 (Cys515Ser) in a Family with Medullary Thyroid Carcinoma

(2008) Francesca Fazioli et al.   THYROID

Prognostic Significance of SomaticRETOncogene Mutations in Sporadic Medullary Thyroid Cancer: A 10-Year Follow-Up Study

(2007) Rossella Elisei et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM