Article
Oncology
Lirong Wang, Yong Fan, Yu Zhou, Gang Zhong
Summary: The effectiveness of limb-salvage treatment for osteosarcoma in adolescent patients was evaluated. The findings showed that limb-salvage treatment had longer overall survival and progression-free survival compared to amputation treatment, with a higher five-year survival rate. However, limb-salvage treatment had a significantly higher local recurrence rate, while the distant metastasis rate did not differ significantly between the two treatment groups.
Article
Oncology
Yan Li, Yiwei Fu, Zhaohui Zhang, Zhuo Wang, Junqiang Yin, Jingnan Shen
Summary: Osteosarcoma, a common primary bone malignancy in children and adolescents, is typically treated with surgery and chemotherapy. The use of ifosfamide in neoadjuvant chemotherapy regimens for osteosarcoma is controversial, with limited studies focusing on surgical options. This retrospective study compares the characteristics of amputation and limb salvage osteosarcoma patients and analyzes the role of ifosfamide in surgical decision-making, particularly in mediating tumor response and volume change.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Saminathan Suresh Nathan, Grace Tan Lay Hua, Chan Mei Yoke, Tan Mann Hong, Barry Peter Pereira
Summary: The study indicates that joint salvage is crucial in maintaining the relevance of limb salvage ethos. Results show that patients who undergo joint preservation surgery have significantly better physical health scores compared to those who undergo joint replacement surgery.
EUROPEAN JOURNAL OF CANCER CARE
(2021)
Article
Dermatology
Mohamed A. Abdelgawad, Della G. T. Parambi, Mohammed M. Ghoneim, Nasser Hadal Alotaibi, Abdulaziz Ibrahim Alzarea, Ahmed Hm Hassan, Mohamed E. A. Abdelrahim
Summary: The study aimed to establish the relationship between the effect of limb salvage surgery (LSS) and amputation in patients with osteogenic sarcoma. The results showed that patients treated with LSS had a higher local recurrence rate than those treated with amputation, but they also had higher overall survival rates at 5 years. However, there was no significant difference in the 5-year disease-free survival rates between LSS and amputation.
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Surgery
Zane B. Perkins, Alexander J. Kersey, Joseph M. White, Alexis L. Lauria, Brandon W. Propper, Nigel R. M. Tai, Todd E. Rasmussen
Summary: The study found that successful limb salvage is closely related to the duration of ischemia, with a 10% reduction in the probability of successful limb salvage for every hour delay to revascularization. Military trauma systems should prioritize rapid hemorrhage control and early limb revascularization.
Article
Surgery
Jinkui Wang, Jie Tang, Xiaojun Tan, Chenghao Zhanghuang, Liming Jin, Mujie Li, Zhaoxia Zhang, Tao Mi, Dawei He
Summary: Using propensity score matching analysis, this study compared the difference in cancer-specific mortality between amputation and limb-salvage surgery in pediatric patients with limb osteosarcoma. The results indicated that limb salvage surgery is associated with a lower cancer-specific mortality rate.
FRONTIERS IN SURGERY
(2022)
Article
Oncology
Kaixu Yu, Ying Chen, Kehan Song, Fanxiu Xiong, Yahao Tian, Hanfeng Guan, Feng Li
Summary: Limb salvage surgery has positive impact on prognosis of patients with EBST sarcomas, but the extent of impact varies depending on the pathological subtype and stage.
FRONTIERS IN ONCOLOGY
(2022)
Article
Surgery
Jorge A. Miranda, Zachary Pallister, Sherene Sharath, Lucas Ferrer, Jayer Chung, Brian Lepow, Joseph L. Mills, Miguel Montero-Baker
Summary: This study reviewed the outcomes of venous arterialization (VA) in chronic limb-threatening ischemia (CLTI). The findings suggest that superficial and deep VA are feasible options for limb salvage in patients who cannot undergo conventional revascularization methods.
