Article
Biology
Mahmoud I. Khalil, Alaa F. Agamy, Salma S. Elshewemi, Ahmed S. Sultan, Nabila E. Abdelmeguid
Summary: This study investigated the effect of PTE on HepG2 cells and found that PTE can suppress cell proliferation and survival, induce apoptosis, and alter cellular ultrastructure morphology and expression of key proteins.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Endocrinology & Metabolism
Simona Censi, Jacopo Manso, Caterina Mian
Summary: Medullary thyroid cancer (MTC) is a rare neuroendocrine tumor originating from parafollicular C-cells. An early diagnosis is crucial for proper treatment. Currently, there is insufficient evidence to establish effective evaluation flowcharts for MTC involving alternative serum markers. Further studies are needed to shed more light on this challenge.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Karin Saljo, Anders Thornell, Chunsheng Jin, Olov Norlen, Susann Teneberg
Summary: The study found higher levels of acid glycosphingolipids in human MTCs and identified potential tumor-specific markers; Immunohistochemistry showed extensive expression of Le(y) in MTC cells, as well as variable intensity and prevalence of Globo H and Le(x); One individual with multiple endocrine neoplasia type 2B expressed the rare Forssman determinant.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ruye Ma, Dandan Yu, Yu Peng, Hongfei Yi, Yingcong Wang, Taofang Cheng, Bingqing Shi, Guang Yang, Weiming Lai, Xiaosong Wu, Ye Lu, Jumei Shi
Summary: Resveratrol showed anti-tumor effects against multiple myeloma (MM) by promoting apoptosis and autophagy, leading to inhibition of cell viability and colony formation in MM cell lines U266, RPMI-8226, and NCI-H929. The involvement of autophagy in the anti-MM activity of resveratrol was confirmed, suggesting that resveratrol may be a potential therapeutic strategy for MM treatment.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Endocrinology & Metabolism
Canxiao Li, Han Zhang, Shijie Li, Daqi Zhang, Jingting Li, Gianlorenzo Dionigi, Nan Liang, Hui Sun
Summary: This study investigated the relationship between inflammatory indices and postoperative calcitonin progression in medullary thyroid carcinoma (MTC), and found that PLR, LMR, PDW, and MPV were associated with clinicopathological features and postoperative Ctn progression in MTC.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ding-Ping Sun, Jui-Tai Chen, Shun-Tai Yang, Tso-Hsiao Chen, Shing-Hwa Liu, Ruei-Ming Chen
Summary: This study investigated the effect of resveratrol on neuroblastoma cells and the survival of mice with neuroblastomas. Resveratrol induced apoptosis and autophagy in neuroblastoma cells and triggered ER stress and iROS production. It also suppressed cell migration by inhibiting the ER stress-iROS axis. Resveratrol had minimal side effects and extended the survival of neuroblastoma-bearing mice. This research suggests that resveratrol could be a potential drug candidate for neuroblastoma chemotherapy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Medicine, Research & Experimental
Jiahua Zheng, Shaochai Wei, Tingting Xiao, Guanwu Li
Summary: This study demonstrates that resveratrol induces non-canonical autophagy and apoptosis activation simultaneously in A549 lung cancer cells, while mitophagy mediated by LC3B/p62 interaction protects tumor cells against apoptosis.
Article
Oncology
Davide Saronni, Germano Gaudenzi, Alessandra Dicitore, Silvia Carra, Maria Celeste Cantone, Maria Orietta Borghi, Andrea Barbieri, Luca Mignani, Leo J. Hofland, Luca Persani, Giovanni Vitale
Summary: Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor that originates from the parafollicular C cells of the thyroid gland. This preclinical study aimed to evaluate the efficacy of three tyrosine-kinase inhibitors (TKIs), SU5402, sulfatinib, and SPP86, for the treatment of MTC. In vitro experiments were conducted using two human MTC cell lines, and in vivo experiments were performed using xenografts of MTC cells in zebrafish embryos. The results showed that these TKIs reduced cell viability and induced apoptosis in MTC cells. Furthermore, they inhibited cell migration and angiogenesis in zebrafish embryos. These findings suggest that targeting the FGFR and VEGFR signaling pathways may be a potential alternative therapy for MTC.
Article
Chemistry, Multidisciplinary
Tong Sun, Yu-jia Xu, Shuo-yi Jiang, Zhuan Xu, Bi-yin Cao, Gautam Sethi, Yuan-ying Zeng, Yan Kong, Xin-liang Mao
Summary: Recent studies have shown that the expression of CCND1 and the dysregulation of USP10 play crucial roles in glioma progression. Interactions between CCND1 and USP10 affect cell cycle control and apoptosis in GBM cells, highlighting their potential as therapeutic targets for GBM patients. The natural product acevaltrate (AVT) derived from Valeriana jatamansi Jones has shown promising effects in inducing GBM cell apoptosis by suppressing USP10-mediated deubiquitination on CCND1.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Endocrinology & Metabolism
Hamdy A. A. Aly
Summary: Diabetes induces testicular damage, partially through inducing mitochondria-mediated apoptosis and oxidative stress. Resveratrol administration improves diabetes-induced testicular dysfunction through its antioxidant and anti-apoptotic effects.
Review
Microbiology
Darshika J. Udawatte, Alan L. Rothman
Summary: RIPK1 serves as a key regulator of cell death and inflammation, affecting the outcome of virus infections through activation of different signaling pathways. Viruses manipulate host immune responses by targeting RIPK1, highlighting potential directions for future research.