JOURNAL OF VASCULAR SURGERY
(2022)
Article
Surgery
Maarten C. Verwer, Joep G. J. Wijnand, Martin Teraa, Marianne C. Verhaar, Gert J. de Borst
Summary: The study found that five years after inclusion, 43% of patients with non-revascularisable CLTI survived without amputation. However, this outcome was mainly driven by all cause mortality and amputation rate, especially in the first year.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2021)
Article
Medicine, General & Internal
Alessia Scatena, Pasquale Petruzzi, Filippo Maioli, Francesca Lucaroni, Cristina Ambrosone, Giorgio Ventoruzzo, Francesco Liistro, Danilo Tacconi, Marianna Di Filippi, Nico Attempati, Leonardo Palombi, Leonardo Ercolini, Leonardo Bolognese
Summary: The study showed that treatment with autologous PBMNC implants in NO-CLI patients with DFUs significantly reduced amputation rate, improved survival, and promoted wound healing. Autologous PBMNC injection may effectively prevent amputations in patients with DFUs.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Surgery
Ombretta Martinelli, Francesca Miceli, Simone Cuozzo, Francesco Giosue Irace, Stefano Avenia, Immacolata Iannone, Ilaria Clementi, Paolo Sapienza, Maria Irene Bellini
Summary: This study assessed the impact of TIVS on limb salvage in complex civilian vascular traumas and found that TIVS can minimize revascularization time and improve the probability of limb salvage.
FRONTIERS IN SURGERY
(2023)
Article
Orthopedics
Tiao Lin, Qinglin Jin, Xiaolin Mo, Zhiqiang Zhao, Xianbiao Xie, Changye Zou, Gang Huang, Junqiang Yin, Jingnan Shen
Summary: This study analyzed 53 patients with periprosthetic infection after segmental tumor endoprosthetic replacement for osteosarcoma in the lower extremities between January 2010 and July 2019. The findings suggest that total operation time and blood loss during limb salvage surgery are major risk factors for early periprosthetic joint infection. A two-stage revision strategy remains effective for managing PJI patients.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Medicine, General & Internal
Stephen M. Goldman, Susan L. Eskridge, Sarah R. Franco, Jason M. Souza, Scott M. Tintle, Thomas C. Dowd, Joseph Alderete, Benjamin K. Potter, Christopher L. Dearth
Summary: The aim of this study was to develop a data-driven approach for identifying limb salvage cases and studying their clinical outcomes. With the use of medical code data, a population of 2018 US Service members who underwent limb salvage was identified, representing 59.5% of the combat-related lower extremity trauma population. Comparison with expert opinion showed moderate agreement, and the approach demonstrated potential for future retrospective analyses of short- and long-term outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Vikas S. Kotha, Kenneth L. Fan, Jonathan A. Schwitzer, Richard Youn, Cara K. Black, Christopher E. Attinger, Karen K. Evans
Summary: Among diabetic patients undergoing lower extremity free flap surgery, risk factors for future amputation include end-stage renal disease, hindfoot wounds, hemoglobin A1C level greater than 8.4 percent, and positive wound cultures. However, successful limb preservation after free flap limb salvage is possible.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Article
Medicine, General & Internal
Sorin Barac, Roxana Ramona Onofrei, Petru Vlad Neagoe, Alexandra Ioana Popescu, Stelian Pantea, Andreea Luciana Rata
Summary: In an observational study on patients with acute limb ischemia and SARS-CoV-2 infection, it was found that the presence of SARS-CoV-2 did not influence amputation-free survival rate, but was associated with arterial thrombosis and acute ischemic events. The standard treatment of open surgery or endovascular revascularization in these patients is crucial for lower limb salvage.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Giulia Ottaviani, L. Maximilian Buja
CARDIOVASCULAR PATHOLOGY
(2020)
Review
Cardiac & Cardiovascular Systems
Louis Maximilian Buja, Dwayne A. Wolf, Bihong Zhao, Bindu Akkanti, Michelle McDonald, Laura Lelenwa, Noah Reilly, Giulia Ottaviani, M. Tarek Elghetany, Daniel Ocazionez Trujillo, Gabriel M. Aisenberg, Mohammad Madjid, Biswajit Kar
CARDIOVASCULAR PATHOLOGY
(2020)
Review
Pathology
Simone Gusmao Ramos, Bruna Amanda da Cruz Rattis, Giulia Ottaviani, Mara Rubia Nunes Celes, Eliane Pedra Dias
Summary: COVID-19, caused by SARS-CoV-2, produces extensive damage to the body and affects important organ systems, leading to changes in microcirculation and injury mechanisms in different organs. The research provides a new assessment of COVID-19, exploring it as a transient molecular disease, and offers new insights for a rational treatment strategy.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Louis Maximilian Buja, Bihong Zhao, Michelle McDonald, Giulia Ottaviani, Dwayne A. Wolf
CARDIOVASCULAR PATHOLOGY
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
J. Howard Jaster, Roberto Biagi, Aldo Bruno Gianni, Giulia Ottaviani
CARDIOVASCULAR PATHOLOGY
(2021)
Letter
Cardiac & Cardiovascular Systems
J. Howard Jaster, Giulia Ottaviani
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Giulia Ottaviani, Graziella Alfonsi, Simone G. Ramos, L. Maximilian Buja
Summary: A retrospective study analyzed 23 hearts diagnosed as ACM from 1109 consecutive cases, with focus on CCS anomalies. The majority of ACM cases were SUCD, characterized by arrhythmias possibly due to CCS abnormalities. Future research should further explore the implications of CCS anomalies in diagnostic criteria and risk assessment for sudden cardiac death.