Article
Oncology
Imran Ahmad, Saurabh Pal, Ranjana Singh, Khursheed Ahmad, Nilanjan Dey, Aditi Srivastava, Rumana Ahmad, Muath Suliman, Mohammad Y. Alshahrani, Md. Abul Barkat, Sahabjada Siddiqui
Summary: This study investigates the anticancer potential and underlying mechanism of moricin peptide-induced cell death in triple negative cancer cells. In silico analysis predicts the anticancer potential of moricin, while molecular docking reveals a strong binding interaction between moricin and signaling proteins. In vitro studies demonstrate that moricin exposure leads to dose dependent inhibition of cell viability and caspase-dependent cell death.
CANCER CELL INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Minh-Hanh Thi Nguyen, Dat Da Ly, Nhung Thi Nguyen, Xu-Feng Qi, Hyon-Seung Yi, Minho Shong, Seung-Kuy Cha, Sangkyu Park, Kyu-Sang Park
Summary: Short-term exposure to T-3 induces UCP1 upregulation and mitochondrial activation in brown adipocytes through PLC-mediated elevation of [Ca2+].
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Qinqin Xu, Ryan P. Mackay, Adam Y. Xiao, John A. Copland, Paul M. Weinberger
Summary: ATC is a highly lethal malignancy with no effective treatment currently available. YM155, identified as a promising candidate in a high-throughput screen, shows potential as a targeted therapy for ATC by inhibiting proliferation of cancer cells while sparing normal cells, inducing DNA damage, cell cycle arrest, and apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pathology
Maryam Zarkesh, Noman Arab, Seyed Mohmmad Tavangar, Zahra Nozhat, S. Melika Fanaei, Mehdi Hedayati
Summary: Medullary thyroid cancer (MTC) is the third most common subtype of thyroid cancer, with calcitonin (CT) and carcinoembryonic antigen (CEA) playing important roles in its diagnosis. Combining multiple biomarkers may offer new avenues for the diagnosis, prognosis, and prediction of MTC.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Urology & Nephrology
M. L. Blute, J. M. Shiau, M. Truong, Fangfang Shi, E. J. Abel, T. M. Downs, D. F. Jarrard
WORLD JOURNAL OF UROLOGY
(2017)
Article
Oncology
Selvi Kunnimalaiyaan, Victoriana K. Schwartz, Iris Alao Jackson, T. Clark Gamblin, Muthusamy Kunnimalaiyaan
Editorial Material
Urology & Nephrology
Matthew Truong
JOURNAL OF UROLOGY
(2018)
Article
Urology & Nephrology
Matthew Truong, Changyong Feng, Gary Hollenberg, Eric Weinberg, Edward M. Messing, Hiroshi Miyamoto, Thomas P. Frye
JOURNAL OF UROLOGY
(2018)
Review
Urology & Nephrology
Matthew Truong, Thomas Frye, Edward Messing, Hiroshi Miyamoto
NATURE REVIEWS UROLOGY
(2018)
Editorial Material
Urology & Nephrology
Matthew Truong
Article
Multidisciplinary Sciences
Samuel Engelsgjerd, Selvi Kunnimalaiyaan, Emad Kandil, T. Clark Gamblin, Muthusamy Kunnimalaiyaan
Article
Urology & Nephrology
Marc A. Bjurlin, Audrey Renson, Soroush Rais-Bahrami, Matthew Truong, Andrew B. Rosenkrantz, Richard Huang, Samir S. Taneja
EUROPEAN UROLOGY FOCUS
(2019)
Article
Oncology
Matthew Truong, Janet E. Baack Kukreja, Soroush Rais-Bahrami, Nimrod S. Barashi, Bokai Wang, Zachary Nuffer, Ji Hae Park, Khoa Lam, Thomas P. Frye, Jeffrey W. Nix, John Thomas, Changyong Feng, Brian F. Chapin, John W. Davis, Gary Hollenberg, Aytekin Oto, Scott E. Eggener, Jean Joseph, Eric Weinberg, Edward M. Messing
EUROPEAN UROLOGY ONCOLOGY
(2019)
Article
Urology & Nephrology
Matthew Truong, Eric Weinberg, Gary Hollenberg, Marianne Borch, Ji Hae Park, Jacob Gantz, Changyong Feng, Thomas Frye, Ahmed Ghazi, Guan Wu, Jean Joseph, Hani Rashid, Edward Messing
Letter
Oncology
Jennifer B. Gordetsky, Matthew Truong, Soroush Rais-Bahrami
Article
Oncology
Matthew Truong, Bokai Wang, Jennifer B. Gordetsky, Jeffrey W. Nix, Thomas P. Frye, Edward M. Messing, John V. Thomas, Changyong Feng, Soroush Rais-Bahrami
Article
Urology & Nephrology
Matthew Truong, Lorraine Liang, Janet Kukreja, Jeanne O'Brien, Jerome Jean-Gilles, Edward Messing
CUAJ-CANADIAN UROLOGICAL ASSOCIATION JOURNAL
(2017)
Article
Surgery
Selvi Kunnimalaiyaan, Kevin Sokolowski, T. Clark Gamblin, Muthusamy Kunnimalaiyaan
AMERICAN JOURNAL OF SURGERY
(2017)
Review
Andrology
Matthew Truong, Thomas P. Frye
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2017)