Editorial Material
Medicine, General & Internal
Simone Gusmao Ramos, Giulia Ottaviani, Luiz Cesar Peres, Bruna Amanda Cruz Rattis, Patricia Santos Leao, Thamiris Nadaf Akel, Leticia Ussem, Caio Antonio Campos Prado, Elaine Christine Dantas Moises, Lilian Christiane Andrade Grimm, Eliane Pedra Dias
Letter
Critical Care Medicine
J. Howard Jaster, Giulia Ottaviani
ACUTE AND CRITICAL CARE
(2022)
Letter
Clinical Neurology
J. Howard Jaster, Giulia Ottaviani
NEUROLOGICAL SCIENCES
(2022)
Article
Medicine, General & Internal
J. Howard Jaster, Giulia Ottaviani
Summary: This study investigates the relationship between sudden death after heart failure and brain-related causes, identifying severe cardiac arrhythmia and neurogenic pulmonary edema as two causes of sudden death, both related to the brainstem autonomic nuclei. The study proposes a new research avenue of intervening in cardiac arrhythmias through head-tilting and other head repositioning maneuvers.
Article
Cardiac & Cardiovascular Systems
Michelle M. McDonald, Maks Mihalj, Bihong Zhao, Sriram Nathan, Stanislava Matejin, Giulia Ottaviani, Mateja K. Jezovnik, Rajko Radovancevic, Biswajit Kar, Igor D. Gregoric, L. Maximilian Buja
Summary: This study identifies acute myocardial injury (AMI) as a common pathological phenomenon in patients who underwent orthotopic heart transplantation (OHT) and experienced death or re-transplantation. The presence of AMI correlates with the occurrence of severe primary graft dysfunction and shorter survival times.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Biographical-Item
Oncology
Giulia Ottaviani
Summary: Outcomes are favorable for children with type I and Ir pleuropulmonary blastoma, but some children may progress to advanced disease. Chemotherapy may be beneficial for a subset of type I pleuropulmonary blastoma children at increased risk for recurrence/progression.
Article
Medicine, General & Internal
Giulia Ottaviani, Simone G. Ramos
Summary: Sudden unexpected death (SUD) is a fatal event that occurs suddenly in apparently healthy individuals without any prediction. SUD can occur as the first manifestation of an unknown underlying disease or within a few hours of the presentation of a disease. The study examined 75 SUD victims and found frequent congenital alterations of the cardiac conduction system in fetuses and infants.
Review
Dentistry, Oral Surgery & Medicine
Jack A. Harris, Giulia Ottaviani, Nathaniel S. Treister, Glenn J. Hanna
Summary: With the increasing incidence of cancer, the utilization of cancer therapeutics and their oral and dental complications are on the rise. The acute and chronic oral toxicities of cancer therapy, while mostly unavoidable, can be managed appropriately and in a timely manner to improve outcomes. Multidisciplinary healthcare teams composed of medical oncologists, dentists, and other oral healthcare specialists are essential for increasing awareness, prevention, and treatment of the significant impacts of cancer therapy on oral health.
FRONTIERS IN ORAL HEALTH
(2022)